A role for the small GTPase Rac1 in vaccinia actin-based motility
- Autores
- Alvarez, Diego Ezequiel; Agaisse, Herve
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Vaccinia virus dissemination relies on the recruitment of the nucleation promoting factor N-WASP underneath cell-associated extracellular virus (CEVs) and subsequent recruitment and activation of the ARP2/3 complex, a major actin nucleator of the host cell. We have recently discovered that, in addition to the N-WASP/ARP2/3 pathway, vaccinia actin-based motility also relies on the small GTPase Rac1 and its downstream effector the formin-type actin nucleator FHOD1. Here we discuss the potential signaling mechanisms supporting the integration of the N-WASP/ARP2/3 and Rac1/FHOD1 pathways. We suggest the existence of a receptor tyrosine kinase family member that would integrate the Src-dependent activation of the N-WASP/ ARP2/3 pathway and the GTP exchange factor-dependent activation of the Rac1/ FHOD1 pathway.
Fil: Alvarez, Diego Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Agaisse, Herve. University of Yale. School of Medicine; Estados Unidos - Materia
-
ACTIN-BASED MOTILITY
ARP2/3 COMPLEX
DISSEMINATION
FHOD1
N-WASP
RAC1
SPREAD FROM CELL TO CELL
VACCINIA VIRUS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/93519
Ver los metadatos del registro completo
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A role for the small GTPase Rac1 in vaccinia actin-based motilityAlvarez, Diego EzequielAgaisse, HerveACTIN-BASED MOTILITYARP2/3 COMPLEXDISSEMINATIONFHOD1N-WASPRAC1SPREAD FROM CELL TO CELLVACCINIA VIRUShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Vaccinia virus dissemination relies on the recruitment of the nucleation promoting factor N-WASP underneath cell-associated extracellular virus (CEVs) and subsequent recruitment and activation of the ARP2/3 complex, a major actin nucleator of the host cell. We have recently discovered that, in addition to the N-WASP/ARP2/3 pathway, vaccinia actin-based motility also relies on the small GTPase Rac1 and its downstream effector the formin-type actin nucleator FHOD1. Here we discuss the potential signaling mechanisms supporting the integration of the N-WASP/ARP2/3 and Rac1/FHOD1 pathways. We suggest the existence of a receptor tyrosine kinase family member that would integrate the Src-dependent activation of the N-WASP/ ARP2/3 pathway and the GTP exchange factor-dependent activation of the Rac1/ FHOD1 pathway.Fil: Alvarez, Diego Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Agaisse, Herve. University of Yale. School of Medicine; Estados UnidosTaylor & Francis2014-10-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/93519Alvarez, Diego Ezequiel; Agaisse, Herve; A role for the small GTPase Rac1 in vaccinia actin-based motility; Taylor & Francis; Small GTPases; 5; 2; 31-10-2014; 1-4; e290382154-12482154-1256CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.4161/sgtp.29038info:eu-repo/semantics/altIdentifier/doi/10.4161/sgtp.29038info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:01:35Zoai:ri.conicet.gov.ar:11336/93519instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:01:35.281CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
A role for the small GTPase Rac1 in vaccinia actin-based motility |
title |
A role for the small GTPase Rac1 in vaccinia actin-based motility |
spellingShingle |
A role for the small GTPase Rac1 in vaccinia actin-based motility Alvarez, Diego Ezequiel ACTIN-BASED MOTILITY ARP2/3 COMPLEX DISSEMINATION FHOD1 N-WASP RAC1 SPREAD FROM CELL TO CELL VACCINIA VIRUS |
title_short |
A role for the small GTPase Rac1 in vaccinia actin-based motility |
title_full |
A role for the small GTPase Rac1 in vaccinia actin-based motility |
title_fullStr |
A role for the small GTPase Rac1 in vaccinia actin-based motility |
title_full_unstemmed |
A role for the small GTPase Rac1 in vaccinia actin-based motility |
title_sort |
A role for the small GTPase Rac1 in vaccinia actin-based motility |
dc.creator.none.fl_str_mv |
Alvarez, Diego Ezequiel Agaisse, Herve |
author |
Alvarez, Diego Ezequiel |
author_facet |
Alvarez, Diego Ezequiel Agaisse, Herve |
author_role |
author |
author2 |
Agaisse, Herve |
author2_role |
author |
dc.subject.none.fl_str_mv |
ACTIN-BASED MOTILITY ARP2/3 COMPLEX DISSEMINATION FHOD1 N-WASP RAC1 SPREAD FROM CELL TO CELL VACCINIA VIRUS |
topic |
ACTIN-BASED MOTILITY ARP2/3 COMPLEX DISSEMINATION FHOD1 N-WASP RAC1 SPREAD FROM CELL TO CELL VACCINIA VIRUS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Vaccinia virus dissemination relies on the recruitment of the nucleation promoting factor N-WASP underneath cell-associated extracellular virus (CEVs) and subsequent recruitment and activation of the ARP2/3 complex, a major actin nucleator of the host cell. We have recently discovered that, in addition to the N-WASP/ARP2/3 pathway, vaccinia actin-based motility also relies on the small GTPase Rac1 and its downstream effector the formin-type actin nucleator FHOD1. Here we discuss the potential signaling mechanisms supporting the integration of the N-WASP/ARP2/3 and Rac1/FHOD1 pathways. We suggest the existence of a receptor tyrosine kinase family member that would integrate the Src-dependent activation of the N-WASP/ ARP2/3 pathway and the GTP exchange factor-dependent activation of the Rac1/ FHOD1 pathway. Fil: Alvarez, Diego Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina Fil: Agaisse, Herve. University of Yale. School of Medicine; Estados Unidos |
description |
Vaccinia virus dissemination relies on the recruitment of the nucleation promoting factor N-WASP underneath cell-associated extracellular virus (CEVs) and subsequent recruitment and activation of the ARP2/3 complex, a major actin nucleator of the host cell. We have recently discovered that, in addition to the N-WASP/ARP2/3 pathway, vaccinia actin-based motility also relies on the small GTPase Rac1 and its downstream effector the formin-type actin nucleator FHOD1. Here we discuss the potential signaling mechanisms supporting the integration of the N-WASP/ARP2/3 and Rac1/FHOD1 pathways. We suggest the existence of a receptor tyrosine kinase family member that would integrate the Src-dependent activation of the N-WASP/ ARP2/3 pathway and the GTP exchange factor-dependent activation of the Rac1/ FHOD1 pathway. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-10-31 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/93519 Alvarez, Diego Ezequiel; Agaisse, Herve; A role for the small GTPase Rac1 in vaccinia actin-based motility; Taylor & Francis; Small GTPases; 5; 2; 31-10-2014; 1-4; e29038 2154-1248 2154-1256 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/93519 |
identifier_str_mv |
Alvarez, Diego Ezequiel; Agaisse, Herve; A role for the small GTPase Rac1 in vaccinia actin-based motility; Taylor & Francis; Small GTPases; 5; 2; 31-10-2014; 1-4; e29038 2154-1248 2154-1256 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.4161/sgtp.29038 info:eu-repo/semantics/altIdentifier/doi/10.4161/sgtp.29038 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Taylor & Francis |
publisher.none.fl_str_mv |
Taylor & Francis |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613811014729728 |
score |
13.070432 |