Vitamin C based nanostructures: potential utility in ocular and transdermal therapy

Autores
Palma, Santiago Daniel; Ullio Gamboa, Gabriela Veronica; Allemandi, Daniel Alberto
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Alkyl vitamin C derivatives (ASCn) combine in their structure a lipophilic and a hydrophilic moiety and exhibit properties of typical surfactant molecules. Self-assembly properties of ASCn depend on the length of n-alkyl fatty chain. ASCn start to aggregate at temperatures (CMT, Krafft point) at which the solubility reaches the critical micellar concentration (CMC). Above this temperature, ASCn can aggregate in micelles or gel phase, depending of alkyl side chain. Upon cooling, for less soluble derivatives (ASC12, ASC14 and ASC16) liquid–crystal structures named coagels are obtained. They are able to solubilize insoluble and unstable drugs, protect them from any possible aggressive environment and promote their permeation through skin and mucosa. These systems possess very interesting properties making ASCn coagels promising pharmaceutical platforms for drug delivery. Results from investigations about all these properties will be described and analyzed in the present review with particular emphasis on the use of these systems for drug administration through ocular and transdermal routes.
Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Ullio Gamboa, Gabriela Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Materia
Ocular Therapy
Ascorbyl Palmitate Derivatives
Permeation
Dermal Therapy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24654
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Vitamin C based nanostructures: potential utility in ocular and transdermal therapyPalma, Santiago DanielUllio Gamboa, Gabriela VeronicaAllemandi, Daniel AlbertoOcular TherapyAscorbyl Palmitate DerivativesPermeationDermal Therapyhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Alkyl vitamin C derivatives (ASCn) combine in their structure a lipophilic and a hydrophilic moiety and exhibit properties of typical surfactant molecules. Self-assembly properties of ASCn depend on the length of n-alkyl fatty chain. ASCn start to aggregate at temperatures (CMT, Krafft point) at which the solubility reaches the critical micellar concentration (CMC). Above this temperature, ASCn can aggregate in micelles or gel phase, depending of alkyl side chain. Upon cooling, for less soluble derivatives (ASC12, ASC14 and ASC16) liquid–crystal structures named coagels are obtained. They are able to solubilize insoluble and unstable drugs, protect them from any possible aggressive environment and promote their permeation through skin and mucosa. These systems possess very interesting properties making ASCn coagels promising pharmaceutical platforms for drug delivery. Results from investigations about all these properties will be described and analyzed in the present review with particular emphasis on the use of these systems for drug administration through ocular and transdermal routes.Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Ullio Gamboa, Gabriela Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaAmerican Scientific Publishers2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24654Palma, Santiago Daniel; Ullio Gamboa, Gabriela Veronica; Allemandi, Daniel Alberto; Vitamin C based nanostructures: potential utility in ocular and transdermal therapy; American Scientific Publishers; Journal of Biomaterials and Tissue Engineering; 3; 1; 2-2013; 61-692157-90832157-9091CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1166/jbt.2013.1068info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/contentone/asp/jbte/2013/00000003/00000001/art00005info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:42Zoai:ri.conicet.gov.ar:11336/24654instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:42.343CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Vitamin C based nanostructures: potential utility in ocular and transdermal therapy
title Vitamin C based nanostructures: potential utility in ocular and transdermal therapy
spellingShingle Vitamin C based nanostructures: potential utility in ocular and transdermal therapy
Palma, Santiago Daniel
Ocular Therapy
Ascorbyl Palmitate Derivatives
Permeation
Dermal Therapy
title_short Vitamin C based nanostructures: potential utility in ocular and transdermal therapy
title_full Vitamin C based nanostructures: potential utility in ocular and transdermal therapy
title_fullStr Vitamin C based nanostructures: potential utility in ocular and transdermal therapy
title_full_unstemmed Vitamin C based nanostructures: potential utility in ocular and transdermal therapy
title_sort Vitamin C based nanostructures: potential utility in ocular and transdermal therapy
dc.creator.none.fl_str_mv Palma, Santiago Daniel
Ullio Gamboa, Gabriela Veronica
Allemandi, Daniel Alberto
author Palma, Santiago Daniel
author_facet Palma, Santiago Daniel
Ullio Gamboa, Gabriela Veronica
Allemandi, Daniel Alberto
author_role author
author2 Ullio Gamboa, Gabriela Veronica
Allemandi, Daniel Alberto
author2_role author
author
dc.subject.none.fl_str_mv Ocular Therapy
Ascorbyl Palmitate Derivatives
Permeation
Dermal Therapy
topic Ocular Therapy
Ascorbyl Palmitate Derivatives
Permeation
Dermal Therapy
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Alkyl vitamin C derivatives (ASCn) combine in their structure a lipophilic and a hydrophilic moiety and exhibit properties of typical surfactant molecules. Self-assembly properties of ASCn depend on the length of n-alkyl fatty chain. ASCn start to aggregate at temperatures (CMT, Krafft point) at which the solubility reaches the critical micellar concentration (CMC). Above this temperature, ASCn can aggregate in micelles or gel phase, depending of alkyl side chain. Upon cooling, for less soluble derivatives (ASC12, ASC14 and ASC16) liquid–crystal structures named coagels are obtained. They are able to solubilize insoluble and unstable drugs, protect them from any possible aggressive environment and promote their permeation through skin and mucosa. These systems possess very interesting properties making ASCn coagels promising pharmaceutical platforms for drug delivery. Results from investigations about all these properties will be described and analyzed in the present review with particular emphasis on the use of these systems for drug administration through ocular and transdermal routes.
Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Ullio Gamboa, Gabriela Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
description Alkyl vitamin C derivatives (ASCn) combine in their structure a lipophilic and a hydrophilic moiety and exhibit properties of typical surfactant molecules. Self-assembly properties of ASCn depend on the length of n-alkyl fatty chain. ASCn start to aggregate at temperatures (CMT, Krafft point) at which the solubility reaches the critical micellar concentration (CMC). Above this temperature, ASCn can aggregate in micelles or gel phase, depending of alkyl side chain. Upon cooling, for less soluble derivatives (ASC12, ASC14 and ASC16) liquid–crystal structures named coagels are obtained. They are able to solubilize insoluble and unstable drugs, protect them from any possible aggressive environment and promote their permeation through skin and mucosa. These systems possess very interesting properties making ASCn coagels promising pharmaceutical platforms for drug delivery. Results from investigations about all these properties will be described and analyzed in the present review with particular emphasis on the use of these systems for drug administration through ocular and transdermal routes.
publishDate 2013
dc.date.none.fl_str_mv 2013-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24654
Palma, Santiago Daniel; Ullio Gamboa, Gabriela Veronica; Allemandi, Daniel Alberto; Vitamin C based nanostructures: potential utility in ocular and transdermal therapy; American Scientific Publishers; Journal of Biomaterials and Tissue Engineering; 3; 1; 2-2013; 61-69
2157-9083
2157-9091
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24654
identifier_str_mv Palma, Santiago Daniel; Ullio Gamboa, Gabriela Veronica; Allemandi, Daniel Alberto; Vitamin C based nanostructures: potential utility in ocular and transdermal therapy; American Scientific Publishers; Journal of Biomaterials and Tissue Engineering; 3; 1; 2-2013; 61-69
2157-9083
2157-9091
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1166/jbt.2013.1068
info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/contentone/asp/jbte/2013/00000003/00000001/art00005
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Scientific Publishers
publisher.none.fl_str_mv American Scientific Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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