Morph-specific genetic and environmental variation in innate and acquired immune response in a color polymorphic raptor

Autores
Gangoso, Laura; Roulin, Alexandre; Ducrest, Anna-Lyse; Grande, Juan Manuel; Figuerola, Jordi
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Genetic color polymorphism is widespread in nature. There is an increasing interest in understanding the adaptive value of heritable color variation and trade-off resolution by differently colored individuals. Melanin-based pigmentation is often associated with variation in many different life history traits. These associations have recently been suggested to be the outcome of pleiotropic effects of the melanocortin system. Although pharmacological research supports that MC1R, a gene with a major role in vertebrate pigmentation, has important immunomodulatory effects, evidence regarding pleiotropy at MC1R in natural populations is still under debate. We experimentally assessed whether MC1R-based pigmentation covaries with both inflammatory and humoral immune responses in the color polymorphic Eleonora’s falcon. By means of a cross-fostering experiment, we disentangled potential genetic effects from environmental effects on the covariation between coloration and immunity. Variation in both immune responses was primarily due to genetic factors via the nestlings’ MC1R-related color genotype/phenotype, although environmental effects via the color morph of the foster father also had an influence. Overall, dark nestlings had lower immune responses than pale ones. The effect of the color morph of the foster father was also high, but in the opposite direction, and nestlings raised by dark eumelanic foster fathers had higher immune responses than those raised by pale foster fathers. Although we cannot completely discard alternative explanations, our results suggest that MC1R might influence immunity in this species. Morph-specific variation in immunity as well as pathogen pressure may therefore contribute to the long-term maintenance of genetic color polymorphism in natural populations.
Fil: Gangoso, Laura. Consejo Superior de Investigaciones Científicas. Estación Biológica de Doñana; España
Fil: Roulin, Alexandre. Universite de Lausanne; Suiza
Fil: Ducrest, Anna-Lyse. Universite de Lausanne; Suiza
Fil: Grande, Juan Manuel. Universidad Nacional de La Pampa. Facultad de Ciencia Exactas y Naturales. Departamento de Recursos Naturales. Centro para el Estudio y Conservación de Aves Rapaces; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Figuerola, Jordi. Consejo Superior de Investigaciones Científicas. Estación Biológica de Doñana; España
Materia
Genetic Color Polymosrphism
Immune Response
Melanocortin 1 Receptor
Newcastle Disease Vaccine
Phytohemagglutinin Skin-Swelling Test
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/19123
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/19123
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Morph-specific genetic and environmental variation in innate and acquired immune response in a color polymorphic raptorGangoso, LauraRoulin, AlexandreDucrest, Anna-LyseGrande, Juan ManuelFiguerola, JordiGenetic Color PolymosrphismImmune ResponseMelanocortin 1 ReceptorNewcastle Disease VaccinePhytohemagglutinin Skin-Swelling Testhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Genetic color polymorphism is widespread in nature. There is an increasing interest in understanding the adaptive value of heritable color variation and trade-off resolution by differently colored individuals. Melanin-based pigmentation is often associated with variation in many different life history traits. These associations have recently been suggested to be the outcome of pleiotropic effects of the melanocortin system. Although pharmacological research supports that MC1R, a gene with a major role in vertebrate pigmentation, has important immunomodulatory effects, evidence regarding pleiotropy at MC1R in natural populations is still under debate. We experimentally assessed whether MC1R-based pigmentation covaries with both inflammatory and humoral immune responses in the color polymorphic Eleonora’s falcon. By means of a cross-fostering experiment, we disentangled potential genetic effects from environmental effects on the covariation between coloration and immunity. Variation in both immune responses was primarily due to genetic factors via the nestlings’ MC1R-related color genotype/phenotype, although environmental effects via the color morph of the foster father also had an influence. Overall, dark nestlings had lower immune responses than pale ones. The effect of the color morph of the foster father was also high, but in the opposite direction, and nestlings raised by dark eumelanic foster fathers had higher immune responses than those raised by pale foster fathers. Although we cannot completely discard alternative explanations, our results suggest that MC1R might influence immunity in this species. Morph-specific variation in immunity as well as pathogen pressure may therefore contribute to the long-term