MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the Eleonora's falcon

Autores
Gangoso, L.; Grande, Juan Manuel; Ducrest, A. L.; Figuerola, J.; Bortolotti, G. R.; Andrés, J. A.; Roulin, A.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Colour polymorphism in vertebrates is usually under genetic control and may be associated with variation in physiological traits. The melanocortin 1 receptor (Mc1r) has been involved repeatedly in melanin-based pigmentation but it was thought to have few other physiological effects. However, recent pharmacological studies suggest that MC1R could regulate the aspects of immunity. We investigated whether variation at Mc1r underpins plumage colouration in the Eleonora's falcon. We also examined whether nestlings of the different morphs differed in their inflammatory response induced by phytohemagglutinin (PHA). Variation in colouration was due to a deletion of four amino acids at the Mc1r gene. Cellular immune response was morph specific. In males, but not in females, dark nestling mounted a lower PHA response than pale ones. Although correlative, our results raise the neglected possibility that MC1R has pleiotropic effects, suggesting a potential role of immune capacity and pathogen pressure on the maintenance of colour polymorphism in this species.
Fil: Gangoso, L.. Universite de Lausanne; Suiza. Consejo Superior de Investigaciones Científicas; España
Fil: Grande, Juan Manuel. Universidad Nacional de La Pampa. Facultad de Ciencia Exactas y Naturales. Departamento de Recursos Naturales. Centro para el Estudio y Conservación de Aves Rapaces; Argentina. University of Saskatchewan; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; Argentina
Fil: Ducrest, A. L.. Universite de Lausanne; Suiza
Fil: Figuerola, J.. Consejo Superior de Investigaciones Científicas; España
Fil: Bortolotti, G. R.. University of Saskatchewan; Canadá
Fil: Andrés, J. A.. University of Saskatchewan; Canadá
Fil: Roulin, A.. Universite de Lausanne; Suiza
Materia
Falco Eleonorae
Genetic Colour Polymorphism
Inflammatory Response
Melanin-Based Pigmentation
Melanocortin 1 Receptor
Phytohemagglutinin Skin-Swelling Test
Pleiotropy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/81632
Acceder
id CONICETDig_c4a3f6f227de4d07bb6a34d54785027f
oai_identifier_str oai:ri.conicet.gov.ar:11336/81632
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the Eleonora's falconGangoso, L.Grande, Juan ManuelDucrest, A. L.Figuerola, J.Bortolotti, G. R.Andrés, J. A.Roulin, A.Falco EleonoraeGenetic Colour PolymorphismInflammatory ResponseMelanin-Based PigmentationMelanocortin 1 ReceptorPhytohemagglutinin Skin-Swelling TestPleiotropyhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Colour polymorphism in vertebrates is usually under genetic control and may be associated with variation in physiological traits. The melanocortin 1 receptor (Mc1r) has been involved repeatedly in melanin-based pigmentation but it was thought to have few other physiological effects. However, recent pharmacological studies suggest that MC1R could regulate the aspects of immunity. We investigated whether variation at Mc1r underpins plumage colouration in the Eleonora's falcon. We also examined whether nestlings of the different morphs differed in their inflammatory response induced by phytohemagglutinin (PHA). Variation in colouration was due to a deletion of four amino acids at the Mc1r gene. Cellular immune response was morph specific. In males, but not in females, dark nestling mounted a lower PHA response than pale ones. Although correlative, our results raise the neglected possibility that MC1R has pleiotropic effects, suggesting a potential role of immune capacity and pathogen pressure on the maintenance of colour polymorphism in this species.Fil: Gangoso, L.. Universite de Lausanne; Suiza. Consejo Superior de Investigaciones Científicas; EspañaFil: Grande, Juan Manuel. Universidad Nacional de La Pampa. Facultad de Ciencia Exactas y Naturales. Departamento de Recursos Naturales. Centro para el Estudio y Conservación de Aves Rapaces; Argentina. University of Saskatchewan; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; ArgentinaFil: Ducrest, A. L.. Universite de Lausanne; SuizaFil: Figuerola, J.. Consejo Superior de Investigaciones Científicas; EspañaFil: Bortolotti, G. R.. University of Saskatchewan; CanadáFil: Andrés, J. A.. University of Saskatchewan; CanadáFil: Roulin, A.. Universite de Lausanne; SuizaWiley Blackwell Publishing, Inc2011-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/81632Gangoso, L.; Grande, Juan Manuel; Ducrest, A. L.; Figuerola, J.; Bortolotti, G. R.; et al.; MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the Eleonora's falcon; Wiley Blackwell Publishing, Inc; Journal of Evolutionary Biology; 24; 9; 9-2011; 2055-20631010-061XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1420-9101.2011.02336.xinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1420-9101.2011.02336.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:43:18Zoai:ri.conicet.gov.ar:11336/81632instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:43:19.02CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the Eleonora's falcon
title MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the Eleonora's falcon
spellingShingle MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the Eleonora's falcon
Gangoso, L.
