A review of the methods of magnetic nanocomposites synthesis and their applications as drug delivery systems and immobilization supports for lipases

Autores
Lassalle, Verónica Leticia; Avena, Marcelo Javier; Ferreira, María Luján
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Iron oxide-based magnetic nanoparticles (IONP) that display high saturation and high magnetic susceptibility are of great interest for biotechnological and biomedical applications. Magnetite displays strong ferrimagnetic behaviour and is less sensitive to oxidation than other magnetic transition metaloxides. It is then not surprising that IONP include magnetite in their formulation. The role of IONP technology in the cited areas requires specific characteristics with regard to the particle size and surface functionality. Therefore the incorporation of polymeric moieties appears as a valuable tool to achieve the desired properties. On this context surface-modified IONP and magnetic nanocomposites (MNC) can be obtained depending on the role of the polymeric network in the formulation process. The methods to prepare each kind of magnetic-polymeric composite are reviewed in this work. First, the different kinds of IONP are carefully analyzed and second, the techniques available to incorporate polymer and other modifiers, are addressed. An investigation of the relationship between the nature of the modifier and the tailored application of the generated particles is also included with the focus mainly in the effect of some experimental A review of the methods of magnetic nanocomposites synthesis and their applications as drug delivery systems and immobilization supports for lipases variables on the nanoparticle size. Finally, two specific applications of magnetic nanocomposites in novel and relevant fields will be discussed. The role of magnetic nanoparticles as drug delivery systems (DDS) is of high significance and consequently, the available information is rich, but it is mostly dedicated to the sustained release of anticancer drugs. Here we will show other drugs, able to be delivered from magnetic DDS. MNC have recently emerged as effective supports for lipase immobilization. The reported data concerning to this topic is still quite limited and therefore novel published advances are reviewed here.
Fil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Avena, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Ferreira, María Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Materia
Magnetic Nanocomposites
Magnetite
Co-Precipitation
Magnetic Supports
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/61660
Acceder
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network_name_str CONICET Digital (CONICET)
spelling A review of the methods of magnetic nanocomposites synthesis and their applications as drug delivery systems and immobilization supports for lipasesLassalle, Verónica LeticiaAvena, Marcelo JavierFerreira, María LujánMagnetic NanocompositesMagnetiteCo-PrecipitationMagnetic Supportshttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2Iron oxide-based magnetic nanoparticles (IONP) that display high saturation and high magnetic susceptibility are of great interest for biotechnological and biomedical applications. Magnetite displays strong ferrimagnetic behaviour and is less sensitive to oxidation than other magnetic transition metaloxides. It is then not surprising that IONP include magnetite in their formulation. The role of IONP technology in the cited areas requires specific characteristics with regard to the particle size and surface functionality. Therefore the incorporation of polymeric moieties appears as a valuable tool to achieve the desired properties. On this context surface-modified IONP and magnetic nanocomposites (MNC) can be obtained depending on the role of the polymeric network in the formulation process. The methods to prepare each kind of magnetic-polymeric composite are reviewed in this work. First, the different kinds of IONP are carefully analyzed and second, the techniques available to incorporate polymer and other modifiers, are addressed. An investigation of the relationship between the nature of the modifier and the tailored application of the generated particles is also included with the focus mainly in the effect of some experimental A review of the methods of magnetic nanocomposites synthesis and their applications as drug delivery systems and immobilization supports for lipases variables on the nanoparticle size. Finally, two specific applications of magnetic nanocomposites in novel and relevant fields will be discussed. The role of magnetic nanoparticles as drug delivery systems (DDS) is of high significance and consequently, the available information is rich, but it is mostly dedicated to the sustained release of anticancer drugs. Here we will show other drugs, able to be delivered from magnetic DDS. MNC have recently emerged as effective supports for lipase immobilization. The reported data concerning to this topic is still quite limited and therefore novel published advances are reviewed here.Fil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Avena, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Ferreira, María Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaResearch Trends Ltd.2009-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/61660Lassalle, Verónica Leticia; Avena, Marcelo Javier; Ferreira, María Luján; A review of the methods of magnetic nanocomposites synthesis and their applications as drug delivery systems and immobilization supports for lipases; Research Trends Ltd.; Current Trends in Polymer Science; 13; 11-2009; 37-670972-446XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.researchtrends.net/tia/abstract.asp?in=0&vn=13&tid=2&aid=2855&pub=2009&type=3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:11:15Zoai:ri.conicet.gov.ar:11336/61660instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:11:15.949CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A review of the methods of magnetic nanocomposites synthesis and their applications as drug delivery systems and immobilization supports for lipases
title A review of the methods of magnetic nanocomposites synthesis and their applications as drug delivery systems and immobilization supports for lipases
spellingShingle A review of the methods of magnetic nanocomposites synthesis and their applications as drug delivery systems and immobilization supports for lipases
Lassalle, Verónica Leticia
Magnetic Nanocomposites
Magnetite
Co-Precipitation
Magnetic Supports
title_short A review of the methods of magnetic nanocomposites synthesis and their applications as drug delivery systems and immobilization supports for lipases
