Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model

Autores
Bianconi, Santiago; Santillan, Maria Emilia; Solís, María del Rosario; Martini, Ana Carolina; Ponzio, Marina Flavia; Vincenti, Laura María; Schiöth, Helgi B.; Carlini, Valeria Paola; Stutz, Graciela
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) are relevant to fetal and infant growth and development. Objective: to assess whether long-term exposure to dietary ω-3 PUFA imbalance alters pre- and/or postnatal pups' development and reproductive function later in life. Mice dams were fed with ω-3 PUFA Control (soybean oil, 7%), Deficient (sunflower oil, 7%) or Excess (blend oil; 4.2% cod-liver+2.8% soybean) diet before conception and throughout gestation-lactation and later on, their pups received the same diet from weaning to adulthood. Offspring somatic, neurobiological and reproductive parameters were evaluated. Excess pups were lighter during the preweaning period and shorter in length from postnatal day (PND) 7 to 49, compared to Control pups (P<.05). On PND14, the percentage of pups with eye opening in Excess group was lower than those from Control and Deficient groups (P<.05). In Excess female offspring, puberty onset (vaginal opening and first estrus) occurred significantly later and the percentage of parthenogenetic oocytes on PND63 was higher than Control and Deficient ones (P<.05). Deficient pups were shorter in length (males: on PND14, 21, 35 and 49; females: on PND14, 21 and 42) compared with Control pups (P<.05). Deficient offspring exhibited higher percentage of bending spermatozoa compared to Control and Excess offspring (P<.05). These results show that either an excessively high or insufficient ω-3 PUFA consumption prior to conception until adulthood seems inadvisable because of the potential risks of short-term adverse effects on growth and development of the progeny or long-lasting effects on their reproductive maturation and function.
Fil: Bianconi, Santiago. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Santillan, Maria Emilia. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Solís, María del Rosario. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Martini, Ana Carolina. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Ponzio, Marina Flavia. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Vincenti, Laura María. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Schiöth, Helgi B.. Uppsala University; Suecia
Fil: Carlini, Valeria Paola. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina; Argentina
Fil: Stutz, Graciela. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Materia
ALPHA-LINOLENIC ACID (PUBCHEM CID: 5280934)
DOCOSAHEXAENOIC ACID (PUBCHEM CID: 445580)
EICOSAPENTAENOIC ACID (PUBCHEM CID: 446284)
FISH OIL
NEUROBEHAVIOR
PERINATAL DEVELOPMENT
REPRODUCTIVE FUNCTION
SUNFLOWER OIL
Ω-3 PUFA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/88576
Acceder
id CONICETDig_3517d3793b349a673541031949931be2
oai_identifier_str oai:ri.conicet.gov.ar:11336/88576
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine modelBianconi, SantiagoSantillan, Maria EmiliaSolís, María del RosarioMartini, Ana CarolinaPonzio, Marina FlaviaVincenti, Laura MaríaSchiöth, Helgi B.Carlini, Valeria PaolaStutz, GracielaALPHA-LINOLENIC ACID (PUBCHEM CID: 5280934)DOCOSAHEXAENOIC ACID (PUBCHEM CID: 445580)EICOSAPENTAENOIC ACID (PUBCHEM CID: 446284)FISH OILNEUROBEHAVIORPERINATAL DEVELOPMENTREPRODUCTIVE FUNCTIONSUNFLOWER OILΩ-3 PUFAhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) are relevant to fetal and infant growth and development. Objective: to assess whether long-term exposure to dietary ω-3 PUFA imbalance alters pre- and/or postnatal pups' development and reproductive function later in life. Mice dams were fed with ω-3 PUFA Control (soybean oil, 7%), Deficient (sunflower oil, 7%) or Excess (blend oil; 4.2% cod-liver+2.8% soybean) diet before conception and throughout gestation-lactation and later on, their pups received