Examining international practices in the management of pregnant women with von Willebrand disease

Autores
Lavin, Michelle; Sánchez Luceros, Analía Gabriela; Kouides, Peter; Abdul-Kadir, Rezan; O’Donnell, James S.; Baker, Ross I.; Othman, Maha; Haberichter, Sandra L.
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: The management of pregnant women with von Willebrand disease (VWD) is complex as physiological pregnancy-induced increases in plasma von Willebrand factor (VWF) may be blunted or absent. Women with VWD experience a heightened risk of postpartum hemorrhage (PPH) and special consideration must be given regarding neuraxial anesthesia (NA) and the need for prophylaxis at time of delivery. These challenges are compounded by a lack of robust evidence to guide clinical decision-making. Objectives and Methods: To determine the current international clinical practices in the management of pregnancy for women with VWD, the International Society on Thrombosis and Haemostasis (ISTH) conducted an international survey of health-care providers (HCP). Results: One hundred thirty-two respondents from 39 countries were included in the final analysis. Variations in clinical practice were identified in antenatal (monitoring of plasma VWF and ferritin levels), peripartum (optimal plasma VWF target at delivery) and postpartum management (definitions used for PPH and postpartum monitoring). A key area of divergence was suitability for NA for women with type 2 and type 3 VWD, with many respondents advising against the use of NA even with VWF supplementation (29% type 2 VWD, 37% type 3 VWD) but others advising use once plasma VWF activity was >50 IU/dL (57% type 2 VWD; 50% type 3 VWD). Conclusions: This survey highlighted areas of uncertainty surrounding common management issues for pregnant women with VWD. These data underscore the need for international collaborative research efforts focused on peripartum management to improve care for pregnant women with VWD.
Fil: Lavin, Michelle. St. James’ Hospital; Irlanda
Fil: Sánchez Luceros, Analía Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Kouides, Peter. Mary M. Gooley Hemophilia Center; Estados Unidos
Fil: Abdul-Kadir, Rezan. Colegio Universitario de Londres; Reino Unido
Fil: O’Donnell, James S.. St. James’ Hospital; Irlanda
Fil: Baker, Ross I.. Murdoch University; Aruba
Fil: Othman, Maha. Queens University; Canadá
Fil: Haberichter, Sandra L.. Medical College Of Wisconsin; Estados Unidos
Materia
ANESTHESIA
POSTPARTUM
PREGNANCY
VON WILLEBRAND DISEASE
VON WILLEBRAND FACTOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/210656

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network_name_str CONICET Digital (CONICET)
spelling Examining international practices in the management of pregnant women with von Willebrand diseaseLavin, MichelleSánchez Luceros, Analía GabrielaKouides, PeterAbdul-Kadir, RezanO’Donnell, James S.Baker, Ross I.Othman, MahaHaberichter, Sandra L.ANESTHESIAPOSTPARTUMPREGNANCYVON WILLEBRAND DISEASEVON WILLEBRAND FACTORhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: The management of pregnant women with von Willebrand disease (VWD) is complex as physiological pregnancy-induced increases in plasma von Willebrand factor (VWF) may be blunted or absent. Women with VWD experience a heightened risk of postpartum hemorrhage (PPH) and special consideration must be given regarding neuraxial anesthesia (NA) and the need for prophylaxis at time of delivery. These challenges are compounded by a lack of robust evidence to guide clinical decision-making. Objectives and Methods: To determine the current international clinical practices in the management of pregnancy for