Nanoberries for topical delivery of antioxidants

Autores
Martinetti Montanari, Jorge Anibal; Vera, Maria; Mensi, Emanuel; Morilla, María José; Romero, Eder Lilia
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
With the aim of improving the antioxidant activity of polyphenols from blueberries (Vaccinium myrtillus) on skin targets after topical application, ethanolic extracts from three blueberry varieties (named Millenia, O?Neal and Blue Crisp) were loaded into ultradeformable liposomes. These nanocarriers are known to be capable of penetrating through the stratum corneum reaching its deeper layers and the viable epidermis. On the other hand, blueberries contain large amounts of polyphenols, whose antioxidant properties as tissue protectors against processes mediated by reactive oxygen species have been extensively proved. Blueberries are usually consumed as edible products, but their antioxidant compounds are poorly absorbed. The antioxidant properties of the extracts were screened before and after being loaded into ultradeformable liposomes made of soy phosphatidylcholine and sodium cholate, of nearly 100 nm in size at 0.223 extract/lipid w/w. The ethanolic extract-loaded ultradeformable liposomes (nano-berries) from Millenia variety retained an 85 % of the antioxidant capacity of the free extract and showed low cytotoxicity on HaCaT cells (less than 20%) at active concentration against free radicals.
Fil: Martinetti Montanari, Jorge Anibal. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vera, Maria. Universidad Nacional de Quilmes; Argentina
Fil: Mensi, Emanuel. Universidad Nacional de Quilmes; Argentina
Fil: Morilla, María José. Universidad Nacional de Quilmes; Argentina
Fil: Romero, Eder Lilia. Universidad Nacional de Quilmes; Argentina
Materia
Blueberry
Nanocosmetics
Ultradeformable
Liposomes
Antioxidants
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24741
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Nanoberries for topical delivery of antioxidantsMartinetti Montanari, Jorge AnibalVera, MariaMensi, EmanuelMorilla, María JoséRomero, Eder LiliaBlueberryNanocosmeticsUltradeformableLiposomesAntioxidantshttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2With the aim of improving the antioxidant activity of polyphenols from blueberries (Vaccinium myrtillus) on skin targets after topical application, ethanolic extracts from three blueberry varieties (named Millenia, O?Neal and Blue Crisp) were loaded into ultradeformable liposomes. These nanocarriers are known to be capable of penetrating through the stratum corneum reaching its deeper layers and the viable epidermis. On the other hand, blueberries contain large amounts of polyphenols, whose antioxidant properties as tissue protectors against processes mediated by reactive oxygen species have been extensively proved. Blueberries are usually consumed as edible products, but their antioxidant compounds are poorly absorbed. The antioxidant properties of the extracts were screened before and after being loaded into ultradeformable liposomes made of soy phosphatidylcholine and sodium cholate, of nearly 100 nm in size at 0.223 extract/lipid w/w. The ethanolic extract-loaded ultradeformable liposomes (nano-berries) from Millenia variety retained an 85 % of the antioxidant capacity of the free extract and showed low cytotoxicity on HaCaT cells (less than 20%) at active concentration against free radicals.Fil: Martinetti Montanari, Jorge Anibal. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vera, Maria. Universidad Nacional de Quilmes; ArgentinaFil: Mensi, Emanuel. Universidad Nacional de Quilmes; ArgentinaFil: Morilla, María José. Universidad Nacional de Quilmes; ArgentinaFil: Romero, Eder Lilia. Universidad Nacional de Quilmes; ArgentinaSociety of Cosmetic Chemists2013-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/zipapplication/pdfhttp://hdl.handle.net/11336/24741Martinetti Montanari, Jorge Anibal; Vera, Maria; Mensi, Emanuel; Morilla, María José; Romero, Eder Lilia; Nanoberries for topical delivery of antioxidants; Society of Cosmetic Chemists; Journal of Cosmetic Science; 64; 6; 11-2013; 469-4821525-7886CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journal.scconline.org/abstracts/cc2013/cc064n06/p00469-p00482.htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:26:25Zoai:ri.conicet.gov.ar:11336/24741instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:26:26.226CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Nanoberries for topical delivery of antioxidants
title Nanoberries for topical delivery of antioxidants
spellingShingle Nanoberries for topical delivery of antioxidants
Martinetti Montanari, Jorge Anibal
Blueberry
Nanocosmetics
Ultradeformable
Liposomes
Antioxidants
