Examining international practices in the management of pregnant women with von Willebrand disease
- Autores
- Lavin, Michelle; Sánchez Luceros, Analía Gabriela; Kouides, Peter; Abdul-Kadir, Rezan; O’Donnell, James S.; Baker, Ross I.; Othman, Maha; Haberichter, Sandra L.
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: The management of pregnant women with von Willebrand disease (VWD) is complex as physiological pregnancy-induced increases in plasma von Willebrand factor (VWF) may be blunted or absent. Women with VWD experience a heightened risk of postpartum hemorrhage (PPH) and special consideration must be given regarding neuraxial anesthesia (NA) and the need for prophylaxis at time of delivery. These challenges are compounded by a lack of robust evidence to guide clinical decision-making. Objectives and Methods: To determine the current international clinical practices in the management of pregnancy for women with VWD, the International Society on Thrombosis and Haemostasis (ISTH) conducted an international survey of health-care providers (HCP). Results: One hundred thirty-two respondents from 39 countries were included in the final analysis. Variations in clinical practice were identified in antenatal (monitoring of plasma VWF and ferritin levels), peripartum (optimal plasma VWF target at delivery) and postpartum management (definitions used for PPH and postpartum monitoring). A key area of divergence was suitability for NA for women with type 2 and type 3 VWD, with many respondents advising against the use of NA even with VWF supplementation (29% type 2 VWD, 37% type 3 VWD) but others advising use once plasma VWF activity was >50 IU/dL (57% type 2 VWD; 50% type 3 VWD). Conclusions: This survey highlighted areas of uncertainty surrounding common management issues for pregnant women with VWD. These data underscore the need for international collaborative research efforts focused on peripartum management to improve care for pregnant women with VWD.
Fil: Lavin, Michelle. St. James’ Hospital; Irlanda
Fil: Sánchez Luceros, Analía Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Kouides, Peter. Mary M. Gooley Hemophilia Center; Estados Unidos
Fil: Abdul-Kadir, Rezan. Colegio Universitario de Londres; Reino Unido
Fil: O’Donnell, James S.. St. James’ Hospital; Irlanda
Fil: Baker, Ross I.. Murdoch University; Aruba
Fil: Othman, Maha. Queens University; Canadá
Fil: Haberichter, Sandra L.. Medical College Of Wisconsin; Estados Unidos - Materia
-
ANESTHESIA
POSTPARTUM
PREGNANCY
VON WILLEBRAND DISEASE
VON WILLEBRAND FACTOR - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/210656
Ver los metadatos del registro completo
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Examining international practices in the management of pregnant women with von Willebrand diseaseLavin, MichelleSánchez Luceros, Analía GabrielaKouides, PeterAbdul-Kadir, RezanO’Donnell, James S.Baker, Ross I.Othman, MahaHaberichter, Sandra L.ANESTHESIAPOSTPARTUMPREGNANCYVON WILLEBRAND DISEASEVON WILLEBRAND FACTORhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: The management of pregnant women with von Willebrand disease (VWD) is complex as physiological pregnancy-induced increases in plasma von Willebrand factor (VWF) may be blunted or absent. Women with VWD experience a heightened risk of postpartum hemorrhage (PPH) and special consideration must be given regarding neuraxial anesthesia (NA) and the need for prophylaxis at time of delivery. These challenges are compounded by a lack of robust evidence to guide clinical decision-making. Objectives and Methods: To determine the current international clinical practices in the management of pregnancy for women with VWD, the International Society on Thrombosis and Haemostasis (ISTH) conducted an international survey of health-care providers (HCP). Results: One hundred thirty-two respondents from 39 countries were included in the final analysis. Variations in clinical practice were identified in antenatal (monitoring of plasma VWF and ferritin levels), peripartum (optimal plasma VWF target at delivery) and postpartum management (definitions used for PPH and postpartum monitoring). A key area of divergence was suitability for NA for