Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems

Autores
Pérez, Rocío Laura; Escandar, Graciela Monica
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
For the first time, the spectrofluorimetric properties of estrone (E1), 17β-estradiol (E2), estriol (E3), and 17α-ethinylestradiol (EE2) are studied in aqueous solutions after the addition of native and derivative cyclodextrins. In contrast to previous reports, the behavior of the systems is analysed in the absence of organic solvents able to modify the guest-host interaction. The significant differences between the obtained association constants with those reported in solvent mixtures are shown and discussed. In order to evaluate the influence of both the estrogen structure and the presence of cyclodextrin substituents in the inclusion phenomena, fluorescent and acid-base behaviors of the systems are compared and discussed. The interaction of estrogens with micellar media formed by selected surfactants is also studied. It is demonstrated that estrogen-cyclodextrin complexes in aqueous solution are useful for improving fluorimetric detection limits and, since cyclodextrins are non-toxic and mitigate most of the solubility problems which require the use of organic solvents, the studied complexes are excellent candidates for extraction, separation, pre-concentration and removal processes maintaining the principles of the green analytical chemistry.
Fil: Pérez, Rocío Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Escandar, Graciela Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Materia
Fluorescence
Cyclodextrin
Estrogens
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6077
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systemsPérez, Rocío LauraEscandar, Graciela MonicaFluorescenceCyclodextrinEstrogenshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1For the first time, the spectrofluorimetric properties of estrone (E1), 17β-estradiol (E2), estriol (E3), and 17α-ethinylestradiol (EE2) are studied in aqueous solutions after the addition of native and derivative cyclodextrins. In contrast to previous reports, the behavior of the systems is analysed in the absence of organic solvents able to modify the guest-host interaction. The significant differences between the obtained association constants with those reported in solvent mixtures are shown and discussed. In order to evaluate the influence of both the estrogen structure and the presence of cyclodextrin substituents in the inclusion phenomena, fluorescent and acid-base behaviors of the systems are compared and discussed. The interaction of estrogens with micellar media formed by selected surfactants is also studied. It is demonstrated that estrogen-cyclodextrin complexes in aqueous solution are useful for improving fluorimetric detection limits and, since cyclodextrins are non-toxic and mitigate most of the solubility problems which require the use of organic solvents, the studied complexes are excellent candidates for extraction, separation, pre-concentration and removal processes maintaining the principles of the green analytical chemistry.Fil: Pérez, Rocío Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaFil: Escandar, Graciela Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaRoyal Society of Chemistry2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6077Pérez, Rocío Laura; Escandar, Graciela Monica; Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems; Royal Society of Chemistry; Analyst; 138; 4; 2-2013; 1239-12480003-2654enginfo:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/content/articlelanding/2012/an/c2an36395jinfo:eu-repo/semantics/altIdentifier/doi/10.1039/C2AN36395Jinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:30Zoai:ri.conicet.gov.ar:11336/6077instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:30.575CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems
title Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems
spellingShingle Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems
Pérez, Rocío Laura
Fluorescence
Cyclodextrin
Estrogens
title_short Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems
title_full Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems
title_fullStr Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems
title_full_unstemmed Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems
title_sort Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems
dc.creator.none.fl_str_mv Pérez, Rocío Laura
Escandar, Graciela Monica
author Pérez, Rocío Laura
author_facet Pérez, Rocío Laura
Escandar, Graciela Monica
author_role author
author2 Escandar, Graciela Monica
author2_role author
dc.subject.none.fl_str_mv Fluorescence
Cyclodextrin
Estrogens
topic Fluorescence
Cyclodextrin
Estrogens
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv For the first time, the spectrofluorimetric properties of estrone (E1), 17β-estradiol (E2), estriol (E3), and 17α-ethinylestradiol (EE2) are studied in aqueous solutions after the addition of native and derivative cyclodextrins. In contrast to previous reports, the behavior of the systems is analysed in the absence of organic solvents able to modify the guest-host interaction. The significant differences between the obtained association constants with those reported in solvent mixtures are shown and discussed. In order to evaluate the influence of both the estrogen structure and the presence of cyclodextrin substituents in the inclusion phenomena, fluorescent and acid-base behaviors of the systems are compared and discussed. The interaction of estrogens with micellar media formed by selected surfactants is also studied. It is demonstrated that estrogen-cyclodextrin complexes in aqueous solution are useful for improving fluorimetric detection limits and, since cyclodextrins are non-toxic and mitigate most of the solubility problems which require the use of organic solvents, the studied complexes are excellent candidates for extraction, separation, pre-concentration and removal processes maintaining the principles of the green analytical chemistry.
Fil: Pérez, Rocío Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Escandar, Graciela Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
description For the first time, the spectrofluorimetric properties of estrone (E1), 17β-estradiol (E2), estriol (E3), and 17α-ethinylestradiol (EE2) are studied in aqueous solutions after the addition of native and derivative cyclodextrins. In contrast to previous reports, the behavior of the systems is analysed in the absence of organic solvents able to modify the guest-host interaction. The significant differences between the obtained association constants with those reported in solvent mixtures are shown and discussed. In order to evaluate the influence of both the estrogen structure and the presence of cyclodextrin substituents in the inclusion phenomena, fluorescent and acid-base behaviors of the systems are compared and discussed. The interaction of estrogens with micellar media formed by selected surfactants is also studied. It is demonstrated that estrogen-cyclodextrin complexes in aqueous solution are useful for improving fluorimetric detection limits and, since cyclodextrins are non-toxic and mitigate most of the solubility problems which require the use of organic solvents, the studied complexes are excellent candidates for extraction, separation, pre-concentration and removal processes maintaining the principles of the green analytical chemistry.
publishDate 2013
dc.date.none.fl_str_mv 2013-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6077
Pérez, Rocío Laura; Escandar, Graciela Monica; Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems; Royal Society of Chemistry; Analyst; 138; 4; 2-2013; 1239-1248
0003-2654
url http://hdl.handle.net/11336/6077
identifier_str_mv Pérez, Rocío Laura; Escandar, Graciela Monica; Spectroflurimetric study of estrogen-cyclodextrin inclusion complexes in aqueous systems; Royal Society of Chemistry; Analyst; 138; 4; 2-2013; 1239-1248
0003-2654
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/content/articlelanding/2012/an/c2an36395j
info:eu-repo/semantics/altIdentifier/doi/10.1039/C2AN36395J
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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