Re: Effect of ADAM28 on carcinoma cell metastasis by cleavage of von willebrand factor

Autores
Alonso, Daniel Fernando
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
I read with great interest the elegant work by Mochizuki et al. ( 1 ) providing novel experimental evidence for the crucial role of von Willebrand factor (VWF), a prominent plasma protein associated with blood coagulation, in resistance to metastasis. The authors found that aggressive human breast and non-small cell lung carcinoma cells expressing high levels of ADAM28 are able to avoid VWF-induced apoptosis at metastatic sites. ADAM28 binds and cleaves VWF, thus enhancing metastasis by favoring cancer cell survival within the blood vessels. I completely agree with the authors in the sense that ADAM28 can be a potential molecular target for cancer therapy, and the development of selective inhibitors of the proteinase is expected. However, another strategy could be to raise the levels of VWF by a pharmacological intervention to stimulate a natural defense against metastasis formation.
Fil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Metastasis
Von Willebrand factor
Desmopressin
Treatment
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/198765
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Re: Effect of ADAM28 on carcinoma cell metastasis by cleavage of von willebrand factorAlonso, Daniel FernandoMetastasisVon Willebrand factorDesmopressinTreatmenthttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3I read with great interest the elegant work by Mochizuki et al. ( 1 ) providing novel experimental evidence for the crucial role of von Willebrand factor (VWF), a prominent plasma protein associated with blood coagulation, in resistance to metastasis. The authors found that aggressive human breast and non-small cell lung carcinoma cells expressing high levels of ADAM28 are able to avoid VWF-induced apoptosis at metastatic sites. ADAM28 binds and cleaves VWF, thus enhancing metastasis by favoring cancer cell survival within the blood vessels. I completely agree with the authors in the sense that ADAM28 can be a potential molecular target for cancer therapy, and the development of selective inhibitors of the proteinase is expected. However, another strategy could be to raise the levels of VWF by a pharmacological intervention to stimulate a natural defense against metastasis formation.Fil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaOxford Univ Press Inc2012-12-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/198765Alonso, Daniel Fernando; Re: Effect of ADAM28 on carcinoma cell metastasis by cleavage of von willebrand factor; Oxford Univ Press Inc; Journal Of The National Cancer Institute.; 104; 24; 19-12-2012; 1917-19170027-88741460-2105CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jnci/article/104/24/1917/920548?searchresult=1info:eu-repo/semantics/altIdentifier/doi/10.1093/jnci/djs459info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:57:03Zoai:ri.conicet.gov.ar:11336/198765instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:57:04.022CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Re: Effect of ADAM28 on carcinoma cell metastasis by cleavage of von willebrand factor
title Re: Effect of ADAM28 on carcinoma cell metastasis by cleavage of von willebrand factor
spellingShingle Re: Effect of ADAM28 on carcinoma cell metastasis by cleavage of von willebrand factor
Alonso, Daniel Fernando
Metastasis
Von Willebrand factor
Desmopressin
Treatment
title_short Re: Effect of ADAM28 on carcinoma cell metastasis by cleavage of von willebrand factor
title_full Re: Effect of ADAM28 on carcinoma cell metastasis by cleavage of von willebrand factor
title_fullStr Re: Effect of ADAM28 on carcinoma cell metastasis by cleavage of von willebrand factor
title_full_unstemmed Re: Effect of ADAM28 on carcinoma cell metastasis by cleavage of von willebrand factor
title_sort Re: Effect of ADAM28 on carcinoma cell metastasis by cleavage of von willebrand factor
dc.creator.none.fl_str_mv Alonso, Daniel Fernando
author Alonso, Daniel Fernando
author_facet Alonso, Daniel Fernando
author_role author
dc.subject.none.fl_str_mv Metastasis
Von Willebrand factor
Desmopressin
Treatment
topic Metastasis
Von Willebrand factor
Desmopressin
Treatment
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv I read with great interest the elegant work by Mochizuki et al. ( 1 ) providing novel experimental evidence for the crucial role of von Willebrand factor (VWF), a prominent plasma protein associated with blood coagulation, in resistance to metastasis. The authors found that aggressive human breast and non-small cell lung carcinoma cells expressing high levels of ADAM28 are able to avoid VWF-induced apoptosis at metastatic sites. ADAM28 binds and cleaves VWF, thus enhancing metastasis by favoring cancer cell survival within the blood vessels. I completely agree with the authors in the sense that ADAM28 can be a potential molecular target for cancer therapy, and the development of selective inhibitors of the proteinase is expected. However, another strategy could be to raise the levels of VWF by a pharmacological intervention to stimulate a natural defense against metastasis formation.
Fil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description I read with great interest the elegant work by Mochizuki et al. ( 1 ) providing novel experimental evidence for the crucial role of von Willebrand factor (VWF), a prominent plasma protein associated with blood coagulation, in resistance to metastasis. The authors found that aggressive human breast and non-small cell lung carcinoma cells expressing high levels of ADAM28 are able to avoid VWF-induced apoptosis at metastatic sites. ADAM28 binds and cleaves VWF, thus enhancing metastasis by favoring cancer cell survival within the blood vessels. I completely agree with the authors in the sense that ADAM28 can be a potential molecular target for cancer therapy, and the development of selective inhibitors of the proteinase is expected. However, another strategy could be to raise the levels of VWF by a pharmacological intervention to stimulate a natural defense against metastasis formation.
publishDate 2012
dc.date.none.fl_str_mv 2012-12-19
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/198765
Alonso, Daniel Fernando; Re: Effect of ADAM28 on carcinoma cell metastasis by cleavage of von willebrand factor; Oxford Univ Press Inc; Journal Of The National Cancer Institute.; 104; 24; 19-12-2012; 1917-1917
0027-8874
1460-2105
CONICET Digital
CONICET
url http://hdl.handle.net/11336/198765
identifier_str_mv Alonso, Daniel Fernando; Re: Effect of ADAM28 on carcinoma cell metastasis by cleavage of von willebrand factor; Oxford Univ Press Inc; Journal Of The National Cancer Institute.; 104; 24; 19-12-2012; 1917-1917
0027-8874
1460-2105
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jnci/article/104/24/1917/920548?searchresult=1
info:eu-repo/semantics/altIdentifier/doi/10.1093/jnci/djs459
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford Univ Press Inc
publisher.none.fl_str_mv Oxford Univ Press Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613709719142400
score 13.070432

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