Novel interactions of GRP78: UPR and estrogen responses in the brain

Autores
Avila, Marco Fidel; Cabezas, Ricardo; Torrente, Daniel; Gonzalez, Janneth; Morales, Ludis; Alvarez, Lisandro; Capani, Francisco; Barreto, George E.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Glucose-regulated protein 78 (GRP78; 78 kDa) belongs to a group of highly conserved heat shock proteins (Hsp) with important functions at the cellular level. The emerging interest for GRP78 relies on its different functions, both in normal and pathological circumstances. GRP78 regulates intracellular calcium, protein shaping, endoplasmic reticulum (ER) stress and cell survival by an immediate response to insults, and that its expression may also be regulated by estrogens. Although these roles are well explored, the mechanisms by which GRP78 induces these changes are not completely understood. In this review, we highlight various aspects related to the GRP78 functioning in cellular protection and repair in response to ER stress and unfolded protein response by the regulation of intracellular Ca2+ and other mechanisms. In this respect, the novel interactions between GRP78 and estrogens, such as estradiol and others, are analyzed in the context of the central nervous system (CNS). We also discuss the importance of GRP78 and estrogens in brain diseases including ischemia, Alzheimer's and Huntington's disorders. Finally, the main protective mechanisms of GRP78 and estrogens during ER dysfunction in the brain are described, and the prospective roles of GRP78 in therapeutic processes.
Fil: Avila, Marco Fidel. Pontificia Universidad Javeriana; Colombia
Fil: Cabezas, Ricardo. Pontificia Universidad Javeriana; Colombia
Fil: Torrente, Daniel. Pontificia Universidad Javeriana; Colombia
Fil: Gonzalez, Janneth. Pontificia Universidad Javeriana; Colombia
Fil: Morales, Ludis. Pontificia Universidad Javeriana; Colombia
Fil: Alvarez, Lisandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
Fil: Barreto, George E.. Pontificia Universidad Javeriana; Colombia
Materia
Calcium
Estrogens
Grp78
Neuroprotection
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/7871
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Novel interactions of GRP78: UPR and estrogen responses in the brainAvila, Marco FidelCabezas, RicardoTorrente, DanielGonzalez, JannethMorales, LudisAlvarez, LisandroCapani, FranciscoBarreto, George E.CalciumEstrogensGrp78Neuroprotectionhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Glucose-regulated protein 78 (GRP78; 78 kDa) belongs to a group of highly conserved heat shock proteins (Hsp) with important functions at the cellular level. The emerging interest for GRP78 relies on its different functions, both in normal and pathological circumstances. GRP78 regulates intracellular calcium, protein shaping, endoplasmic reticulum (ER) stress and cell survival by an immediate response to insults, and that its expression may also be regulated by estrogens. Although these roles are well explored, the mechanisms by which GRP78 induces these changes are not completely understood. In this review, we highlight various aspects related to the GRP78 functioning in cellular protection and repair in response to ER stress and unfolded protein response by the regulation of intracellular Ca2+ and other mechanisms. In this respect, the novel interactions between GRP78 and estrogens, such as estradiol and others, are analyzed in the context of the central nervous system (CNS). We also discuss the importance of GRP78 and estrogens in brain diseases including ischemia, Alzheimer's and Huntington's disorders. Finally, the main protective mechanisms of GRP78 and estrogens during ER dysfunction in the brain are described, and the prospective roles of GRP78 in therapeutic processes.Fil: Avila, Marco Fidel. Pontificia Universidad Javeriana; ColombiaFil: Cabezas, Ricardo. Pontificia Universidad Javeriana; ColombiaFil: Torrente, Daniel. Pontificia Universidad Javeriana; ColombiaFil: Gonzalez, Janneth. Pontificia Universidad Javeriana; ColombiaFil: Morales, Ludis. Pontificia Universidad Javeriana; ColombiaFil: Alvarez, Lisandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); ArgentinaFil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); ArgentinaFil: Barreto, George E.. Pontificia Universidad Javeriana; ColombiaWiley2013-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7871Avila, Marco Fidel; Cabezas, Ricardo; Torrente, Daniel; Gonzalez, Janneth; Morales, Ludis; et al.; Novel interactions of GRP78: UPR and estrogen responses in the brain; Wiley; Cell Biology International; 37; 6; 6-2013; 522-5321065-6995enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/cbin.10058/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1002/cbin.10058info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:57:28Zoai:ri.conicet.gov.ar:11336/7871instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:57:28.449CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Novel interactions of GRP78: UPR and estrogen responses in the brain
title Novel interactions of GRP78: UPR and estrogen responses in the brain
spellingShingle Novel interactions of GRP78: UPR and estrogen responses in the brain
Avila, Marco Fidel
Calcium
Estrogens
Grp78
Neuroprotection
title_short Novel interactions of GRP78: UPR and estrogen responses in the brain
title_full Novel interactions of GRP78: UPR and estrogen responses in the brain
title_fullStr Novel interactions of GRP78: UPR and estrogen responses in the brain
title_full_unstemmed Novel interactions of GRP78: UPR and estrogen responses in the brain
title_sort Novel interactions of GRP78: UPR and estrogen responses in the brain
dc.creator.none.fl_str_mv Avila, Marco Fidel
Cabezas, Ricardo
Torrente, Daniel
Gonzalez, Janneth
Morales, Ludis
Alvarez, Lisandro
Capani, Francisco
Barreto, George E.