women with VWD, the International Society on Thrombosis and Haemostasis (ISTH) conducted an international survey of health-care providers (HCP). Results: One hundred thirty-two respondents from 39 countries were included in the final analysis. Variations in clinical practice were identified in antenatal (monitoring of plasma VWF and ferritin levels), peripartum (optimal plasma VWF target at delivery) and postpartum management (definitions used for PPH and postpartum monitoring). A key area of divergence was suitability for NA for women with type 2 and type 3 VWD, with many respondents advising against the use of NA even with VWF supplementation (29% type 2 VWD, 37% type 3 VWD) but others advising use once plasma VWF activity was >50 IU/dL (57% type 2 VWD; 50% type 3 VWD). Conclusions: This survey highlighted areas of uncertainty surrounding common management issues for pregnant women with VWD. These data underscore the need for international collaborative research efforts focused on peripartum management to improve care for pregnant women with VWD.Fil: Lavin, Michelle. St. James’ Hospital; IrlandaFil: Sánchez Luceros, Analía Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Kouides, Peter. Mary M. Gooley Hemophilia Center; Estados UnidosFil: Abdul-Kadir, Rezan. Colegio Universitario de Londres; Reino UnidoFil: O’Donnell, James S.. St. James’ Hospital; IrlandaFil: Baker, Ross I.. Murdoch University; ArubaFil: Othman, Maha. Queens University; CanadáFil: Haberichter, Sandra L.. Medical College Of Wisconsin; Estados UnidosWiley Blackwell Publishing, Inc2022-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/210656Lavin, Michelle; Sánchez Luceros, Analía Gabriela; Kouides, Peter; Abdul-Kadir, Rezan; O’Donnell, James S.; et al.; Examining international practices in the management of pregnant women with von Willebrand disease; Wiley Blackwell Publishing, Inc; Journal of Thrombosis and Haemostasis; 20; 1; 1-2022; 82-911538-7933CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/jth.15561info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:29Zoai:ri.conicet.gov.ar:11336/210656instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:30.104CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Examining international practices in the management of pregnant women with von Willebrand disease
title Examining international practices in the management of pregnant women with von Willebrand disease
spellingShingle Examining international practices in the management of pregnant women with von Willebrand disease
Lavin, Michelle
ANESTHESIA
POSTPARTUM
PREGNANCY
VON WILLEBRAND DISEASE
VON WILLEBRAND FACTOR
title_short Examining international practices in the management of pregnant women with von Willebrand disease
title_full Examining international practices in the management of pregnant women with von Willebrand disease
title_fullStr Examining international practices in the management of pregnant women with von Willebrand disease
title_full_unstemmed Examining international practices in the management of pregnant women with von Willebrand disease
title_sort Examining international practices in the management of pregnant women with von Willebrand disease
dc.creator.none.fl_str_mv Lavin, Michelle
Sánchez Luceros, Analía Gabriela
Kouides, Peter
Abdul-Kadir, Rezan
O’Donnell, James S.
Baker, Ross I.
Othman, Maha
Haberichter, Sandra L.
author Lavin, Michelle
author_facet Lavin, Michelle
Sánchez Luceros, Analía Gabriela
Kouides, Peter
Abdul-Kadir, Rezan
O’Donnell, James S.
Baker, Ross I.
Othman, Maha
Haberichter, Sandra L.
author_role author
author2 Sánchez Luceros, Analía Gabriela
Kouides, Peter
Abdul-Kadir, Rezan
O’Donnell, James S.
Baker, Ross I.
