From celiac disease to coccidia infection and vice-versa: the polyQ peptide CXCR3-interaction axis

Autores
Lauxmann, Martin Alexander; Vazquez, Diego Sebastian; Schilbert, Hanna M.; Neubauer, Pia R.; Lammers, Karen M.; Dodero, Veronica Isabel
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Zonulin is a physiological modulator of intercellular tight junctions, which upregulation is involved in several diseases like celiac disease (CeD). The polyQ gliadin fragment binds to the CXCR3 chemokine receptor that activates zonulin upregulation, leading to increased intestinal permeability in humans. Here, we report a general hypothesis based on the structural connection between the polyQ sequence of the immunogenic CeD protein, gliadin, and enteric coccidian parasites proteins. Firstly, a novel interaction pathway between the parasites and the host is described based on the structural similarities between polyQ gliadin fragments and the parasite proteins. Secondly, a potential connection between coccidial infections as a novel environmental trigger of CeD is hypothesized. Therefore, this report represents a promising breakthrough for coccidian research and points out the potential role of coccidian parasites as a novel trigger of CeD that might define a preventive strategy for gluten-related disorders in general. Also see the video abstract here: https://youtu.be/oMaQasStcFI.
Fil: Lauxmann, Martin Alexander. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Brandenburg Medical School; Alemania
Fil: Vazquez, Diego Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB; Argentina
Fil: Schilbert, Hanna M.. Universitat Bielefeld; Alemania
Fil: Neubauer, Pia R.. Universitat Bielefeld; Alemania
Fil: Lammers, Karen M.. Tubascan Ltd; Países Bajos
Fil: Dodero, Veronica Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universitat Bielefeld; Alemania
Materia
CHEMOKINE RECEPTOR CXCR3
COCCIDIOSIS
EIMERIA
GLIADIN
GLUTEN-RELATED DISORDERS
POLYQ SEQUENCE
ZONULIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/181141
Acceder
id CONICETDig_3dc5a44ed91f8b7a8aa4a95c034d72e8
oai_identifier_str oai:ri.conicet.gov.ar:11336/181141
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling From celiac disease to coccidia infection and vice-versa: the polyQ peptide CXCR3-interaction axisLauxmann, Martin AlexanderVazquez, Diego SebastianSchilbert, Hanna M.Neubauer, Pia R.Lammers, Karen M.Dodero, Veronica IsabelCHEMOKINE RECEPTOR CXCR3COCCIDIOSISEIMERIAGLIADINGLUTEN-RELATED DISORDERSPOLYQ SEQUENCEZONULINhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Zonulin is a physiological modulator of intercellular tight junctions, which upregulation is involved in several diseases like celiac disease (CeD). The polyQ gliadin fragment binds to the CXCR3 chemokine receptor that activates zonulin upregulation, leading to increased intestinal permeability in humans. Here, we report a general hypothesis based on the structural connection between the polyQ sequence of the immunogenic CeD protein, gliadin, and enteric coccidian parasites proteins. Firstly, a novel interaction pathway between the parasites and the host is described based on the structural similarities between polyQ gliadin fragments and the parasite proteins. Secondly, a potential connection between coccidial infections as a novel environmental trigger of CeD is hypothesized. Therefore, this report represents a promising breakthrough for coccidian research and points out the potential role of coccidian parasites as a novel trigger of CeD that might define a preventive strategy for gluten-related disorders in general. Also see the video abstract here: https://youtu.be/oMaQasStcFI.Fil: Lauxmann, Martin Alexander. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Brandenburg Medical School; AlemaniaFil: Vazquez, Diego Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB; ArgentinaFil: Schilbert, Hanna M.. Universitat Bielefeld; AlemaniaFil: Neubauer, Pia R.. Universitat Bielefeld; AlemaniaFil: Lammers, Karen M.. Tubascan Ltd; Países BajosFil: Dodero, Veronica Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universitat Bielefeld; AlemaniaJohn Wiley & Sons Inc.2021-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/181141Lauxmann, Martin Alexander; Vazquez, Diego Sebastian; Schilbert, Hanna M.; Neubauer, Pia R.; Lammers, Karen M.; et al.; From celiac disease to coccidia infection and vice-versa: the polyQ peptide CXCR3-interaction axis; John Wiley & Sons Inc.; Bioessays; 43; 12; 10-2021; 1-150265-9247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/bies.202100101info:eu-repo/semantics/altIdentifier/doi/10.1002/bies.202100101info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:51Zoai:ri.conicet.gov.ar:11336/181141instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:51.545CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv From celiac disease to coccidia infection and vice-versa: the polyQ peptide CXCR3-interaction axis
title From celiac disease to coccidia infection and vice-versa: the polyQ peptide CXCR3-interaction axis
spellingShingle From celiac disease to coccidia infection and vice-versa: the polyQ peptide CXCR3-interaction axis
Lauxmann, Martin Alexander
CHEMOKINE RECEPTOR CXCR3
COCCIDIOSIS
EIMERIA
GLIADIN
GLUTEN-RELATED DISORDERS
POLYQ SEQUENCE
ZONULIN
title_short From celiac disease to coccidia infection and vice-versa: the polyQ peptide CXCR3-interaction axis
title_full From celiac disease to coccidia infection and vice-versa: the polyQ peptide CXCR3-interaction axis
title_fullStr From celiac disease to coccidia infection and vice-versa: the polyQ peptide CXCR3-interaction axis
title_full_unstemmed From celiac disease to coccidia infection and vice-versa: the polyQ peptide CXCR3-interaction axis
title_sort From celiac disease to coccidia infection and vice-versa: the polyQ peptide CXCR3-interaction axis
dc.creator.none.fl_str_mv Lauxmann, Martin Alexander
Vazquez, Diego Sebastian
Schilbert, Hanna M.
