Novedad y modulación de la memoria: Mecanismos neurobiológicos implicados

Autores
Justel, Nadia; Psyrdellis, Mariana
Año de publicación
2014
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
La exposición a estímulos novedosos es un protocolo simple de emplear que involucra múltiples sistemas y procesos de memoria tales como codificación, consolidación y recuperación de la información. Esto hace plausible de emplearlo como un tratamiento útil para estudiar los mecanismos comportamentales, fisiológicos y moleculares implicados en esta función cognitiva. Se presentan estudios en modelos animales que dan cuenta de cómo la exploración de un ambiente novedoso puede ser útil para mejorar o deteriorar la memoria, en diferentes períodos ontogenéticos. Además, se presentan investigaciones que demuestran la participación de los diversos sistemas de neurotransmisión en este fenómeno así como los mecanismos moleculares implicados en este tipo de tratamiento. De este modo este tipo de tratamiento, no invasivo y sencillo de aplicar, adquiere relevancia para la ciencia aplicada como una posible alternativa para el desarrollo de estrategias de intervención en la temática.
Exposure to novel stimuli is a simple procedure to use that involved several systems and memory processes, such as acquisition, consolidation and recall of the information. Which make it a possible treatment to study the behavioral, physiological and molecular mechanism involved in this cognitive function. Novelty detection plays an important role in adaptation to the environmental changes and in the avoidance of possible dangerous. A novel stimulus elicits a response that will produce habituation when it becomes familiar. When animals are first exposed to a novel environment they explore it actively and in parallel they compare it to previous experiences, stored in its memory to evaluate the degree of novelty. On one side, it includes the response to novelty, activation, and stress-related factors and on the other hand, a response that decreases as the environment becomes familiar, which requires different processes related to learning, recall and recognition. Also, multiple studies showed that animals prefer to explore novel objects, compared with those with whom they had previous experience. Moreover, it has been shown that the ability to respond to novel stimuli is related to self-administration of various drugs, the discovery of spontaneous tumors, and even life expectancy since it was found that neophobic animals die younger than their counterpart's neophilic. In this work we presented studies that indicated how the exploration of a novel environment could be a useful tool to enhanced or deteriorated memory in different ontogenetic stages. The modulation of memory depends on the different characteristic of the treatment presentation. It was reported that the novelty presented prior to an acquisition of some training task can generate an improvement in memory performance. Although, it was founded that the novelty exploration produce an amnesic effect if it was presented after learning, showing the opposite effect. This have been shown in different paradigms such us consummatory successive negative contrast (cSNC) paradigm and inhibition avoidance, in different phases of the training. It was also important to note that this phenomenon involves different time window parameters, for example it is required that the novelty were presented at least one hour before the learning. Furthermore we mentioned data that shows that exposure to novelty during infancy induces a lasting effect of improved cognition and long-term memory that persists even in adulthood. The study of the effect of novelty in the postnatal period and its subsequent influence on other periods opens the possibility of the creative developing of strategies to improve learning and memory processes throughout the subject's life. Besides, we presented research that exhibited the implication of several neurotransmitter systems in this phenomenon and the molecular mechanisms involved in this treatment. Practically all the principal neurotransmitter systems, such as cholinergic, glutamatergic, adrenergic, among others, are involved. A lot of studies indicate that cholinergic neurotransmission plays a critical role in the processes of attention, learning and memory. The same functions correspond to the adrenergic system. The gabaergic system is also involved in the perception of novel stimuli. Glutamate receptors play an important role in the memory processes mainly. In addition, a vast number of studies also reported that the molecular brain activation is very extensive in all the process of explore a novel environment, realizing the complexity of this mechanism. Thus, this type of treatment, non-invasive and easy to apply, becomes relevant for applied science as a possible alternative for the development of many intervention strategies in the topic. Also the study of this phenomenon in post -natal period, allows thinking about possible strategies applicable in the development of this cognitive function.
