Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations
- Autores
- Strauss, Mariana; Acosta Herrera, Marialbert; Alcaraz, Alexia; Casares Marfil, Desiré; Bosch Nicolau, Pau; Lo Presti, Maria Silvina; Molina, Israel; González, Clara Isabel; Martín, Javier; Chagas Genetics CYTED Network
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Host genetic factors have been suggested to play an important role in the susceptibility to Chagas disease. Given the influence of interleukin 18 (IL-18) in the development of the disease, in the present study, we analyzed three IL18 genetic variants (rs2043055, rs1946518, rs360719) regarding the predisposition to Trypanosoma cruzi infection and the development of chronic Chagas cardiomyopathy (CCC), in different Latin America populations. Genetic data of 3,608 patients from Colombia, Bolivia, Argentina, and Brazil were meta-analyzed to validate previous findings with increased statistical power. Seropositive and seronegative individuals were compared for T. cruzi infection susceptibility. In the Colombian cohort, the allelic frequencies of the three variants showed a significant association, with adjustment for sex and age, and also after applying multiple testing adjustments. Among the Colombian and Argentinean cohorts, rs360719 showed a significant genetic effect in a fixed-effects meta-analysis after a Bonferroni correction (OR: 0.76, CI: 0.66-0.89, P = 0.001). For CCC, the rs2043055 showed an association with protection from cardiomyopathy in the Colombian cohort (OR: 0.79, CI: 0.64-0.99, P = 0.037), with adjustment for sex and age, and after applying multiple testing adjustments. The meta-analysis of the CCC vs. asymptomatic patients from the four cohorts showed no evidence of association. In conclusion, our results validated the association found previously in the Colombian cohort suggesting that IL18 rs360719 plays an important role in the susceptibility to T. cruzi infection and no evidence of association was found between the IL18 genetic variants and CCC in the Latin American population studied.
Fil: Strauss, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Acosta Herrera, Marialbert. Consejo Superior de Investigaciones Científicas; España
Fil: Alcaraz, Alexia. Consejo Superior de Investigaciones Científicas; España
Fil: Casares Marfil, Desiré. Consejo Superior de Investigaciones Científicas; España
Fil: Bosch Nicolau, Pau. Internacional Hospital Universitari Vall d’Hebron; España
Fil: Lo Presti, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Molina, Israel. Internacional Hospital Universitari Vall d’Hebron; España
Fil: González, Clara Isabel. Universidad Industrial Santander; Colombia
Fil: Martín, Javier. Consejo Superior de Investigaciones Científicas; España
Fil: Chagas Genetics CYTED Network. No especifíca; - Materia
-
CHAGAS DISEASE
IL18
TRYPANOSOMA CRUZI INFECTION
CARDIOMYOPATHY
META-ANALYSIS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/125654
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oai:ri.conicet.gov.ar:11336/125654 |
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Association of IL18 genetic polymorphisms with Chagas disease in Latin American populationsStrauss, MarianaAcosta Herrera, MarialbertAlcaraz, AlexiaCasares Marfil, DesiréBosch Nicolau, PauLo Presti, Maria SilvinaMolina, IsraelGonzález, Clara IsabelMartín, JavierChagas Genetics CYTED NetworkCHAGAS DISEASEIL18TRYPANOSOMA CRUZI INFECTIONCARDIOMYOPATHYMETA-ANALYSIShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Host genetic factors have been suggested to play an important role in the susceptibility to Chagas disease. Given the influence of interleukin 18 (IL-18) in the development of the disease, in the present study, we analyzed three IL18 genetic variants (rs2043055, rs1946518, rs360719) regarding the predisposition to Trypanosoma cruzi infection and the development of chronic Chagas cardiomyopathy (CCC), in different Latin America populations. Genetic data of 3,608 patients from Colombia, Bolivia, Argentina, and Brazil were meta-analyzed to validate previous findings with increased statistical power. Seropositive and seronegative individuals were compared for T. cruzi infection susceptibility. In the Colombian cohort, the allelic frequencies of the three variants showed a significant association, with adjustment for sex and age, and also after applying multiple testing adjustments. Among the Colombian and Argentinean cohorts, rs360719 showed a significant genetic effect in a fixed-effects