Predictive coding in autism spectrum disorder and attention deficit hyperactivity disorder

Autores
González Gadea, María Luz; Chennu, Srivas; Bekinschtein, Tristán Andrés; Rattazzi, Alexia; Beraudi, Ana; Tripicchio, Paula; Moyano, Beatriz; Soffita, Yamila; Steinberg, Laura; Gonzalez Adolfi, Federico; Sigman, Mariano; Marino, Julián Carlos; Manes, Facundo Francisco; Ibanez Barassi, Agustin Mariano
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Predictive coding has been proposed as a framework to understand neural processes in neuropsychiatric disorders. We used this approach to describe mechanisms responsible for attentional abnormalities in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). We monitored brain dynamics of 59 children (8-15 yr old) who had ASD or ADHD or who were control participants via high-density electroencephalography. We performed analysis at the scalp and source-space levels while participants listened to standard and deviant tone sequences. Through task instructions, we manipulated top-down expectation by presenting expected and unexpected deviant sequences. Children with ASD showed reduced superior frontal cortex (FC) responses to unexpected events but increased dorsolateral prefrontal cortex (PFC) activation to expected events. In contrast, children with ADHD exhibited reduced cortical responses in superior FC to expected events but strong PFC activation to unexpected events. Moreover, neural abnormalities were associated with specific control mechanisms, namely, inhibitory control in ASD and set-shifting in ADHD. Based on the predictive coding account, top-down expectation abnormalities could be attributed to a disproportionate reliance (precision) allocated to prior beliefs in ASD and to sensory input in ADHD.
Fil: González Gadea, María Luz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile
Fil: Chennu, Srivas. University of Cambridge; Reino Unido
Fil: Bekinschtein, Tristán Andrés. University of Cambridge; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rattazzi, Alexia. No especifíca;
Fil: Beraudi, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Tripicchio, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Moyano, Beatriz. Centro Interdisciplinario de Tourette, TOC, TDAH, y Trastornos Asociados; Argentina
Fil: Soffita, Yamila. Centro Interdisciplinario de Tourette, TOC, TDAH, y Trastornos Asociados; Argentina
Fil: Steinberg, Laura. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Gonzalez Adolfi, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Sigman, Mariano. Universidad Torcuato Di Tella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Marino, Julián Carlos. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile
Fil: Ibanez Barassi, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile. Universidad Autónoma del Caribe; Colombia
Materia
ADHD
ASD
MMN
P300
PREDICTIVE CODING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/114520
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/114520
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Predictive coding in autism spectrum disorder and attention deficit hyperactivity disorderGonzález Gadea, María LuzChennu, SrivasBekinschtein, Tristán AndrésRattazzi, AlexiaBeraudi, AnaTripicchio, PaulaMoyano, BeatrizSoffita, YamilaSteinberg, LauraGonzalez Adolfi, FedericoSigman, MarianoMarino, Julián CarlosManes, Facundo FranciscoIbanez Barassi, Agustin MarianoADHDASDMMNP300PREDICTIVE CODINGhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Predictive coding has been proposed as a framework to understand neural processes in neuropsychiatric disorders. We used this approach to describe mechanisms responsible for attentional abnormalities in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). We monitored brain dynamics of 59 children (8-15 yr old) who had ASD or ADHD or who were control participants via high-density electroencephalography. We performed analysis at the scalp and source-space levels while participants listened to standard and deviant tone sequences. Through task instructions, we manipulated top-down expectation by presenting expected and unexpected deviant sequences. Children with ASD showed reduced superior frontal cortex (FC) responses to unexpected events but increased dorsolateral prefrontal cortex (PFC) activation to expected events. In contrast, children with ADHD exhibited reduced cortical responses in superior FC to expected events but strong PFC activation to unexpected events. Moreover, neural abnormalities were associated with specific control mechanisms, namely, inhibitory control in ASD and set-shifting in ADHD. Based on the predictive coding account, top-down expectation abnormalities could be attributed to a disproportionate reliance (precision) allocated to prior beliefs in ASD and to sensory input in ADHD.Fil: González Gadea, María Luz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; ChileFil: Chennu, Srivas. University of Cambridge; Reino UnidoFil: Bekinschtein, Tristán Andrés. University of Cambridge; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rattazzi, Alexia. No especifíca;Fil: Beraudi, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Tripicchio, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Moyano, Beatriz. Centro Interdisciplinario de Tourette, TOC, TDAH, y Trastornos Asociados; ArgentinaFil: Soffita, Yamila. Centro Interdisciplinario de Tourette, TOC, TDAH, y Trastornos Asociados; ArgentinaFil: Steinberg, Laura. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; ArgentinaFil: Gonzalez Adolfi, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Sigman, Mariano. Universidad Torcuato Di Tella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Marino, Julián Carlos. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; ChileFil: Ibanez Barassi, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile. Universidad Autónoma del Caribe; ColombiaAmerican Physiological Society2015-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/114520González Gadea, María Luz; Chennu, Srivas; Bekinschtein, Tristán Andrés; Rattazzi, Alexia; Beraudi, Ana; et al.; Predictive coding in autism spectrum disorder and attention deficit hyperactivity disorder; American Physiological Society; Journal of Neurophysiology; 114; 5; 11-2015; 2625-26360022-3077CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/full/10.1152/jn.00543.2015info:eu-repo/semantics/altIdentifier/doi/10.1152/jn.00543.2015info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:38Zoai:ri.conicet.gov.ar:11336/114520instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:38.286CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Predictive coding in autism spectrum disorder and attention deficit hyperactivity disorder
title Predictive coding in autism spectrum disorder and attention deficit hyperactivity disorder
spellingShingle Predictive coding in autism spectrum disorder and attention deficit hyperactivity disorder
González Gadea, María Luz
ADHD
ASD
MMN
P300
PREDICTIVE CODING
title_short Predictive coding in autism spectrum disorder and attention deficit hyperactivity disorder
title_full Predictive coding in autism spectrum disorder and attention deficit hyperactivity disorder
title_fullStr Predictive coding in autism spectrum disorder and attention deficit hyperactivity disorder
title_full_unstemmed Predictive coding in autism spectrum disorder and attention deficit hyperactivity disorder
title_sort Predictive coding in autism spectrum disorder and attention deficit hyperactivity disorder
dc.creator.none.fl_str_mv González Gadea, María Luz
Chennu, Srivas
Bekinschtein, Tristán Andrés
Rattazzi, Alexia
Beraudi, Ana
Tripicchio, Paula
Moyano, Beatriz
Soffita, Yamila
Steinberg, Laura
Gonzalez Adolfi, Federico
Sigman, Mariano
Marino, Julián Carlos
Manes, Facundo Francisco
Ibanez Barassi, Agustin Mariano
author González Gadea, María Luz
author_facet González Gadea, María Luz
Chennu, Srivas
Bekinschtein, Tristán Andrés
Rattazzi, Alexia
Beraudi, Ana
Tripicchio, Paula
Moyano, Beatriz
Soffita, Yamila
Steinberg, Laura
Gonzalez Adolfi, Federico
Sigman, Mariano
Marino, Julián Carlos
Manes, Facundo Francisco
Ibanez Barassi, Agustin Mariano
author_role author
author2 Chennu, Srivas
Bekinschtein, Tristán Andrés
Rattazzi, Alexia
Beraudi, Ana
Tripicchio, Paula
Moyano, Beatriz
Soffita, Yamila
Steinberg, Laura
Gonzalez Adolfi, Federico
Sigman, Mariano
Marino, Julián Carlos
Manes, Facundo Francisco
Ibanez Barassi, Agustin Mariano
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ADHD
ASD
MMN
P300
PREDICTIVE CODING
topic ADHD
ASD
MMN
P300
PREDICTIVE CODING
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Predictive coding has been proposed as a framework to understand neural processes in neuropsychiatric disorders. We used this approach to describe mechanisms responsible for attentional abnormalities in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). We monitored brain dynamics of 59 children (8-15 yr old) who had ASD or ADHD or who were control participants via high-density electroencephalography. We performed analysis at the scalp and source-space levels while participants listened to standard and deviant tone sequences. Through task instructions, we manipulated top-down expectation by presenting expected and unexpected deviant sequences. Children with ASD showed reduced superior frontal cortex (FC) responses to unexpected events but increased dorsolateral prefrontal cortex (PFC) activation to expected events. In contrast, children with ADHD exhibited reduced cortical responses in superior FC to expected events but strong PFC activation to unexpected events. Moreover, neural abnormalities were associated with specific control mechanisms, namely, inhibitory control in ASD and set-shifting in ADHD. Based on the predictive coding account, top-down expectation abnormalities could be attributed to a disproportionate reliance (precision) allocated to prior beliefs in ASD and to sensory input in ADHD.
