Structural and physicochemical aspects of drug release from layered double hydroxides and layered hydroxide salts

Autores
Rojas Delgado, Ricardo; Garro Linck, Yamila; Cuffini, Silvia Lucia; Monti, Gustavo Alberto; Giacomelli, Carla Eugenia
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Layered double hydroxides (LDHs) and Zn layered hydroxide salts (LHSs) present different physicochemical and interfacial properties derived from their dissimilar structure and composition, which affect the release behavior of the intercalated drug. In this work, these aspects are studied using LDHs and LHSs intercalated with ibuprofen (Ibu), naproxen (Nap) or ketoprofen (Ket) to understand the behavior of intercalation compounds as drug carriers. The structure of the solids and the interaction mode between the drugs and the layers were determined by chemical analysis, PXRD, FTIR and NMR. Further, the interfacial properties (potential zeta and hydrophilic/hydrophobic character) of the solids, as well as their drug release profiles were also comparatively studied. The drugs were attached by electrostatic interactions to LDH layers while coordinate bond was produced in the case of LHSs. The different interaction modes, together with the higher drug density between LHS layers produced more crystalline solids with larger basal spacing values than the corresponding LDH. This detailed structural study allowed for establishing the correlations between structure, interactions, morphology, interfacial properties and drug release behavior. Thus, the different interaction modes determined the surface charging behavior, while the solubility of LHS layers led to a fast drug release in neutral media. Finally, the loose drug arrangement in the hybrids caused a solubility increase in acid media. These correlations are helpful to predict and optimize the behavior of drug delivery systems based on both LDHs and Zn–LHSs.
Fil: Rojas Delgado, Ricardo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina
Fil: Garro Linck, Yamila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Cuffini, Silvia Lucia. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Universidade Federal de São Paulo; Brasil
Fil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Giacomelli, Carla Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Materia
Layered Double Hydroxides
Layered Hydroxide Salts
Anion Exchange
Ligand Exchange
Charging Behavior
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/47163
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/47163
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Structural and physicochemical aspects of drug release from layered double hydroxides and layered hydroxide saltsRojas Delgado, RicardoGarro Linck, YamilaCuffini, Silvia LuciaMonti, Gustavo AlbertoGiacomelli, Carla EugeniaLayered Double HydroxidesLayered Hydroxide SaltsAnion ExchangeLigand ExchangeCharging Behaviorhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Layered double hydroxides (LDHs) and Zn layered hydroxide salts (LHSs) present different physicochemical and interfacial properties derived from their dissimilar structure and composition, which affect the release behavior of the intercalated drug. In this work, these aspects are studied using LDHs and LHSs intercalated with ibuprofen (Ibu), naproxen (Nap) or ketoprofen (Ket) to understand the behavior of intercalation compounds as drug carriers. The structure of the solids and the interaction mode between the drugs and the layers were determined by chemical analysis, PXRD, FTIR and NMR. Further, the interfacial properties (potential zeta and hydrophilic/hydrophobic character) of the solids, as well as their drug release profiles were also comparatively studied. The drugs were attached by electrostatic interactions to LDH layers while coordinate bond was produced in the case of LHSs. The different interaction modes, together with the higher drug density between LHS layers produced more crystalline solids with larger basal spacing values than the corresponding LDH. This detailed structural study allowed for establishing the correlations between structure, interactions, morphology, interfacial properties and drug release behavior. Thus, the different interaction modes determined the surface charging behavior, while the solubility of LHS layers led to a fast drug release in neutral media. Finally, the loose drug arrangement in the hybrids caused a solubility increase in acid media. These correlations are helpful to predict and optimize the behavior of drug delivery systems based on both LDHs and Zn–LHSs.Fil: Rojas Delgado, Ricardo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; ArgentinaFil: Garro Linck, Yamila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Cuffini, Silvia Lucia. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Universidade Federal de São Paulo; BrasilFil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; ArgentinaFil: Giacomelli, Carla Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaElsevier Science2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47163Rojas Delgado, Ricardo; Garro Linck, Yamila; Cuffini, Silvia Lucia; Monti, Gustavo Alberto; Giacomelli, Carla Eugenia; Structural and physicochemical aspects of drug release from layered double hydroxides and layered hydroxide salts; Elsevier Science; Applied Clay Science; 109-110; 3-2015; 119-1260169-1317CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0169131715000903info:eu-repo/semantics/altIdentifier/doi/10.1016/j.clay.2015.02.030info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:28Zoai:ri.conicet.gov.ar:11336/47163instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:28.515CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Structural and physicochemical aspects of drug release from layered double hydroxides and layered hydroxide salts
title Structural and physicochemical aspects of drug release from layered double hydroxides and layered hydroxide salts
spellingShingle Structural and physicochemical aspects of drug release from layered double hydroxides and layered hydroxide salts
Rojas Delgado, Ricardo
Layered Double Hydroxides
Layered Hydroxide Salts
Anion Exchange
