Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism

Autores
Vidal, Patricia Noemi; Miceli, Diego Daniel; Arias, Elber Soler; Danna, Elena Blanca; García, Jorge D.; Castillo, Victor Alejandro
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Hyperadrenocorticism is a frequent disease in dogs. The excess of circulating cortisol affects different organs and metabolic pathways, producing severe adverse effects that endanger the animal’s life. Among these effects, hypertension and renal damage can be mentioned. A group of 20 dogs with pituitary dependent hyperadrenocorticism (PDH) and 12 control dogs were used to study the following parameters: cortisol and nitric oxide (NO nit/nit) concentrations, diastolic and systolic blood pressure, renal artery resistance index by Doppler ultrasound, the rate of glomerular filtration by radio-renogram excretion and the presence of proteins in urine. Dogs with PDH showed a significantly lower NO nit/nit (P<0.0001) than the controls and this correlated with high values of diastolic and systolic pressure (r =-0.87; P<0.0001 and r =-0.81; P<0.0001 respectively). Most dogs (80%) are hypertensive mainly due to an increase in diastolic pressure, which correlated positively with the UPC (r = 0.8; P<0.001) and negatively with the glomerular rate of filtration (r =-0.58; P=0.007). Systolic pressure only increased in 60% of the cases and did not correlate with the mentioned variables. In PDH the decrease of NO affects blood pressure. The diastolic pressure would seem to have the greatest impact on the kidneys, therefore its evaluation and control are important to avoid and/or control renal damage.
Fil: Vidal, Patricia Noemi. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Pequeños; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Hospital Escuela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Pequeños; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Hospital Escuela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Arias, Elber Soler. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Pequeños; Argentina
Fil: Danna, Elena Blanca. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Hospital Escuela; Argentina. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Pequeños; Argentina
Fil: García, Jorge D.. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Pequeños; Argentina
Fil: Castillo, Victor Alejandro. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Pequeños; Argentina
Materia
BLOOD PRESSION
HYPERADRENOCORTICISM PITUITARY DEPENDENT
NITRIC OXIDE
RENAL FUNCTION
SCINTIGRAPHY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/87376
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/87376
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticismVidal, Patricia NoemiMiceli, Diego DanielArias, Elber SolerDanna, Elena BlancaGarcía, Jorge D.Castillo, Victor AlejandroBLOOD PRESSIONHYPERADRENOCORTICISM PITUITARY DEPENDENTNITRIC OXIDERENAL FUNCTIONSCINTIGRAPHYhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Hyperadrenocorticism is a frequent disease in dogs. The excess of circulating cortisol affects different organs and metabolic pathways, producing severe adverse effects that endanger the animal’s life. Among these effects, hypertension and renal damage can be mentioned. A group of 20 dogs with pituitary dependent hyperadrenocorticism (PDH) and 12 control dogs were used to study the following parameters: cortisol and nitric oxide (NO nit/nit) concentrations, diastolic and systolic blood pressure, renal artery resistance index by Doppler ultrasound, the rate of glomerular filtration by radio-renogram excretion and the presence of proteins in urine. Dogs with PDH showed a significantly lower NO nit/nit (P<0.0001) than the controls and this correlated with high values of diastolic and systolic pressure (r =-0.87; P<0.0001 and r =-0.81; P<0.0001 respectively). Most dogs (80%) are hypertensive mainly due to an increase in diastolic pressure, which correlated positively with the UPC (r = 0.8; P<0.001) and negatively with the glomerular rate of filtration (r =-0.58; P=0.007). Systolic pressure only increased in 60% of the cases and did not correlate with the mentioned variables. In PDH the decrease of NO affects blood pressure. The diastolic pressure would seem to have the greatest impact on the kidneys, therefore its evaluation and control are important to avoid and/or control renal damage.Fil: Vidal, Patricia Noemi. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Pequeños; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Hospital Escuela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Pequeños; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Hospital Escuela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Arias, Elber Soler. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Pequeños; ArgentinaFil: Danna, Elena Blanca. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Hospital Escuela; Argentina. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Pequeños; ArgentinaFil: García, Jorge D.. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Pequeños; ArgentinaFil: Castillo, Victor Alejandro. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Pequeños; ArgentinaUniversity of Tripoli. Faculty of Veterinary Medicine2018-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/87376Vidal, Patricia Noemi; Miceli, Diego Daniel; Arias, Elber Soler; Danna, Elena Blanca; García, Jorge D.; et al.; Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism; University of Tripoli. Faculty of Veterinary Medicine; Open Veterinary Journal; 8; 1; 3-2018; 86-952226-4485CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ajol.info/index.php/ovj/article/view/168605info:eu-repo/semantics/altIdentifier/doi/10.4314/ovj.v8i1.14info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:47Zoai:ri.conicet.gov.ar:11336/87376instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:47.616CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism
title Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism
spellingShingle Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism
Vidal, Patricia Noemi
BLOOD PRESSION
HYPERADRENOCORTICISM PITUITARY DEPENDENT
NITRIC OXIDE
RENAL FUNCTION
SCINTIGRAPHY
title_short Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism
title_full Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism
title_fullStr Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism
title_full_unstemmed Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism
title_sort Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism
dc.creator.none.fl_str_mv Vidal, Patricia Noemi
Miceli, Diego Daniel
Arias, Elber Soler
Danna, Elena Blanca
García, Jorge D.