title_full A review of the methods of magnetic nanocomposites synthesis and their applications as drug delivery systems and immobilization supports for lipases
title_fullStr A review of the methods of magnetic nanocomposites synthesis and their applications as drug delivery systems and immobilization supports for lipases
title_full_unstemmed A review of the methods of magnetic nanocomposites synthesis and their applications as drug delivery systems and immobilization supports for lipases
title_sort A review of the methods of magnetic nanocomposites synthesis and their applications as drug delivery systems and immobilization supports for lipases
dc.creator.none.fl_str_mv Lassalle, Verónica Leticia
Avena, Marcelo Javier
Ferreira, María Luján
author Lassalle, Verónica Leticia
author_facet Lassalle, Verónica Leticia
Avena, Marcelo Javier
Ferreira, María Luján
author_role author
author2 Avena, Marcelo Javier
Ferreira, María Luján
author2_role author
author
dc.subject.none.fl_str_mv Magnetic Nanocomposites
Magnetite
Co-Precipitation
Magnetic Supports
topic Magnetic Nanocomposites
Magnetite
Co-Precipitation
Magnetic Supports
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Iron oxide-based magnetic nanoparticles (IONP) that display high saturation and high magnetic susceptibility are of great interest for biotechnological and biomedical applications. Magnetite displays strong ferrimagnetic behaviour and is less sensitive to oxidation than other magnetic transition metaloxides. It is then not surprising that IONP include magnetite in their formulation. The role of IONP technology in the cited areas requires specific characteristics with regard to the particle size and surface functionality. Therefore the incorporation of polymeric moieties appears as a valuable tool to achieve the desired properties. On this context surface-modified IONP and magnetic nanocomposites (MNC) can be obtained depending on the role of the polymeric network in the formulation process. The methods to prepare each kind of magnetic-polymeric composite are reviewed in this work. First, the different kinds of IONP are carefully analyzed and second, the techniques available to incorporate polymer and other modifiers, are addressed. An investigation of the relationship between the nature of the modifier and the tailored application of the generated particles is also included with the focus mainly in the effect of some experimental A review of the methods of magnetic nanocomposites synthesis and their applications as drug delivery systems and immobilization supports for lipases variables on the nanoparticle size. Finally, two specific applications of magnetic nanocomposites in novel and relevant fields will be discussed. The role of magnetic nanoparticles as drug delivery systems (DDS) is of high significance and consequently, the available information is rich, but it is mostly dedicated to the sustained release of anticancer drugs. Here we will show other drugs, able to be delivered from magnetic DDS. MNC have recently emerged as effective supports for lipase immobilization. The reported data concerning to this topic is still quite limited and therefore novel published advances are reviewed here.
Fil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Avena, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Ferreira, María Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
description Iron oxide-based magnetic nanoparticles (IONP) that display high saturation and high magnetic susceptibility are of great interest for biotechnological and biomedical applications. Magnetite displays strong ferrimagnetic behaviour and is less sensitive to oxidation than other magnetic transition metaloxides. It is then not surprising that IONP include magnetite in their formulation. The role of IONP technology in the cited areas requires specific characteristics with regard to the particle size and surface functionality. Therefore the incorporation of polymeric moieties appears as a valuable tool to achieve the desired properties. On this context surface-modified IONP and magnetic nanocomposites (MNC) can be obtained depending on the role of the polymeric network in the formulation process. The methods to prepare each kind of magnetic-polymeric composite are reviewed in this work. First, the different kinds of IONP are carefully analyzed and second, the techniques available to incorporate polymer and other modifiers, are addressed. An investigation of the relationship between the nature of the modifier and the tailored application of the generated particles is also included with the focus mainly in the effect of some experimental A review of the methods of magnetic nanocomposites synthesis and their applications as drug delivery systems and immobilization supports for lipases variables on the nanoparticle size. Finally, two specific applications of magnetic nanocomposites in novel and relevant fields will be discussed. The role of magnetic nanoparticles as drug delivery systems (DDS) is of high significance and consequently, the available information is rich, but it is mostly dedicated to the sustained release of anticancer drugs. Here we will show other drugs, able to be delivered from magnetic DDS. MNC have recently emerged as effective supports for lipase immobilization. The reported data concerning to this topic is still quite limited and therefore novel published advances are reviewed here.
publishDate 2009
dc.date.none.fl_str_mv 2009-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/61660
Lassalle, Verónica Leticia; Avena, Marcelo Javier; Ferreira, María Luján; A review of the methods of magnetic nanocomposites synthesis and their applications as drug delivery systems and immobilization supports for lipases; Research Trends Ltd.; Current Trends in Polymer Science; 13; 11-2009; 37-67
0972-446X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/61660
identifier_str_mv Lassalle, Verónica Leticia; Avena, Marcelo Javier; Ferreira, María Luján; A review of the methods of magnetic nanocomposites synthesis and their applications as drug delivery systems and immobilization supports for lipases; Research Trends Ltd.; Current Trends in Polymer Science; 13; 11-2009; 37-67
0972-446X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.researchtrends.net/tia/abstract.asp?in=0&vn=13&tid=2&aid=2855&pub=2009&type=3
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Research Trends Ltd.
publisher.none.fl_str_mv Research Trends Ltd.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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