Genetic polymorphisms of IL17A associated with Chagas disease: Results from a meta-analysis in Latin American populations

Autores
Strauss, Mariana; Palma-Vega, Miriam; Casares Marfil, Desiré; Pau Bosch, Nicolau; Lo Presti, Maria Silvina; Molina, Israel; Gonzáles, Clara Isabel; Martin, Javier; Acosta Herrera, Marialbert
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Genetic factors and the immunologic response have been suggested to determine the susceptibility against the infection and the outcome of Chagas disease. In the present study, we analysed three IL17A genetic variants (rs4711998, rs8193036 and rs2275913) regarding the predisposition to Trypanosoma cruzi infection and the development of chronic Chagas cardiomyopathy (CCC) in different Latin American populations. A total of 2,967 individuals from Colombia, Argentina, Bolivia and Brazil, were included in this study. The individuals were classified as seronegative and seropositive for T. cruzi antigens, and this last group were divided into asymptomatic and CCC. For T. cruzi infection susceptibility, the IL17A rs2275913*A showed a significant association in a fixed-effect meta-analysis after a Bonferroni correction (P = 0.016, OR = 1.21, 95%CI = 1.06–1.41). No evidence of association was detected when comparing CCC vs. asymptomatic patients. However, when CCC were compared with seronegative individuals, it showed a nominal association in the meta-analysis (P = 0.040, OR = 1.20, 95%CI = 1.01–1.45). For the IL17A rs4711998 and rs8193036, no association was observed. In conclusion, our results suggest that IL17A rs2275913 plays an important role in the susceptibility to T. cruzi infection and could also be implicated in the development of chronic cardiomyopathy in the studied Latin American population.
Fil: Strauss, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Palma-Vega, Miriam. Instituto de Parasitología y Biomedicina López Neyra; España
Fil: Casares Marfil, Desiré. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; España
Fil: Pau Bosch, Nicolau. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; España
Fil: Lo Presti, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Molina, Israel. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; España
Fil: Gonzáles, Clara Isabel. Universidad Industrial de Santander; Colombia
Fil: Martin, Javier. Instituto de Parasitología y Biomedicina López Neyra; España
Fil: Acosta Herrera, Marialbert. Instituto de Parasitología y Biomedicina López Neyra; España
Materia
HOST GENETIC POLYMORPHISMS
IL17A
CHAGAS DISEASE
LATINAMERICAN POPULATIONS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/147571
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/147571
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Genetic polymorphisms of IL17A associated with Chagas disease: Results from a meta-analysis in Latin American populationsStrauss, MarianaPalma-Vega, MiriamCasares Marfil, DesiréPau Bosch, NicolauLo Presti, Maria SilvinaMolina, IsraelGonzáles, Clara IsabelMartin, JavierAcosta Herrera, MarialbertHOST GENETIC POLYMORPHISMSIL17ACHAGAS DISEASELATINAMERICAN POPULATIONShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Genetic factors and the immunologic response have been suggested to determine the susceptibility against the infection and the outcome of Chagas disease. In the present study, we analysed three IL17A genetic variants (rs4711998, rs8193036 and rs2275913) regarding the predisposition to Trypanosoma cruzi infection and the development of chronic Chagas cardiomyopathy (CCC) in different Latin American populations. A total of 2,967 individuals from Colombia, Argentina, Bolivia and Brazil, were included in this study. The individuals were classified as seronegative and seropositive for T. cruzi antigens, and this last group were divided into asymptomatic and CCC. For T. cruzi infection susceptibility, the IL17A rs2275913*A showed a significant association in a fixed-effect meta-analysis after a Bonferroni correction (P = 0.016, OR = 1.21, 95%CI = 1.06–1.41). No evidence of association was detected when comparing CCC vs. asymptomatic patients. However, when CCC were compared with seronegative individuals, it showed a nominal association in the meta-analysis (P = 0.040, OR = 1.20, 95%CI = 1.01–1.45). For the IL17A rs4711998 and rs8193036, no association was observed. In conclusion, our results suggest that IL17A rs2275913 plays an important role in the susceptibility to T. cruzi infection and could also be implicated in the development of chronic cardiomyopathy in the studied Latin American population.Fil: Strauss, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Palma-Vega, Miriam. Instituto de Parasitología y Biomedicina López Neyra; EspañaFil: Casares Marfil, Desiré. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; EspañaFil: Pau Bosch, Nicolau. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; EspañaFil: Lo Presti, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Molina, Israel. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; EspañaFil: Gonzáles, Clara Isabel. Universidad Industrial de Santander; ColombiaFil: Martin, Javier. Instituto de Parasitología y Biomedicina López Neyra; EspañaFil: Acosta Herrera, Marialbert. Instituto de Parasitología y Biomedicina López Neyra; EspañaNature Research2020-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/147571Strauss, Mariana; Palma-Vega, Miriam; Casares Marfil, Desiré; Pau Bosch, Nicolau; Lo Presti, Maria Silvina; et al.; Genetic polymorphisms of IL17A associated with Chagas disease: Results from a meta-analysis in Latin American populations; Nature Research; Scientific Reports; 10; 1; 12-2020; 1-82045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://rdcu.be/b27B1info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-020-61965-5info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:07:19Zoai:ri.conicet.gov.ar:11336/147571instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:07:19.905CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Genetic polymorphisms of IL17A associated with Chagas disease: Results from a meta-analysis in Latin American populations
title Genetic polymorphisms of IL17A associated with Chagas disease: Results from a meta-analysis in Latin American populations
spellingShingle Genetic polymorphisms of IL17A associated with Chagas disease: Results from a meta-analysis in Latin American populations
Strauss, Mariana
HOST GENETIC POLYMORPHISMS
IL17A
CHAGAS DISEASE
LATINAMERICAN POPULATIONS
title_short Genetic polymorphisms of IL17A associated with Chagas disease: Results from a meta-analysis in Latin American populations
title_full Genetic polymorphisms of IL17A associated with Chagas disease: Results from a meta-analysis in Latin American populations
title_fullStr Genetic polymorphisms of IL17A associated with Chagas disease: Results from a meta-analysis in Latin American populations
title_full_unstemmed Genetic polymorphisms of IL17A associated with Chagas disease: Results from a meta-analysis in Latin American populations
title_sort Genetic polymorphisms of IL17A associated with Chagas disease: Results from a meta-analysis in Latin American populations
dc.creator.none.fl_str_mv Strauss, Mariana
Palma-Vega, Miriam
Casares Marfil, Desiré
Pau Bosch, Nicolau
Lo Presti, Maria Silvina
Molina, Israel
Gonzáles, Clara Isabel
Martin, Javier
Acosta Herrera, Marialbert
author Strauss, Mariana
author_facet Strauss, Mariana
Palma-Vega, Miriam
Casares Marfil, Desiré
Pau Bosch, Nicolau
Lo Presti, Maria Silvina
Molina, Israel
Gonzáles, Clara Isabel
Martin, Javier
Acosta Herrera, Marialbert
author_role author
author2 Palma-Vega, Miriam
Casares Marfil, Desiré
Pau Bosch, Nicolau
Lo Presti, Maria Silvina
Molina, Israel
Gonzáles, Clara Isabel
Martin, Javier
Acosta Herrera, Marialbert
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HOST GENETIC POLYMORPHISMS
IL17A
CHAGAS DISEASE
LATINAMERICAN POPULATIONS
topic HOST GENETIC POLYMORPHISMS
IL17A
CHAGAS DISEASE
LATINAMERICAN POPULATIONS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Genetic factors and the immunologic response have been suggested to determine the susceptibility against the infection and the outcome of Chagas disease. In the present study, we analysed three IL17A genetic variants (rs4711998, rs8193036 and rs2275913) regarding the predisposition to Trypanosoma cruzi infection and the development of chronic Chagas cardiomyopathy (CCC) in different Latin American populations. A total of 2,967 individuals from Colombia, Argentina, Bolivia and Brazil, were included in this study. The individuals were classified as seronegative and seropositive for T. cruzi antigens, and this last group were divided into asymptomatic and CCC. For T. cruzi infection susceptibility, the IL17A rs2275913*A showed a significant association in a fixed-effect meta-analysis after a Bonferroni correction (P = 0.016, OR = 1.21, 95%CI = 1.06–1.41). No evidence of association was detected when comparing CCC vs. asymptomatic patients. However, when CCC were compared with seronegative individuals, it showed a nominal association in the meta-analysis (P = 0.040, OR = 1.20, 95%CI = 1.01–1.45). For the IL17A rs4711998 and rs8193036, no association was observed. In conclusion, our results suggest that IL17A rs2275913 plays an important role in the susceptibility to T. cruzi infection and could also be implicated in the development of chronic cardiomyopathy in the studied Latin American population.
