The bovine CXCR1 gene is highly polymorphic

Autores
Pighetti, Gina M.; Kojima, Cheryl J.; Wojakiewicz, Leszek; Rambeaud, Magdalena
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Several single nucleotide polymorphisms (SNP) in the bovine CXCR1 gene have been implicated in resistance to mastitis and milk somatic cell counts in several sample populations of Holstein dairy cows. As such, a more thorough understanding of SNP present in and near the bovine CXCR1 gene is needed. This study identified 36 SNP in the coding region and surrounding sequences of CXCR1 in 88 Holstein dairy cows. Four SNP induced amino acid changes and 1 SNP an early stop codon. Two amino acid changes occur in the third intracellular loop and C-terminus in locations tied to intracellular signaling. The 36 SNP could be subdivided into 4 separate linkage groups. Using representative or 'tag' SNP from each linkage group, haplotypes or the combination of SNP found on a single allele were generated to increase the specificity of an animal's genetic background. Four haplotypes were identified that represented 99% of the sample population. The haplotypes generated using tag SNP agreed with haplotypes generated from SNP causing amino acid changes. In conclusion, the CXCR1 gene is highly polymorphic and has potential implications towards genetic selection and understanding host factors that increase the risk of infection.
Fil: Pighetti, Gina M.. University of Tennessee; Estados Unidos
Fil: Kojima, Cheryl J.. University of Tennessee; Estados Unidos
Fil: Wojakiewicz, Leszek. University of Tennessee; Estados Unidos
Fil: Rambeaud, Magdalena. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Materia
Bovine
Chemokine
Cxcr1
Polymorphism
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/79651
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The bovine CXCR1 gene is highly polymorphicPighetti, Gina M.Kojima, Cheryl J.Wojakiewicz, LeszekRambeaud, MagdalenaBovineChemokineCxcr1Polymorphismhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Several single nucleotide polymorphisms (SNP) in the bovine CXCR1 gene have been implicated in resistance to mastitis and milk somatic cell counts in several sample populations of Holstein dairy cows. As such, a more thorough understanding of SNP present in and near the bovine CXCR1 gene is needed. This study identified 36 SNP in the coding region and surrounding sequences of CXCR1 in 88 Holstein dairy cows. Four SNP induced amino acid changes and 1 SNP an early stop codon. Two amino acid changes occur in the third intracellular loop and C-terminus in locations tied to intracellular signaling. The 36 SNP could be subdivided into 4 separate linkage groups. Using representative or 'tag' SNP from each linkage group, haplotypes or the combination of SNP found on a single allele were generated to increase the specificity of an animal's genetic background. Four haplotypes were identified that represented 99% of the sample population. The haplotypes generated using tag SNP agreed with haplotypes generated from SNP causing amino acid changes. In conclusion, the CXCR1 gene is highly polymorphic and has potential implications towards genetic selection and understanding host factors that increase the risk of infection.Fil: Pighetti, Gina M.. University of Tennessee; Estados UnidosFil: Kojima, Cheryl J.. University of Tennessee; Estados UnidosFil: Wojakiewicz, Leszek. University of Tennessee; Estados UnidosFil: Rambeaud, Magdalena. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaElsevier Science2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79651Pighetti, Gina M.; Kojima, Cheryl J.; Wojakiewicz, Leszek; Rambeaud, Magdalena; The bovine CXCR1 gene is highly polymorphic; Elsevier Science; Veterinary Immunology And Immunopathology; 145; 1-2; 1-2012; 464-4700165-2427CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.vetimm.2011.09.012info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165242711003680info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:12:30Zoai:ri.conicet.gov.ar:11336/79651instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:12:30.364CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The bovine CXCR1 gene is highly polymorphic
title The bovine CXCR1 gene is highly polymorphic
spellingShingle The bovine CXCR1 gene is highly polymorphic
Pighetti, Gina M.
