Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations

Autores
Strauss, Mariana; Acosta Herrera, Marialbert; Alcaraz, Alexia; Casares Marfil, Desiré; Bosch Nicolau, Pau; Lo Presti, Maria Silvina; Molina, Israel; González, Clara Isabel; Martín, Javier; Chagas Genetics CYTED Network
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Host genetic factors have been suggested to play an important role in the susceptibility to Chagas disease. Given the influence of interleukin 18 (IL-18) in the development of the disease, in the present study, we analyzed three IL18 genetic variants (rs2043055, rs1946518, rs360719) regarding the predisposition to Trypanosoma cruzi infection and the development of chronic Chagas cardiomyopathy (CCC), in different Latin America populations. Genetic data of 3,608 patients from Colombia, Bolivia, Argentina, and Brazil were meta-analyzed to validate previous findings with increased statistical power. Seropositive and seronegative individuals were compared for T. cruzi infection susceptibility. In the Colombian cohort, the allelic frequencies of the three variants showed a significant association, with adjustment for sex and age, and also after applying multiple testing adjustments. Among the Colombian and Argentinean cohorts, rs360719 showed a significant genetic effect in a fixed-effects meta-analysis after a Bonferroni correction (OR: 0.76, CI: 0.66-0.89, P = 0.001). For CCC, the rs2043055 showed an association with protection from cardiomyopathy in the Colombian cohort (OR: 0.79, CI: 0.64-0.99, P = 0.037), with adjustment for sex and age, and after applying multiple testing adjustments. The meta-analysis of the CCC vs. asymptomatic patients from the four cohorts showed no evidence of association. In conclusion, our results validated the association found previously in the Colombian cohort suggesting that IL18 rs360719 plays an important role in the susceptibility to T. cruzi infection and no evidence of association was found between the IL18 genetic variants and CCC in the Latin American population studied.
Fil: Strauss, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Acosta Herrera, Marialbert. Consejo Superior de Investigaciones Científicas; España
Fil: Alcaraz, Alexia. Consejo Superior de Investigaciones Científicas; España
Fil: Casares Marfil, Desiré. Consejo Superior de Investigaciones Científicas; España
Fil: Bosch Nicolau, Pau. Internacional Hospital Universitari Vall d’Hebron; España
Fil: Lo Presti, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Molina, Israel. Internacional Hospital Universitari Vall d’Hebron; España
Fil: González, Clara Isabel. Universidad Industrial Santander; Colombia
Fil: Martín, Javier. Consejo Superior de Investigaciones Científicas; España
Fil: Chagas Genetics CYTED Network. No especifíca;
Materia
CHAGAS DISEASE
IL18
TRYPANOSOMA CRUZI INFECTION
CARDIOMYOPATHY
META-ANALYSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/125654
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/125654
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Association of IL18 genetic polymorphisms with Chagas disease in Latin American populationsStrauss, MarianaAcosta Herrera, MarialbertAlcaraz, AlexiaCasares Marfil, DesiréBosch Nicolau, PauLo Presti, Maria SilvinaMolina, IsraelGonzález, Clara IsabelMartín, JavierChagas Genetics CYTED NetworkCHAGAS DISEASEIL18TRYPANOSOMA CRUZI INFECTIONCARDIOMYOPATHYMETA-ANALYSIShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Host genetic factors have been suggested to play an important role in the susceptibility to Chagas disease. Given the influence of interleukin 18 (IL-18) in the development of the disease, in the present study, we analyzed three IL18 genetic variants (rs2043055, rs1946518, rs360719) regarding the predisposition to Trypanosoma cruzi infection and the development of chronic Chagas cardiomyopathy (CCC), in different Latin America populations. Genetic data of 3,608 patients from Colombia, Bolivia, Argentina, and Brazil were meta-analyzed to validate previous findings with increased statistical power. Seropositive and seronegative individuals were compared for T. cruzi infection susceptibility. In the Colombian cohort, the allelic frequencies of the three variants showed a significant association, with adjustment for sex and age, and also after applying multiple testing adjustments. Among the Colombian and Argentinean cohorts, rs360719 showed a significant genetic effect in a fixed-effects meta-analysis after a Bonferroni correction (OR: 0.76, CI: 0.66-0.89, P = 0.001). For CCC, the rs2043055 showed an association with protection from