Ligand Exchange
Charging Behavior
title_short Structural and physicochemical aspects of drug release from layered double hydroxides and layered hydroxide salts
title_full Structural and physicochemical aspects of drug release from layered double hydroxides and layered hydroxide salts
title_fullStr Structural and physicochemical aspects of drug release from layered double hydroxides and layered hydroxide salts
title_full_unstemmed Structural and physicochemical aspects of drug release from layered double hydroxides and layered hydroxide salts
title_sort Structural and physicochemical aspects of drug release from layered double hydroxides and layered hydroxide salts
dc.creator.none.fl_str_mv Rojas Delgado, Ricardo
Garro Linck, Yamila
Cuffini, Silvia Lucia
Monti, Gustavo Alberto
Giacomelli, Carla Eugenia
author Rojas Delgado, Ricardo
author_facet Rojas Delgado, Ricardo
Garro Linck, Yamila
Cuffini, Silvia Lucia
Monti, Gustavo Alberto
Giacomelli, Carla Eugenia
author_role author
author2 Garro Linck, Yamila
Cuffini, Silvia Lucia
Monti, Gustavo Alberto
Giacomelli, Carla Eugenia
author2_role author
author
author
author
dc.subject.none.fl_str_mv Layered Double Hydroxides
Layered Hydroxide Salts
Anion Exchange
Ligand Exchange
Charging Behavior
topic Layered Double Hydroxides
Layered Hydroxide Salts
Anion Exchange
Ligand Exchange
Charging Behavior
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Layered double hydroxides (LDHs) and Zn layered hydroxide salts (LHSs) present different physicochemical and interfacial properties derived from their dissimilar structure and composition, which affect the release behavior of the intercalated drug. In this work, these aspects are studied using LDHs and LHSs intercalated with ibuprofen (Ibu), naproxen (Nap) or ketoprofen (Ket) to understand the behavior of intercalation compounds as drug carriers. The structure of the solids and the interaction mode between the drugs and the layers were determined by chemical analysis, PXRD, FTIR and NMR. Further, the interfacial properties (potential zeta and hydrophilic/hydrophobic character) of the solids, as well as their drug release profiles were also comparatively studied. The drugs were attached by electrostatic interactions to LDH layers while coordinate bond was produced in the case of LHSs. The different interaction modes, together with the higher drug density between LHS layers produced more crystalline solids with larger basal spacing values than the corresponding LDH. This detailed structural study allowed for establishing the correlations between structure, interactions, morphology, interfacial properties and drug release behavior. Thus, the different interaction modes determined the surface charging behavior, while the solubility of LHS layers led to a fast drug release in neutral media. Finally, the loose drug arrangement in the hybrids caused a solubility increase in acid media. These correlations are helpful to predict and optimize the behavior of drug delivery systems based on both LDHs and Zn–LHSs.
Fil: Rojas Delgado, Ricardo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Fisicoquímica; Argentina
Fil: Garro Linck, Yamila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Cuffini, Silvia Lucia. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Universidade Federal de São Paulo; Brasil
Fil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina. Universidad Nacional de Córdoba. Facultad de Matemática, Astronomía y Física; Argentina
Fil: Giacomelli, Carla Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
description Layered double hydroxides (LDHs) and Zn layered hydroxide salts (LHSs) present different physicochemical and interfacial properties derived from their dissimilar structure and composition, which affect the release behavior of the intercalated drug. In this work, these aspects are studied using LDHs and LHSs intercalated with ibuprofen (Ibu), naproxen (Nap) or ketoprofen (Ket) to understand the behavior of intercalation compounds as drug carriers. The structure of the solids and the interaction mode between the drugs and the layers were determined by chemical analysis, PXRD, FTIR and NMR. Further, the interfacial properties (potential zeta and hydrophilic/hydrophobic character) of the solids, as well as their drug release profiles were also comparatively studied. The drugs were attached by electrostatic interactions to LDH layers while coordinate bond was produced in the case of LHSs. The different interaction modes, together with the higher drug density between LHS layers produced more crystalline solids with larger basal spacing values than the corresponding LDH. This detailed structural study allowed for establishing the correlations between structure, interactions, morphology, interfacial properties and drug release behavior. Thus, the different interaction modes determined the surface charging behavior, while the solubility of LHS layers led to a fast drug release in neutral media. Finally, the loose drug arrangement in the hybrids caused a solubility increase in acid media. These correlations are helpful to predict and optimize the behavior of drug delivery systems based on both LDHs and Zn–LHSs.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/47163
Rojas Delgado, Ricardo; Garro Linck, Yamila; Cuffini, Silvia Lucia; Monti, Gustavo Alberto; Giacomelli, Carla Eugenia; Structural and physicochemical aspects of drug release from layered double hydroxides and layered hydroxide salts; Elsevier Science; Applied Clay Science; 109-110; 3-2015; 119-126
0169-1317
CONICET Digital
CONICET
url http://hdl.handle.net/11336/47163
identifier_str_mv Rojas Delgado, Ricardo; Garro Linck, Yamila; Cuffini, Silvia Lucia; Monti, Gustavo Alberto; Giacomelli, Carla Eugenia; Structural and physicochemical aspects of drug release from layered double hydroxides and layered hydroxide salts; Elsevier Science; Applied Clay Science; 109-110; 3-2015; 119-126
0169-1317
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0169131715000903
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.clay.2015.02.030
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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