Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice

Autores
Daveri, Elena; Cremonini, Eleonora; Mastaloudis, Angela; Hester, Shelly N.; Wood, Steven M.; Waterhouse, Andrew L.; Anderson, Mauri; Fraga, César Guillermo; Oteiza, Patricia Isabel
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Consumption of diets high in fat and/or fructose content promotes tissue inflammation, oxidative stress, and insulin resistance, activating signals (e.g. NF-κB/JNK) that downregulate the insulin cascade. Current evidence supports the concept that select flavonoids can mitigate obesity and type 2 diabetes (T2D). This work investigated if supplementation with the anthocyanidins (AC) cyanidin and delphinidin could attenuate the adverse consequences of consuming a high fat diet (HFD) in mice. Consumption of an AC-rich blend mitigated HFD-induced obesity, dyslipidemia and insulin resistance (impaired responses to insulin and glucose). HFD-fed mice were characterized by increased liver lipid deposition and inflammation, which were also attenuated upon AC supplementation. HFD caused liver oxidative stress showing an increased expression of NADPH oxidases, generators of superoxide and H2O2, and high levels of oxidized lipid-protein adducts. This was associated with the activation of the redox sensitive signals IKK/NF-κB and JNK1/2, and increased expression of the NF-κB-regulated PTP1B phosphatase, all known inhibitors of the insulin pathway. In agreement with an improved insulin sensitivity, AC supplementation inhibited oxidative stress, NF-κB and JNK activation, and PTP1B overexpression. Thus, cyanidin and delphinidin consumption either through diet or by supplementation could be a positive strategy to control the adverse effects of Western style diets, including overweight, obesity, and T2D. Modulation of inflammation, oxidative stress, and NF-κB/JNK activation emerge as relevant targets of AC beneficial actions.
Fil: Daveri, Elena. University of California. Department of Nutrition and Department of Environmental Toxicology; Estados Unidos
Fil: Cremonini, Eleonora. University of California. Department of Nutrition and Department of Environmental Toxicology; Estados Unidos
Fil: Mastaloudis, Angela. Nse Products, Inc.; Estados Unidos
Fil: Hester, Shelly N.. Nse Products, Inc.; Estados Unidos
Fil: Wood, Steven M.. Nse Products, Inc.; Estados Unidos
Fil: Waterhouse, Andrew L.. University of California; Estados Unidos
Fil: Anderson, Mauri. University of California; Estados Unidos
Fil: Fraga, César Guillermo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analitica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Oteiza, Patricia Isabel. University of California. Department of Nutrition and Department of Environmental Toxicology; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
FLAVONOIDS
ANTHOCYANINS
OBESITY
DIABETES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/88361

id CONICETDig_c46192f85ffa9426ed589fd9b7edec34
oai_identifier_str oai:ri.conicet.gov.ar:11336/88361
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed miceDaveri, ElenaCremonini, EleonoraMastaloudis, AngelaHester, Shelly N.Wood, Steven M.Waterhouse, Andrew L.Anderson, MauriFraga, César GuillermoOteiza, Patricia IsabelFLAVONOIDSANTHOCYANINSOBESITYDIABETEShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Consumption of diets high in fat and/or fructose content promotes tissue inflammation, oxidative stress, and insulin resistance, activating signals (e.g. NF-κB/JNK) that downregulate the insulin cascade. Current evidence supports the concept that select flavonoids can mitigate obesity and type 2 diabetes (T2D). This work investigated if supplementation with the anthocyanidins (AC) cyanidin and delphinidin could attenuate the adverse consequences of consuming a high fat diet (HFD) in mice. Consumption of an AC-rich blend mitigated HFD-induced obesity, dyslipidemia and insulin resistance (impaired responses to insulin and glucose). HFD-fed mice were characterized by increased liver lipid deposition and inflammation, which were also attenuated upon AC supplementation. HFD caused liver oxidative stress showing an increased expression of NADPH oxidases, generators of superoxide and H2O2, and high levels of oxidized lipid-protein adducts. This was associated with the activation of the redox sensitive signals IKK/NF-κB and JNK1/2, and increased expression of the NF-κB-regulated PTP1B phosphatase, all known inhibitors of the insulin pathway. In agreement with an improved insulin sensitivity, AC supplementation inhibited oxidative stress, NF-κB and JNK activation, and PTP1B overexpression. Thus, cyanidin and delphinidin consumption either through diet or by supplementation