Neubauer, Pia R.
Lammers, Karen M.
Dodero, Veronica Isabel
author Lauxmann, Martin Alexander
author_facet Lauxmann, Martin Alexander
Vazquez, Diego Sebastian
Schilbert, Hanna M.
Neubauer, Pia R.
Lammers, Karen M.
Dodero, Veronica Isabel
author_role author
author2 Vazquez, Diego Sebastian
Schilbert, Hanna M.
Neubauer, Pia R.
Lammers, Karen M.
Dodero, Veronica Isabel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CHEMOKINE RECEPTOR CXCR3
COCCIDIOSIS
EIMERIA
GLIADIN
GLUTEN-RELATED DISORDERS
POLYQ SEQUENCE
ZONULIN
topic CHEMOKINE RECEPTOR CXCR3
COCCIDIOSIS
EIMERIA
GLIADIN
GLUTEN-RELATED DISORDERS
POLYQ SEQUENCE
ZONULIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Zonulin is a physiological modulator of intercellular tight junctions, which upregulation is involved in several diseases like celiac disease (CeD). The polyQ gliadin fragment binds to the CXCR3 chemokine receptor that activates zonulin upregulation, leading to increased intestinal permeability in humans. Here, we report a general hypothesis based on the structural connection between the polyQ sequence of the immunogenic CeD protein, gliadin, and enteric coccidian parasites proteins. Firstly, a novel interaction pathway between the parasites and the host is described based on the structural similarities between polyQ gliadin fragments and the parasite proteins. Secondly, a potential connection between coccidial infections as a novel environmental trigger of CeD is hypothesized. Therefore, this report represents a promising breakthrough for coccidian research and points out the potential role of coccidian parasites as a novel trigger of CeD that might define a preventive strategy for gluten-related disorders in general. Also see the video abstract here: https://youtu.be/oMaQasStcFI.
Fil: Lauxmann, Martin Alexander. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Brandenburg Medical School; Alemania
Fil: Vazquez, Diego Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB; Argentina
Fil: Schilbert, Hanna M.. Universitat Bielefeld; Alemania
Fil: Neubauer, Pia R.. Universitat Bielefeld; Alemania
Fil: Lammers, Karen M.. Tubascan Ltd; Países Bajos
Fil: Dodero, Veronica Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universitat Bielefeld; Alemania
description Zonulin is a physiological modulator of intercellular tight junctions, which upregulation is involved in several diseases like celiac disease (CeD). The polyQ gliadin fragment binds to the CXCR3 chemokine receptor that activates zonulin upregulation, leading to increased intestinal permeability in humans. Here, we report a general hypothesis based on the structural connection between the polyQ sequence of the immunogenic CeD protein, gliadin, and enteric coccidian parasites proteins. Firstly, a novel interaction pathway between the parasites and the host is described based on the structural similarities between polyQ gliadin fragments and the parasite proteins. Secondly, a potential connection between coccidial infections as a novel environmental trigger of CeD is hypothesized. Therefore, this report represents a promising breakthrough for coccidian research and points out the potential role of coccidian parasites as a novel trigger of CeD that might define a preventive strategy for gluten-related disorders in general. Also see the video abstract here: https://youtu.be/oMaQasStcFI.
publishDate 2021
dc.date.none.fl_str_mv 2021-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/181141
Lauxmann, Martin Alexander; Vazquez, Diego Sebastian; Schilbert, Hanna M.; Neubauer, Pia R.; Lammers, Karen M.; et al.; From celiac disease to coccidia infection and vice-versa: the polyQ peptide CXCR3-interaction axis; John Wiley & Sons Inc.; Bioessays; 43; 12; 10-2021; 1-15
0265-9247
CONICET Digital
CONICET
url http://hdl.handle.net/11336/181141
identifier_str_mv Lauxmann, Martin Alexander; Vazquez, Diego Sebastian; Schilbert, Hanna M.; Neubauer, Pia R.; Lammers, Karen M.; et al.; From celiac disease to coccidia infection and vice-versa: the polyQ peptide CXCR3-interaction axis; John Wiley & Sons Inc.; Bioessays; 43; 12; 10-2021; 1-15
0265-9247
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/bies.202100101
info:eu-repo/semantics/altIdentifier/doi/10.1002/bies.202100101
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Inc.
publisher.none.fl_str_mv John Wiley & Sons Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269824447676416
score 13.13397

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