Beta-lactam antibiotics and viridans group streptococci

Autores
Lopardo, Horacio Angel; Vigliarolo, Laura; Bonofiglio, Laura; Gagetti, Paula Silvana; García Gabarrot, Gabriela; Kaufman, Sara; Mollerach, Marta Eugenia; Toresani, Inés; Von Specht, Martha Helena
Año de publicación
2022
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this review is to present an update on the susceptibility of viridans group streptococci (VGS) to β-lactam antimicrobials, with emphasis on the Argentinean scenario. VGS are a heterogeneous group including five groups of species, each one exhibiting peculiar susceptibility patterns to penicillin (PEN). Species of the Streptococcus mitis group are frequently nonsusceptible to PEN. PEN resistance is associated with changes in PEN-binding proteins. In Argentina, one to two thirds of VGS are nonsusceptible to PEN. Third generation cephalosporins and carbapenems are currently more effective in vitro than PEN against VGS. Mortality was associated to nonsusceptibility to PEN in at least two studies involving patients with bacteremia caused by VGS. Treatment of endocarditis due to VGS should be adjusted/to the PEN susceptibility of the isolates. Vancomycin may be an alternative choice for treating endocarditis caused by PEN-resistant isolates (MIC ≥ 4 μg/ml).
Fil: Lopardo, Horacio Angel. Universidad Nacional de La Plata. Fundación Ciencias Exactas; Argentina
Fil: Vigliarolo, Laura. Universidad Nacional de La Plata. Fundación Ciencias Exactas; Argentina
Fil: Bonofiglio, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Gagetti, Paula Silvana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: García Gabarrot, Gabriela. Universidad de la Republica; Uruguay
Fil: Kaufman, Sara. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Mollerach, Marta Eugenia. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Toresani, Inés. Universidad Nacional de Rosario; Argentina
Fil: Von Specht, Martha Helena. Universidad Nacional de Misiones; Argentina
Materia
ENDOCARDITIS
PENICILLIN-BINDING PROTEINS
RESISTANCE
VIRIDANS GROUP STREPTOCOCCI
Β-LACTAMS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/218221
Acceder
id CONICETDig_be62e4ceafd19eefe8cd6b026dc8cfbf
oai_identifier_str oai:ri.conicet.gov.ar:11336/218221
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Beta-lactam antibiotics and viridans group streptococciAntibióticos beta-lactámicos y estreptococos grupo viridansLopardo, Horacio AngelVigliarolo, LauraBonofiglio, LauraGagetti, Paula SilvanaGarcía Gabarrot, GabrielaKaufman, SaraMollerach, Marta EugeniaToresani, InésVon Specht, Martha HelenaENDOCARDITISPENICILLIN-BINDING PROTEINSRESISTANCEVIRIDANS GROUP STREPTOCOCCIΒ-LACTAMShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The aim of this review is to present an update on the susceptibility of viridans group streptococci (VGS) to β-lactam antimicrobials, with emphasis on the Argentinean scenario. VGS are a heterogeneous group including five groups of species, each one exhibiting peculiar susceptibility patterns to penicillin (PEN). Species of the Streptococcus mitis group are frequently nonsusceptible to PEN. PEN resistance is associated with changes in PEN-binding proteins. In Argentina, one to two thirds of VGS are nonsusceptible to PEN. Third generation cephalosporins and carbapenems are currently more effective in vitro than PEN against VGS. Mortality was associated to nonsusceptibility to PEN in at least two studies involving patients with bacteremia caused by VGS. Treatment of endocarditis due to VGS should be adjusted/to the PEN susceptibility of the isolates. Vancomycin may be an alternative choice for treating endocarditis caused by PEN-resistant isolates (MIC ≥ 4 μg/ml).Fil: Lopardo, Horacio Angel. Universidad Nacional de La Plata. Fundación Ciencias Exactas; ArgentinaFil: Vigliarolo, Laura. Universidad Nacional de La Plata. Fundación Ciencias Exactas; ArgentinaFil: Bonofiglio, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Gagetti, Paula Silvana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; ArgentinaFil: García Gabarrot, Gabriela. Universidad de la Republica; UruguayFil: Kaufman, Sara. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: Mollerach, Marta Eugenia. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Toresani, Inés. Universidad Nacional de Rosario; ArgentinaFil: Von Specht, Martha Helena. Universidad Nacional de Misiones; ArgentinaAsociación Argentina de Microbiología2022-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/218221Lopardo, Horacio Angel; Vigliarolo, Laura; Bonofiglio, Laura; Gagetti, Paula Silvana; García Gabarrot, Gabriela; et al.; Beta-lactam antibiotics and viridans group streptococci ; Asociación Argentina de Microbiología; Revista Argentina de Microbiología; 54; 4; 10-2022; 335-3430325-75411851-7617CONICET DigitalCONICETspainfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ram.2022.06.004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:57:35Zoai:ri.conicet.gov.ar:11336/218221instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:57:35.837CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Beta-lactam antibiotics and viridans group streptococci
Antibióticos beta-lactámicos y estreptococos grupo viridans
title Beta-lactam antibiotics and viridans group streptococci
