Gonadectomy influences blood pressure through the kallikrein-kinin system
- Autores
- Azurmendi, Pablo Javier; Oddo, Elisabet Mónica; Obika, Leonard F.; Corbera, Natalia Leonor; Martin, Rodolfo Santiago; Ibarra, Fernando Raúl; Arrizurieta, Elvira
- Año de publicación
- 2009
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The kallikrein-kinin system (KKS) appears to be involved in blood pressure regulation. We showed that ovariectomy (oVx) stimulates urinary kallikrein activity (UKa). So, we test whether gonadectomy (Gx) would affect blood pressure through an increase in KKS activity and which mechanism(s) were involved. We studied adult Wistar rats of either sex, with and without Gx. At baseline all groups were normotensive although the oVx mean arterial pressure (MAP) was lower than female MAP (p < 0.05). KKS blockade by aprotinin increased MAP (p < 0.05) exclusively in the oVx group. The probably mechanism(s) involved in KKS regulation (synthesis, renal content and UKa) were also studied. Previous Gx, kallikrein content (nkat/g kidney weight) and UKa (nkat/g kidney weight/day) were higher in female than in male rats: 12 ± 1.1 versus 6 ± 0.7 and 40 ± 6.8 versus 26 ± 3.4, respectively. After Gx, kallikrein content increased significantly in both orchiectomized (oRx) and oVx rats, and UKa showed a similar tendency (NS). Kallikrein synthesis did not show gender difference in non-Gx rats, but an increase after oVx was observed. KKS was found to be involved in blood pressure regulation in oVx animals. oVx may trigger the increase in kallikrein synthesis and content and UKa to act upon blood pressure.
Fil: Azurmendi, Pablo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Oddo, Elisabet Mónica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Obika, Leonard F.. University of Benin; Nigeria
Fil: Corbera, Natalia Leonor. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Martin, Rodolfo Santiago. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ibarra, Fernando Raúl. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Arrizurieta, Elvira. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina - Materia
-
BLOOD PRESSURE
OVARIECTOMY
RENAL CORTEX
RENAL KALLIKREIN - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/139389
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Gonadectomy influences blood pressure through the kallikrein-kinin systemAzurmendi, Pablo JavierOddo, Elisabet MónicaObika, Leonard F.Corbera, Natalia LeonorMartin, Rodolfo SantiagoIbarra, Fernando RaúlArrizurieta, ElviraBLOOD PRESSUREOVARIECTOMYRENAL CORTEXRENAL KALLIKREINhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The kallikrein-kinin system (KKS) appears to be involved in blood pressure regulation. We showed that ovariectomy (oVx) stimulates urinary kallikrein activity (UKa). So, we test whether gonadectomy (Gx) would affect blood pressure through an increase in KKS activity and which mechanism(s) were involved. We studied adult Wistar rats of either sex, with and without Gx. At baseline all groups were normotensive although the oVx mean arterial pressure (MAP) was lower than female MAP (p < 0.05). KKS blockade by aprotinin increased MAP (p < 0.05) exclusively in the oVx group. The probably mechanism(s) involved in KKS regulation (synthesis, renal content and UKa) were also studied. Previous Gx, kallikrein content (nkat/g kidney weight) and UKa (nkat/g kidney weight/day) were higher in female than in male rats: 12 ± 1.1 versus 6 ± 0.7 and 40 ± 6.8 versus 26 ± 3.4, respectively. After Gx, kallikrein content increased significantly in both orchiectomized (oRx) and oVx rats, and UKa showed a similar tendency (NS). Kallikrein synthesis did not show gender difference in non-Gx rats, but an increase after oVx was observed. KKS was found to be involved in blood pressure regulation in oVx animals. oVx may trigger the increase in kallikrein synthesis and content and UKa to act upon blood pressure.Fil: Azurmendi, Pablo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Oddo, Elisabet Mónica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Obika, Leonard F.. University of Benin; NigeriaFil: Corbera, Natalia Leonor. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Martin, Rodolfo Santiago. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ibarra, Fernando Raúl. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Arrizurieta, Elvira. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaKarger2009-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/139389Azurmendi, Pablo Javier; Oddo, Elisabet Mónica; Obika, Leonard F.; Corbera, Natalia Leonor; Martin, Rodolfo Santiago; et al.; Gonadectomy influences blood pressure through the kallikrein-kinin system; Karger; Kidney And Blood Pressure Research; 32; 5; 11-2009; 342-3481420-40961423-0143CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/245037info:eu-repo/semantics/altIdentifier/doi/10.1159/000245037info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:13Zoai:ri.conicet.gov.ar:11336/139389instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:13.917CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Gonadectomy influences blood pressure through the kallikrein-kinin system |
title |
Gonadectomy influences blood pressure through the kallikrein-kinin system |
spellingShingle |
Gonadectomy influences blood pressure through the kallikrein-kinin system Azurmendi, Pablo Javier BLOOD PRESSURE OVARIECTOMY RENAL CORTEX RENAL KALLIKREIN |
