Von Willebrand's disease diagnosis and laboratory issues

Authors
Castaman, G.; Montgomery, R. R.; Meschengieser, S. S.; Haberichter, S. L.; Woods, Adriana Inés; Lazzari, María Ángela
Publication Year
2010
Language
English
Format
article
Status
Published version
Description
In this paper, the recent developments in the diagnosis and laboratory issues of von Willebrand's disease (VWD) are presented. Dr. Castaman reviews the functional tests available for the diagnosis of VWD and their pathophysiological significance, focusing on which tests are best used in the diagnosis and classification of VWD. Dr Montgomery reviews an emerging issue that is accelerated clearance of von Willebrand factor (VWF) occurring in some variants of VWD. This phenotype can be suspected by the presence of an increased ratio between the VWF propeptide and the VWF antigen. These patients have typically a robust, but short-lived increase of FVIII and VWF after desmopressin. Dr Meschengieser reviews the determinants of bleeding after surgery in patients with VWD, emphasizing the role of bleeding history in predicting this risk. © 2010 The Authors. Journal compilation © 2010 Blackwell Publishing Ltd.
Fil: Castaman, G.. Hospital San Bartolo; Italia
Fil: Montgomery, R. R.. Blood Research Institute; Estados Unidos
Fil: Meschengieser, S. S.. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Haberichter, S. L.. Blood Research Institute; Estados Unidos
Fil: Woods, Adriana Inés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Lazzari, María Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
Subject
DESMOPRESSIN
INHERITED BLEEDING DISORDERS
VON WILLEBRAND DISEASE
VON WILLEBRAND FACTOR
Medicina Critica y de Emergencia
Medicina Clínica
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Restricted access
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/52933