Long term consequences of in utero endocrine disruptors exposure on male offspring development

Autores
Pallares, Maria Eugenia; Antonelli, Marta Cristina
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Early life events have long lasting impacts on tissue structure and function. It is accepted that there is an association between environmental challenge during pregnancy and later pathophysiology, a concept that has been named ‘developmental programming’ The environmental adversity acts on specific tissues of the foetus during sensitive periods in its development to change developmental trajectories and thus their organisation and function. During the prenatal period, gonadal steroid hormones (i.e. oestrogens and androgens) organise the developing brain by changing the architecture of several neural substrates which later in puberty are activated by the gonadal steroids surge in a directed manner. Endocrine disruptors may distort or shift the organism´s normal patterns of response to environmental or internal conditions and if present during the gestational period, severe morphological and functional impairments have been observed in the offpring. In this mini-review we will summarize the literature available on endocrine disruptors (ED) exposure during pregnancy and the influence on the outcome of the male offspring. Additionally, the effects of the non-steroidal ED flutamide will be discussed in view of the simmilarities detected with the prenatal stress effects observed on male offspring.
Fil: Pallares, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Materia
Developmental Programming
Gonadal Steroid Hormones
Male Rat Offspring
Dopaminergic System
Prenatal Stress
Flutamide
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/17201
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/17201
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Long term consequences of in utero endocrine disruptors exposure on male offspring developmentPallares, Maria EugeniaAntonelli, Marta CristinaDevelopmental ProgrammingGonadal Steroid HormonesMale Rat OffspringDopaminergic SystemPrenatal StressFlutamidehttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Early life events have long lasting impacts on tissue structure and function. It is accepted that there is an association between environmental challenge during pregnancy and later pathophysiology, a concept that has been named ‘developmental programming’ The environmental adversity acts on specific tissues of the foetus during sensitive periods in its development to change developmental trajectories and thus their organisation and function. During the prenatal period, gonadal steroid hormones (i.e. oestrogens and androgens) organise the developing brain by changing the architecture of several neural substrates which later in puberty are activated by the gonadal steroids surge in a directed manner. Endocrine disruptors may distort or shift the organism´s normal patterns of response to environmental or internal conditions and if present during the gestational period, severe morphological and functional impairments have been observed in the offpring. In this mini-review we will summarize the literature available on endocrine disruptors (ED) exposure during pregnancy and the influence on the outcome of the male offspring. Additionally, the effects of the non-steroidal ED flutamide will be discussed in view of the simmilarities detected with the prenatal stress effects observed on male offspring.Fil: Pallares, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaFil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaSociedad de Farmacología de Chile2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/17201Pallares, Maria Eugenia; Antonelli, Marta Cristina; Long term consequences of in utero endocrine disruptors exposure on male offspring development; Sociedad de Farmacología de Chile; Revista de Farmacología de Chile; 7; 3; 12-2014; 39-440718-88110718-882Xenginfo:eu-repo/semantics/altIdentifier/url/http://www.sofarchi.cl/publicaciones-sofarchi/revista-de-farmacologa-de-chile-2014-v7-n3.htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:30Zoai:ri.conicet.gov.ar:11336/17201instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:30.829CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Long term consequences of in utero endocrine disruptors exposure on male offspring development
title Long term consequences of in utero endocrine disruptors exposure on male offspring development
spellingShingle Long term consequences of in utero endocrine disruptors exposure on male offspring development
Pallares, Maria Eugenia
Developmental Programming
Gonadal Steroid Hormones
Male Rat Offspring
Dopaminergic System
Prenatal Stress
Flutamide
title_short Long term consequences of in utero endocrine disruptors exposure on male offspring development
title_full Long term consequences of in utero endocrine disruptors exposure on male offspring development
title_fullStr Long term consequences of in utero endocrine disruptors exposure on male offspring development
title_full_unstemmed Long term consequences of in utero endocrine disruptors exposure on male offspring development
title_sort Long term consequences of in utero endocrine disruptors exposure on male offspring development
dc.creator.none.fl_str_mv Pallares, Maria Eugenia
Antonelli, Marta Cristina
author Pallares, Maria Eugenia
author_facet Pallares, Maria Eugenia
Antonelli, Marta Cristina
author_role author
author2 Antonelli, Marta Cristina
author2_role author
dc.subject.none.fl_str_mv Developmental Programming
Gonadal Steroid Hormones
Male Rat Offspring
Dopaminergic System
Prenatal Stress
Flutamide
topic Developmental Programming
Gonadal Steroid Hormones
Male Rat Offspring
Dopaminergic System
Prenatal Stress
Flutamide
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Early life events have long lasting impacts on tissue structure and function. It is accepted that there is an association between environmental challenge during pregnancy and later pathophysiology, a concept that has been named ‘developmental programming’ The environmental adversity acts on specific tissues of the foetus during sensitive periods in its development to change developmental trajectories and thus their organisation and function. During the prenatal period, gonadal steroid hormones (i.e. oestrogens and androgens) organise the developing brain by changing the architecture of several neural substrates which later in puberty are activated by the gonadal steroids surge in a directed manner. Endocrine disruptors may distort or shift the organism´s normal patterns of response to environmental or internal conditions and if present during the gestational period, severe morphological and functional impairments have been observed in the offpring. In this mini-review we will summarize the literature available on endocrine disruptors (ED) exposure during pregnancy and the influence on the outcome of the male offspring. Additionally, the effects of the non-steroidal ED flutamide will be discussed in view of the simmilarities detected with the prenatal stress effects observed on male offspring.
Fil: Pallares, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
description Early life events have long lasting impacts on tissue structure and function. It is accepted that there is an association between environmental challenge during pregnancy and later pathophysiology, a concept that has been named ‘developmental programming’ The environmental adversity acts on specific tissues of the foetus during sensitive periods in its development to change developmental trajectories and thus their organisation and function. During the prenatal period, gonadal steroid hormones (i.e. oestrogens and androgens) organise the developing brain by changing the architecture of several neural substrates which later in puberty are activated by the gonadal steroids surge in a directed manner. Endocrine disruptors may distort or shift the organism´s normal patterns of response to environmental or internal conditions and if present during the gestational period, severe morphological and functional impairments have been observed in the offpring. In this mini-review we will summarize the literature available on endocrine disruptors (ED) exposure during pregnancy and the influence on the outcome of the male offspring. Additionally, the effects of the non-steroidal ED flutamide will be discussed in view of the simmilarities detected with the prenatal stress effects observed on male offspring.
publishDate 2014
dc.date.none.fl_str_mv 2014-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/17201
Pallares, Maria Eugenia; Antonelli, Marta Cristina; Long term consequences of in utero endocrine disruptors exposure on male offspring development; Sociedad de Farmacología de Chile; Revista de Farmacología de Chile; 7; 3; 12-2014; 39-44
0718-8811
0718-882X
url http://hdl.handle.net/11336/17201
identifier_str_mv Pallares, Maria Eugenia; Antonelli, Marta Cristina; Long term consequences of in utero endocrine disruptors exposure on male offspring development; Sociedad de Farmacología de Chile; Revista de Farmacología de Chile; 7; 3; 12-2014; 39-44
0718-8811
0718-882X
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sofarchi.cl/publicaciones-sofarchi/revista-de-farmacologa-de-chile-2014-v7-n3.html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedad de Farmacología de Chile
publisher.none.fl_str_mv Sociedad de Farmacología de Chile
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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