author Avila, Marco Fidel
author_facet Avila, Marco Fidel
Cabezas, Ricardo
Torrente, Daniel
Gonzalez, Janneth
Morales, Ludis
Alvarez, Lisandro
Capani, Francisco
Barreto, George E.
author_role author
author2 Cabezas, Ricardo
Torrente, Daniel
Gonzalez, Janneth
Morales, Ludis
Alvarez, Lisandro
Capani, Francisco
Barreto, George E.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Calcium
Estrogens
Grp78
Neuroprotection
topic Calcium
Estrogens
Grp78
Neuroprotection
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Glucose-regulated protein 78 (GRP78; 78 kDa) belongs to a group of highly conserved heat shock proteins (Hsp) with important functions at the cellular level. The emerging interest for GRP78 relies on its different functions, both in normal and pathological circumstances. GRP78 regulates intracellular calcium, protein shaping, endoplasmic reticulum (ER) stress and cell survival by an immediate response to insults, and that its expression may also be regulated by estrogens. Although these roles are well explored, the mechanisms by which GRP78 induces these changes are not completely understood. In this review, we highlight various aspects related to the GRP78 functioning in cellular protection and repair in response to ER stress and unfolded protein response by the regulation of intracellular Ca2+ and other mechanisms. In this respect, the novel interactions between GRP78 and estrogens, such as estradiol and others, are analyzed in the context of the central nervous system (CNS). We also discuss the importance of GRP78 and estrogens in brain diseases including ischemia, Alzheimer's and Huntington's disorders. Finally, the main protective mechanisms of GRP78 and estrogens during ER dysfunction in the brain are described, and the prospective roles of GRP78 in therapeutic processes.
Fil: Avila, Marco Fidel. Pontificia Universidad Javeriana; Colombia
Fil: Cabezas, Ricardo. Pontificia Universidad Javeriana; Colombia
Fil: Torrente, Daniel. Pontificia Universidad Javeriana; Colombia
Fil: Gonzalez, Janneth. Pontificia Universidad Javeriana; Colombia
Fil: Morales, Ludis. Pontificia Universidad Javeriana; Colombia
Fil: Alvarez, Lisandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
Fil: Barreto, George E.. Pontificia Universidad Javeriana; Colombia
description Glucose-regulated protein 78 (GRP78; 78 kDa) belongs to a group of highly conserved heat shock proteins (Hsp) with important functions at the cellular level. The emerging interest for GRP78 relies on its different functions, both in normal and pathological circumstances. GRP78 regulates intracellular calcium, protein shaping, endoplasmic reticulum (ER) stress and cell survival by an immediate response to insults, and that its expression may also be regulated by estrogens. Although these roles are well explored, the mechanisms by which GRP78 induces these changes are not completely understood. In this review, we highlight various aspects related to the GRP78 functioning in cellular protection and repair in response to ER stress and unfolded protein response by the regulation of intracellular Ca2+ and other mechanisms. In this respect, the novel interactions between GRP78 and estrogens, such as estradiol and others, are analyzed in the context of the central nervous system (CNS). We also discuss the importance of GRP78 and estrogens in brain diseases including ischemia, Alzheimer's and Huntington's disorders. Finally, the main protective mechanisms of GRP78 and estrogens during ER dysfunction in the brain are described, and the prospective roles of GRP78 in therapeutic processes.
publishDate 2013
dc.date.none.fl_str_mv 2013-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/7871
Avila, Marco Fidel; Cabezas, Ricardo; Torrente, Daniel; Gonzalez, Janneth; Morales, Ludis; et al.; Novel interactions of GRP78: UPR and estrogen responses in the brain; Wiley; Cell Biology International; 37; 6; 6-2013; 522-532
1065-6995
url http://hdl.handle.net/11336/7871
identifier_str_mv Avila, Marco Fidel; Cabezas, Ricardo; Torrente, Daniel; Gonzalez, Janneth; Morales, Ludis; et al.; Novel interactions of GRP78: UPR and estrogen responses in the brain; Wiley; Cell Biology International; 37; 6; 6-2013; 522-532
1065-6995
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/cbin.10058/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1002/cbin.10058
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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