Fil: Justel, Nadia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Psyrdellis, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Materia
Memoria
Novedad
Mecanismos Oculares
Neurotransmisión
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/20662

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spelling Novedad y modulación de la memoria: Mecanismos neurobiológicos implicadosNovelty and modulation of memory: Neurobiological mechanisms involvedJustel, NadiaPsyrdellis, MarianaMemoriaNovedadMecanismos OcularesNeurotransmisiónhttps://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5La exposición a estímulos novedosos es un protocolo simple de emplear que involucra múltiples sistemas y procesos de memoria tales como codificación, consolidación y recuperación de la información. Esto hace plausible de emplearlo como un tratamiento útil para estudiar los mecanismos comportamentales, fisiológicos y moleculares implicados en esta función cognitiva. Se presentan estudios en modelos animales que dan cuenta de cómo la exploración de un ambiente novedoso puede ser útil para mejorar o deteriorar la memoria, en diferentes períodos ontogenéticos. Además, se presentan investigaciones que demuestran la participación de los diversos sistemas de neurotransmisión en este fenómeno así como los mecanismos moleculares implicados en este tipo de tratamiento. De este modo este tipo de tratamiento, no invasivo y sencillo de aplicar, adquiere relevancia para la ciencia aplicada como una posible alternativa para el desarrollo de estrategias de intervención en la temática.Exposure to novel stimuli is a simple procedure to use that involved several systems and memory processes, such as acquisition, consolidation and recall of the information. Which make it a possible treatment to study the behavioral, physiological and molecular mechanism involved in this cognitive function. Novelty detection plays an important role in adaptation to the environmental changes and in the avoidance of possible dangerous. A novel stimulus elicits a response that will produce habituation when it becomes familiar. When animals are first exposed to a novel environment they explore it actively and in parallel they compare it to previous experiences, stored in its memory to evaluate the degree of novelty. On one side, it includes the response to novelty, activation, and stress-related factors and on the other hand, a response that decreases as the environment becomes familiar, which requires different processes related to learning, recall and recognition. Also, multiple studies showed that animals prefer to explore novel objects, compared with those with whom they had previous experience. Moreover, it has been shown that the ability to respond to novel stimuli is related to self-administration of various drugs, the discovery of spontaneous tumors, and even life expectancy since it was found that neophobic animals die younger than their counterpart's neophilic. In this work we presented studies that indicated how the exploration of a novel environment could be a useful tool to enhanced or deteriorated memory in different ontogenetic stages. The modulation of memory depends on the different characteristic of the treatment presentation. It was reported that the novelty presented prior to an acquisition of some training task can generate an improvement in memory performance. Although, it was founded that the novelty exploration produce an amnesic effect if it was presented after learning, showing the opposite effect. This have been shown in different paradigms such us consummatory successive negative contrast (cSNC) paradigm and inhibition avoidance, in different phases of the training. It was also important to note that this phenomenon involves different time window parameters, for example it is required that the novelty were presented at least one hour before the learning. Furthermore we mentioned data that shows that exposure to novelty during infancy induces a lasting effect of improved cognition and long-term memory that persists even in adulthood. The study of the effect of novelty in the postnatal period and its subsequent influence on other periods opens the possibility of the creative developing of strategies to improve learning and memory processes throughout the subject's life. Besides, we presented research that exhibited the implication of several neurotransmitter systems in