women with type 2 and type 3 VWD, with many respondents advising against the use of NA even with VWF supplementation (29% type 2 VWD, 37% type 3 VWD) but others advising use once plasma VWF activity was >50 IU/dL (57% type 2 VWD; 50% type 3 VWD). Conclusions: This survey highlighted areas of uncertainty surrounding common management issues for pregnant women with VWD. These data underscore the need for international collaborative research efforts focused on peripartum management to improve care for pregnant women with VWD.Fil: Lavin, Michelle. St. James’ Hospital; IrlandaFil: Sánchez Luceros, Analía Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Kouides, Peter. Mary M. Gooley Hemophilia Center; Estados UnidosFil: Abdul-Kadir, Rezan. Colegio Universitario de Londres; Reino UnidoFil: O’Donnell, James S.. St. James’ Hospital; IrlandaFil: Baker, Ross I.. Murdoch University; ArubaFil: Othman, Maha. Queens University; CanadáFil: Haberichter, Sandra L.. Medical College Of Wisconsin; Estados UnidosWiley Blackwell Publishing, Inc2022-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/210656Lavin, Michelle; Sánchez Luceros, Analía Gabriela; Kouides, Peter; Abdul-Kadir, Rezan; O’Donnell, James S.; et al.; Examining international practices in the management of pregnant women with von Willebrand disease; Wiley Blackwell Publishing, Inc; Journal of Thrombosis and Haemostasis; 20; 1; 1-2022; 82-911538-7933CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/jth.15561info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:29Zoai:ri.conicet.gov.ar:11336/210656instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:30.104CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Examining international practices in the management of pregnant women with von Willebrand disease |
title |
Examining international practices in the management of pregnant women with von Willebrand disease |
spellingShingle |
Examining international practices in the management of pregnant women with von Willebrand disease Lavin, Michelle ANESTHESIA POSTPARTUM PREGNANCY VON WILLEBRAND DISEASE VON WILLEBRAND FACTOR |
title_short |
Examining international practices in the management of pregnant women with von Willebrand disease |
title_full |
Examining international practices in the management of pregnant women with von Willebrand disease |
title_fullStr |
Examining international practices in the management of pregnant women with von Willebrand disease |
title_full_unstemmed |
Examining international practices in the management of pregnant women with von Willebrand disease |
title_sort |
Examining international practices in the management of pregnant women with von Willebrand disease |
dc.creator.none.fl_str_mv |
Lavin, Michelle Sánchez Luceros, Analía Gabriela Kouides, Peter Abdul-Kadir, Rezan O’Donnell, James S. Baker, Ross I. Othman, Maha Haberichter, Sandra L. |
author |
Lavin, Michelle |
author_facet |
Lavin, Michelle Sánchez Luceros, Analía Gabriela Kouides, Peter Abdul-Kadir, Rezan O’Donnell, James S. Baker, Ross I. Othman, Maha Haberichter, Sandra L. |
author_role |
author |
author2 |
Sánchez Luceros, Analía Gabriela Kouides, Peter Abdul-Kadir, Rezan O’Donnell, James S. Baker, Ross I. Othman, Maha Haberichter, Sandra L. |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
ANESTHESIA POSTPARTUM PREGNANCY VON WILLEBRAND DISEASE VON WILLEBRAND FACTOR |
topic |
ANESTHESIA POSTPARTUM PREGNANCY VON WILLEBRAND DISEASE VON WILLEBRAND FACTOR |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Background: The management of pregnant women with von Willebrand disease (VWD) is complex as physiological pregnancy-induced increases in plasma von Willebrand factor (VWF) may be blunted or absent. Women with VWD experience a heightened risk of postpartum hemorrhage (PPH) and special consideration must be given regarding neuraxial anesthesia (NA) and the need for prophylaxis at time of delivery. These challenges are compounded by a lack of robust evidence to guide clinical decision-making. Objectives and Methods: To determine the current international clinical practices in the management of pregnancy for women with VWD, the International Society on Thrombosis and Haemostasis (ISTH) conducted an