Developmental and neurobehavioral effects of perinatal exposure to diets with different ω-6:ω-3 ratios in mice

Autores
Santillan, Maria Emilia; Vincenti, Laura María; Martini, Ana Carolina; Fiol, Marta Haydee; Ruiz, Ruben Daniel; Mangeaud, Arnaldo Pedro; Stutz, Graciela
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: To investigate in mice the effect of diets enriched with soy or sunflower oil with differentm ω-6:ω-3 ratios on gestation, reproductive success, physical maturation, and the neurobiological development of the pups. Methods: Dams were assigned, throughout gestation and lactation, to different groups: a comercial diet (CD), a soy oil?enriched diet (SOD), or a sunflower oil?enriched diet (SFOD). Measurements during gestation were dams? body weights and daily food intakes. Measurements in the offspring were physical parameters (body weight, body length, body mass index, fur appearance, pinna detachment, incisor eruption, eye opening, and puberty onset) and behavioral preweaning tests (surface righting reflex, negative geotaxis, and cliff avoidance). Results: The SOD and SFOD dams became significantly heavier than the CD dams from gestational days 14 and 19, respectively, to parturition. There were no significant differences in gestational length or food consumption during pregnancy or lactation or in maternal weight during lactation. Diets did not modify litter size, sex ratio, survival index at weaning, or body weight. The SFOD and SOD offspring were significantly shorter than the CD offspring at weaning. The mean offspring physical scores of SOD and SFOD offspring were higher than CD offspring and simple reflexes were earlier in the SOD and SFOD groups. In SFOD offspring, puberty onset was significantly delayed, at postnatal days 26 and 27 in male and female offspring, respectively. Conclusion: This study suggests that the maintenance of an adequate u-6:u-3 ratio is necessary for the optimal growth and development of murine offspring. In populations that do not have sufficient provision of polyunsaturated fatty acids in the diet, their consumption would be advisable during gestation and lactation because these improve most neurodevelopmental outcomes included in this study.
Fil: Santillan, Maria Emilia. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina
Fil: Vincenti, Laura María. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina
Fil: Martini, Ana Carolina. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Fiol, Marta Haydee. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Ruiz, Ruben Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina
Fil: Mangeaud, Arnaldo Pedro. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina
Fil: Stutz, Graciela. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina
Materia
SOY OIL
SUNFLOWER OIL
PERINATAL DEVELOPMENT
POLYUNSATURATED FATTY ACID
NEUROBEHAVIOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/278679
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/278679
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Developmental and neurobehavioral effects of perinatal exposure to diets with different ω-6:ω-3 ratios in miceSantillan, Maria EmiliaVincenti, Laura MaríaMartini, Ana CarolinaFiol, Marta HaydeeRuiz, Ruben DanielMangeaud, Arnaldo PedroStutz, GracielaSOY OILSUNFLOWER OILPERINATAL DEVELOPMENTPOLYUNSATURATED FATTY ACIDNEUROBEHAVIORhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Objective: To investigate in mice the effect of diets enriched with soy or sunflower oil with differentm ω-6:ω-3 ratios on gestation, reproductive success, physical maturation, and the neurobiological development of the pups. Methods: Dams were assigned, throughout gestation and lactation, to different groups: a comercial diet (CD), a soy oil?enriched diet (SOD), or a sunflower oil?enriched diet (SFOD). Measurements during gestation were dams? body weights and daily food intakes. Measurements in the offspring were physical parameters (body weight, body length, body mass index, fur appearance, pinna detachment, incisor eruption, eye opening, and puberty onset) and behavioral preweaning tests (surface righting reflex, negative geotaxis, and cliff avoidance). Results: The SOD and SFOD dams became significantly heavier than the CD dams from gestational days 14 and 19, respectively, to parturition. There were no significant differences in gestational length or food consumption during pregnancy or lactation or in maternal weight during lactation. Diets did not modify litter size, sex ratio, survival index at weaning, or body weight. The SFOD and SOD offspring were significantly shorter than the CD offspring at weaning. The mean offspring physical scores of SOD and SFOD offspring were higher than CD offspring and simple reflexes were earlier in the SOD and SFOD groups. In SFOD offspring, puberty onset was significantly delayed, at postnatal days 26 and 27 in male and female offspring, respectively. Conclusion: This study suggests that the maintenance of an adequate u-6:u-3 ratio is necessary for the optimal growth and development of murine offspring. In populations that do not have sufficient provision of polyunsaturated fatty acids in the diet, their consumption would be advisable during gestation and lactation because these improve most neurodevelopmental outcomes included in this study.Fil: Santillan, Maria Emilia. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; ArgentinaFil: Vincenti, Laura María. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; ArgentinaFil: Martini, Ana Carolina. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Fiol, Marta Haydee. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Ruiz, Ruben Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; ArgentinaFil: Mangeaud, Arnaldo Pedro. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; ArgentinaFil: Stutz, Graciela. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; ArgentinaElsevier Science Inc.2010-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/278679Santillan, Maria Emilia; Vincenti, Laura María; Martini, Ana Carolina; Fiol, Marta Haydee; Ruiz, Ruben Daniel; et al.; Developmental and neurobehavioral effects of perinatal exposure to diets with different ω-6:ω-3 ratios in mice; Elsevier Science Inc.; Nutrition; 26; 4; 6-2010; 423-4310899-9007CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0899900709002512info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nut.2009.06.005info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-01-14T12:40:05Zoai:ri.conicet.gov.ar:11336/278679instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-01-14 12:40:06.025CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Developmental and neurobehavioral effects of perinatal exposure to diets with different ω-6:ω-3 ratios in mice
title Developmental and neurobehavioral effects of perinatal exposure to diets with different ω-6:ω-3 ratios in mice
spellingShingle Developmental and neurobehavioral effects of perinatal exposure to diets with different ω-6:ω-3 ratios in mice
Santillan, Maria Emilia
SOY OIL
SUNFLOWER OIL
PERINATAL DEVELOPMENT
POLYUNSATURATED FATTY ACID
NEUROBEHAVIOR
title_short Developmental and neurobehavioral effects of perinatal exposure to diets with different ω-6:ω-3 ratios in mice
title_full Developmental and neurobehavioral effects of perinatal exposure to diets with different ω-6:ω-3 ratios in mice
title_fullStr Developmental and neurobehavioral effects of perinatal exposure to diets with different ω-6:ω-3 ratios in mice
title_full_unstemmed Developmental and neurobehavioral effects of perinatal exposure to diets with different ω-6:ω-3 ratios in mice
title_sort Developmental and neurobehavioral effects of perinatal exposure to diets with different ω-6:ω-3 ratios in mice
dc.creator.none.fl_str_mv Santillan, Maria Emilia
Vincenti, Laura María
Martini, Ana Carolina
Fiol, Marta Haydee
Ruiz, Ruben Daniel
Mangeaud, Arnaldo Pedro
Stutz, Graciela
author Santillan, Maria Emilia
author_facet Santillan, Maria Emilia
Vincenti, Laura María
Martini, Ana Carolina
Fiol, Marta Haydee
Ruiz, Ruben Daniel
Mangeaud, Arnaldo Pedro
Stutz, Graciela
author_role author
author2 Vincenti, Laura María
Martini, Ana Carolina
Fiol, Marta Haydee
Ruiz, Ruben Daniel
Mangeaud, Arnaldo Pedro
Stutz, Graciela
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv SOY OIL
SUNFLOWER OIL
PERINATAL DEVELOPMENT
POLYUNSATURATED FATTY ACID
NEUROBEHAVIOR
topic SOY OIL
SUNFLOWER OIL
PERINATAL DEVELOPMENT
POLYUNSATURATED FATTY ACID
NEUROBEHAVIOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: To investigate in mice the effect of diets enriched with soy or sunflower oil with differentm ω-6:ω-3 ratios on gestation, reproductive success, physical maturation, and the neurobiological development of the pups. Methods: Dams were assigned, throughout gestation and lactation, to different groups: a comercial diet (CD), a soy oil?enriched diet (SOD), or a sunflower oil?enriched diet (SFOD). Measurements during gestation were dams? body weights and daily food intakes. Measurements in the offspring were physical parameters (body weight, body length, body mass index, fur appearance, pinna detachment, incisor eruption, eye opening, and puberty onset) and behavioral preweaning tests (surface righting reflex, negative geotaxis, and cliff avoidance). Results: The SOD and SFOD dams became significantly heavier than the CD dams from gestational days 14 and 19, respectively, to parturition. There were no significant differences in gestational length or food consumption during pregnancy or lactation or in maternal weight during lactation. Diets did not modify litter size, sex ratio, survival index at weaning, or body weight. The SFOD and SOD offspring were significantly shorter than the CD offspring at weaning. The mean offspring physical scores of SOD and SFOD offspring were higher than CD offspring and simple reflexes were earlier in the SOD and SFOD groups. In SFOD offspring, puberty onset was significantly delayed, at postnatal days 26 and 27 in male and female offspring, respectively. Conclusion: This study suggests that the maintenance of an adequate u-6:u-3 ratio is necessary for the optimal growth and development of murine offspring. In populations that do not have sufficient provision of polyunsaturated fatty acids in the diet, their consumption would be advisable during gestation and lactation because these improve most neurodevelopmental outcomes included in this study.