the same diet from weaning to adulthood. Offspring somatic, neurobiological and reproductive parameters were evaluated. Excess pups were lighter during the preweaning period and shorter in length from postnatal day (PND) 7 to 49, compared to Control pups (P<.05). On PND14, the percentage of pups with eye opening in Excess group was lower than those from Control and Deficient groups (P<.05). In Excess female offspring, puberty onset (vaginal opening and first estrus) occurred significantly later and the percentage of parthenogenetic oocytes on PND63 was higher than Control and Deficient ones (P<.05). Deficient pups were shorter in length (males: on PND14, 21, 35 and 49; females: on PND14, 21 and 42) compared with Control pups (P<.05). Deficient offspring exhibited higher percentage of bending spermatozoa compared to Control and Excess offspring (P<.05). These results show that either an excessively high or insufficient ω-3 PUFA consumption prior to conception until adulthood seems inadvisable because of the potential risks of short-term adverse effects on growth and development of the progeny or long-lasting effects on their reproductive maturation and function.Fil: Bianconi, Santiago. Universidad Nacional de Córdoba. Facultad de Medicina; ArgentinaFil: Santillan, Maria Emilia. Universidad Nacional de Córdoba. Facultad de Medicina; ArgentinaFil: Solís, María del Rosario. Universidad Nacional de Córdoba. Facultad de Medicina; ArgentinaFil: Martini, Ana Carolina. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Ponzio, Marina Flavia. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Vincenti, Laura María. Universidad Nacional de Córdoba. Facultad de Medicina; ArgentinaFil: Schiöth, Helgi B.. Uppsala University; SueciaFil: Carlini, Valeria Paola. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina; ArgentinaFil: Stutz, Graciela. Universidad Nacional de Córdoba. Facultad de Medicina; ArgentinaElsevier Science Inc2018-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/88576Bianconi, Santiago; Santillan, Maria Emilia; Solís, María del Rosario; Martini, Ana Carolina; Ponzio, Marina Flavia; et al.; Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model; Elsevier Science Inc; Journal Of Nutritional Biochemistry; 61; 11-2018; 82-900955-2863CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jnutbio.2018.07.007info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0955286317310513info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:35:06Zoai:ri.conicet.gov.ar:11336/88576instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:35:07.273CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model
title Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model
spellingShingle Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model
Bianconi, Santiago
ALPHA-LINOLENIC ACID (PUBCHEM CID: 5280934)
DOCOSAHEXAENOIC ACID (PUBCHEM CID: 445580)
EICOSAPENTAENOIC ACID (PUBCHEM CID: 446284)
FISH OIL
NEUROBEHAVIOR
PERINATAL DEVELOPMENT
REPRODUCTIVE FUNCTION
SUNFLOWER OIL
Ω-3 PUFA
title_short Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model
title_full Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model
title_fullStr Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model
title_full_unstemmed Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model
title_sort Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model
dc.creator.none.fl_str_mv Bianconi, Santiago
Santillan, Maria Emilia
Solís, María del Rosario
Martini, Ana Carolina
Ponzio, Marina Flavia
Vincenti, Laura María
Schiöth, Helgi B.
Carlini, Valeria Paola
Stutz, Graciela
author Bianconi, Santiago
author_facet Bianconi, Santiago
Santillan, Maria Emilia
Solís, María del Rosario
Martini, Ana Carolina
Ponzio, Marina Flavia
Vincenti, Laura María
Schiöth, Helgi B.
Carlini, Valeria Paola
Stutz, Graciela
author_role author
author2 Santillan, Maria Emilia
Solís, María del Rosario
Martini, Ana Carolina
Ponzio, Marina Flavia
Vincenti, Laura María
Schiöth, Helgi B.
