Hybrid nanomaterials based on gum Arabic and magnetite for hyperthermia treatments

Autores
Horst, María Fernanda; Coral, Diego Fernando; Fernández van Raap, Marcela Beatriz; Alvarez, Mariana; Lassalle, Verónica Leticia
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this study, one–step co-precipitation method was conveniently adapted to obtain novel nanomaterials based on Gum Arabic and magnetite. Two synthesis procedures were evaluated: one employing the solid biopolymer in the co-precipitation media; a second using an aqueous solution of the polysaccharide. An exhaustive characterization of both formulations was performed using several specific techniques. The obtained data confirmed the successful incorporation of the gum Arabic on the magnetic core. Values of hydrodynamic diameters, measured by dynamic light scattering, in aqueous dispersions were about 70–80 nm, while sizes lower than 20 nm were registered by TEM microscopy. Surface charge of gum Arabic coated magnetic nanoparticles was significantly different from the corresponding to raw materials (magnetite and GA). This fact confirmed the formation of hybrid nanosystems with novel and specific properties. The potential utility of these materials was tested regarding to magnetic hyperthermia therapy under radiofrequency fields. Magnetocalorimetric measurements were performed in a wide range of field amplitude and frequency. Specific absorption rate of 218 W/gFe was determined at field frequency of 260 kHz and amplitude of 52 kA/m. These results demonstrate their viability to be applied in tumor ablation treatments. Using the linear response theory and restricting field parameters to the accepted biomedical window, maximum useful value of 74 w/gFe is predicted at 417 kHz and 12 kA/m.
Fil: Horst, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Coral, Diego Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Fernández van Raap, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Alvarez, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Materia
Gum Arabic
Hyperthermia
Magnetic Nanoparticles
Magnetite
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/55811
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/55811
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Hybrid nanomaterials based on gum Arabic and magnetite for hyperthermia treatmentsHorst, María FernandaCoral, Diego FernandoFernández van Raap, Marcela BeatrizAlvarez, MarianaLassalle, Verónica LeticiaGum ArabicHyperthermiaMagnetic NanoparticlesMagnetitehttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2In this study, one–step co-precipitation method was conveniently adapted to obtain novel nanomaterials based on Gum Arabic and magnetite. Two synthesis procedures were evaluated: one employing the solid biopolymer in the co-precipitation media; a second using an aqueous solution of the polysaccharide. An exhaustive characterization of both formulations was performed using several specific techniques. The obtained data confirmed the successful incorporation of the gum Arabic on the magnetic core. Values of hydrodynamic diameters, measured by dynamic light scattering, in aqueous dispersions were about 70–80 nm, while sizes lower than 20 nm were registered by TEM microscopy. Surface charge of gum Arabic coated magnetic nanoparticles was significantly different from the corresponding to raw materials (magnetite and GA). This fact confirmed the formation of hybrid nanosystems with novel and specific properties. The potential utility of these materials was tested regarding to magnetic hyperthermia therapy under radiofrequency fields. Magnetocalorimetric measurements were performed in a wide range of field amplitude and frequency. Specific absorption rate of 218 W/gFe was determined at field frequency of 260 kHz and amplitude of 52 kA/m. These results demonstrate their viability to be applied in tumor ablation treatments. Using the linear response theory and restricting field parameters to the accepted biomedical window, maximum useful value of 74 w/gFe is predicted at 417 kHz and 12 kA/m.Fil: Horst, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Coral, Diego Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Fernández van Raap, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Alvarez, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaElsevier Science2017-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/55811Horst, María Fernanda; Coral, Diego Fernando; Fernández van Raap, Marcela Beatriz; Alvarez, Mariana; Lassalle, Verónica Leticia; Hybrid nanomaterials based on gum Arabic and magnetite for hyperthermia treatments; Elsevier Science; Materials Science and Engineering: C; 74; 5-2017; 443-4500928-4931CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0928493116308189info:eu-repo/semantics/altIdentifier/doi/10.1016/j.msec.2016.12.035info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:29Zoai:ri.conicet.gov.ar:11336/55811instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:29.789CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hybrid nanomaterials based on gum Arabic and magnetite for hyperthermia treatments
title Hybrid nanomaterials based on gum Arabic and magnetite for hyperthermia treatments
spellingShingle Hybrid nanomaterials based on gum Arabic and magnetite for hyperthermia treatments
Horst, María Fernanda
Gum Arabic
Hyperthermia
Magnetic Nanoparticles
Magnetite