maintenance of genetic color polymorphism in natural populations.Fil: Gangoso, Laura. Consejo Superior de Investigaciones Científicas. Estación Biológica de Doñana; EspañaFil: Roulin, Alexandre. Universite de Lausanne; SuizaFil: Ducrest, Anna-Lyse. Universite de Lausanne; SuizaFil: Grande, Juan Manuel. Universidad Nacional de La Pampa. Facultad de Ciencia Exactas y Naturales. Departamento de Recursos Naturales. Centro para el Estudio y Conservación de Aves Rapaces; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Figuerola, Jordi. Consejo Superior de Investigaciones Científicas. Estación Biológica de Doñana; EspañaSpringer Heidelberg2015-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/19123Gangoso, Laura; Roulin, Alexandre; Ducrest, Anna-Lyse; Grande, Juan Manuel; Figuerola, Jordi; Morph-specific genetic and environmental variation in innate and acquired immune response in a color polymorphic raptor; Springer Heidelberg; Oecologia; 178; 4; 8-2015; 1113-11230029-85491432-1939CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00442-015-3306-6info:eu-repo/semantics/altIdentifier/doi/10.1007/s00442-015-3306-6info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:19:48Zoai:ri.conicet.gov.ar:11336/19123instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:19:49.219CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Morph-specific genetic and environmental variation in innate and acquired immune response in a color polymorphic raptor
title Morph-specific genetic and environmental variation in innate and acquired immune response in a color polymorphic raptor
spellingShingle Morph-specific genetic and environmental variation in innate and acquired immune response in a color polymorphic raptor
Gangoso, Laura
Genetic Color Polymosrphism
Immune Response
Melanocortin 1 Receptor
Newcastle Disease Vaccine
Phytohemagglutinin Skin-Swelling Test
title_short Morph-specific genetic and environmental variation in innate and acquired immune response in a color polymorphic raptor
title_full Morph-specific genetic and environmental variation in innate and acquired immune response in a color polymorphic raptor
title_fullStr Morph-specific genetic and environmental variation in innate and acquired immune response in a color polymorphic raptor
title_full_unstemmed Morph-specific genetic and environmental variation in innate and acquired immune response in a color polymorphic raptor
title_sort Morph-specific genetic and environmental variation in innate and acquired immune response in a color polymorphic raptor
dc.creator.none.fl_str_mv Gangoso, Laura
Roulin, Alexandre
Ducrest, Anna-Lyse
Grande, Juan Manuel
Figuerola, Jordi
author Gangoso, Laura
author_facet Gangoso, Laura
Roulin, Alexandre
Ducrest, Anna-Lyse
Grande, Juan Manuel
Figuerola, Jordi
author_role author
author2 Roulin, Alexandre
Ducrest, Anna-Lyse
Grande, Juan Manuel
Figuerola, Jordi
author2_role author
author
author
author
dc.subject.none.fl_str_mv Genetic Color Polymosrphism
Immune Response
Melanocortin 1 Receptor
Newcastle Disease Vaccine
Phytohemagglutinin Skin-Swelling Test
topic Genetic Color Polymosrphism
Immune Response
Melanocortin 1 Receptor
Newcastle Disease Vaccine
Phytohemagglutinin Skin-Swelling Test
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Genetic color polymorphism is widespread in nature. There is an increasing interest in understanding the adaptive value of heritable color variation and trade-off resolution by differently colored individuals. Melanin-based pigmentation is often associated with variation in many different life history traits. These associations have recently been suggested to be the outcome of pleiotropic effects of the melanocortin system. Although pharmacological research supports that MC1R, a gene with a major role in vertebrate pigmentation, has important immunomodulatory effects, evidence regarding pleiotropy at MC1R in natural populations is still under debate. We experimentally assessed whether MC1R-based pigmentation covaries with both inflammatory and humoral immune responses in the color polymorphic Eleonora’s falcon. By means of a cross-fostering experiment, we disentangled potential genetic effects from environmental effects on the covariation between coloration and immunity. Variation in both immune responses was primarily due to genetic factors via the nestlings’ MC1R-related color genotype/phenotype, although environmental effects via the color morph of the foster father also had an influence. Overall, dark nestlings had lower immune responses than pale ones. The effect of the color morph of the foster father was also high, but in the opposite direction, and nestlings raised by dark eumelanic foster fathers had higher immune responses than those raised by pale foster fathers. Although we cannot completely discard alternative explanations, our results suggest that MC1R might influence immunity in this species. Morph-specific variation in immunity as well as pathogen pressure may therefore contribute to the long-term maintenance of genetic color polymorphism in natural populations.
