Resistance to β-lactams in Streptococcus pneumoniae

Autores
Von Specht, Martha Helena; García Gabarrot, Gabriela; Mollerach, Marta Eugenia; Bonofiglio, Laura; Gagetti, Paula Silvana; Kaufman, Sara; Vigliarolo, Laura; Toresani, Silvia María Ines; Lopardo, Horacio Angel
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Streptococcus pneumoniae is an important causal agent of pneumonia, meningitis, sepsis, bacteremia, and otitis media. Penicillin resistance rates in S. pneumoniae have remained stable in Argentina in the last years. In the late ?90s more isolates with MIC of penicillin ≥2 μg/ml were observed; however, their frequency has decreased in recent years. The phenotypic expression of penicillin resistance is due to a modification in penicillin-binding proteins associated with a mosaic structure in the coding genes. The expansion of successful resistant clones varies among the different regions and is influenced by the use of antibiotics, vaccines, particularly conjugated ones, as well as population density. Parenteral treatment with high doses of penicillin G continues to be effective for the treatment of pneumonia and bacteremia, oral aminopenicillins for otitis media and sinusitis and third generation cephalosporins for meningitis.
Fil: Von Specht, Martha Helena. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Departamento de Microbiología; Argentina
Fil: García Gabarrot, Gabriela. Universidad de la República; Uruguay
Fil: Mollerach, Marta Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina
Fil: Bonofiglio, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina
Fil: Gagetti, Paula Silvana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina
Fil: Kaufman, Sara. No especifíca;
Fil: Vigliarolo, Laura. No especifíca;
Fil: Toresani, Silvia María Ines. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina
Fil: Lopardo, Horacio Angel. Universidad Nacional de La Plata; Argentina
Materia
Streptococcus pneumoniae
BETA LACTAMS
RESISTANCE
PENICILLIN-BINDING-PROTEINS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/157597
Acceder
id CONICETDig_86e7a06e9c4348e4d4e54c0a40957570
oai_identifier_str oai:ri.conicet.gov.ar:11336/157597
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Resistance to β-lactams in Streptococcus pneumoniaeVon Specht, Martha HelenaGarcía Gabarrot, GabrielaMollerach, Marta EugeniaBonofiglio, LauraGagetti, Paula SilvanaKaufman, SaraVigliarolo, LauraToresani, Silvia María InesLopardo, Horacio AngelStreptococcus pneumoniaeBETA LACTAMSRESISTANCEPENICILLIN-BINDING-PROTEINShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Streptococcus pneumoniae is an important causal agent of pneumonia, meningitis, sepsis, bacteremia, and otitis media. Penicillin resistance rates in S. pneumoniae have remained stable in Argentina in the last years. In the late ?90s more isolates with MIC of penicillin ≥2 μg/ml were observed; however, their frequency has decreased in recent years. The phenotypic expression of penicillin resistance is due to a modification in penicillin-binding proteins associated with a mosaic structure in the coding genes. The expansion of successful resistant clones varies among the different regions and is influenced by the use of antibiotics, vaccines, particularly conjugated ones, as well as population density. Parenteral treatment with high doses of penicillin G continues to be effective for the treatment of pneumonia and bacteremia, oral aminopenicillins for otitis media and sinusitis and third generation cephalosporins for meningitis.Fil: Von Specht, Martha Helena. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Departamento de Microbiología; ArgentinaFil: García Gabarrot, Gabriela. Universidad de la República; UruguayFil: Mollerach, Marta Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; ArgentinaFil: Bonofiglio, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; ArgentinaFil: Gagetti, Paula Silvana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; ArgentinaFil: Kaufman, Sara. No especifíca;Fil: Vigliarolo, Laura. No especifíca;Fil: Toresani, Silvia María Ines. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; ArgentinaFil: Lopardo, Horacio Angel. Universidad Nacional de La Plata; ArgentinaAsociación Argentina de Microbiología2021-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/157597Von Specht, Martha Helena; García Gabarrot, Gabriela; Mollerach, Marta Eugenia; Bonofiglio, Laura; Gagetti, Paula Silvana; et al.; Resistance to β-lactams in Streptococcus pneumoniae; Asociación Argentina de Microbiología; Revista Argentina de Microbiología; 53; 7-2021; 1-61851-76171851-7617CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ram.2021.02.007info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0325754121000419?via%3Dihubinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:47Zoai:ri.conicet.gov.ar:11336/157597instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:47.547CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Resistance to β-lactams in Streptococcus pneumoniae
title Resistance to β-lactams in Streptococcus pneumoniae
spellingShingle Resistance to β-lactams in Streptococcus pneumoniae
