Von Willebrand's disease diagnosis and laboratory issues

Autores
Castaman, G.; Montgomery, R. R.; Meschengieser, S. S.; Haberichter, S. L.; Woods, Adriana Inés; Lazzari, María Ángela
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this paper, the recent developments in the diagnosis and laboratory issues of von Willebrand's disease (VWD) are presented. Dr. Castaman reviews the functional tests available for the diagnosis of VWD and their pathophysiological significance, focusing on which tests are best used in the diagnosis and classification of VWD. Dr Montgomery reviews an emerging issue that is accelerated clearance of von Willebrand factor (VWF) occurring in some variants of VWD. This phenotype can be suspected by the presence of an increased ratio between the VWF propeptide and the VWF antigen. These patients have typically a robust, but short-lived increase of FVIII and VWF after desmopressin. Dr Meschengieser reviews the determinants of bleeding after surgery in patients with VWD, emphasizing the role of bleeding history in predicting this risk. © 2010 The Authors. Journal compilation © 2010 Blackwell Publishing Ltd.
Fil: Castaman, G.. Hospital San Bartolo; Italia
Fil: Montgomery, R. R.. Blood Research Institute; Estados Unidos
Fil: Meschengieser, S. S.. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Haberichter, S. L.. Blood Research Institute; Estados Unidos
Fil: Woods, Adriana Inés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Lazzari, María Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
Materia
Desmopressin
Inherited Bleeding Disorders
Von Willebrand Disease
Von Willebrand Factor
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/52933
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/52933
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network_name_str CONICET Digital (CONICET)
spelling Von Willebrand's disease diagnosis and laboratory issuesCastaman, G.Montgomery, R. R.Meschengieser, S. S.Haberichter, S. L.Woods, Adriana InésLazzari, María ÁngelaDesmopressinInherited Bleeding DisordersVon Willebrand DiseaseVon Willebrand Factorhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3In this paper, the recent developments in the diagnosis and laboratory issues of von Willebrand's disease (VWD) are presented. Dr. Castaman reviews the functional tests available for the diagnosis of VWD and their pathophysiological significance, focusing on which tests are best used in the diagnosis and classification of VWD. Dr Montgomery reviews an emerging issue that is accelerated clearance of von Willebrand factor (VWF) occurring in some variants of VWD. This phenotype can be suspected by the presence of an increased ratio between the VWF propeptide and the VWF antigen. These patients have typically a robust, but short-lived increase of FVIII and VWF after desmopressin. Dr Meschengieser reviews the determinants of bleeding after surgery in patients with VWD, emphasizing the role of bleeding history in predicting this risk. © 2010 The Authors. Journal compilation © 2010 Blackwell Publishing Ltd.Fil: Castaman, G.. Hospital San Bartolo; ItaliaFil: Montgomery, R. R.. Blood Research Institute; Estados UnidosFil: Meschengieser, S. S.. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Haberichter, S. L.. Blood Research Institute; Estados UnidosFil: Woods, Adriana Inés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Lazzari, María Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; ArgentinaWiley Blackwell Publishing, Inc2010-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/52933Castaman, G.; Montgomery, R. R.; Meschengieser, S. S.; Haberichter, S. L.; Woods, Adriana Inés; et al.; Von Willebrand's disease diagnosis and laboratory issues; Wiley Blackwell Publishing, Inc; Haemophilia The Official Journal Of The World Federation Of Hemophilia; 16; SUPPL. 5; 7-2010; 67-731351-8216CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2516.2010.02296.xinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2516.2010.02296.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:44Zoai:ri.conicet.gov.ar:11336/52933instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:45.02CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Von Willebrand's disease diagnosis and laboratory issues
title Von Willebrand's disease diagnosis and laboratory issues
spellingShingle Von Willebrand's disease diagnosis and laboratory issues
Castaman, G.
