Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics

Autores
Chindamo, Giulia; Sapino, Simona; Peira, Elena; Chirio, Daniela; Gonzalez, Monica Cristina; Gallarate, Marina
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Bone diseases include a wide group of skeletal-related disorders that cause mobility limitations and mortality. In some cases, e.g., in osteosarcoma (OS) and metastatic bone cancer, current treatments are not fully effective, mainly due to low patient compliance and to adverse side effects. To overcome these drawbacks, nanotechnology is currently under study as a potential strategy allowing specific drug release kinetics and enhancing bone regeneration. Polymers, ceramics, semiconductors, metals, and self-assembled molecular complexes are some of the most used nanoscale materials, although in most cases their surface properties need to be tuned by chemical or physical reactions. Among all, scaffolds, nanoparticles (NPs), cements, and hydrogels exhibit more advantages than drawbacks when compared to other nanosystems and are therefore the object of several studies. The aim of this review is to provide information about the current therapies of different bone diseases focusing the attention on new discoveries in the field of targeted delivery systems. The authors hope that this paper could help to pursue further directions about bone targeted nanosystems and their application for bone diseases and bone regeneration.
Fil: Chindamo, Giulia. Università di Torino; Italia
Fil: Sapino, Simona. Università di Torino; Italia
Fil: Peira, Elena. Università di Torino; Italia
Fil: Chirio, Daniela. University of Torino; Italia
Fil: Gonzalez, Monica Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Gallarate, Marina. Università di Torino; Italia
Materia
BONE DISEASES
BONE REGENERATION
CALCIUM PHOSPHATE
NANOTECHNOLOGY
TARGETED DELIVERY SYSTEMS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/141721
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeuticsChindamo, GiuliaSapino, SimonaPeira, ElenaChirio, DanielaGonzalez, Monica CristinaGallarate, MarinaBONE DISEASESBONE REGENERATIONCALCIUM PHOSPHATENANOTECHNOLOGYTARGETED DELIVERY SYSTEMShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Bone diseases include a wide group of skeletal-related disorders that cause mobility limitations and mortality. In some cases, e.g., in osteosarcoma (OS) and metastatic bone cancer, current treatments are not fully effective, mainly due to low patient compliance and to adverse side effects. To overcome these drawbacks, nanotechnology is currently under study as a potential strategy allowing specific drug release kinetics and enhancing bone regeneration. Polymers, ceramics, semiconductors, metals, and self-assembled molecular complexes are some of the most used nanoscale materials, although in most cases their surface properties need to be tuned by chemical or physical reactions. Among all, scaffolds, nanoparticles (NPs), cements, and hydrogels exhibit more advantages than drawbacks when compared to other nanosystems and are therefore the object of several studies. The aim of this review is to provide information about the current therapies of different bone diseases focusing the attention on new discoveries in the field of targeted delivery systems. The authors hope that this paper could help to pursue further directions about bone targeted nanosystems and their application for bone diseases and bone regeneration.Fil: Chindamo, Giulia. Università di Torino; ItaliaFil: Sapino, Simona. Università di Torino; ItaliaFil: Peira, Elena. Università di Torino; ItaliaFil: Chirio, Daniela. University of Torino; ItaliaFil: Gonzalez, Monica Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Gallarate, Marina. Università di Torino; ItaliaMultidisciplinary Digital Publishing Institute AG2020-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/141721Chindamo, Giulia; Sapino, Simona; Peira, Elena; Chirio, Daniela; Gonzalez, Monica Cristina; et al.; Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics; Multidisciplinary Digital Publishing Institute AG; Nanomaterials; 10; 5; 01-5-2020; 1-352079-4991CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-4991/10/5/875info:eu-repo/semantics/altIdentifier/doi/10.3390/nano10050875info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:42:18Zoai:ri.conicet.gov.ar:11336/141721instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:42:19.156CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics
title Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics
spellingShingle Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics
Chindamo, Giulia
BONE DISEASES
BONE REGENERATION
CALCIUM PHOSPHATE
NANOTECHNOLOGY
TARGETED DELIVERY SYSTEMS
title_short Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics
title_full Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics
title_fullStr Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics
title_full_unstemmed Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics
title_sort Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics
dc.creator.none.fl_str_mv Chindamo, Giulia
Sapino, Simona
Peira, Elena
Chirio, Daniela
Gonzalez, Monica Cristina
Gallarate, Marina
author Chindamo, Giulia
author_facet Chindamo, Giulia
Sapino, Simona
Peira, Elena
Chirio, Daniela
Gonzalez, Monica Cristina
Gallarate, Marina
author_role author
author2 Sapino, Simona
Peira, Elena
Chirio, Daniela
Gonzalez, Monica Cristina
Gallarate, Marina
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv BONE DISEASES
BONE REGENERATION
CALCIUM PHOSPHATE
NANOTECHNOLOGY
TARGETED DELIVERY SYSTEMS
topic BONE DISEASES
BONE REGENERATION
CALCIUM PHOSPHATE
NANOTECHNOLOGY
TARGETED DELIVERY SYSTEMS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Bone diseases include a wide group of skeletal-related disorders that cause mobility limitations and mortality. In some cases, e.g., in osteosarcoma (OS) and metastatic bone cancer, current treatments are not fully effective, mainly due to low patient compliance and to adverse side effects. To overcome these drawbacks, nanotechnology is currently under study as a potential strategy allowing specific drug release kinetics and enhancing bone regeneration. Polymers, ceramics, semiconductors, metals, and self-assembled molecular complexes are some of the most used nanoscale materials, although in most cases their surface properties need to be tuned by chemical or physical reactions. Among all, scaffolds, nanoparticles (NPs), cements, and hydrogels exhibit more advantages than drawbacks when compared to other nanosystems and are therefore the object of several studies. The aim of this review is to provide information about the current therapies of different bone diseases focusing the attention on new discoveries in the field of targeted delivery systems. The authors hope that this paper could help to pursue further directions about bone targeted nanosystems and their application for bone diseases and bone regeneration.
Fil: Chindamo, Giulia. Università di Torino; Italia
Fil: Sapino, Simona. Università di Torino; Italia
Fil: Peira, Elena. Università di Torino; Italia
Fil: Chirio, Daniela. University of Torino; Italia
Fil: Gonzalez, Monica Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Gallarate, Marina. Università di Torino; Italia
description Bone diseases include a wide group of skeletal-related disorders that cause mobility limitations and mortality. In some cases, e.g., in osteosarcoma (OS) and metastatic bone cancer, current treatments are not fully effective, mainly due to low patient compliance and to adverse side effects. To overcome these drawbacks, nanotechnology is currently under study as a potential strategy allowing specific drug release kinetics and enhancing bone regeneration. Polymers, ceramics, semiconductors, metals, and self-assembled molecular complexes are some of the most used nanoscale materials, although in most cases their surface properties need to be tuned by chemical or physical reactions. Among all, scaffolds, nanoparticles (NPs), cements, and hydrogels exhibit more advantages than drawbacks when compared to other nanosystems and are therefore the object of several studies. The aim of this review is to provide information about the current therapies of different bone diseases focusing the attention on new discoveries in the field of targeted delivery systems. The authors hope that this paper could help to pursue further directions about bone targeted nanosystems and their application for bone diseases and bone regeneration.
publishDate 2020
dc.date.none.fl_str_mv 2020-05-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/141721
Chindamo, Giulia; Sapino, Simona; Peira, Elena; Chirio, Daniela; Gonzalez, Monica Cristina; et al.; Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics; Multidisciplinary Digital Publishing Institute AG; Nanomaterials; 10; 5; 01-5-2020; 1-35
2079-4991
CONICET Digital
CONICET
url http://hdl.handle.net/11336/141721
identifier_str_mv Chindamo, Giulia; Sapino, Simona; Peira, Elena; Chirio, Daniela; Gonzalez, Monica Cristina; et al.; Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics; Multidisciplinary Digital Publishing Institute AG; Nanomaterials; 10; 5; 01-5-2020; 1-35
2079-4991
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-4991/10/5/875
info:eu-repo/semantics/altIdentifier/doi/10.3390/nano10050875
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute AG
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute AG
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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