title_short Hybrid nanomaterials based on gum Arabic and magnetite for hyperthermia treatments
title_full Hybrid nanomaterials based on gum Arabic and magnetite for hyperthermia treatments
title_fullStr Hybrid nanomaterials based on gum Arabic and magnetite for hyperthermia treatments
title_full_unstemmed Hybrid nanomaterials based on gum Arabic and magnetite for hyperthermia treatments
title_sort Hybrid nanomaterials based on gum Arabic and magnetite for hyperthermia treatments
dc.creator.none.fl_str_mv Horst, María Fernanda
Coral, Diego Fernando
Fernández van Raap, Marcela Beatriz
Alvarez, Mariana
Lassalle, Verónica Leticia
author Horst, María Fernanda
author_facet Horst, María Fernanda
Coral, Diego Fernando
Fernández van Raap, Marcela Beatriz
Alvarez, Mariana
Lassalle, Verónica Leticia
author_role author
author2 Coral, Diego Fernando
Fernández van Raap, Marcela Beatriz
Alvarez, Mariana
Lassalle, Verónica Leticia
author2_role author
author
author
author
dc.subject.none.fl_str_mv Gum Arabic
Hyperthermia
Magnetic Nanoparticles
Magnetite
topic Gum Arabic
Hyperthermia
Magnetic Nanoparticles
Magnetite
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv In this study, one–step co-precipitation method was conveniently adapted to obtain novel nanomaterials based on Gum Arabic and magnetite. Two synthesis procedures were evaluated: one employing the solid biopolymer in the co-precipitation media; a second using an aqueous solution of the polysaccharide. An exhaustive characterization of both formulations was performed using several specific techniques. The obtained data confirmed the successful incorporation of the gum Arabic on the magnetic core. Values of hydrodynamic diameters, measured by dynamic light scattering, in aqueous dispersions were about 70–80 nm, while sizes lower than 20 nm were registered by TEM microscopy. Surface charge of gum Arabic coated magnetic nanoparticles was significantly different from the corresponding to raw materials (magnetite and GA). This fact confirmed the formation of hybrid nanosystems with novel and specific properties. The potential utility of these materials was tested regarding to magnetic hyperthermia therapy under radiofrequency fields. Magnetocalorimetric measurements were performed in a wide range of field amplitude and frequency. Specific absorption rate of 218 W/gFe was determined at field frequency of 260 kHz and amplitude of 52 kA/m. These results demonstrate their viability to be applied in tumor ablation treatments. Using the linear response theory and restricting field parameters to the accepted biomedical window, maximum useful value of 74 w/gFe is predicted at 417 kHz and 12 kA/m.
Fil: Horst, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Coral, Diego Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Fernández van Raap, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Alvarez, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
description In this study, one–step co-precipitation method was conveniently adapted to obtain novel nanomaterials based on Gum Arabic and magnetite. Two synthesis procedures were evaluated: one employing the solid biopolymer in the co-precipitation media; a second using an aqueous solution of the polysaccharide. An exhaustive characterization of both formulations was performed using several specific techniques. The obtained data confirmed the successful incorporation of the gum Arabic on the magnetic core. Values of hydrodynamic diameters, measured by dynamic light scattering, in aqueous dispersions were about 70–80 nm, while sizes lower than 20 nm were registered by TEM microscopy. Surface charge of gum Arabic coated magnetic nanoparticles was significantly different from the corresponding to raw materials (magnetite and GA). This fact confirmed the formation of hybrid nanosystems with novel and specific properties. The potential utility of these materials was tested regarding to magnetic hyperthermia therapy under radiofrequency fields. Magnetocalorimetric measurements were performed in a wide range of field amplitude and frequency. Specific absorption rate of 218 W/gFe was determined at field frequency of 260 kHz and amplitude of 52 kA/m. These results demonstrate their viability to be applied in tumor ablation treatments. Using the linear response theory and restricting field parameters to the accepted biomedical window, maximum useful value of 74 w/gFe is predicted at 417 kHz and 12 kA/m.
publishDate 2017
dc.date.none.fl_str_mv 2017-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/55811
Horst, María Fernanda; Coral, Diego Fernando; Fernández van Raap, Marcela Beatriz; Alvarez, Mariana; Lassalle, Verónica Leticia; Hybrid nanomaterials based on gum Arabic and magnetite for hyperthermia treatments; Elsevier Science; Materials Science and Engineering: C; 74; 5-2017; 443-450
0928-4931
CONICET Digital
CONICET
url http://hdl.handle.net/11336/55811
identifier_str_mv Horst, María Fernanda; Coral, Diego Fernando; Fernández van Raap, Marcela Beatriz; Alvarez, Mariana; Lassalle, Verónica Leticia; Hybrid nanomaterials based on gum Arabic and magnetite for hyperthermia treatments; Elsevier Science; Materials Science and Engineering: C; 74; 5-2017; 443-450
0928-4931
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0928493116308189
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.msec.2016.12.035
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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