this phenomenon and the molecular mechanisms involved in this treatment. Practically all the principal neurotransmitter systems, such as cholinergic, glutamatergic, adrenergic, among others, are involved. A lot of studies indicate that cholinergic neurotransmission plays a critical role in the processes of attention, learning and memory. The same functions correspond to the adrenergic system. The gabaergic system is also involved in the perception of novel stimuli. Glutamate receptors play an important role in the memory processes mainly. In addition, a vast number of studies also reported that the molecular brain activation is very extensive in all the process of explore a novel environment, realizing the complexity of this mechanism. Thus, this type of treatment, non-invasive and easy to apply, becomes relevant for applied science as a possible alternative for the development of many intervention strategies in the topic. Also the study of this phenomenon in post -natal period, allows thinking about possible strategies applicable in the development of this cognitive function.Fil: Justel, Nadia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Psyrdellis, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaConsejo Nacional de Investigaciones Científicas y Técnicas. Centro Interamericano de Investigaciones Psicológicas y Ciencias Afines; Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20662Justel, Nadia; Psyrdellis, Mariana; Novedad y modulación de la memoria: Mecanismos neurobiológicos implicados; Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Interamericano de Investigaciones Psicológicas y Ciencias Afines; Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental; Interdisciplinaria; 31; 2; 12-2014; 195-2111668-7027CONICET DigitalCONICETspainfo:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/54xn6xinfo:eu-repo/semantics/altIdentifier/url/http://www.ciipme-conicet.gov.ar/ojs/index.php/interdisciplinaria/indexinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:45:02Zoai:ri.conicet.gov.ar:11336/20662instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:45:03.063CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Novedad y modulación de la memoria: Mecanismos neurobiológicos implicados
Novelty and modulation of memory: Neurobiological mechanisms involved
title Novedad y modulación de la memoria: Mecanismos neurobiológicos implicados
spellingShingle Novedad y modulación de la memoria: Mecanismos neurobiológicos implicados
Justel, Nadia
Memoria
Novedad
Mecanismos Oculares
Neurotransmisión
title_short Novedad y modulación de la memoria: Mecanismos neurobiológicos implicados
title_full Novedad y modulación de la memoria: Mecanismos neurobiológicos implicados
title_fullStr Novedad y modulación de la memoria: Mecanismos neurobiológicos implicados
title_full_unstemmed Novedad y modulación de la memoria: Mecanismos neurobiológicos implicados
title_sort Novedad y modulación de la memoria: Mecanismos neurobiológicos implicados
dc.creator.none.fl_str_mv Justel, Nadia
Psyrdellis, Mariana
author Justel, Nadia
author_facet Justel, Nadia
Psyrdellis, Mariana
author_role author
author2 Psyrdellis, Mariana
author2_role author
dc.subject.none.fl_str_mv Memoria
Novedad
Mecanismos Oculares
Neurotransmisión
topic Memoria
Novedad
Mecanismos Oculares
Neurotransmisión
purl_subject.fl_str_mv https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
dc.description.none.fl_txt_mv La exposición a estímulos novedosos es un protocolo simple de emplear que involucra múltiples sistemas y procesos de memoria tales como codificación, consolidación y recuperación de la información. Esto hace plausible de emplearlo como un tratamiento útil para estudiar los mecanismos comportamentales, fisiológicos y moleculares implicados en esta función cognitiva. Se presentan estudios en modelos animales que dan cuenta de cómo la exploración de un ambiente novedoso puede ser útil para mejorar o deteriorar la memoria, en diferentes períodos ontogenéticos. Además, se presentan investigaciones que demuestran la participación de los diversos sistemas de neurotransmisión en este fenómeno así como los mecanismos moleculares implicados en este tipo de tratamiento. De este modo este tipo de tratamiento, no invasivo y sencillo de aplicar, adquiere relevancia para la ciencia aplicada como una posible alternativa para el desarrollo de estrategias de intervención en la temática.
