Ciprofloxacin in Layered Double Hydroxides: Looking for the Best Synthesis Method

Autores
Lopez, Nicolas Alfredo; Avena, Marcelo Javier; Luengo, Carina Vanesa
Año de publicación
2023
Idioma
inglés
Tipo de recurso
conjunto de datos
Estado
Descripción
It is important to develop new methods of release to improve pharmacokinetic parameters of drugs, especially antibiotics, whose plasmatic concentration is determinant to ensure an effective treatment. Layered double hydroxides (LDH) are inorganic and biocompatible materials with high drug intercalation capacity and release properties that can be tuned by controlling the pH value. These materials can be an excellent choice to achieve a sustained release and an optimal drug concentration in plasm. In this work, LDH were synthesized with intercalated ciprofloxacin (CIP) by three different methods: coprecipitation, reconstruction and ion exchange. LDH-CIP complexes were characterized by XRD, TG-DSC, TEM, SEM, FTIR, electrophoretic mobilities, and drug release and dissolution kinetics in NaCl solutions and under physiological conditions. The coprecipitation and reconstruction methods lead to the formation of ill-defined products, whereas the ion exchange method rendered the best intercalation results. CIP release was controlled by dissolution at pH<3 and by desorption and ion exchange at intermediate and high pH. In comparison with a commercial formulation, the LDH-CIP complex prepared by ion exchange presented a slower release profile. The fast dissolution at gastric pH raises the need of developing some type of coating for protecting LDH materials.
Fil: Lopez, Nicolas Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Avena, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Luengo, Carina Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Datos sujetos al derecho de propiedad industrial
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/184176
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spelling Ciprofloxacin in Layered Double Hydroxides: Looking for the Best Synthesis MethodLopez, Nicolas AlfredoAvena, Marcelo JavierLuengo, Carina Vanesahttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1It is important to develop new methods of release to improve pharmacokinetic parameters of drugs, especially antibiotics, whose plasmatic concentration is determinant to ensure an effective treatment. Layered double hydroxides (LDH) are inorganic and biocompatible materials with high drug intercalation capacity and release properties that can be tuned by controlling the pH value. These materials can be an excellent choice to achieve a sustained release and an optimal drug concentration in plasm. In this work, LDH were synthesized with intercalated ciprofloxacin (CIP) by three different methods: coprecipitation, reconstruction and ion exchange. LDH-CIP complexes were characterized by XRD, TG-DSC, TEM, SEM, FTIR, electrophoretic mobilities, and drug release and dissolution kinetics in NaCl solutions and under physiological conditions. The coprecipitation and reconstruction methods lead to the formation of ill-defined products, whereas the ion exchange method rendered the best intercalation results. CIP release was controlled by dissolution at pH<3 and by desorption and ion exchange at intermediate and high pH. In comparison with a commercial formulation, the LDH-CIP complex prepared by ion exchange presented a slower release profile. The fast dissolution at gastric pH raises the need of developing some type of coating for protecting LDH materials.Fil: Lopez, Nicolas Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Avena, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Luengo, Carina Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina2023info:ar-repo/semantics/conjuntoDeDatosv1.0info:eu-repo/semantics/dataSetimage/tiffimage/tiffapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffimage/tiffhttp://hdl.handle.net/11336/184176Lopez, Nicolas Alfredo; Avena, Marcelo Javier; Luengo, Carina Vanesa; (2023): Ciprofloxacin in Layered Double Hydroxides: Looking for the Best Synthesis Method. Consejo Nacional de Investigaciones Científicas y Técnicas. (dataset). http://hdl.handle.net/11336/184176CONICET DigitalCONICETenginfo:eu-repo/grantAgreement/Universidad Nacional del Sur/PGI UNS 24-Q083info:eu-repo/grantAgreement/Ministerio de Ciencia. Tecnología e Innovación Productiva. Agencia Nacional de Promoción Científica y Tecnológica/PGI UNS 24-Q083info:eu-repo/grantAgreement//PGI UNS 24-Q083info:eu-repo/grantAgreement//PGI UNS 24-Q083info:eu-repo/grantAgreement//PGI UNS 24-Q083info:eu-repo/semantics/restrictedAccessDatos sujetos al derecho de propiedad industrialreponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-12-23T14:19:04Zoai:ri.conicet.gov.ar:11336/184176instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-12-23 14:19:04.799CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ciprofloxacin in Layered Double Hydroxides: Looking for the Best Synthesis Method
