Drug delivery vehicles on a nano-engineering perspective
- Autores
- Felice, Betiana; Prabhakaran, Molamma P.; Rodriguez, Andrea Paola; Ramakrishna,Seeram
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Nanoengineered drug delivery systems (nDDS) have been successfully used as clinical tools for not only modulation of pharmacological drug release profile but also specific targeting of diseased tissues. Until now, encapsulation of anti-cancer molecules such as paclitaxel, vincristin and doxorubicin has been the main target of nDDS, whereby liposomes and polymer-drug conjugates remained as the most popular group of nDDS used for this purpose. The success reached by these nanocarriers can be imitated by careful selection and optimization of the different factors that affect drug release profile (i.e. type of biomaterial, size, system architecture, and biodegradability mechanisms) along with the selection of an appropriate manufacture technique that does not compromise the desired release profile, while it also offers possibilities to scale up for future industrialization. This review focuses from an engineering perspective on the different parameters that should be considered before and during the design of new nDDS, and the different manufacturing techniques available, in such a way to ensure success in clinical application.
Fil: Felice, Betiana. Universidad Nacional de Tucumán; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Prabhakaran, Molamma P.. National University Of Singapore; Singapur. Start Create; Singapur
Fil: Rodriguez, Andrea Paola. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Ramakrishna,Seeram. National University Of Singapore; Singapur - Materia
-
Liposomes
Biodegradable Polymers
Cancer
Nanotechnology
Targeted Drug Delivery
Controlled Release - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/77081
Ver los metadatos del registro completo
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Drug delivery vehicles on a nano-engineering perspectiveFelice, BetianaPrabhakaran, Molamma P.Rodriguez, Andrea PaolaRamakrishna,SeeramLiposomesBiodegradable PolymersCancerNanotechnologyTargeted Drug DeliveryControlled Releasehttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3Nanoengineered drug delivery systems (nDDS) have been successfully used as clinical tools for not only modulation of pharmacological drug release profile but also specific targeting of diseased tissues. Until now, encapsulation of anti-cancer molecules such as paclitaxel, vincristin and doxorubicin has been the main target of nDDS, whereby liposomes and polymer-drug conjugates remained as the most popular group of nDDS used for this purpose. The success reached by these nanocarriers can be imitated by careful selection and optimization of the different factors that affect drug release profile (i.e. type of biomaterial, size, system architecture, and biodegradability mechanisms) along with the selection of an appropriate manufacture technique that does not compromise the desired release profile, while it also offers possibilities to scale up for future industrialization. This review focuses from an engineering perspective on the different parameters that should be considered before and during the design of new nDDS, and the different manufacturing techniques available, in such a way to ensure success in clinical application.Fil: Felice, Betiana. Universidad Nacional de Tucumán; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Prabhakaran, Molamma P.. National University Of Singapore; Singapur. Start Create; SingapurFil: Rodriguez, Andrea Paola. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Ramakrishna,Seeram. National University Of Singapore; SingapurElsevier2014-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/77081Felice, Betiana; Prabhakaran, Molamma P.; Rodriguez, Andrea Paola; Ramakrishna,Seeram ; Drug delivery vehicles on a nano-engineering perspective; Elsevier; Material Science and Engineering: C; 41; 4-2014; 178-1950928-4931CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0928493114002410?via%3Dihubinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.msec.2014.04.049info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:53:53Zoai:ri.conicet.gov.ar:11336/77081instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:53:54.043CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Drug delivery vehicles on a nano-engineering perspective |
title |
Drug delivery vehicles on a nano-engineering perspective |
spellingShingle |
Drug delivery vehicles on a nano-engineering perspective Felice, Betiana Liposomes Biodegradable Polymers Cancer Nanotechnology Targeted Drug Delivery Controlled Release |