meta-analysis after a Bonferroni correction (OR: 0.76, CI: 0.66-0.89, P = 0.001). For CCC, the rs2043055 showed an association with protection from cardiomyopathy in the Colombian cohort (OR: 0.79, CI: 0.64-0.99, P = 0.037), with adjustment for sex and age, and after applying multiple testing adjustments. The meta-analysis of the CCC vs. asymptomatic patients from the four cohorts showed no evidence of association. In conclusion, our results validated the association found previously in the Colombian cohort suggesting that IL18 rs360719 plays an important role in the susceptibility to T. cruzi infection and no evidence of association was found between the IL18 genetic variants and CCC in the Latin American population studied.Fil: Strauss, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Acosta Herrera, Marialbert. Consejo Superior de Investigaciones Científicas; EspañaFil: Alcaraz, Alexia. Consejo Superior de Investigaciones Científicas; EspañaFil: Casares Marfil, Desiré. Consejo Superior de Investigaciones Científicas; EspañaFil: Bosch Nicolau, Pau. Internacional Hospital Universitari Vall d’Hebron; EspañaFil: Lo Presti, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Molina, Israel. Internacional Hospital Universitari Vall d’Hebron; EspañaFil: González, Clara Isabel. Universidad Industrial Santander; ColombiaFil: Martín, Javier. Consejo Superior de Investigaciones Científicas; EspañaFil: Chagas Genetics CYTED Network. No especifíca;Public Library of Science2019-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/125654Strauss, Mariana; Acosta Herrera, Marialbert; Alcaraz, Alexia; Casares Marfil, Desiré; Bosch Nicolau, Pau; et al.; Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations; Public Library of Science; Neglected Tropical Diseases; 13; 11; 10-2019; 1-131935-2735CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0007859info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0007859info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:39:08Zoai:ri.conicet.gov.ar:11336/125654instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:39:09.101CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations |
title |
Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations |
spellingShingle |
Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations Strauss, Mariana CHAGAS DISEASE IL18 TRYPANOSOMA CRUZI INFECTION CARDIOMYOPATHY META-ANALYSIS |
title_short |
Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations |
title_full |
Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations |
title_fullStr |
Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations |
title_full_unstemmed |
Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations |
title_sort |
Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations |
dc.creator.none.fl_str_mv |
Strauss, Mariana Acosta Herrera, Marialbert Alcaraz, Alexia Casares Marfil, Desiré Bosch Nicolau, Pau Lo Presti, Maria Silvina Molina, Israel González, Clara Isabel Martín, Javier Chagas Genetics CYTED Network |
author |
Strauss, Mariana |
author_facet |
Strauss, Mariana Acosta Herrera, Marialbert Alcaraz, Alexia Casares Marfil, Desiré Bosch Nicolau, Pau Lo Presti, Maria Silvina Molina, Israel González, Clara Isabel Martín, Javier Chagas Genetics CYTED Network |
author_role |
author |
author2 |
Acosta Herrera, Marialbert Alcaraz, Alexia Casares Marfil, Desiré Bosch Nicolau, Pau Lo Presti, Maria Silvina Molina, Israel González, Clara Isabel Martín, Javier Chagas Genetics CYTED Network |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
CHAGAS DISEASE IL18 TRYPANOSOMA CRUZI INFECTION CARDIOMYOPATHY META-ANALYSIS |
topic |
CHAGAS DISEASE IL18 TRYPANOSOMA CRUZI INFECTION CARDIOMYOPATHY META-ANALYSIS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Host genetic factors have been suggested to play an important role in the susceptibility to Chagas disease. Given the influence of interleukin 18 (IL-18) in the development of the disease, in the present study, we analyzed three IL18 genetic variants (rs2043055, rs1946518, rs360719) regarding the predisposition to Trypanosoma cruzi infection and the development of chronic Chagas cardiomyopathy (CCC), in different Latin America populations. Genetic data of 3,608 patients from Colombia, Bolivia, Argentina, and Brazil were meta-analyzed to validate previous findings with increased statistical power. Seropositive and seronegative individuals were compared for T. cruzi infection susceptibility. In the Colombian cohort, the