Controlled fluoride release for osteoporosis treatment using orally administered chitosan hydrogels

Autores
Fookes, Federico Adrian; Mengatto, Luciano Nicolas; Rigalli, Alfredo; Luna, Julio Alberto
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chitosan - β-glycerophosphate hydrogels have been widely studied for biomedical applications in recent years. In the current study a Chitosan - β-glycerophosphate hydrogel was evaluated as a platform for sodium fluoride release in the gastrointestinal tract. For this purpose, microscopy observation, infrared spectroscopy, stability, rheology studies and in vitro release assays were carried out. The hydrogel was stable for at least 48 h when exposed to an aqueous media in a pH range from 4 to 7 and the release of sodium fluoride was controlled for more than 6 h. In vivo studies were carried out in order to evaluate the oral administration of sodium fluoride using the hydrogel in comparison to a water solution. Fluoride pharmacokinetic was similar when the drug was administered with both formulations. Nevertheless, fluoride absorption was greater when the drug was given with the hydrogel, and further, drug-related side effects were absents. These results suggest that Chitosan - β-glycerophosphate hydrogel could be a good candidate for sustained release of fluoride in oral formulation.
Fil: Fookes, Federico Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Mengatto, Luciano Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Materia
CHITOSAN HYDROGEL
FLUORIDE
GASTROINTESTINAL DELIVERY
OSTEOPOROSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/86617
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Controlled fluoride release for osteoporosis treatment using orally administered chitosan hydrogelsFookes, Federico AdrianMengatto, Luciano NicolasRigalli, AlfredoLuna, Julio AlbertoCHITOSAN HYDROGELFLUORIDEGASTROINTESTINAL DELIVERYOSTEOPOROSIShttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2Chitosan - β-glycerophosphate hydrogels have been widely studied for biomedical applications in recent years. In the current study a Chitosan - β-glycerophosphate hydrogel was evaluated as a platform for sodium fluoride release in the gastrointestinal tract. For this purpose, microscopy observation, infrared spectroscopy, stability, rheology studies and in vitro release assays were carried out. The hydrogel was stable for at least 48 h when exposed to an aqueous media in a pH range from 4 to 7 and the release of sodium fluoride was controlled for more than 6 h. In vivo studies were carried out in order to evaluate the oral administration of sodium fluoride using the hydrogel in comparison to a water solution. Fluoride pharmacokinetic was similar when the drug was administered with both formulations. Nevertheless, fluoride absorption was greater when the drug was given with the hydrogel, and further, drug-related side effects were absents. These results suggest that Chitosan - β-glycerophosphate hydrogel could be a good candidate for sustained release of fluoride in oral formulation.Fil: Fookes, Federico Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Mengatto, Luciano Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaEditions Sante2019-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/86617Fookes, Federico Adrian; Mengatto, Luciano Nicolas; Rigalli, Alfredo; Luna, Julio Alberto; Controlled fluoride release for osteoporosis treatment using orally administered chitosan hydrogels; Editions Sante; Journal of Drug Delivery Science and Technology; 51; 6-2019; 268-2751773-2247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jddst.2019.03.004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:00:26Zoai:ri.conicet.gov.ar:11336/86617instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:00:26.733CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Controlled fluoride release for osteoporosis treatment using orally administered chitosan hydrogels
title Controlled fluoride release for osteoporosis treatment using orally administered chitosan hydrogels
spellingShingle Controlled fluoride release for osteoporosis treatment using orally administered chitosan hydrogels
Fookes, Federico Adrian
CHITOSAN HYDROGEL
FLUORIDE
GASTROINTESTINAL DELIVERY
OSTEOPOROSIS
title_short Controlled fluoride release for osteoporosis treatment using orally administered chitosan hydrogels
title_full Controlled fluoride release for osteoporosis treatment using orally administered chitosan hydrogels