could be a positive strategy to control the adverse effects of Western style diets, including overweight, obesity, and T2D. Modulation of inflammation, oxidative stress, and NF-κB/JNK activation emerge as relevant targets of AC beneficial actions.Fil: Daveri, Elena. University of California. Department of Nutrition and Department of Environmental Toxicology; Estados UnidosFil: Cremonini, Eleonora. University of California. Department of Nutrition and Department of Environmental Toxicology; Estados UnidosFil: Mastaloudis, Angela. Nse Products, Inc.; Estados UnidosFil: Hester, Shelly N.. Nse Products, Inc.; Estados UnidosFil: Wood, Steven M.. Nse Products, Inc.; Estados UnidosFil: Waterhouse, Andrew L.. University of California; Estados UnidosFil: Anderson, Mauri. University of California; Estados UnidosFil: Fraga, César Guillermo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analitica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Oteiza, Patricia Isabel. University of California. Department of Nutrition and Department of Environmental Toxicology; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2018-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/88361Daveri, Elena; Cremonini, Eleonora; Mastaloudis, Angela; Hester, Shelly N.; Wood, Steven M.; et al.; Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice; Elsevier; Redox Biology; 18; 9-2018; 16-242213-2317CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.redox.2018.05.012info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2213231718303112info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:21:40Zoai:ri.conicet.gov.ar:11336/88361instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:21:41.053CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice
title Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice
spellingShingle Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice
Daveri, Elena
FLAVONOIDS
ANTHOCYANINS
OBESITY
DIABETES
title_short Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice
title_full Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice
title_fullStr Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice
title_full_unstemmed Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice
title_sort Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice
dc.creator.none.fl_str_mv Daveri, Elena
Cremonini, Eleonora
Mastaloudis, Angela
Hester, Shelly N.
Wood, Steven M.
Waterhouse, Andrew L.
Anderson, Mauri
Fraga, César Guillermo
Oteiza, Patricia Isabel
author Daveri, Elena
author_facet Daveri, Elena
Cremonini, Eleonora
Mastaloudis, Angela
Hester, Shelly N.
Wood, Steven M.
Waterhouse, Andrew L.
Anderson, Mauri
Fraga, César Guillermo
Oteiza, Patricia Isabel
author_role author
author2 Cremonini, Eleonora
Mastaloudis, Angela
Hester, Shelly N.
Wood, Steven M.
Waterhouse, Andrew L.
Anderson, Mauri
Fraga, César Guillermo
Oteiza, Patricia Isabel
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv FLAVONOIDS
ANTHOCYANINS
OBESITY
DIABETES
topic FLAVONOIDS
ANTHOCYANINS
OBESITY
DIABETES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Consumption of diets high in fat and/or fructose content promotes tissue inflammation, oxidative stress, and insulin resistance, activating signals (e.g. NF-κB/JNK) that downregulate the insulin cascade. Current evidence supports the concept that select flavonoids can mitigate obesity and type 2 diabetes (T2D). This work investigated if supplementation with the anthocyanidins (AC) cyanidin and delphinidin could attenuate the adverse consequences of consuming a high fat diet (HFD) in mice. Consumption of an AC-rich blend mitigated HFD-induced obesity, dyslipidemia and insulin resistance (impaired responses to insulin and glucose). HFD-fed mice were characterized by increased liver lipid deposition and inflammation, which were also attenuated upon AC supplementation. HFD caused liver oxidative stress showing an increased expression of NADPH oxidases, generators of superoxide and H2O2, and high levels of oxidized lipid-protein adducts. This was associated with the activation of the redox sensitive signals IKK/NF-κB and JNK1/2, and increased expression of the NF-κB-regulated PTP1B phosphatase, all known inhibitors of the insulin pathway. In agreement with an improved insulin sensitivity, AC supplementation inhibited oxidative stress, NF-κB and JNK activation, and PTP1B overexpression. Thus, cyanidin and delphinidin consumption either through diet or by supplementation could be a positive strategy to control the adverse effects of Western style diets, including overweight, obesity, and T2D. Modulation of inflammation, oxidative stress, and NF-κB/JNK activation emerge as relevant targets of AC beneficial actions.