Fil: Gangoso, Laura. Consejo Superior de Investigaciones Científicas. Estación Biológica de Doñana; España
Fil: Roulin, Alexandre. Universite de Lausanne; Suiza
Fil: Ducrest, Anna-Lyse. Universite de Lausanne; Suiza
Fil: Grande, Juan Manuel. Universidad Nacional de La Pampa. Facultad de Ciencia Exactas y Naturales. Departamento de Recursos Naturales. Centro para el Estudio y Conservación de Aves Rapaces; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Figuerola, Jordi. Consejo Superior de Investigaciones Científicas. Estación Biológica de Doñana; España
description Genetic color polymorphism is widespread in nature. There is an increasing interest in understanding the adaptive value of heritable color variation and trade-off resolution by differently colored individuals. Melanin-based pigmentation is often associated with variation in many different life history traits. These associations have recently been suggested to be the outcome of pleiotropic effects of the melanocortin system. Although pharmacological research supports that MC1R, a gene with a major role in vertebrate pigmentation, has important immunomodulatory effects, evidence regarding pleiotropy at MC1R in natural populations is still under debate. We experimentally assessed whether MC1R-based pigmentation covaries with both inflammatory and humoral immune responses in the color polymorphic Eleonora’s falcon. By means of a cross-fostering experiment, we disentangled potential genetic effects from environmental effects on the covariation between coloration and immunity. Variation in both immune responses was primarily due to genetic factors via the nestlings’ MC1R-related color genotype/phenotype, although environmental effects via the color morph of the foster father also had an influence. Overall, dark nestlings had lower immune responses than pale ones. The effect of the color morph of the foster father was also high, but in the opposite direction, and nestlings raised by dark eumelanic foster fathers had higher immune responses than those raised by pale foster fathers. Although we cannot completely discard alternative explanations, our results suggest that MC1R might influence immunity in this species. Morph-specific variation in immunity as well as pathogen pressure may therefore contribute to the long-term maintenance of genetic color polymorphism in natural populations.
publishDate 2015
dc.date.none.fl_str_mv 2015-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/19123
Gangoso, Laura; Roulin, Alexandre; Ducrest, Anna-Lyse; Grande, Juan Manuel; Figuerola, Jordi; Morph-specific genetic and environmental variation in innate and acquired immune response in a color polymorphic raptor; Springer Heidelberg; Oecologia; 178; 4; 8-2015; 1113-1123
0029-8549
1432-1939
CONICET Digital
CONICET
url http://hdl.handle.net/11336/19123
identifier_str_mv Gangoso, Laura; Roulin, Alexandre; Ducrest, Anna-Lyse; Grande, Juan Manuel; Figuerola, Jordi; Morph-specific genetic and environmental variation in innate and acquired immune response in a color polymorphic raptor; Springer Heidelberg; Oecologia; 178; 4; 8-2015; 1113-1123
0029-8549
1432-1939
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00442-015-3306-6
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00442-015-3306-6
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Heidelberg
publisher.none.fl_str_mv Springer Heidelberg
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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