Class 2 integrons dissemination among multidrug resistance (MDR) clones of Acinetobacter baumannii

Autores
Ramirez, Maria Soledad; Morales, Amanda; Vilacoba, Elisabet; Márquez, Carolina; Centron, Daniela
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Acinetobacter baumannii has emerged as a serious problem in the hospital environment at a global scale. Previous results from our laboratory showed a high frequency of class 2 integrons in A. baumannii strains from Argentina regarding the low rate of this element in A. baumannii isolates from the rest of the world. To reveal the current epidemiology of class 2 integrons, a molecular surveillance analyzing 78 multidrug resistant (MDR) A. baumannii isolates from Argentina and Uruguay was performed, exposing the presence of class 2 integron in the 36.61% of the isolates. Class 2 integron characterization showed that the typical Tn7::In2-7 array was present in 26 out of 27 intI2 positive isolates. All intI2 positive isolates contained at least one of the Tn7 transposition genes. In addition, we identified that 18 intI2 positive isolates possessed the Tn7::In2-7 within the attTn7 site. The molecular typing evidenced that clones I and IV that do not belong to widespread European clones I and II were found among the intI2 positive isolates. Our results exposed the widely dissemination of class 2 integron among MDR A. baumannii isolates from Argentina and Uruguay, also showing the persistence of two novel clones in our region, which could explain in part the high frequency of class 2 integron found in our region.
Fil: Ramirez, Maria Soledad. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones En Microbiología y Parasitología Medica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones En Microbiología y Parasitología Medica; Argentina
Fil: Morales, Amanda. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
Fil: Vilacoba, Elisabet. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Márquez, Carolina. Universidad de la República; Uruguay
Fil: Centron, Daniela. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones En Microbiología y Parasitología Medica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones En Microbiología y Parasitología Medica; Argentina
Materia
Acinetobacter baumannii
Class 2 integron
Transposon
Multirresistance
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/16282
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/16282
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Class 2 integrons dissemination among multidrug resistance (MDR) clones of Acinetobacter baumanniiRamirez, Maria SoledadMorales, AmandaVilacoba, ElisabetMárquez, CarolinaCentron, DanielaAcinetobacter baumanniiClass 2 integronTransposonMultirresistancehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Acinetobacter baumannii has emerged as a serious problem in the hospital environment at a global scale. Previous results from our laboratory showed a high frequency of class 2 integrons in A. baumannii strains from Argentina regarding the low rate of this element in A. baumannii isolates from the rest of the world. To reveal the current epidemiology of class 2 integrons, a molecular surveillance analyzing 78 multidrug resistant (MDR) A. baumannii isolates from Argentina and Uruguay was performed, exposing the presence of class 2 integron in the 36.61% of the isolates. Class 2 integron characterization showed that the typical Tn7::In2-7 array was present in 26 out of 27 intI2 positive isolates. All intI2 positive isolates contained at least one of the Tn7 transposition genes. In addition, we identified that 18 intI2 positive isolates possessed the Tn7::In2-7 within the attTn7 site. The molecular typing evidenced that clones I and IV that do not belong to widespread European clones I and II were found among the intI2 positive isolates. Our results exposed the widely dissemination of class 2 integron among MDR A. baumannii isolates from Argentina and Uruguay, also showing the persistence of two novel clones in our region, which could explain in part the high frequency of class 2 integron found in our region.Fil: Ramirez, Maria Soledad. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones En Microbiología y Parasitología Medica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones En Microbiología y Parasitología Medica; ArgentinaFil: Morales, Amanda. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; ArgentinaFil: Vilacoba, Elisabet. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Márquez, Carolina. Universidad de la República; UruguayFil: Centron, Daniela. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones En Microbiología y Parasitología Medica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones En Microbiología y Parasitología Medica; ArgentinaSpringer2012-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16282Ramirez, Maria Soledad; Morales, Amanda; Vilacoba, Elisabet; Márquez, Carolina; Centron, Daniela; Class 2 integrons dissemination among multidrug resistance (MDR) clones of Acinetobacter baumannii; Springer; Current Microbiology; 64; 3; 3-2012; 290-2930343-86511432-0991enginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00284-011-0068-1info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00284-011-0068-1info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234302/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:39:45Zoai:ri.conicet.gov.ar:11336/16282instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:39:45.83CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Class 2 integrons dissemination among multidrug resistance (MDR) clones of Acinetobacter baumannii
title Class 2 integrons dissemination among multidrug resistance (MDR) clones of Acinetobacter baumannii