title Ciprofloxacin in Layered Double Hydroxides: Looking for the Best Synthesis Method
spellingShingle Ciprofloxacin in Layered Double Hydroxides: Looking for the Best Synthesis Method
Lopez, Nicolas Alfredo
title_short Ciprofloxacin in Layered Double Hydroxides: Looking for the Best Synthesis Method
title_full Ciprofloxacin in Layered Double Hydroxides: Looking for the Best Synthesis Method
title_fullStr Ciprofloxacin in Layered Double Hydroxides: Looking for the Best Synthesis Method
title_full_unstemmed Ciprofloxacin in Layered Double Hydroxides: Looking for the Best Synthesis Method
title_sort Ciprofloxacin in Layered Double Hydroxides: Looking for the Best Synthesis Method
dc.creator.none.fl_str_mv Lopez, Nicolas Alfredo
Avena, Marcelo Javier
Luengo, Carina Vanesa
author Lopez, Nicolas Alfredo
author_facet Lopez, Nicolas Alfredo
Avena, Marcelo Javier
Luengo, Carina Vanesa
author_role author
author2 Avena, Marcelo Javier
Luengo, Carina Vanesa
author2_role author
author
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv It is important to develop new methods of release to improve pharmacokinetic parameters of drugs, especially antibiotics, whose plasmatic concentration is determinant to ensure an effective treatment. Layered double hydroxides (LDH) are inorganic and biocompatible materials with high drug intercalation capacity and release properties that can be tuned by controlling the pH value. These materials can be an excellent choice to achieve a sustained release and an optimal drug concentration in plasm. In this work, LDH were synthesized with intercalated ciprofloxacin (CIP) by three different methods: coprecipitation, reconstruction and ion exchange. LDH-CIP complexes were characterized by XRD, TG-DSC, TEM, SEM, FTIR, electrophoretic mobilities, and drug release and dissolution kinetics in NaCl solutions and under physiological conditions. The coprecipitation and reconstruction methods lead to the formation of ill-defined products, whereas the ion exchange method rendered the best intercalation results. CIP release was controlled by dissolution at pH<3 and by desorption and ion exchange at intermediate and high pH. In comparison with a commercial formulation, the LDH-CIP complex prepared by ion exchange presented a slower release profile. The fast dissolution at gastric pH raises the need of developing some type of coating for protecting LDH materials.
Fil: Lopez, Nicolas Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Avena, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Luengo, Carina Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
description It is important to develop new methods of release to improve pharmacokinetic parameters of drugs, especially antibiotics, whose plasmatic concentration is determinant to ensure an effective treatment. Layered double hydroxides (LDH) are inorganic and biocompatible materials with high drug intercalation capacity and release properties that can be tuned by controlling the pH value. These materials can be an excellent choice to achieve a sustained release and an optimal drug concentration in plasm. In this work, LDH were synthesized with intercalated ciprofloxacin (CIP) by three different methods: coprecipitation, reconstruction and ion exchange. LDH-CIP complexes were characterized by XRD, TG-DSC, TEM, SEM, FTIR, electrophoretic mobilities, and drug release and dissolution kinetics in NaCl solutions and under physiological conditions. The coprecipitation and reconstruction methods lead to the formation of ill-defined products, whereas the ion exchange method rendered the best intercalation results. CIP release was controlled by dissolution at pH<3 and by desorption and ion exchange at intermediate and high pH. In comparison with a commercial formulation, the LDH-CIP complex prepared by ion exchange presented a slower release profile. The fast dissolution at gastric pH raises the need of developing some type of coating for protecting LDH materials.
publishDate 2023
dc.date.none.fl_str_mv 2023
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dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/184176
Lopez, Nicolas Alfredo; Avena, Marcelo Javier; Luengo, Carina Vanesa; (2023): Ciprofloxacin in Layered Double Hydroxides: Looking for the Best Synthesis Method. Consejo Nacional de Investigaciones Científicas y Técnicas. (dataset). http://hdl.handle.net/11336/184176
CONICET Digital
CONICET
url http://hdl.handle.net/11336/184176
identifier_str_mv Lopez, Nicolas Alfredo; Avena, Marcelo Javier; Luengo, Carina Vanesa; (2023): Ciprofloxacin in Layered Double Hydroxides: Looking for the Best Synthesis Method. Consejo Nacional de Investigaciones Científicas y Técnicas. (dataset). http://hdl.handle.net/11336/184176
CONICET Digital
CONICET
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