title_short Nanoberries for topical delivery of antioxidants
title_full Nanoberries for topical delivery of antioxidants
title_fullStr Nanoberries for topical delivery of antioxidants
title_full_unstemmed Nanoberries for topical delivery of antioxidants
title_sort Nanoberries for topical delivery of antioxidants
dc.creator.none.fl_str_mv Martinetti Montanari, Jorge Anibal
Vera, Maria
Mensi, Emanuel
Morilla, María José
Romero, Eder Lilia
author Martinetti Montanari, Jorge Anibal
author_facet Martinetti Montanari, Jorge Anibal
Vera, Maria
Mensi, Emanuel
Morilla, María José
Romero, Eder Lilia
author_role author
author2 Vera, Maria
Mensi, Emanuel
Morilla, María José
Romero, Eder Lilia
author2_role author
author
author
author
dc.subject.none.fl_str_mv Blueberry
Nanocosmetics
Ultradeformable
Liposomes
Antioxidants
topic Blueberry
Nanocosmetics
Ultradeformable
Liposomes
Antioxidants
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv With the aim of improving the antioxidant activity of polyphenols from blueberries (Vaccinium myrtillus) on skin targets after topical application, ethanolic extracts from three blueberry varieties (named Millenia, O?Neal and Blue Crisp) were loaded into ultradeformable liposomes. These nanocarriers are known to be capable of penetrating through the stratum corneum reaching its deeper layers and the viable epidermis. On the other hand, blueberries contain large amounts of polyphenols, whose antioxidant properties as tissue protectors against processes mediated by reactive oxygen species have been extensively proved. Blueberries are usually consumed as edible products, but their antioxidant compounds are poorly absorbed. The antioxidant properties of the extracts were screened before and after being loaded into ultradeformable liposomes made of soy phosphatidylcholine and sodium cholate, of nearly 100 nm in size at 0.223 extract/lipid w/w. The ethanolic extract-loaded ultradeformable liposomes (nano-berries) from Millenia variety retained an 85 % of the antioxidant capacity of the free extract and showed low cytotoxicity on HaCaT cells (less than 20%) at active concentration against free radicals.
Fil: Martinetti Montanari, Jorge Anibal. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vera, Maria. Universidad Nacional de Quilmes; Argentina
Fil: Mensi, Emanuel. Universidad Nacional de Quilmes; Argentina
Fil: Morilla, María José. Universidad Nacional de Quilmes; Argentina
Fil: Romero, Eder Lilia. Universidad Nacional de Quilmes; Argentina
description With the aim of improving the antioxidant activity of polyphenols from blueberries (Vaccinium myrtillus) on skin targets after topical application, ethanolic extracts from three blueberry varieties (named Millenia, O?Neal and Blue Crisp) were loaded into ultradeformable liposomes. These nanocarriers are known to be capable of penetrating through the stratum corneum reaching its deeper layers and the viable epidermis. On the other hand, blueberries contain large amounts of polyphenols, whose antioxidant properties as tissue protectors against processes mediated by reactive oxygen species have been extensively proved. Blueberries are usually consumed as edible products, but their antioxidant compounds are poorly absorbed. The antioxidant properties of the extracts were screened before and after being loaded into ultradeformable liposomes made of soy phosphatidylcholine and sodium cholate, of nearly 100 nm in size at 0.223 extract/lipid w/w. The ethanolic extract-loaded ultradeformable liposomes (nano-berries) from Millenia variety retained an 85 % of the antioxidant capacity of the free extract and showed low cytotoxicity on HaCaT cells (less than 20%) at active concentration against free radicals.
publishDate 2013
dc.date.none.fl_str_mv 2013-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24741
Martinetti Montanari, Jorge Anibal; Vera, Maria; Mensi, Emanuel; Morilla, María José; Romero, Eder Lilia; Nanoberries for topical delivery of antioxidants; Society of Cosmetic Chemists; Journal of Cosmetic Science; 64; 6; 11-2013; 469-482
1525-7886
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24741
identifier_str_mv Martinetti Montanari, Jorge Anibal; Vera, Maria; Mensi, Emanuel; Morilla, María José; Romero, Eder Lilia; Nanoberries for topical delivery of antioxidants; Society of Cosmetic Chemists; Journal of Cosmetic Science; 64; 6; 11-2013; 469-482
1525-7886
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journal.scconline.org/abstracts/cc2013/cc064n06/p00469-p00482.html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/zip
application/pdf
dc.publisher.none.fl_str_mv Society of Cosmetic Chemists
publisher.none.fl_str_mv Society of Cosmetic Chemists
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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