Exposure to novel stimuli is a simple procedure to use that involved several systems and memory processes, such as acquisition, consolidation and recall of the information. Which make it a possible treatment to study the behavioral, physiological and molecular mechanism involved in this cognitive function. Novelty detection plays an important role in adaptation to the environmental changes and in the avoidance of possible dangerous. A novel stimulus elicits a response that will produce habituation when it becomes familiar. When animals are first exposed to a novel environment they explore it actively and in parallel they compare it to previous experiences, stored in its memory to evaluate the degree of novelty. On one side, it includes the response to novelty, activation, and stress-related factors and on the other hand, a response that decreases as the environment becomes familiar, which requires different processes related to learning, recall and recognition. Also, multiple studies showed that animals prefer to explore novel objects, compared with those with whom they had previous experience. Moreover, it has been shown that the ability to respond to novel stimuli is related to self-administration of various drugs, the discovery of spontaneous tumors, and even life expectancy since it was found that neophobic animals die younger than their counterpart's neophilic. In this work we presented studies that indicated how the exploration of a novel environment could be a useful tool to enhanced or deteriorated memory in different ontogenetic stages. The modulation of memory depends on the different characteristic of the treatment presentation. It was reported that the novelty presented prior to an acquisition of some training task can generate an improvement in memory performance. Although, it was founded that the novelty exploration produce an amnesic effect if it was presented after learning, showing the opposite effect. This have been shown in different paradigms such us consummatory successive negative contrast (cSNC) paradigm and inhibition avoidance, in different phases of the training. It was also important to note that this phenomenon involves different time window parameters, for example it is required that the novelty were presented at least one hour before the learning. Furthermore we mentioned data that shows that exposure to novelty during infancy induces a lasting effect of improved cognition and long-term memory that persists even in adulthood. The study of the effect of novelty in the postnatal period and its subsequent influence on other periods opens the possibility of the creative developing of strategies to improve learning and memory processes throughout the subject's life. Besides, we presented research that exhibited the implication of several neurotransmitter systems in this phenomenon and the molecular mechanisms involved in this treatment. Practically all the principal neurotransmitter systems, such as cholinergic, glutamatergic, adrenergic, among others, are involved. A lot of studies indicate that cholinergic neurotransmission plays a critical role in the processes of attention, learning and memory. The same functions correspond to the adrenergic system. The gabaergic system is also involved in the perception of novel stimuli. Glutamate receptors play an important role in the memory processes mainly. In addition, a vast number of studies also reported that the molecular brain activation is very extensive in all the process of explore a novel environment, realizing the complexity of this mechanism. Thus, this type of treatment, non-invasive and easy to apply, becomes relevant for applied science as a possible alternative for the development of many intervention strategies in the topic. Also the study of this phenomenon in post -natal period, allows thinking about possible strategies applicable in the development of this cognitive function.
Fil: Justel, Nadia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Psyrdellis, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
description La exposición a estímulos novedosos es un protocolo simple de emplear que involucra múltiples sistemas y procesos de memoria tales como codificación, consolidación y recuperación de la información. Esto hace plausible de emplearlo como un tratamiento útil para estudiar los mecanismos comportamentales, fisiológicos y moleculares implicados en esta función cognitiva. Se presentan estudios en modelos animales que dan cuenta de cómo la exploración de un ambiente novedoso puede ser útil para mejorar o deteriorar la memoria, en diferentes períodos ontogenéticos. Además, se presentan investigaciones que demuestran la participación de los diversos sistemas de neurotransmisión en este fenómeno así como los mecanismos moleculares implicados en este tipo de tratamiento. De este modo este tipo de tratamiento, no invasivo y sencillo de aplicar, adquiere relevancia para la ciencia aplicada como una posible alternativa para el desarrollo de estrategias de intervención en la temática.
publishDate 2014
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status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20662
Justel, Nadia; Psyrdellis, Mariana; Novedad y modulación de la memoria: Mecanismos neurobiológicos implicados; Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Interamericano de Investigaciones Psicológicas y Ciencias Afines; Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental; Interdisciplinaria; 31; 2; 12-2014; 195-211
1668-7027
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20662
identifier_str_mv Justel, Nadia; Psyrdellis, Mariana; Novedad y modulación de la memoria: Mecanismos neurobiológicos implicados; Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Interamericano de Investigaciones Psicológicas y Ciencias Afines; Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental; Interdisciplinaria; 31; 2; 12-2014; 195-211
1668-7027
CONICET Digital
CONICET
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publisher.none.fl_str_mv Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Interamericano de Investigaciones Psicológicas y Ciencias Afines; Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Interdisciplinario de Investigaciones en Psicología Matemática y Experimental
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