Fil: Santillan, Maria Emilia. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina
Fil: Vincenti, Laura María. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina
Fil: Martini, Ana Carolina. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Fiol, Marta Haydee. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Ruiz, Ruben Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina
Fil: Mangeaud, Arnaldo Pedro. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina
Fil: Stutz, Graciela. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina
description Objective: To investigate in mice the effect of diets enriched with soy or sunflower oil with differentm ω-6:ω-3 ratios on gestation, reproductive success, physical maturation, and the neurobiological development of the pups. Methods: Dams were assigned, throughout gestation and lactation, to different groups: a comercial diet (CD), a soy oil?enriched diet (SOD), or a sunflower oil?enriched diet (SFOD). Measurements during gestation were dams? body weights and daily food intakes. Measurements in the offspring were physical parameters (body weight, body length, body mass index, fur appearance, pinna detachment, incisor eruption, eye opening, and puberty onset) and behavioral preweaning tests (surface righting reflex, negative geotaxis, and cliff avoidance). Results: The SOD and SFOD dams became significantly heavier than the CD dams from gestational days 14 and 19, respectively, to parturition. There were no significant differences in gestational length or food consumption during pregnancy or lactation or in maternal weight during lactation. Diets did not modify litter size, sex ratio, survival index at weaning, or body weight. The SFOD and SOD offspring were significantly shorter than the CD offspring at weaning. The mean offspring physical scores of SOD and SFOD offspring were higher than CD offspring and simple reflexes were earlier in the SOD and SFOD groups. In SFOD offspring, puberty onset was significantly delayed, at postnatal days 26 and 27 in male and female offspring, respectively. Conclusion: This study suggests that the maintenance of an adequate u-6:u-3 ratio is necessary for the optimal growth and development of murine offspring. In populations that do not have sufficient provision of polyunsaturated fatty acids in the diet, their consumption would be advisable during gestation and lactation because these improve most neurodevelopmental outcomes included in this study.
publishDate 2010
dc.date.none.fl_str_mv 2010-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/278679
Santillan, Maria Emilia; Vincenti, Laura María; Martini, Ana Carolina; Fiol, Marta Haydee; Ruiz, Ruben Daniel; et al.; Developmental and neurobehavioral effects of perinatal exposure to diets with different ω-6:ω-3 ratios in mice; Elsevier Science Inc.; Nutrition; 26; 4; 6-2010; 423-431
0899-9007
CONICET Digital
CONICET
url http://hdl.handle.net/11336/278679
identifier_str_mv Santillan, Maria Emilia; Vincenti, Laura María; Martini, Ana Carolina; Fiol, Marta Haydee; Ruiz, Ruben Daniel; et al.; Developmental and neurobehavioral effects of perinatal exposure to diets with different ω-6:ω-3 ratios in mice; Elsevier Science Inc.; Nutrition; 26; 4; 6-2010; 423-431
0899-9007
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nut.2009.06.005
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Elsevier Science Inc.
publisher.none.fl_str_mv Elsevier Science Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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