title_fullStr Controlled fluoride release for osteoporosis treatment using orally administered chitosan hydrogels
title_full_unstemmed Controlled fluoride release for osteoporosis treatment using orally administered chitosan hydrogels
title_sort Controlled fluoride release for osteoporosis treatment using orally administered chitosan hydrogels
dc.creator.none.fl_str_mv Fookes, Federico Adrian
Mengatto, Luciano Nicolas
Rigalli, Alfredo
Luna, Julio Alberto
author Fookes, Federico Adrian
author_facet Fookes, Federico Adrian
Mengatto, Luciano Nicolas
Rigalli, Alfredo
Luna, Julio Alberto
author_role author
author2 Mengatto, Luciano Nicolas
Rigalli, Alfredo
Luna, Julio Alberto
author2_role author
author
author
dc.subject.none.fl_str_mv CHITOSAN HYDROGEL
FLUORIDE
GASTROINTESTINAL DELIVERY
OSTEOPOROSIS
topic CHITOSAN HYDROGEL
FLUORIDE
GASTROINTESTINAL DELIVERY
OSTEOPOROSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.4
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Chitosan - β-glycerophosphate hydrogels have been widely studied for biomedical applications in recent years. In the current study a Chitosan - β-glycerophosphate hydrogel was evaluated as a platform for sodium fluoride release in the gastrointestinal tract. For this purpose, microscopy observation, infrared spectroscopy, stability, rheology studies and in vitro release assays were carried out. The hydrogel was stable for at least 48 h when exposed to an aqueous media in a pH range from 4 to 7 and the release of sodium fluoride was controlled for more than 6 h. In vivo studies were carried out in order to evaluate the oral administration of sodium fluoride using the hydrogel in comparison to a water solution. Fluoride pharmacokinetic was similar when the drug was administered with both formulations. Nevertheless, fluoride absorption was greater when the drug was given with the hydrogel, and further, drug-related side effects were absents. These results suggest that Chitosan - β-glycerophosphate hydrogel could be a good candidate for sustained release of fluoride in oral formulation.
Fil: Fookes, Federico Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Mengatto, Luciano Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Rigalli, Alfredo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
description Chitosan - β-glycerophosphate hydrogels have been widely studied for biomedical applications in recent years. In the current study a Chitosan - β-glycerophosphate hydrogel was evaluated as a platform for sodium fluoride release in the gastrointestinal tract. For this purpose, microscopy observation, infrared spectroscopy, stability, rheology studies and in vitro release assays were carried out. The hydrogel was stable for at least 48 h when exposed to an aqueous media in a pH range from 4 to 7 and the release of sodium fluoride was controlled for more than 6 h. In vivo studies were carried out in order to evaluate the oral administration of sodium fluoride using the hydrogel in comparison to a water solution. Fluoride pharmacokinetic was similar when the drug was administered with both formulations. Nevertheless, fluoride absorption was greater when the drug was given with the hydrogel, and further, drug-related side effects were absents. These results suggest that Chitosan - β-glycerophosphate hydrogel could be a good candidate for sustained release of fluoride in oral formulation.
publishDate 2019
dc.date.none.fl_str_mv 2019-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/86617
Fookes, Federico Adrian; Mengatto, Luciano Nicolas; Rigalli, Alfredo; Luna, Julio Alberto; Controlled fluoride release for osteoporosis treatment using orally administered chitosan hydrogels; Editions Sante; Journal of Drug Delivery Science and Technology; 51; 6-2019; 268-275
1773-2247
CONICET Digital
CONICET
url http://hdl.handle.net/11336/86617
identifier_str_mv Fookes, Federico Adrian; Mengatto, Luciano Nicolas; Rigalli, Alfredo; Luna, Julio Alberto; Controlled fluoride release for osteoporosis treatment using orally administered chitosan hydrogels; Editions Sante; Journal of Drug Delivery Science and Technology; 51; 6-2019; 268-275
1773-2247
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jddst.2019.03.004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Editions Sante
publisher.none.fl_str_mv Editions Sante
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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