Bovine
Chemokine
Cxcr1
Polymorphism
title_short The bovine CXCR1 gene is highly polymorphic
title_full The bovine CXCR1 gene is highly polymorphic
title_fullStr The bovine CXCR1 gene is highly polymorphic
title_full_unstemmed The bovine CXCR1 gene is highly polymorphic
title_sort The bovine CXCR1 gene is highly polymorphic
dc.creator.none.fl_str_mv Pighetti, Gina M.
Kojima, Cheryl J.
Wojakiewicz, Leszek
Rambeaud, Magdalena
author Pighetti, Gina M.
author_facet Pighetti, Gina M.
Kojima, Cheryl J.
Wojakiewicz, Leszek
Rambeaud, Magdalena
author_role author
author2 Kojima, Cheryl J.
Wojakiewicz, Leszek
Rambeaud, Magdalena
author2_role author
author
author
dc.subject.none.fl_str_mv Bovine
Chemokine
Cxcr1
Polymorphism
topic Bovine
Chemokine
Cxcr1
Polymorphism
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Several single nucleotide polymorphisms (SNP) in the bovine CXCR1 gene have been implicated in resistance to mastitis and milk somatic cell counts in several sample populations of Holstein dairy cows. As such, a more thorough understanding of SNP present in and near the bovine CXCR1 gene is needed. This study identified 36 SNP in the coding region and surrounding sequences of CXCR1 in 88 Holstein dairy cows. Four SNP induced amino acid changes and 1 SNP an early stop codon. Two amino acid changes occur in the third intracellular loop and C-terminus in locations tied to intracellular signaling. The 36 SNP could be subdivided into 4 separate linkage groups. Using representative or 'tag' SNP from each linkage group, haplotypes or the combination of SNP found on a single allele were generated to increase the specificity of an animal's genetic background. Four haplotypes were identified that represented 99% of the sample population. The haplotypes generated using tag SNP agreed with haplotypes generated from SNP causing amino acid changes. In conclusion, the CXCR1 gene is highly polymorphic and has potential implications towards genetic selection and understanding host factors that increase the risk of infection.
Fil: Pighetti, Gina M.. University of Tennessee; Estados Unidos
Fil: Kojima, Cheryl J.. University of Tennessee; Estados Unidos
Fil: Wojakiewicz, Leszek. University of Tennessee; Estados Unidos
Fil: Rambeaud, Magdalena. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
description Several single nucleotide polymorphisms (SNP) in the bovine CXCR1 gene have been implicated in resistance to mastitis and milk somatic cell counts in several sample populations of Holstein dairy cows. As such, a more thorough understanding of SNP present in and near the bovine CXCR1 gene is needed. This study identified 36 SNP in the coding region and surrounding sequences of CXCR1 in 88 Holstein dairy cows. Four SNP induced amino acid changes and 1 SNP an early stop codon. Two amino acid changes occur in the third intracellular loop and C-terminus in locations tied to intracellular signaling. The 36 SNP could be subdivided into 4 separate linkage groups. Using representative or 'tag' SNP from each linkage group, haplotypes or the combination of SNP found on a single allele were generated to increase the specificity of an animal's genetic background. Four haplotypes were identified that represented 99% of the sample population. The haplotypes generated using tag SNP agreed with haplotypes generated from SNP causing amino acid changes. In conclusion, the CXCR1 gene is highly polymorphic and has potential implications towards genetic selection and understanding host factors that increase the risk of infection.
publishDate 2012
dc.date.none.fl_str_mv 2012-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79651
Pighetti, Gina M.; Kojima, Cheryl J.; Wojakiewicz, Leszek; Rambeaud, Magdalena; The bovine CXCR1 gene is highly polymorphic; Elsevier Science; Veterinary Immunology And Immunopathology; 145; 1-2; 1-2012; 464-470
0165-2427
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79651
identifier_str_mv Pighetti, Gina M.; Kojima, Cheryl J.; Wojakiewicz, Leszek; Rambeaud, Magdalena; The bovine CXCR1 gene is highly polymorphic; Elsevier Science; Veterinary Immunology And Immunopathology; 145; 1-2; 1-2012; 464-470
0165-2427
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.vetimm.2011.09.012
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165242711003680
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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