Carlini, Valeria Paola
Stutz, Graciela
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ALPHA-LINOLENIC ACID (PUBCHEM CID: 5280934)
DOCOSAHEXAENOIC ACID (PUBCHEM CID: 445580)
EICOSAPENTAENOIC ACID (PUBCHEM CID: 446284)
FISH OIL
NEUROBEHAVIOR
PERINATAL DEVELOPMENT
REPRODUCTIVE FUNCTION
SUNFLOWER OIL
Ω-3 PUFA
topic ALPHA-LINOLENIC ACID (PUBCHEM CID: 5280934)
DOCOSAHEXAENOIC ACID (PUBCHEM CID: 445580)
EICOSAPENTAENOIC ACID (PUBCHEM CID: 446284)
FISH OIL
NEUROBEHAVIOR
PERINATAL DEVELOPMENT
REPRODUCTIVE FUNCTION
SUNFLOWER OIL
Ω-3 PUFA
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) are relevant to fetal and infant growth and development. Objective: to assess whether long-term exposure to dietary ω-3 PUFA imbalance alters pre- and/or postnatal pups' development and reproductive function later in life. Mice dams were fed with ω-3 PUFA Control (soybean oil, 7%), Deficient (sunflower oil, 7%) or Excess (blend oil; 4.2% cod-liver+2.8% soybean) diet before conception and throughout gestation-lactation and later on, their pups received the same diet from weaning to adulthood. Offspring somatic, neurobiological and reproductive parameters were evaluated. Excess pups were lighter during the preweaning period and shorter in length from postnatal day (PND) 7 to 49, compared to Control pups (P<.05). On PND14, the percentage of pups with eye opening in Excess group was lower than those from Control and Deficient groups (P<.05). In Excess female offspring, puberty onset (vaginal opening and first estrus) occurred significantly later and the percentage of parthenogenetic oocytes on PND63 was higher than Control and Deficient ones (P<.05). Deficient pups were shorter in length (males: on PND14, 21, 35 and 49; females: on PND14, 21 and 42) compared with Control pups (P<.05). Deficient offspring exhibited higher percentage of bending spermatozoa compared to Control and Excess offspring (P<.05). These results show that either an excessively high or insufficient ω-3 PUFA consumption prior to conception until adulthood seems inadvisable because of the potential risks of short-term adverse effects on growth and development of the progeny or long-lasting effects on their reproductive maturation and function.
Fil: Bianconi, Santiago. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Santillan, Maria Emilia. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Solís, María del Rosario. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Martini, Ana Carolina. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Ponzio, Marina Flavia. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Vincenti, Laura María. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Schiöth, Helgi B.. Uppsala University; Suecia
Fil: Carlini, Valeria Paola. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina; Argentina
Fil: Stutz, Graciela. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
description Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) are relevant to fetal and infant growth and development. Objective: to assess whether long-term exposure to dietary ω-3 PUFA imbalance alters pre- and/or postnatal pups' development and reproductive function later in life. Mice dams were fed with ω-3 PUFA Control (soybean oil, 7%), Deficient (sunflower oil, 7%) or Excess (blend oil; 4.2% cod-liver+2.8% soybean) diet before conception and throughout gestation-lactation and later on, their pups received the same diet from weaning to adulthood. Offspring somatic, neurobiological and reproductive parameters were evaluated. Excess pups were lighter during the preweaning period and shorter in length from postnatal day (PND) 7 to 49, compared to Control pups (P<.05). On PND14, the percentage of pups with eye opening in Excess group was lower than those from Control and Deficient groups (P<.05). In Excess female offspring, puberty onset (vaginal opening and first estrus) occurred significantly later and the percentage of parthenogenetic oocytes on PND63 was higher than Control and Deficient ones (P<.05). Deficient pups were shorter in length (males: on PND14, 21, 35 and 49; females: on PND14, 21 and 42) compared with Control pups (P<.05). Deficient offspring exhibited higher percentage of bending spermatozoa compared to Control and Excess offspring (P<.05). These results show that either an excessively high or insufficient ω-3 PUFA consumption prior to conception until adulthood seems inadvisable because of the potential risks of short-term adverse effects on growth and development of the progeny or long-lasting effects on their reproductive maturation and function.
publishDate 2018
dc.date.none.fl_str_mv 2018-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/88576
Bianconi, Santiago; Santillan, Maria Emilia; Solís, María del Rosario; Martini, Ana Carolina; Ponzio, Marina Flavia; et al.; Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model; Elsevier Science Inc; Journal Of Nutritional Biochemistry; 61; 11-2018; 82-90
0955-2863
CONICET Digital
CONICET
url http://hdl.handle.net/11336/88576
identifier_str_mv Bianconi, Santiago; Santillan, Maria Emilia; Solís, María del Rosario; Martini, Ana Carolina; Ponzio, Marina Flavia; et al.; Effects of dietary omega-3 PUFAs on growth and development: Somatic, neurobiological and reproductive functions in a murine model; Elsevier Science Inc; Journal Of Nutritional Biochemistry; 61; 11-2018; 82-90
0955-2863
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jnutbio.2018.07.007
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0955286317310513
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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