Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics
- Autores
- Chindamo, Giulia; Sapino, Simona; Peira, Elena; Chirio, Daniela; Gonzalez, Monica Cristina; Gallarate, Marina
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Bone diseases include a wide group of skeletal-related disorders that cause mobility limitations and mortality. In some cases, e.g., in osteosarcoma (OS) and metastatic bone cancer, current treatments are not fully effective, mainly due to low patient compliance and to adverse side effects. To overcome these drawbacks, nanotechnology is currently under study as a potential strategy allowing specific drug release kinetics and enhancing bone regeneration. Polymers, ceramics, semiconductors, metals, and self-assembled molecular complexes are some of the most used nanoscale materials, although in most cases their surface properties need to be tuned by chemical or physical reactions. Among all, scaffolds, nanoparticles (NPs), cements, and hydrogels exhibit more advantages than drawbacks when compared to other nanosystems and are therefore the object of several studies. The aim of this review is to provide information about the current therapies of different bone diseases focusing the attention on new discoveries in the field of targeted delivery systems. The authors hope that this paper could help to pursue further directions about bone targeted nanosystems and their application for bone diseases and bone regeneration.
Fil: Chindamo, Giulia. Università di Torino; Italia
Fil: Sapino, Simona. Università di Torino; Italia
Fil: Peira, Elena. Università di Torino; Italia
Fil: Chirio, Daniela. University of Torino; Italia
Fil: Gonzalez, Monica Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Gallarate, Marina. Università di Torino; Italia - Materia
-
BONE DISEASES
BONE REGENERATION
CALCIUM PHOSPHATE
NANOTECHNOLOGY
TARGETED DELIVERY SYSTEMS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/141721
Ver los metadatos del registro completo
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Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeuticsChindamo, GiuliaSapino, SimonaPeira, ElenaChirio, DanielaGonzalez, Monica CristinaGallarate, MarinaBONE DISEASESBONE REGENERATIONCALCIUM PHOSPHATENANOTECHNOLOGYTARGETED DELIVERY SYSTEMShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Bone diseases include a wide group of skeletal-related disorders that cause mobility limitations and mortality. In some cases, e.g., in osteosarcoma (OS) and metastatic bone cancer, current treatments are not fully effective, mainly due to low patient compliance and to adverse side effects. To overcome these drawbacks, nanotechnology is currently under study as a potential strategy allowing specific drug release kinetics and enhancing bone regeneration. Polymers, ceramics, semiconductors, metals, and self-assembled molecular complexes are some of the most used nanoscale materials, although in most cases their surface properties need to be tuned by chemical or physical reactions. Among all, scaffolds, nanoparticles (NPs), cements, and hydrogels exhibit more advantages than drawbacks when compared to other nanosystems and are therefore the object of several studies. The aim of this review is to provide information about the current therapies of different bone diseases focusing the attention on new discoveries in the field of targeted delivery systems. The authors hope that this paper could help to pursue further directions about bone targeted nanosystems and their application for bone diseases and bone regeneration.Fil: Chindamo, Giulia. Università di Torino; ItaliaFil: Sapino, Simona. Università di Torino; ItaliaFil: Peira, Elena. Università di Torino; ItaliaFil: Chirio, Daniela. University of Torino; ItaliaFil: Gonzalez, Monica Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Gallarate, Marina. Università di Torino; ItaliaMultidisciplinary Digital Publishing Institute AG2020-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/141721Chindamo, Giulia; Sapino, Simona; Peira, Elena; Chirio, Daniela; Gonzalez, Monica Cristina; et al.; Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics; Multidisciplinary Digital Publishing Institute AG; Nanomaterials; 10; 5; 01-5-2020; 1-352079-4991CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-4991/10/5/875info:eu-repo/semantics/altIdentifier/doi/10.3390/nano10050875info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:17Zoai:ri.conicet.gov.ar:11336/141721instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:17.816CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics |
title |
Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics |
spellingShingle |
Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics Chindamo, Giulia BONE DISEASES BONE REGENERATION CALCIUM PHOSPHATE NANOTECHNOLOGY TARGETED DELIVERY SYSTEMS |
title_short |
Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics |
title_full |
Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics |
title_fullStr |
Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics |
title_full_unstemmed |
Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics |
title_sort |
Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics |
dc.creator.none.fl_str_mv |
Chindamo, Giulia Sapino, Simona Peira, Elena Chirio, Daniela Gonzalez, Monica Cristina Gallarate, Marina |
author |
Chindamo, Giulia |
author_facet |
Chindamo, Giulia Sapino, Simona Peira, Elena Chirio, Daniela Gonzalez, Monica Cristina Gallarate, Marina |
author_role |
author |
author2 |
Sapino, Simona Peira, Elena Chirio, Daniela Gonzalez, Monica Cristina Gallarate, Marina |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
BONE DISEASES BONE REGENERATION CALCIUM PHOSPHATE NANOTECHNOLOGY TARGETED DELIVERY SYSTEMS |
topic |
BONE DISEASES BONE REGENERATION CALCIUM PHOSPHATE NANOTECHNOLOGY TARGETED DELIVERY SYSTEMS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Bone diseases include a wide group of skeletal-related disorders that cause mobility limitations and mortality. In some cases, e.g., in osteosarcoma (OS) and metastatic bone cancer, current treatments are not fully effective, mainly due to low patient compliance and to adverse side effects. To overcome these drawbacks, nanotechnology is currently under study as a potential strategy allowing specific drug release kinetics and enhancing bone regeneration. Polymers, ceramics, semiconductors, metals, and self-assembled molecular complexes are some of the most used nanoscale materials, although in most cases their surface properties need to be tuned by chemical or physical reactions. Among all, scaffolds, nanoparticles (NPs), cements, and hydrogels exhibit more advantages than drawbacks when compared to other nanosystems and are therefore the object of several studies. The aim of this review is to provide information about the current therapies of different bone diseases focusing the attention on new discoveries in the field of targeted delivery systems. The authors hope that this paper could help to pursue further directions about bone targeted nanosystems and their application for bone diseases and bone regeneration. Fil: Chindamo, Giulia. Università di Torino; Italia Fil: Sapino, Simona. Università di Torino; Italia Fil: Peira, Elena. Università di Torino; Italia Fil: Chirio, Daniela. University of Torino; Italia Fil: Gonzalez, Monica Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina Fil: Gallarate, Marina. Università di Torino; Italia |
description |
Bone diseases include a wide group of skeletal-related disorders that cause mobility limitations and mortality. In some cases, e.g., in osteosarcoma (OS) and metastatic bone cancer, current treatments are not fully effective, mainly due to low patient compliance and to adverse side effects. To overcome these drawbacks, nanotechnology is currently under study as a potential strategy allowing specific drug release kinetics and enhancing bone regeneration. Polymers, ceramics, semiconductors, metals, and self-assembled molecular complexes are some of the most used nanoscale materials, although in most cases their surface properties need to be tuned by chemical or physical reactions. Among all, scaffolds, nanoparticles (NPs), cements, and hydrogels exhibit more advantages than drawbacks when compared to other nanosystems and are therefore the object of several studies. The aim of this review is to provide information about the current therapies of different bone diseases focusing the attention on new discoveries in the field of targeted delivery systems. The authors hope that this paper could help to pursue further directions about bone targeted nanosystems and their application for bone diseases and bone regeneration. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-05-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/141721 Chindamo, Giulia; Sapino, Simona; Peira, Elena; Chirio, Daniela; Gonzalez, Monica Cristina; et al.; Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics; Multidisciplinary Digital Publishing Institute AG; Nanomaterials; 10; 5; 01-5-2020; 1-35 2079-4991 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/141721 |
identifier_str_mv |
Chindamo, Giulia; Sapino, Simona; Peira, Elena; Chirio, Daniela; Gonzalez, Monica Cristina; et al.; Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics; Multidisciplinary Digital Publishing Institute AG; Nanomaterials; 10; 5; 01-5-2020; 1-35 2079-4991 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-4991/10/5/875 info:eu-repo/semantics/altIdentifier/doi/10.3390/nano10050875 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute AG |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute AG |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.13397 |