Von Specht, Martha Helena
Streptococcus pneumoniae
BETA LACTAMS
RESISTANCE
PENICILLIN-BINDING-PROTEINS
title_short Resistance to β-lactams in Streptococcus pneumoniae
title_full Resistance to β-lactams in Streptococcus pneumoniae
title_fullStr Resistance to β-lactams in Streptococcus pneumoniae
title_full_unstemmed Resistance to β-lactams in Streptococcus pneumoniae
title_sort Resistance to β-lactams in Streptococcus pneumoniae
dc.creator.none.fl_str_mv Von Specht, Martha Helena
García Gabarrot, Gabriela
Mollerach, Marta Eugenia
Bonofiglio, Laura
Gagetti, Paula Silvana
Kaufman, Sara
Vigliarolo, Laura
Toresani, Silvia María Ines
Lopardo, Horacio Angel
author Von Specht, Martha Helena
author_facet Von Specht, Martha Helena
García Gabarrot, Gabriela
Mollerach, Marta Eugenia
Bonofiglio, Laura
Gagetti, Paula Silvana
Kaufman, Sara
Vigliarolo, Laura
Toresani, Silvia María Ines
Lopardo, Horacio Angel
author_role author
author2 García Gabarrot, Gabriela
Mollerach, Marta Eugenia
Bonofiglio, Laura
Gagetti, Paula Silvana
Kaufman, Sara
Vigliarolo, Laura
Toresani, Silvia María Ines
Lopardo, Horacio Angel
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Streptococcus pneumoniae
BETA LACTAMS
RESISTANCE
PENICILLIN-BINDING-PROTEINS
topic Streptococcus pneumoniae
BETA LACTAMS
RESISTANCE
PENICILLIN-BINDING-PROTEINS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Streptococcus pneumoniae is an important causal agent of pneumonia, meningitis, sepsis, bacteremia, and otitis media. Penicillin resistance rates in S. pneumoniae have remained stable in Argentina in the last years. In the late ?90s more isolates with MIC of penicillin ≥2 μg/ml were observed; however, their frequency has decreased in recent years. The phenotypic expression of penicillin resistance is due to a modification in penicillin-binding proteins associated with a mosaic structure in the coding genes. The expansion of successful resistant clones varies among the different regions and is influenced by the use of antibiotics, vaccines, particularly conjugated ones, as well as population density. Parenteral treatment with high doses of penicillin G continues to be effective for the treatment of pneumonia and bacteremia, oral aminopenicillins for otitis media and sinusitis and third generation cephalosporins for meningitis.
Fil: Von Specht, Martha Helena. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales. Departamento de Microbiología; Argentina
Fil: García Gabarrot, Gabriela. Universidad de la República; Uruguay
Fil: Mollerach, Marta Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina
Fil: Bonofiglio, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina
Fil: Gagetti, Paula Silvana. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina
Fil: Kaufman, Sara. No especifíca;
Fil: Vigliarolo, Laura. No especifíca;
Fil: Toresani, Silvia María Ines. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Microbiología; Argentina
Fil: Lopardo, Horacio Angel. Universidad Nacional de La Plata; Argentina
description Streptococcus pneumoniae is an important causal agent of pneumonia, meningitis, sepsis, bacteremia, and otitis media. Penicillin resistance rates in S. pneumoniae have remained stable in Argentina in the last years. In the late ?90s more isolates with MIC of penicillin ≥2 μg/ml were observed; however, their frequency has decreased in recent years. The phenotypic expression of penicillin resistance is due to a modification in penicillin-binding proteins associated with a mosaic structure in the coding genes. The expansion of successful resistant clones varies among the different regions and is influenced by the use of antibiotics, vaccines, particularly conjugated ones, as well as population density. Parenteral treatment with high doses of penicillin G continues to be effective for the treatment of pneumonia and bacteremia, oral aminopenicillins for otitis media and sinusitis and third generation cephalosporins for meningitis.
publishDate 2021
dc.date.none.fl_str_mv 2021-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/157597
Von Specht, Martha Helena; García Gabarrot, Gabriela; Mollerach, Marta Eugenia; Bonofiglio, Laura; Gagetti, Paula Silvana; et al.; Resistance to β-lactams in Streptococcus pneumoniae; Asociación Argentina de Microbiología; Revista Argentina de Microbiología; 53; 7-2021; 1-6
1851-7617
1851-7617
CONICET Digital
CONICET
url http://hdl.handle.net/11336/157597
identifier_str_mv Von Specht, Martha Helena; García Gabarrot, Gabriela; Mollerach, Marta Eugenia; Bonofiglio, Laura; Gagetti, Paula Silvana; et al.; Resistance to β-lactams in Streptococcus pneumoniae; Asociación Argentina de Microbiología; Revista Argentina de Microbiología; 53; 7-2021; 1-6
1851-7617
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ram.2021.02.007
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0325754121000419?via%3Dihub
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Asociación Argentina de Microbiología
publisher.none.fl_str_mv Asociación Argentina de Microbiología
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269875599310848
score 13.13397

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