Desmopressin
Inherited Bleeding Disorders
Von Willebrand Disease
Von Willebrand Factor
title_short Von Willebrand's disease diagnosis and laboratory issues
title_full Von Willebrand's disease diagnosis and laboratory issues
title_fullStr Von Willebrand's disease diagnosis and laboratory issues
title_full_unstemmed Von Willebrand's disease diagnosis and laboratory issues
title_sort Von Willebrand's disease diagnosis and laboratory issues
dc.creator.none.fl_str_mv Castaman, G.
Montgomery, R. R.
Meschengieser, S. S.
Haberichter, S. L.
Woods, Adriana Inés
Lazzari, María Ángela
author Castaman, G.
author_facet Castaman, G.
Montgomery, R. R.
Meschengieser, S. S.
Haberichter, S. L.
Woods, Adriana Inés
Lazzari, María Ángela
author_role author
author2 Montgomery, R. R.
Meschengieser, S. S.
Haberichter, S. L.
Woods, Adriana Inés
Lazzari, María Ángela
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Desmopressin
Inherited Bleeding Disorders
Von Willebrand Disease
Von Willebrand Factor
topic Desmopressin
Inherited Bleeding Disorders
Von Willebrand Disease
Von Willebrand Factor
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In this paper, the recent developments in the diagnosis and laboratory issues of von Willebrand's disease (VWD) are presented. Dr. Castaman reviews the functional tests available for the diagnosis of VWD and their pathophysiological significance, focusing on which tests are best used in the diagnosis and classification of VWD. Dr Montgomery reviews an emerging issue that is accelerated clearance of von Willebrand factor (VWF) occurring in some variants of VWD. This phenotype can be suspected by the presence of an increased ratio between the VWF propeptide and the VWF antigen. These patients have typically a robust, but short-lived increase of FVIII and VWF after desmopressin. Dr Meschengieser reviews the determinants of bleeding after surgery in patients with VWD, emphasizing the role of bleeding history in predicting this risk. © 2010 The Authors. Journal compilation © 2010 Blackwell Publishing Ltd.
Fil: Castaman, G.. Hospital San Bartolo; Italia
Fil: Montgomery, R. R.. Blood Research Institute; Estados Unidos
Fil: Meschengieser, S. S.. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Haberichter, S. L.. Blood Research Institute; Estados Unidos
Fil: Woods, Adriana Inés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Lazzari, María Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Academia Nacional de Medicina de Buenos Aires; Argentina
description In this paper, the recent developments in the diagnosis and laboratory issues of von Willebrand's disease (VWD) are presented. Dr. Castaman reviews the functional tests available for the diagnosis of VWD and their pathophysiological significance, focusing on which tests are best used in the diagnosis and classification of VWD. Dr Montgomery reviews an emerging issue that is accelerated clearance of von Willebrand factor (VWF) occurring in some variants of VWD. This phenotype can be suspected by the presence of an increased ratio between the VWF propeptide and the VWF antigen. These patients have typically a robust, but short-lived increase of FVIII and VWF after desmopressin. Dr Meschengieser reviews the determinants of bleeding after surgery in patients with VWD, emphasizing the role of bleeding history in predicting this risk. © 2010 The Authors. Journal compilation © 2010 Blackwell Publishing Ltd.
publishDate 2010
dc.date.none.fl_str_mv 2010-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/52933
Castaman, G.; Montgomery, R. R.; Meschengieser, S. S.; Haberichter, S. L.; Woods, Adriana Inés; et al.; Von Willebrand's disease diagnosis and laboratory issues; Wiley Blackwell Publishing, Inc; Haemophilia The Official Journal Of The World Federation Of Hemophilia; 16; SUPPL. 5; 7-2010; 67-73
1351-8216
CONICET Digital
CONICET
url http://hdl.handle.net/11336/52933
identifier_str_mv Castaman, G.; Montgomery, R. R.; Meschengieser, S. S.; Haberichter, S. L.; Woods, Adriana Inés; et al.; Von Willebrand's disease diagnosis and laboratory issues; Wiley Blackwell Publishing, Inc; Haemophilia The Official Journal Of The World Federation Of Hemophilia; 16; SUPPL. 5; 7-2010; 67-73
1351-8216
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2516.2010.02296.x
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2516.2010.02296.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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