title_short |
Gonadectomy influences blood pressure through the kallikrein-kinin system |
title_full |
Gonadectomy influences blood pressure through the kallikrein-kinin system |
title_fullStr |
Gonadectomy influences blood pressure through the kallikrein-kinin system |
title_full_unstemmed |
Gonadectomy influences blood pressure through the kallikrein-kinin system |
title_sort |
Gonadectomy influences blood pressure through the kallikrein-kinin system |
dc.creator.none.fl_str_mv |
Azurmendi, Pablo Javier Oddo, Elisabet Mónica Obika, Leonard F. Corbera, Natalia Leonor Martin, Rodolfo Santiago Ibarra, Fernando Raúl Arrizurieta, Elvira |
author |
Azurmendi, Pablo Javier |
author_facet |
Azurmendi, Pablo Javier Oddo, Elisabet Mónica Obika, Leonard F. Corbera, Natalia Leonor Martin, Rodolfo Santiago Ibarra, Fernando Raúl Arrizurieta, Elvira |
author_role |
author |
author2 |
Oddo, Elisabet Mónica Obika, Leonard F. Corbera, Natalia Leonor Martin, Rodolfo Santiago Ibarra, Fernando Raúl Arrizurieta, Elvira |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
BLOOD PRESSURE OVARIECTOMY RENAL CORTEX RENAL KALLIKREIN |
topic |
BLOOD PRESSURE OVARIECTOMY RENAL CORTEX RENAL KALLIKREIN |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The kallikrein-kinin system (KKS) appears to be involved in blood pressure regulation. We showed that ovariectomy (oVx) stimulates urinary kallikrein activity (UKa). So, we test whether gonadectomy (Gx) would affect blood pressure through an increase in KKS activity and which mechanism(s) were involved. We studied adult Wistar rats of either sex, with and without Gx. At baseline all groups were normotensive although the oVx mean arterial pressure (MAP) was lower than female MAP (p < 0.05). KKS blockade by aprotinin increased MAP (p < 0.05) exclusively in the oVx group. The probably mechanism(s) involved in KKS regulation (synthesis, renal content and UKa) were also studied. Previous Gx, kallikrein content (nkat/g kidney weight) and UKa (nkat/g kidney weight/day) were higher in female than in male rats: 12 ± 1.1 versus 6 ± 0.7 and 40 ± 6.8 versus 26 ± 3.4, respectively. After Gx, kallikrein content increased significantly in both orchiectomized (oRx) and oVx rats, and UKa showed a similar tendency (NS). Kallikrein synthesis did not show gender difference in non-Gx rats, but an increase after oVx was observed. KKS was found to be involved in blood pressure regulation in oVx animals. oVx may trigger the increase in kallikrein synthesis and content and UKa to act upon blood pressure. Fil: Azurmendi, Pablo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina Fil: Oddo, Elisabet Mónica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina Fil: Obika, Leonard F.. University of Benin; Nigeria Fil: Corbera, Natalia Leonor. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina Fil: Martin, Rodolfo Santiago. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ibarra, Fernando Raúl. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina Fil: Arrizurieta, Elvira. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina |
description |
The kallikrein-kinin system (KKS) appears to be involved in blood pressure regulation. We showed that ovariectomy (oVx) stimulates urinary kallikrein activity (UKa). So, we test whether gonadectomy (Gx) would affect blood pressure through an increase in KKS activity and which mechanism(s) were involved. We studied adult Wistar rats of either sex, with and without Gx. At baseline all groups were normotensive although the oVx mean arterial pressure (MAP) was lower than female MAP (p < 0.05). KKS blockade by aprotinin increased MAP (p < 0.05) exclusively in the oVx group. The probably mechanism(s) involved in KKS regulation (synthesis, renal content and UKa) were also studied. Previous Gx, kallikrein content (nkat/g kidney weight) and UKa (nkat/g kidney weight/day) were higher in female than in male rats: 12 ± 1.1 versus 6 ± 0.7 and 40 ± 6.8 versus 26 ± 3.4, respectively. After Gx, kallikrein content increased significantly in both orchiectomized (oRx) and oVx rats, and UKa showed a similar tendency (NS). Kallikrein synthesis did not show gender difference in non-Gx rats, but an increase after oVx was observed. KKS was found to be involved in blood pressure regulation in oVx animals. oVx may trigger the increase in kallikrein synthesis and content and UKa to act upon blood pressure. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/139389 Azurmendi, Pablo Javier; Oddo, Elisabet Mónica; Obika, Leonard F.; Corbera, Natalia Leonor; Martin, Rodolfo Santiago; et al.; Gonadectomy influences blood pressure through the kallikrein-kinin system; Karger; Kidney And Blood Pressure Research; 32; 5; 11-2009; 342-348 1420-4096 1423-0143 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/139389 |
identifier_str_mv |
Azurmendi, Pablo Javier; Oddo, Elisabet Mónica; Obika, Leonard F.; Corbera, Natalia Leonor; Martin, Rodolfo Santiago; et al.; Gonadectomy influences blood pressure through the kallikrein-kinin system; Karger; Kidney And Blood Pressure Research; 32; 5; 11-2009; 342-348 1420-4096 1423-0143 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/245037 info:eu-repo/semantics/altIdentifier/doi/10.1159/000245037 |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Karger |
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Karger |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.13397 |