international survey of health-care providers (HCP). Results: One hundred thirty-two respondents from 39 countries were included in the final analysis. Variations in clinical practice were identified in antenatal (monitoring of plasma VWF and ferritin levels), peripartum (optimal plasma VWF target at delivery) and postpartum management (definitions used for PPH and postpartum monitoring). A key area of divergence was suitability for NA for women with type 2 and type 3 VWD, with many respondents advising against the use of NA even with VWF supplementation (29% type 2 VWD, 37% type 3 VWD) but others advising use once plasma VWF activity was >50 IU/dL (57% type 2 VWD; 50% type 3 VWD). Conclusions: This survey highlighted areas of uncertainty surrounding common management issues for pregnant women with VWD. These data underscore the need for international collaborative research efforts focused on peripartum management to improve care for pregnant women with VWD. Fil: Lavin, Michelle. St. James’ Hospital; Irlanda Fil: Sánchez Luceros, Analía Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Kouides, Peter. Mary M. Gooley Hemophilia Center; Estados Unidos Fil: Abdul-Kadir, Rezan. Colegio Universitario de Londres; Reino Unido Fil: O’Donnell, James S.. St. James’ Hospital; Irlanda Fil: Baker, Ross I.. Murdoch University; Aruba Fil: Othman, Maha. Queens University; Canadá Fil: Haberichter, Sandra L.. Medical College Of Wisconsin; Estados Unidos |
description |
Background: The management of pregnant women with von Willebrand disease (VWD) is complex as physiological pregnancy-induced increases in plasma von Willebrand factor (VWF) may be blunted or absent. Women with VWD experience a heightened risk of postpartum hemorrhage (PPH) and special consideration must be given regarding neuraxial anesthesia (NA) and the need for prophylaxis at time of delivery. These challenges are compounded by a lack of robust evidence to guide clinical decision-making. Objectives and Methods: To determine the current international clinical practices in the management of pregnancy for women with VWD, the International Society on Thrombosis and Haemostasis (ISTH) conducted an international survey of health-care providers (HCP). Results: One hundred thirty-two respondents from 39 countries were included in the final analysis. Variations in clinical practice were identified in antenatal (monitoring of plasma VWF and ferritin levels), peripartum (optimal plasma VWF target at delivery) and postpartum management (definitions used for PPH and postpartum monitoring). A key area of divergence was suitability for NA for women with type 2 and type 3 VWD, with many respondents advising against the use of NA even with VWF supplementation (29% type 2 VWD, 37% type 3 VWD) but others advising use once plasma VWF activity was >50 IU/dL (57% type 2 VWD; 50% type 3 VWD). Conclusions: This survey highlighted areas of uncertainty surrounding common management issues for pregnant women with VWD. These data underscore the need for international collaborative research efforts focused on peripartum management to improve care for pregnant women with VWD. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/210656 Lavin, Michelle; Sánchez Luceros, Analía Gabriela; Kouides, Peter; Abdul-Kadir, Rezan; O’Donnell, James S.; et al.; Examining international practices in the management of pregnant women with von Willebrand disease; Wiley Blackwell Publishing, Inc; Journal of Thrombosis and Haemostasis; 20; 1; 1-2022; 82-91 1538-7933 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/210656 |
identifier_str_mv |
Lavin, Michelle; Sánchez Luceros, Analía Gabriela; Kouides, Peter; Abdul-Kadir, Rezan; O’Donnell, James S.; et al.; Examining international practices in the management of pregnant women with von Willebrand disease; Wiley Blackwell Publishing, Inc; Journal of Thrombosis and Haemostasis; 20; 1; 1-2022; 82-91 1538-7933 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1111/jth.15561 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Wiley Blackwell Publishing, Inc |
publisher.none.fl_str_mv |
Wiley Blackwell Publishing, Inc |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613144712839168 |
score |
13.070432 |