Fil: Daveri, Elena. University of California. Department of Nutrition and Department of Environmental Toxicology; Estados Unidos
Fil: Cremonini, Eleonora. University of California. Department of Nutrition and Department of Environmental Toxicology; Estados Unidos
Fil: Mastaloudis, Angela. Nse Products, Inc.; Estados Unidos
Fil: Hester, Shelly N.. Nse Products, Inc.; Estados Unidos
Fil: Wood, Steven M.. Nse Products, Inc.; Estados Unidos
Fil: Waterhouse, Andrew L.. University of California; Estados Unidos
Fil: Anderson, Mauri. University of California; Estados Unidos
Fil: Fraga, César Guillermo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analitica y Fisicoquímica. Cátedra de Fisicoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Oteiza, Patricia Isabel. University of California. Department of Nutrition and Department of Environmental Toxicology; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Consumption of diets high in fat and/or fructose content promotes tissue inflammation, oxidative stress, and insulin resistance, activating signals (e.g. NF-κB/JNK) that downregulate the insulin cascade. Current evidence supports the concept that select flavonoids can mitigate obesity and type 2 diabetes (T2D). This work investigated if supplementation with the anthocyanidins (AC) cyanidin and delphinidin could attenuate the adverse consequences of consuming a high fat diet (HFD) in mice. Consumption of an AC-rich blend mitigated HFD-induced obesity, dyslipidemia and insulin resistance (impaired responses to insulin and glucose). HFD-fed mice were characterized by increased liver lipid deposition and inflammation, which were also attenuated upon AC supplementation. HFD caused liver oxidative stress showing an increased expression of NADPH oxidases, generators of superoxide and H2O2, and high levels of oxidized lipid-protein adducts. This was associated with the activation of the redox sensitive signals IKK/NF-κB and JNK1/2, and increased expression of the NF-κB-regulated PTP1B phosphatase, all known inhibitors of the insulin pathway. In agreement with an improved insulin sensitivity, AC supplementation inhibited oxidative stress, NF-κB and JNK activation, and PTP1B overexpression. Thus, cyanidin and delphinidin consumption either through diet or by supplementation could be a positive strategy to control the adverse effects of Western style diets, including overweight, obesity, and T2D. Modulation of inflammation, oxidative stress, and NF-κB/JNK activation emerge as relevant targets of AC beneficial actions.
publishDate 2018
dc.date.none.fl_str_mv 2018-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/88361
Daveri, Elena; Cremonini, Eleonora; Mastaloudis, Angela; Hester, Shelly N.; Wood, Steven M.; et al.; Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice; Elsevier; Redox Biology; 18; 9-2018; 16-24
2213-2317
CONICET Digital
CONICET
url http://hdl.handle.net/11336/88361
identifier_str_mv Daveri, Elena; Cremonini, Eleonora; Mastaloudis, Angela; Hester, Shelly N.; Wood, Steven M.; et al.; Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice; Elsevier; Redox Biology; 18; 9-2018; 16-24
2213-2317
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.redox.2018.05.012
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2213231718303112
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614205787865088
score 13.070432