A role for the small GTPase Rac1 in vaccinia actin-based motility

Autores
Alvarez, Diego Ezequiel; Agaisse, Herve
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Vaccinia virus dissemination relies on the recruitment of the nucleation promoting factor N-WASP underneath cell-associated extracellular virus (CEVs) and subsequent recruitment and activation of the ARP2/3 complex, a major actin nucleator of the host cell. We have recently discovered that, in addition to the N-WASP/ARP2/3 pathway, vaccinia actin-based motility also relies on the small GTPase Rac1 and its downstream effector the formin-type actin nucleator FHOD1. Here we discuss the potential signaling mechanisms supporting the integration of the N-WASP/ARP2/3 and Rac1/FHOD1 pathways. We suggest the existence of a receptor tyrosine kinase family member that would integrate the Src-dependent activation of the N-WASP/ ARP2/3 pathway and the GTP exchange factor-dependent activation of the Rac1/ FHOD1 pathway.
Fil: Alvarez, Diego Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Agaisse, Herve. University of Yale. School of Medicine; Estados Unidos
Materia
ACTIN-BASED MOTILITY
ARP2/3 COMPLEX
DISSEMINATION
FHOD1
N-WASP
RAC1
SPREAD FROM CELL TO CELL
VACCINIA VIRUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/93519

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network_name_str CONICET Digital (CONICET)
spelling A role for the small GTPase Rac1 in vaccinia actin-based motilityAlvarez, Diego EzequielAgaisse, HerveACTIN-BASED MOTILITYARP2/3 COMPLEXDISSEMINATIONFHOD1N-WASPRAC1SPREAD FROM CELL TO CELLVACCINIA VIRUShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Vaccinia virus dissemination relies on the recruitment of the nucleation promoting factor N-WASP underneath cell-associated extracellular virus (CEVs) and subsequent recruitment and activation of the ARP2/3 complex, a major actin nucleator of the host cell. We have recently discovered that, in addition to the N-WASP/ARP2/3 pathway, vaccinia actin-based motility also relies on the small GTPase Rac1 and its downstream effector the formin-type actin nucleator FHOD1. Here we discuss the potential signaling mechanisms supporting the integration of the N-WASP/ARP2/3 and Rac1/FHOD1 pathways. We suggest the existence of a receptor tyrosine kinase family member that would integrate the Src-dependent activation of the N-WASP/ ARP2/3 pathway and the GTP exchange factor-dependent activation of the Rac1/ FHOD1 pathway.Fil: Alvarez, Diego Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Agaisse, Herve. University of Yale. School of Medicine; Estados UnidosTaylor & Francis2014-10-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/93519Alvarez, Diego Ezequiel; Agaisse, Herve; A role for the small GTPase Rac1 in vaccinia actin-based motility; Taylor & Francis; Small GTPases; 5; 2; 31-10-2014; 1-4; e290382154-12482154-1256CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.4161/sgtp.29038info:eu-repo/semantics/altIdentifier/doi/10.4161/sgtp.29038info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:01:35Zoai:ri.conicet.gov.ar:11336/93519instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:01:35.281CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A role for the small GTPase Rac1 in vaccinia actin-based motility
title A role for the small GTPase Rac1 in vaccinia actin-based motility
spellingShingle A role for the small GTPase Rac1 in vaccinia actin-based motility
Alvarez, Diego Ezequiel
ACTIN-BASED MOTILITY
ARP2/3 COMPLEX
DISSEMINATION
FHOD1
N-WASP
RAC1
SPREAD FROM CELL TO CELL
VACCINIA VIRUS
title_short A role for the small GTPase Rac1 in vaccinia actin-based motility
title_full A role for the small GTPase Rac1 in vaccinia actin-based motility
title_fullStr A role for the small GTPase Rac1 in vaccinia actin-based motility
title_full_unstemmed A role for the small GTPase Rac1 in vaccinia actin-based motility
title_sort A role for the small GTPase Rac1 in vaccinia actin-based motility
dc.creator.none.fl_str_mv Alvarez, Diego Ezequiel
Agaisse, Herve
author Alvarez, Diego Ezequiel
author_facet Alvarez, Diego Ezequiel
Agaisse, Herve
author_role author
author2 Agaisse, Herve
author2_role author
dc.subject.none.fl_str_mv ACTIN-BASED MOTILITY
ARP2/3 COMPLEX
DISSEMINATION
FHOD1
N-WASP
RAC1
SPREAD FROM CELL TO CELL
VACCINIA VIRUS
topic ACTIN-BASED MOTILITY
ARP2/3 COMPLEX
DISSEMINATION
FHOD1
N-WASP
RAC1
SPREAD FROM CELL TO CELL
VACCINIA VIRUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Vaccinia virus dissemination relies on the recruitment of the nucleation promoting factor N-WASP underneath cell-associated extracellular virus (CEVs) and subsequent recruitment and activation of the ARP2/3 complex, a major actin nucleator of the host cell. We have recently discovered that, in addition to the N-WASP/ARP2/3 pathway, vaccinia actin-based motility also relies on the small GTPase Rac1 and its downstream effector the formin-type actin nucleator FHOD1. Here we discuss the potential signaling mechanisms supporting the integration of the N-WASP/ARP2/3 and Rac1/FHOD1 pathways. We suggest the existence of a receptor tyrosine kinase family member that would integrate the Src-dependent activation of the N-WASP/ ARP2/3 pathway and the GTP exchange factor-dependent activation of the Rac1/ FHOD1 pathway.
Fil: Alvarez, Diego Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Agaisse, Herve. University of Yale. School of Medicine; Estados Unidos
description Vaccinia virus dissemination relies on the recruitment of the nucleation promoting factor N-WASP underneath cell-associated extracellular virus (CEVs) and subsequent recruitment and activation of the ARP2/3 complex, a major actin nucleator of the host cell. We have recently discovered that, in addition to the N-WASP/ARP2/3 pathway, vaccinia actin-based motility also relies on the small GTPase Rac1 and its downstream effector the formin-type actin nucleator FHOD1. Here we discuss the potential signaling mechanisms supporting the integration of the N-WASP/ARP2/3 and Rac1/FHOD1 pathways. We suggest the existence of a receptor tyrosine kinase family member that would integrate the Src-dependent activation of the N-WASP/ ARP2/3 pathway and the GTP exchange factor-dependent activation of the Rac1/ FHOD1 pathway.
publishDate 2014
dc.date.none.fl_str_mv 2014-10-31
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/93519
Alvarez, Diego Ezequiel; Agaisse, Herve; A role for the small GTPase Rac1 in vaccinia actin-based motility; Taylor & Francis; Small GTPases; 5; 2; 31-10-2014; 1-4; e29038
2154-1248
2154-1256
CONICET Digital
CONICET
url http://hdl.handle.net/11336/93519
identifier_str_mv Alvarez, Diego Ezequiel; Agaisse, Herve; A role for the small GTPase Rac1 in vaccinia actin-based motility; Taylor & Francis; Small GTPases; 5; 2; 31-10-2014; 1-4; e29038
2154-1248
2154-1256
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.4161/sgtp.29038
info:eu-repo/semantics/altIdentifier/doi/10.4161/sgtp.29038
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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