title_short |
Drug delivery vehicles on a nano-engineering perspective |
title_full |
Drug delivery vehicles on a nano-engineering perspective |
title_fullStr |
Drug delivery vehicles on a nano-engineering perspective |
title_full_unstemmed |
Drug delivery vehicles on a nano-engineering perspective |
title_sort |
Drug delivery vehicles on a nano-engineering perspective |
dc.creator.none.fl_str_mv |
Felice, Betiana Prabhakaran, Molamma P. Rodriguez, Andrea Paola Ramakrishna,Seeram |
author |
Felice, Betiana |
author_facet |
Felice, Betiana Prabhakaran, Molamma P. Rodriguez, Andrea Paola Ramakrishna,Seeram |
author_role |
author |
author2 |
Prabhakaran, Molamma P. Rodriguez, Andrea Paola Ramakrishna,Seeram |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Liposomes Biodegradable Polymers Cancer Nanotechnology Targeted Drug Delivery Controlled Release |
topic |
Liposomes Biodegradable Polymers Cancer Nanotechnology Targeted Drug Delivery Controlled Release |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.4 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Nanoengineered drug delivery systems (nDDS) have been successfully used as clinical tools for not only modulation of pharmacological drug release profile but also specific targeting of diseased tissues. Until now, encapsulation of anti-cancer molecules such as paclitaxel, vincristin and doxorubicin has been the main target of nDDS, whereby liposomes and polymer-drug conjugates remained as the most popular group of nDDS used for this purpose. The success reached by these nanocarriers can be imitated by careful selection and optimization of the different factors that affect drug release profile (i.e. type of biomaterial, size, system architecture, and biodegradability mechanisms) along with the selection of an appropriate manufacture technique that does not compromise the desired release profile, while it also offers possibilities to scale up for future industrialization. This review focuses from an engineering perspective on the different parameters that should be considered before and during the design of new nDDS, and the different manufacturing techniques available, in such a way to ensure success in clinical application. Fil: Felice, Betiana. Universidad Nacional de Tucumán; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina Fil: Prabhakaran, Molamma P.. National University Of Singapore; Singapur. Start Create; Singapur Fil: Rodriguez, Andrea Paola. Universidad Nacional de Tucumán. Facultad de Ciencias Exactas y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina Fil: Ramakrishna,Seeram. National University Of Singapore; Singapur |
description |
Nanoengineered drug delivery systems (nDDS) have been successfully used as clinical tools for not only modulation of pharmacological drug release profile but also specific targeting of diseased tissues. Until now, encapsulation of anti-cancer molecules such as paclitaxel, vincristin and doxorubicin has been the main target of nDDS, whereby liposomes and polymer-drug conjugates remained as the most popular group of nDDS used for this purpose. The success reached by these nanocarriers can be imitated by careful selection and optimization of the different factors that affect drug release profile (i.e. type of biomaterial, size, system architecture, and biodegradability mechanisms) along with the selection of an appropriate manufacture technique that does not compromise the desired release profile, while it also offers possibilities to scale up for future industrialization. This review focuses from an engineering perspective on the different parameters that should be considered before and during the design of new nDDS, and the different manufacturing techniques available, in such a way to ensure success in clinical application. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/77081 Felice, Betiana; Prabhakaran, Molamma P.; Rodriguez, Andrea Paola; Ramakrishna,Seeram ; Drug delivery vehicles on a nano-engineering perspective; Elsevier; Material Science and Engineering: C; 41; 4-2014; 178-195 0928-4931 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/77081 |
identifier_str_mv |
Felice, Betiana; Prabhakaran, Molamma P.; Rodriguez, Andrea Paola; Ramakrishna,Seeram ; Drug delivery vehicles on a nano-engineering perspective; Elsevier; Material Science and Engineering: C; 41; 4-2014; 178-195 0928-4931 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0928493114002410?via%3Dihub info:eu-repo/semantics/altIdentifier/doi/10.1016/j.msec.2014.04.049 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.13397 |