spellingShingle Beta-lactam antibiotics and viridans group streptococci
Lopardo, Horacio Angel
ENDOCARDITIS
PENICILLIN-BINDING PROTEINS
RESISTANCE
VIRIDANS GROUP STREPTOCOCCI
Β-LACTAMS
title_short Beta-lactam antibiotics and viridans group streptococci
title_full Beta-lactam antibiotics and viridans group streptococci
title_fullStr Beta-lactam antibiotics and viridans group streptococci
title_full_unstemmed Beta-lactam antibiotics and viridans group streptococci
title_sort Beta-lactam antibiotics and viridans group streptococci
dc.creator.none.fl_str_mv Lopardo, Horacio Angel
Vigliarolo, Laura
Bonofiglio, Laura
Gagetti, Paula Silvana
García Gabarrot, Gabriela
Kaufman, Sara
Mollerach, Marta Eugenia
Toresani, Inés
Von Specht, Martha Helena
author Lopardo, Horacio Angel
author_facet Lopardo, Horacio Angel
Vigliarolo, Laura
Bonofiglio, Laura
Gagetti, Paula Silvana
García Gabarrot, Gabriela
Kaufman, Sara
Mollerach, Marta Eugenia
Toresani, Inés
Von Specht, Martha Helena
author_role author
author2 Vigliarolo, Laura
Bonofiglio, Laura
Gagetti, Paula Silvana
García Gabarrot, Gabriela
Kaufman, Sara
Mollerach, Marta Eugenia
Toresani, Inés
Von Specht, Martha Helena
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ENDOCARDITIS
PENICILLIN-BINDING PROTEINS
RESISTANCE
VIRIDANS GROUP STREPTOCOCCI
Β-LACTAMS
topic ENDOCARDITIS
PENICILLIN-BINDING PROTEINS
RESISTANCE
VIRIDANS GROUP STREPTOCOCCI
Β-LACTAMS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim of this review is to present an update on the susceptibility of viridans group streptococci (VGS) to β-lactam antimicrobials, with emphasis on the Argentinean scenario. VGS are a heterogeneous group including five groups of species, each one exhibiting peculiar susceptibility patterns to penicillin (PEN). Species of the Streptococcus mitis group are frequently nonsusceptible to PEN. PEN resistance is associated with changes in PEN-binding proteins. In Argentina, one to two thirds of VGS are nonsusceptible to PEN. Third generation cephalosporins and carbapenems are currently more effective in vitro than PEN against VGS. Mortality was associated to nonsusceptibility to PEN in at least two studies involving patients with bacteremia caused by VGS. Treatment of endocarditis due to VGS should be adjusted/to the PEN susceptibility of the isolates. Vancomycin may be an alternative choice for treating endocarditis caused by PEN-resistant isolates (MIC ≥ 4 μg/ml).
Fil: Lopardo, Horacio Angel. Universidad Nacional de La Plata. Fundación Ciencias Exactas; Argentina
Fil: Vigliarolo, Laura. Universidad Nacional de La Plata. Fundación Ciencias Exactas; Argentina
Fil: Bonofiglio, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
Fil: Gagetti, Paula Silvana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: García Gabarrot, Gabriela. Universidad de la Republica; Uruguay
Fil: Kaufman, Sara. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Mollerach, Marta Eugenia. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Toresani, Inés. Universidad Nacional de Rosario; Argentina
Fil: Von Specht, Martha Helena. Universidad Nacional de Misiones; Argentina
description The aim of this review is to present an update on the susceptibility of viridans group streptococci (VGS) to β-lactam antimicrobials, with emphasis on the Argentinean scenario. VGS are a heterogeneous group including five groups of species, each one exhibiting peculiar susceptibility patterns to penicillin (PEN). Species of the Streptococcus mitis group are frequently nonsusceptible to PEN. PEN resistance is associated with changes in PEN-binding proteins. In Argentina, one to two thirds of VGS are nonsusceptible to PEN. Third generation cephalosporins and carbapenems are currently more effective in vitro than PEN against VGS. Mortality was associated to nonsusceptibility to PEN in at least two studies involving patients with bacteremia caused by VGS. Treatment of endocarditis due to VGS should be adjusted/to the PEN susceptibility of the isolates. Vancomycin may be an alternative choice for treating endocarditis caused by PEN-resistant isolates (MIC ≥ 4 μg/ml).
publishDate 2022
dc.date.none.fl_str_mv 2022-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/218221
Lopardo, Horacio Angel; Vigliarolo, Laura; Bonofiglio, Laura; Gagetti, Paula Silvana; García Gabarrot, Gabriela; et al.; Beta-lactam antibiotics and viridans group streptococci ; Asociación Argentina de Microbiología; Revista Argentina de Microbiología; 54; 4; 10-2022; 335-343
0325-7541
1851-7617
CONICET Digital
CONICET
url http://hdl.handle.net/11336/218221
identifier_str_mv Lopardo, Horacio Angel; Vigliarolo, Laura; Bonofiglio, Laura; Gagetti, Paula Silvana; García Gabarrot, Gabriela; et al.; Beta-lactam antibiotics and viridans group streptococci ; Asociación Argentina de Microbiología; Revista Argentina de Microbiología; 54; 4; 10-2022; 335-343
0325-7541
1851-7617
CONICET Digital
CONICET
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ram.2022.06.004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Asociación Argentina de Microbiología
publisher.none.fl_str_mv Asociación Argentina de Microbiología
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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