Castillo, Victor Alejandro
author Vidal, Patricia Noemi
author_facet Vidal, Patricia Noemi
Miceli, Diego Daniel
Arias, Elber Soler
Danna, Elena Blanca
García, Jorge D.
Castillo, Victor Alejandro
author_role author
author2 Miceli, Diego Daniel
Arias, Elber Soler
Danna, Elena Blanca
García, Jorge D.
Castillo, Victor Alejandro
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv BLOOD PRESSION
HYPERADRENOCORTICISM PITUITARY DEPENDENT
NITRIC OXIDE
RENAL FUNCTION
SCINTIGRAPHY
topic BLOOD PRESSION
HYPERADRENOCORTICISM PITUITARY DEPENDENT
NITRIC OXIDE
RENAL FUNCTION
SCINTIGRAPHY
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Hyperadrenocorticism is a frequent disease in dogs. The excess of circulating cortisol affects different organs and metabolic pathways, producing severe adverse effects that endanger the animal’s life. Among these effects, hypertension and renal damage can be mentioned. A group of 20 dogs with pituitary dependent hyperadrenocorticism (PDH) and 12 control dogs were used to study the following parameters: cortisol and nitric oxide (NO nit/nit) concentrations, diastolic and systolic blood pressure, renal artery resistance index by Doppler ultrasound, the rate of glomerular filtration by radio-renogram excretion and the presence of proteins in urine. Dogs with PDH showed a significantly lower NO nit/nit (P<0.0001) than the controls and this correlated with high values of diastolic and systolic pressure (r =-0.87; P<0.0001 and r =-0.81; P<0.0001 respectively). Most dogs (80%) are hypertensive mainly due to an increase in diastolic pressure, which correlated positively with the UPC (r = 0.8; P<0.001) and negatively with the glomerular rate of filtration (r =-0.58; P=0.007). Systolic pressure only increased in 60% of the cases and did not correlate with the mentioned variables. In PDH the decrease of NO affects blood pressure. The diastolic pressure would seem to have the greatest impact on the kidneys, therefore its evaluation and control are important to avoid and/or control renal damage.
Fil: Vidal, Patricia Noemi. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Pequeños; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Hospital Escuela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Miceli, Diego Daniel. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Pequeños; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Hospital Escuela; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Arias, Elber Soler. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Pequeños; Argentina
Fil: Danna, Elena Blanca. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Hospital Escuela; Argentina. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Pequeños; Argentina
Fil: García, Jorge D.. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Pequeños; Argentina
Fil: Castillo, Victor Alejandro. Universidad de Buenos Aires. Facultad de Cs.veterinarias. Departamento de Medicina. Clinica Medica de Animales Pequeños; Argentina
description Hyperadrenocorticism is a frequent disease in dogs. The excess of circulating cortisol affects different organs and metabolic pathways, producing severe adverse effects that endanger the animal’s life. Among these effects, hypertension and renal damage can be mentioned. A group of 20 dogs with pituitary dependent hyperadrenocorticism (PDH) and 12 control dogs were used to study the following parameters: cortisol and nitric oxide (NO nit/nit) concentrations, diastolic and systolic blood pressure, renal artery resistance index by Doppler ultrasound, the rate of glomerular filtration by radio-renogram excretion and the presence of proteins in urine. Dogs with PDH showed a significantly lower NO nit/nit (P<0.0001) than the controls and this correlated with high values of diastolic and systolic pressure (r =-0.87; P<0.0001 and r =-0.81; P<0.0001 respectively). Most dogs (80%) are hypertensive mainly due to an increase in diastolic pressure, which correlated positively with the UPC (r = 0.8; P<0.001) and negatively with the glomerular rate of filtration (r =-0.58; P=0.007). Systolic pressure only increased in 60% of the cases and did not correlate with the mentioned variables. In PDH the decrease of NO affects blood pressure. The diastolic pressure would seem to have the greatest impact on the kidneys, therefore its evaluation and control are important to avoid and/or control renal damage.
publishDate 2018
dc.date.none.fl_str_mv 2018-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/87376
Vidal, Patricia Noemi; Miceli, Diego Daniel; Arias, Elber Soler; Danna, Elena Blanca; García, Jorge D.; et al.; Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism; University of Tripoli. Faculty of Veterinary Medicine; Open Veterinary Journal; 8; 1; 3-2018; 86-95
2226-4485
CONICET Digital
CONICET
url http://hdl.handle.net/11336/87376
identifier_str_mv Vidal, Patricia Noemi; Miceli, Diego Daniel; Arias, Elber Soler; Danna, Elena Blanca; García, Jorge D.; et al.; Decrease of nitric oxide and increase in diastolic blood pressure are two events that affect renal function in dogs with pituitary dependent hyperadrenocorticism; University of Tripoli. Faculty of Veterinary Medicine; Open Veterinary Journal; 8; 1; 3-2018; 86-95
2226-4485
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ajol.info/index.php/ovj/article/view/168605
info:eu-repo/semantics/altIdentifier/doi/10.4314/ovj.v8i1.14
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv University of Tripoli. Faculty of Veterinary Medicine
publisher.none.fl_str_mv University of Tripoli. Faculty of Veterinary Medicine
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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