The bovine CXCR1 gene is highly polymorphic
- Autores
- Pighetti, Gina M.; Kojima, Cheryl J.; Wojakiewicz, Leszek; Rambeaud, Magdalena
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Several single nucleotide polymorphisms (SNP) in the bovine CXCR1 gene have been implicated in resistance to mastitis and milk somatic cell counts in several sample populations of Holstein dairy cows. As such, a more thorough understanding of SNP present in and near the bovine CXCR1 gene is needed. This study identified 36 SNP in the coding region and surrounding sequences of CXCR1 in 88 Holstein dairy cows. Four SNP induced amino acid changes and 1 SNP an early stop codon. Two amino acid changes occur in the third intracellular loop and C-terminus in locations tied to intracellular signaling. The 36 SNP could be subdivided into 4 separate linkage groups. Using representative or 'tag' SNP from each linkage group, haplotypes or the combination of SNP found on a single allele were generated to increase the specificity of an animal's genetic background. Four haplotypes were identified that represented 99% of the sample population. The haplotypes generated using tag SNP agreed with haplotypes generated from SNP causing amino acid changes. In conclusion, the CXCR1 gene is highly polymorphic and has potential implications towards genetic selection and understanding host factors that increase the risk of infection.
Fil: Pighetti, Gina M.. University of Tennessee; Estados Unidos
Fil: Kojima, Cheryl J.. University of Tennessee; Estados Unidos
Fil: Wojakiewicz, Leszek. University of Tennessee; Estados Unidos
Fil: Rambeaud, Magdalena. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina - Materia
-
Bovine
Chemokine
Cxcr1
Polymorphism - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/79651
Ver los metadatos del registro completo
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The bovine CXCR1 gene is highly polymorphicPighetti, Gina M.Kojima, Cheryl J.Wojakiewicz, LeszekRambeaud, MagdalenaBovineChemokineCxcr1Polymorphismhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Several single nucleotide polymorphisms (SNP) in the bovine CXCR1 gene have been implicated in resistance to mastitis and milk somatic cell counts in several sample populations of Holstein dairy cows. As such, a more thorough understanding of SNP present in and near the bovine CXCR1 gene is needed. This study identified 36 SNP in the coding region and surrounding sequences of CXCR1 in 88 Holstein dairy cows. Four SNP induced amino acid changes and 1 SNP an early stop codon. Two amino acid changes occur in the third intracellular loop and C-terminus in locations tied to intracellular signaling. The 36 SNP could be subdivided into 4 separate linkage groups. Using representative or 'tag' SNP from each linkage group, haplotypes or the combination of SNP found on a single allele were generated to increase the specificity of an animal's genetic background. Four haplotypes were identified that represented 99% of the sample population. The haplotypes generated using tag SNP agreed with haplotypes generated from SNP causing amino acid changes. In conclusion, the CXCR1 gene is highly polymorphic and has potential implications towards genetic selection and understanding host factors that increase the risk of infection.Fil: Pighetti, Gina M.. University of Tennessee; Estados UnidosFil: Kojima, Cheryl J.. University of Tennessee; Estados UnidosFil: Wojakiewicz, Leszek. University of Tennessee; Estados UnidosFil: Rambeaud, Magdalena. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaElsevier Science2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79651Pighetti, Gina M.; Kojima, Cheryl J.; Wojakiewicz, Leszek; Rambeaud, Magdalena; The bovine CXCR1 gene is highly polymorphic; Elsevier Science; Veterinary Immunology And Immunopathology; 145; 1-2; 1-2012; 464-4700165-2427CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.vetimm.2011.09.012info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165242711003680info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:15:17Zoai:ri.conicet.gov.ar:11336/79651instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:15:17.562CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The bovine CXCR1 gene is highly polymorphic |
title |
The bovine CXCR1 gene is highly polymorphic |
spellingShingle |
The bovine CXCR1 gene is highly polymorphic Pighetti, Gina M. Bovine Chemokine Cxcr1 Polymorphism |