Othman, Maha
Haberichter, Sandra L.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANESTHESIA
POSTPARTUM
PREGNANCY
VON WILLEBRAND DISEASE
VON WILLEBRAND FACTOR
topic ANESTHESIA
POSTPARTUM
PREGNANCY
VON WILLEBRAND DISEASE
VON WILLEBRAND FACTOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: The management of pregnant women with von Willebrand disease (VWD) is complex as physiological pregnancy-induced increases in plasma von Willebrand factor (VWF) may be blunted or absent. Women with VWD experience a heightened risk of postpartum hemorrhage (PPH) and special consideration must be given regarding neuraxial anesthesia (NA) and the need for prophylaxis at time of delivery. These challenges are compounded by a lack of robust evidence to guide clinical decision-making. Objectives and Methods: To determine the current international clinical practices in the management of pregnancy for women with VWD, the International Society on Thrombosis and Haemostasis (ISTH) conducted an international survey of health-care providers (HCP). Results: One hundred thirty-two respondents from 39 countries were included in the final analysis. Variations in clinical practice were identified in antenatal (monitoring of plasma VWF and ferritin levels), peripartum (optimal plasma VWF target at delivery) and postpartum management (definitions used for PPH and postpartum monitoring). A key area of divergence was suitability for NA for women with type 2 and type 3 VWD, with many respondents advising against the use of NA even with VWF supplementation (29% type 2 VWD, 37% type 3 VWD) but others advising use once plasma VWF activity was >50 IU/dL (57% type 2 VWD; 50% type 3 VWD). Conclusions: This survey highlighted areas of uncertainty surrounding common management issues for pregnant women with VWD. These data underscore the need for international collaborative research efforts focused on peripartum management to improve care for pregnant women with VWD.
Fil: Lavin, Michelle. St. James’ Hospital; Irlanda
Fil: Sánchez Luceros, Analía Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Kouides, Peter. Mary M. Gooley Hemophilia Center; Estados Unidos
Fil: Abdul-Kadir, Rezan. Colegio Universitario de Londres; Reino Unido
Fil: O’Donnell, James S.. St. James’ Hospital; Irlanda
Fil: Baker, Ross I.. Murdoch University; Aruba
Fil: Othman, Maha. Queens University; Canadá
Fil: Haberichter, Sandra L.. Medical College Of Wisconsin; Estados Unidos
description Background: The management of pregnant women with von Willebrand disease (VWD) is complex as physiological pregnancy-induced increases in plasma von Willebrand factor (VWF) may be blunted or absent. Women with VWD experience a heightened risk of postpartum hemorrhage (PPH) and special consideration must be given regarding neuraxial anesthesia (NA) and the need for prophylaxis at time of delivery. These challenges are compounded by a lack of robust evidence to guide clinical decision-making. Objectives and Methods: To determine the current international clinical practices in the management of pregnancy for women with VWD, the International Society on Thrombosis and Haemostasis (ISTH) conducted an international survey of health-care providers (HCP). Results: One hundred thirty-two respondents from 39 countries were included in the final analysis. Variations in clinical practice were identified in antenatal (monitoring of plasma VWF and ferritin levels), peripartum (optimal plasma VWF target at delivery) and postpartum management (definitions used for PPH and postpartum monitoring). A key area of divergence was suitability for NA for women with type 2 and type 3 VWD, with many respondents advising against the use of NA even with VWF supplementation (29% type 2 VWD, 37% type 3 VWD) but others advising use once plasma VWF activity was >50 IU/dL (57% type 2 VWD; 50% type 3 VWD). Conclusions: This survey highlighted areas of uncertainty surrounding common management issues for pregnant women with VWD. These data underscore the need for international collaborative research efforts focused on peripartum management to improve care for pregnant women with VWD.
publishDate 2022
dc.date.none.fl_str_mv 2022-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/210656
Lavin, Michelle; Sánchez Luceros, Analía Gabriela; Kouides, Peter; Abdul-Kadir, Rezan; O’Donnell, James S.; et al.; Examining international practices in the management of pregnant women with von Willebrand disease; Wiley Blackwell Publishing, Inc; Journal of Thrombosis and Haemostasis; 20; 1; 1-2022; 82-91
1538-7933
CONICET Digital
CONICET
url http://hdl.handle.net/11336/210656
identifier_str_mv Lavin, Michelle; Sánchez Luceros, Analía Gabriela; Kouides, Peter; Abdul-Kadir, Rezan; O’Donnell, James S.; et al.; Examining international practices in the management of pregnant women with von Willebrand disease; Wiley Blackwell Publishing, Inc; Journal of Thrombosis and Haemostasis; 20; 1; 1-2022; 82-91
1538-7933
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/jth.15561
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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