Falco Eleonorae
Genetic Colour Polymorphism
Inflammatory Response
Melanin-Based Pigmentation
Melanocortin 1 Receptor
Phytohemagglutinin Skin-Swelling Test
Pleiotropy
title_short MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the Eleonora's falcon
title_full MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the Eleonora's falcon
title_fullStr MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the Eleonora's falcon
title_full_unstemmed MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the Eleonora's falcon
title_sort MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the Eleonora's falcon
dc.creator.none.fl_str_mv Gangoso, L.
Grande, Juan Manuel
Ducrest, A. L.
Figuerola, J.
Bortolotti, G. R.
Andrés, J. A.
Roulin, A.
author Gangoso, L.
author_facet Gangoso, L.
Grande, Juan Manuel
Ducrest, A. L.
Figuerola, J.
Bortolotti, G. R.
Andrés, J. A.
Roulin, A.
author_role author
author2 Grande, Juan Manuel
Ducrest, A. L.
Figuerola, J.
Bortolotti, G. R.
Andrés, J. A.
Roulin, A.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Falco Eleonorae
Genetic Colour Polymorphism
Inflammatory Response
Melanin-Based Pigmentation
Melanocortin 1 Receptor
Phytohemagglutinin Skin-Swelling Test
Pleiotropy
topic Falco Eleonorae
Genetic Colour Polymorphism
Inflammatory Response
Melanin-Based Pigmentation
Melanocortin 1 Receptor
Phytohemagglutinin Skin-Swelling Test
Pleiotropy
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Colour polymorphism in vertebrates is usually under genetic control and may be associated with variation in physiological traits. The melanocortin 1 receptor (Mc1r) has been involved repeatedly in melanin-based pigmentation but it was thought to have few other physiological effects. However, recent pharmacological studies suggest that MC1R could regulate the aspects of immunity. We investigated whether variation at Mc1r underpins plumage colouration in the Eleonora's falcon. We also examined whether nestlings of the different morphs differed in their inflammatory response induced by phytohemagglutinin (PHA). Variation in colouration was due to a deletion of four amino acids at the Mc1r gene. Cellular immune response was morph specific. In males, but not in females, dark nestling mounted a lower PHA response than pale ones. Although correlative, our results raise the neglected possibility that MC1R has pleiotropic effects, suggesting a potential role of immune capacity and pathogen pressure on the maintenance of colour polymorphism in this species.
Fil: Gangoso, L.. Universite de Lausanne; Suiza. Consejo Superior de Investigaciones Científicas; España
Fil: Grande, Juan Manuel. Universidad Nacional de La Pampa. Facultad de Ciencia Exactas y Naturales. Departamento de Recursos Naturales. Centro para el Estudio y Conservación de Aves Rapaces; Argentina. University of Saskatchewan; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Ciencias de la Tierra y Ambientales de La Pampa. Universidad Nacional de La Pampa. Facultad de Ciencias Exactas y Naturales. Instituto de Ciencias de la Tierra y Ambientales de La Pampa; Argentina
Fil: Ducrest, A. L.. Universite de Lausanne; Suiza
Fil: Figuerola, J.. Consejo Superior de Investigaciones Científicas; España
Fil: Bortolotti, G. R.. University of Saskatchewan; Canadá
Fil: Andrés, J. A.. University of Saskatchewan; Canadá
Fil: Roulin, A.. Universite de Lausanne; Suiza
description Colour polymorphism in vertebrates is usually under genetic control and may be associated with variation in physiological traits. The melanocortin 1 receptor (Mc1r) has been involved repeatedly in melanin-based pigmentation but it was thought to have few other physiological effects. However, recent pharmacological studies suggest that MC1R could regulate the aspects of immunity. We investigated whether variation at Mc1r underpins plumage colouration in the Eleonora's falcon. We also examined whether nestlings of the different morphs differed in their inflammatory response induced by phytohemagglutinin (PHA). Variation in colouration was due to a deletion of four amino acids at the Mc1r gene. Cellular immune response was morph specific. In males, but not in females, dark nestling mounted a lower PHA response than pale ones. Although correlative, our results raise the neglected possibility that MC1R has pleiotropic effects, suggesting a potential role of immune capacity and pathogen pressure on the maintenance of colour polymorphism in this species.
publishDate 2011
dc.date.none.fl_str_mv 2011-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/81632
Gangoso, L.; Grande, Juan Manuel; Ducrest, A. L.; Figuerola, J.; Bortolotti, G. R.; et al.; MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the Eleonora's falcon; Wiley Blackwell Publishing, Inc; Journal of Evolutionary Biology; 24; 9; 9-2011; 2055-2063
1010-061X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/81632
identifier_str_mv Gangoso, L.; Grande, Juan Manuel; Ducrest, A. L.; Figuerola, J.; Bortolotti, G. R.; et al.; MC1R-dependent, melanin-based colour polymorphism is associated with cell-mediated response in the Eleonora's falcon; Wiley Blackwell Publishing, Inc; Journal of Evolutionary Biology; 24; 9; 9-2011; 2055-2063
1010-061X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1420-9101.2011.02336.x
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1420-9101.2011.02336.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613362853347328
score 13.070432

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