title_short |
The bovine CXCR1 gene is highly polymorphic |
title_full |
The bovine CXCR1 gene is highly polymorphic |
title_fullStr |
The bovine CXCR1 gene is highly polymorphic |
title_full_unstemmed |
The bovine CXCR1 gene is highly polymorphic |
title_sort |
The bovine CXCR1 gene is highly polymorphic |
dc.creator.none.fl_str_mv |
Pighetti, Gina M. Kojima, Cheryl J. Wojakiewicz, Leszek Rambeaud, Magdalena |
author |
Pighetti, Gina M. |
author_facet |
Pighetti, Gina M. Kojima, Cheryl J. Wojakiewicz, Leszek Rambeaud, Magdalena |
author_role |
author |
author2 |
Kojima, Cheryl J. Wojakiewicz, Leszek Rambeaud, Magdalena |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Bovine Chemokine Cxcr1 Polymorphism |
topic |
Bovine Chemokine Cxcr1 Polymorphism |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 |
dc.description.none.fl_txt_mv |
Several single nucleotide polymorphisms (SNP) in the bovine CXCR1 gene have been implicated in resistance to mastitis and milk somatic cell counts in several sample populations of Holstein dairy cows. As such, a more thorough understanding of SNP present in and near the bovine CXCR1 gene is needed. This study identified 36 SNP in the coding region and surrounding sequences of CXCR1 in 88 Holstein dairy cows. Four SNP induced amino acid changes and 1 SNP an early stop codon. Two amino acid changes occur in the third intracellular loop and C-terminus in locations tied to intracellular signaling. The 36 SNP could be subdivided into 4 separate linkage groups. Using representative or 'tag' SNP from each linkage group, haplotypes or the combination of SNP found on a single allele were generated to increase the specificity of an animal's genetic background. Four haplotypes were identified that represented 99% of the sample population. The haplotypes generated using tag SNP agreed with haplotypes generated from SNP causing amino acid changes. In conclusion, the CXCR1 gene is highly polymorphic and has potential implications towards genetic selection and understanding host factors that increase the risk of infection. Fil: Pighetti, Gina M.. University of Tennessee; Estados Unidos Fil: Kojima, Cheryl J.. University of Tennessee; Estados Unidos Fil: Wojakiewicz, Leszek. University of Tennessee; Estados Unidos Fil: Rambeaud, Magdalena. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina |
description |
Several single nucleotide polymorphisms (SNP) in the bovine CXCR1 gene have been implicated in resistance to mastitis and milk somatic cell counts in several sample populations of Holstein dairy cows. As such, a more thorough understanding of SNP present in and near the bovine CXCR1 gene is needed. This study identified 36 SNP in the coding region and surrounding sequences of CXCR1 in 88 Holstein dairy cows. Four SNP induced amino acid changes and 1 SNP an early stop codon. Two amino acid changes occur in the third intracellular loop and C-terminus in locations tied to intracellular signaling. The 36 SNP could be subdivided into 4 separate linkage groups. Using representative or 'tag' SNP from each linkage group, haplotypes or the combination of SNP found on a single allele were generated to increase the specificity of an animal's genetic background. Four haplotypes were identified that represented 99% of the sample population. The haplotypes generated using tag SNP agreed with haplotypes generated from SNP causing amino acid changes. In conclusion, the CXCR1 gene is highly polymorphic and has potential implications towards genetic selection and understanding host factors that increase the risk of infection. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/79651 Pighetti, Gina M.; Kojima, Cheryl J.; Wojakiewicz, Leszek; Rambeaud, Magdalena; The bovine CXCR1 gene is highly polymorphic; Elsevier Science; Veterinary Immunology And Immunopathology; 145; 1-2; 1-2012; 464-470 0165-2427 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/79651 |
identifier_str_mv |
Pighetti, Gina M.; Kojima, Cheryl J.; Wojakiewicz, Leszek; Rambeaud, Magdalena; The bovine CXCR1 gene is highly polymorphic; Elsevier Science; Veterinary Immunology And Immunopathology; 145; 1-2; 1-2012; 464-470 0165-2427 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.vetimm.2011.09.012 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165242711003680 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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