spellingShingle Class 2 integrons dissemination among multidrug resistance (MDR) clones of Acinetobacter baumannii
Ramirez, Maria Soledad
Acinetobacter baumannii
Class 2 integron
Transposon
Multirresistance
title_short Class 2 integrons dissemination among multidrug resistance (MDR) clones of Acinetobacter baumannii
title_full Class 2 integrons dissemination among multidrug resistance (MDR) clones of Acinetobacter baumannii
title_fullStr Class 2 integrons dissemination among multidrug resistance (MDR) clones of Acinetobacter baumannii
title_full_unstemmed Class 2 integrons dissemination among multidrug resistance (MDR) clones of Acinetobacter baumannii
title_sort Class 2 integrons dissemination among multidrug resistance (MDR) clones of Acinetobacter baumannii
dc.creator.none.fl_str_mv Ramirez, Maria Soledad
Morales, Amanda
Vilacoba, Elisabet
Márquez, Carolina
Centron, Daniela
author Ramirez, Maria Soledad
author_facet Ramirez, Maria Soledad
Morales, Amanda
Vilacoba, Elisabet
Márquez, Carolina
Centron, Daniela
author_role author
author2 Morales, Amanda
Vilacoba, Elisabet
Márquez, Carolina
Centron, Daniela
author2_role author
author
author
author
dc.subject.none.fl_str_mv Acinetobacter baumannii
Class 2 integron
Transposon
Multirresistance
topic Acinetobacter baumannii
Class 2 integron
Transposon
Multirresistance
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Acinetobacter baumannii has emerged as a serious problem in the hospital environment at a global scale. Previous results from our laboratory showed a high frequency of class 2 integrons in A. baumannii strains from Argentina regarding the low rate of this element in A. baumannii isolates from the rest of the world. To reveal the current epidemiology of class 2 integrons, a molecular surveillance analyzing 78 multidrug resistant (MDR) A. baumannii isolates from Argentina and Uruguay was performed, exposing the presence of class 2 integron in the 36.61% of the isolates. Class 2 integron characterization showed that the typical Tn7::In2-7 array was present in 26 out of 27 intI2 positive isolates. All intI2 positive isolates contained at least one of the Tn7 transposition genes. In addition, we identified that 18 intI2 positive isolates possessed the Tn7::In2-7 within the attTn7 site. The molecular typing evidenced that clones I and IV that do not belong to widespread European clones I and II were found among the intI2 positive isolates. Our results exposed the widely dissemination of class 2 integron among MDR A. baumannii isolates from Argentina and Uruguay, also showing the persistence of two novel clones in our region, which could explain in part the high frequency of class 2 integron found in our region.
Fil: Ramirez, Maria Soledad. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones En Microbiología y Parasitología Medica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones En Microbiología y Parasitología Medica; Argentina
Fil: Morales, Amanda. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
Fil: Vilacoba, Elisabet. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Márquez, Carolina. Universidad de la República; Uruguay
Fil: Centron, Daniela. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones En Microbiología y Parasitología Medica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones En Microbiología y Parasitología Medica; Argentina
description Acinetobacter baumannii has emerged as a serious problem in the hospital environment at a global scale. Previous results from our laboratory showed a high frequency of class 2 integrons in A. baumannii strains from Argentina regarding the low rate of this element in A. baumannii isolates from the rest of the world. To reveal the current epidemiology of class 2 integrons, a molecular surveillance analyzing 78 multidrug resistant (MDR) A. baumannii isolates from Argentina and Uruguay was performed, exposing the presence of class 2 integron in the 36.61% of the isolates. Class 2 integron characterization showed that the typical Tn7::In2-7 array was present in 26 out of 27 intI2 positive isolates. All intI2 positive isolates contained at least one of the Tn7 transposition genes. In addition, we identified that 18 intI2 positive isolates possessed the Tn7::In2-7 within the attTn7 site. The molecular typing evidenced that clones I and IV that do not belong to widespread European clones I and II were found among the intI2 positive isolates. Our results exposed the widely dissemination of class 2 integron among MDR A. baumannii isolates from Argentina and Uruguay, also showing the persistence of two novel clones in our region, which could explain in part the high frequency of class 2 integron found in our region.
publishDate 2012
dc.date.none.fl_str_mv 2012-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/16282
Ramirez, Maria Soledad; Morales, Amanda; Vilacoba, Elisabet; Márquez, Carolina; Centron, Daniela; Class 2 integrons dissemination among multidrug resistance (MDR) clones of Acinetobacter baumannii; Springer; Current Microbiology; 64; 3; 3-2012; 290-293
0343-8651
1432-0991
url http://hdl.handle.net/11336/16282
identifier_str_mv Ramirez, Maria Soledad; Morales, Amanda; Vilacoba, Elisabet; Márquez, Carolina; Centron, Daniela; Class 2 integrons dissemination among multidrug resistance (MDR) clones of Acinetobacter baumannii; Springer; Current Microbiology; 64; 3; 3-2012; 290-293
0343-8651
1432-0991
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s00284-011-0068-1
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00284-011-0068-1
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234302/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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