Fil: González Gadea, María Luz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile
Fil: Chennu, Srivas. University of Cambridge; Reino Unido
Fil: Bekinschtein, Tristán Andrés. University of Cambridge; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rattazzi, Alexia. No especifíca;
Fil: Beraudi, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Tripicchio, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Moyano, Beatriz. Centro Interdisciplinario de Tourette, TOC, TDAH, y Trastornos Asociados; Argentina
Fil: Soffita, Yamila. Centro Interdisciplinario de Tourette, TOC, TDAH, y Trastornos Asociados; Argentina
Fil: Steinberg, Laura. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Gonzalez Adolfi, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Sigman, Mariano. Universidad Torcuato Di Tella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Marino, Julián Carlos. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile
Fil: Ibanez Barassi, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile. Universidad Autónoma del Caribe; Colombia
description Predictive coding has been proposed as a framework to understand neural processes in neuropsychiatric disorders. We used this approach to describe mechanisms responsible for attentional abnormalities in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). We monitored brain dynamics of 59 children (8-15 yr old) who had ASD or ADHD or who were control participants via high-density electroencephalography. We performed analysis at the scalp and source-space levels while participants listened to standard and deviant tone sequences. Through task instructions, we manipulated top-down expectation by presenting expected and unexpected deviant sequences. Children with ASD showed reduced superior frontal cortex (FC) responses to unexpected events but increased dorsolateral prefrontal cortex (PFC) activation to expected events. In contrast, children with ADHD exhibited reduced cortical responses in superior FC to expected events but strong PFC activation to unexpected events. Moreover, neural abnormalities were associated with specific control mechanisms, namely, inhibitory control in ASD and set-shifting in ADHD. Based on the predictive coding account, top-down expectation abnormalities could be attributed to a disproportionate reliance (precision) allocated to prior beliefs in ASD and to sensory input in ADHD.
publishDate 2015
dc.date.none.fl_str_mv 2015-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/114520
González Gadea, María Luz; Chennu, Srivas; Bekinschtein, Tristán Andrés; Rattazzi, Alexia; Beraudi, Ana; et al.; Predictive coding in autism spectrum disorder and attention deficit hyperactivity disorder; American Physiological Society; Journal of Neurophysiology; 114; 5; 11-2015; 2625-2636
0022-3077
CONICET Digital
CONICET
url http://hdl.handle.net/11336/114520
identifier_str_mv González Gadea, María Luz; Chennu, Srivas; Bekinschtein, Tristán Andrés; Rattazzi, Alexia; Beraudi, Ana; et al.; Predictive coding in autism spectrum disorder and attention deficit hyperactivity disorder; American Physiological Society; Journal of Neurophysiology; 114; 5; 11-2015; 2625-2636
0022-3077
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/full/10.1152/jn.00543.2015
info:eu-repo/semantics/altIdentifier/doi/10.1152/jn.00543.2015
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Physiological Society
publisher.none.fl_str_mv American Physiological Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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