Fil: Strauss, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Palma-Vega, Miriam. Instituto de Parasitología y Biomedicina López Neyra; España
Fil: Casares Marfil, Desiré. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; España
Fil: Pau Bosch, Nicolau. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; España
Fil: Lo Presti, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Molina, Israel. Universidad Autónoma de Barcelona. Hospital Vall D' Hebron; España
Fil: Gonzáles, Clara Isabel. Universidad Industrial de Santander; Colombia
Fil: Martin, Javier. Instituto de Parasitología y Biomedicina López Neyra; España
Fil: Acosta Herrera, Marialbert. Instituto de Parasitología y Biomedicina López Neyra; España
description Genetic factors and the immunologic response have been suggested to determine the susceptibility against the infection and the outcome of Chagas disease. In the present study, we analysed three IL17A genetic variants (rs4711998, rs8193036 and rs2275913) regarding the predisposition to Trypanosoma cruzi infection and the development of chronic Chagas cardiomyopathy (CCC) in different Latin American populations. A total of 2,967 individuals from Colombia, Argentina, Bolivia and Brazil, were included in this study. The individuals were classified as seronegative and seropositive for T. cruzi antigens, and this last group were divided into asymptomatic and CCC. For T. cruzi infection susceptibility, the IL17A rs2275913*A showed a significant association in a fixed-effect meta-analysis after a Bonferroni correction (P = 0.016, OR = 1.21, 95%CI = 1.06–1.41). No evidence of association was detected when comparing CCC vs. asymptomatic patients. However, when CCC were compared with seronegative individuals, it showed a nominal association in the meta-analysis (P = 0.040, OR = 1.20, 95%CI = 1.01–1.45). For the IL17A rs4711998 and rs8193036, no association was observed. In conclusion, our results suggest that IL17A rs2275913 plays an important role in the susceptibility to T. cruzi infection and could also be implicated in the development of chronic cardiomyopathy in the studied Latin American population.
publishDate 2020
dc.date.none.fl_str_mv 2020-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/147571
Strauss, Mariana; Palma-Vega, Miriam; Casares Marfil, Desiré; Pau Bosch, Nicolau; Lo Presti, Maria Silvina; et al.; Genetic polymorphisms of IL17A associated with Chagas disease: Results from a meta-analysis in Latin American populations; Nature Research; Scientific Reports; 10; 1; 12-2020; 1-8
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/147571
identifier_str_mv Strauss, Mariana; Palma-Vega, Miriam; Casares Marfil, Desiré; Pau Bosch, Nicolau; Lo Presti, Maria Silvina; et al.; Genetic polymorphisms of IL17A associated with Chagas disease: Results from a meta-analysis in Latin American populations; Nature Research; Scientific Reports; 10; 1; 12-2020; 1-8
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-020-61965-5
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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