allelic frequencies of the three variants showed a significant association, with adjustment for sex and age, and also after applying multiple testing adjustments. Among the Colombian and Argentinean cohorts, rs360719 showed a significant genetic effect in a fixed-effects meta-analysis after a Bonferroni correction (OR: 0.76, CI: 0.66-0.89, P = 0.001). For CCC, the rs2043055 showed an association with protection from cardiomyopathy in the Colombian cohort (OR: 0.79, CI: 0.64-0.99, P = 0.037), with adjustment for sex and age, and after applying multiple testing adjustments. The meta-analysis of the CCC vs. asymptomatic patients from the four cohorts showed no evidence of association. In conclusion, our results validated the association found previously in the Colombian cohort suggesting that IL18 rs360719 plays an important role in the susceptibility to T. cruzi infection and no evidence of association was found between the IL18 genetic variants and CCC in the Latin American population studied. Fil: Strauss, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina Fil: Acosta Herrera, Marialbert. Consejo Superior de Investigaciones Científicas; España Fil: Alcaraz, Alexia. Consejo Superior de Investigaciones Científicas; España Fil: Casares Marfil, Desiré. Consejo Superior de Investigaciones Científicas; España Fil: Bosch Nicolau, Pau. Internacional Hospital Universitari Vall d’Hebron; España Fil: Lo Presti, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina Fil: Molina, Israel. Internacional Hospital Universitari Vall d’Hebron; España Fil: González, Clara Isabel. Universidad Industrial Santander; Colombia Fil: Martín, Javier. Consejo Superior de Investigaciones Científicas; España Fil: Chagas Genetics CYTED Network. No especifíca; |
description |
Host genetic factors have been suggested to play an important role in the susceptibility to Chagas disease. Given the influence of interleukin 18 (IL-18) in the development of the disease, in the present study, we analyzed three IL18 genetic variants (rs2043055, rs1946518, rs360719) regarding the predisposition to Trypanosoma cruzi infection and the development of chronic Chagas cardiomyopathy (CCC), in different Latin America populations. Genetic data of 3,608 patients from Colombia, Bolivia, Argentina, and Brazil were meta-analyzed to validate previous findings with increased statistical power. Seropositive and seronegative individuals were compared for T. cruzi infection susceptibility. In the Colombian cohort, the allelic frequencies of the three variants showed a significant association, with adjustment for sex and age, and also after applying multiple testing adjustments. Among the Colombian and Argentinean cohorts, rs360719 showed a significant genetic effect in a fixed-effects meta-analysis after a Bonferroni correction (OR: 0.76, CI: 0.66-0.89, P = 0.001). For CCC, the rs2043055 showed an association with protection from cardiomyopathy in the Colombian cohort (OR: 0.79, CI: 0.64-0.99, P = 0.037), with adjustment for sex and age, and after applying multiple testing adjustments. The meta-analysis of the CCC vs. asymptomatic patients from the four cohorts showed no evidence of association. In conclusion, our results validated the association found previously in the Colombian cohort suggesting that IL18 rs360719 plays an important role in the susceptibility to T. cruzi infection and no evidence of association was found between the IL18 genetic variants and CCC in the Latin American population studied. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/125654 Strauss, Mariana; Acosta Herrera, Marialbert; Alcaraz, Alexia; Casares Marfil, Desiré; Bosch Nicolau, Pau; et al.; Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations; Public Library of Science; Neglected Tropical Diseases; 13; 11; 10-2019; 1-13 1935-2735 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/125654 |
identifier_str_mv |
Strauss, Mariana; Acosta Herrera, Marialbert; Alcaraz, Alexia; Casares Marfil, Desiré; Bosch Nicolau, Pau; et al.; Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations; Public Library of Science; Neglected Tropical Diseases; 13; 11; 10-2019; 1-13 1935-2735 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0007859 info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0007859 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Public Library of Science |
publisher.none.fl_str_mv |
Public Library of Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613238103212032 |
score |
13.070432 |