cardiomyopathy in the Colombian cohort (OR: 0.79, CI: 0.64-0.99, P = 0.037), with adjustment for sex and age, and after applying multiple testing adjustments. The meta-analysis of the CCC vs. asymptomatic patients from the four cohorts showed no evidence of association. In conclusion, our results validated the association found previously in the Colombian cohort suggesting that IL18 rs360719 plays an important role in the susceptibility to T. cruzi infection and no evidence of association was found between the IL18 genetic variants and CCC in the Latin American population studied.Fil: Strauss, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Acosta Herrera, Marialbert. Consejo Superior de Investigaciones Científicas; EspañaFil: Alcaraz, Alexia. Consejo Superior de Investigaciones Científicas; EspañaFil: Casares Marfil, Desiré. Consejo Superior de Investigaciones Científicas; EspañaFil: Bosch Nicolau, Pau. Internacional Hospital Universitari Vall d’Hebron; EspañaFil: Lo Presti, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Molina, Israel. Internacional Hospital Universitari Vall d’Hebron; EspañaFil: González, Clara Isabel. Universidad Industrial Santander; ColombiaFil: Martín, Javier. Consejo Superior de Investigaciones Científicas; EspañaFil: Chagas Genetics CYTED Network. No especifíca;Public Library of Science2019-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/125654Strauss, Mariana; Acosta Herrera, Marialbert; Alcaraz, Alexia; Casares Marfil, Desiré; Bosch Nicolau, Pau; et al.; Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations; Public Library of Science; Neglected Tropical Diseases; 13; 11; 10-2019; 1-131935-2735CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0007859info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0007859info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:28:28Zoai:ri.conicet.gov.ar:11336/125654instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:28:28.544CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations
title Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations
spellingShingle Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations
Strauss, Mariana
CHAGAS DISEASE
IL18
TRYPANOSOMA CRUZI INFECTION
CARDIOMYOPATHY
META-ANALYSIS
title_short Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations
title_full Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations
title_fullStr Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations
title_full_unstemmed Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations
title_sort Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations
dc.creator.none.fl_str_mv Strauss, Mariana
Acosta Herrera, Marialbert
Alcaraz, Alexia
Casares Marfil, Desiré
Bosch Nicolau, Pau
Lo Presti, Maria Silvina
Molina, Israel
González, Clara Isabel
Martín, Javier
Chagas Genetics CYTED Network
author Strauss, Mariana
author_facet Strauss, Mariana
Acosta Herrera, Marialbert
Alcaraz, Alexia
Casares Marfil, Desiré
Bosch Nicolau, Pau
Lo Presti, Maria Silvina
Molina, Israel
González, Clara Isabel
Martín, Javier
Chagas Genetics CYTED Network
author_role author
author2 Acosta Herrera, Marialbert
Alcaraz, Alexia
Casares Marfil, Desiré
Bosch Nicolau, Pau
Lo Presti, Maria Silvina
Molina, Israel
González, Clara Isabel
Martín, Javier
Chagas Genetics CYTED Network
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CHAGAS DISEASE
IL18
TRYPANOSOMA CRUZI INFECTION
CARDIOMYOPATHY
META-ANALYSIS
topic CHAGAS DISEASE
IL18
TRYPANOSOMA CRUZI INFECTION
CARDIOMYOPATHY
META-ANALYSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Host genetic factors have been suggested to play an important role in the susceptibility to Chagas disease. Given the influence of interleukin 18 (IL-18) in the development of the disease, in the present study, we analyzed three IL18 genetic variants (rs2043055, rs1946518, rs360719) regarding the predisposition to Trypanosoma cruzi infection and the development of chronic Chagas cardiomyopathy (CCC), in different Latin America populations. Genetic data of 3,608 patients from Colombia, Bolivia, Argentina, and Brazil were meta-analyzed to validate previous findings with increased statistical power. Seropositive and seronegative individuals were compared for T. cruzi infection susceptibility. In the Colombian cohort, the allelic frequencies of the three variants showed a significant association, with adjustment for sex and age, and also after applying multiple testing adjustments. Among the Colombian and Argentinean cohorts, rs360719 showed a significant genetic effect in a fixed-effects meta-analysis after a Bonferroni correction (OR: 0.76, CI: 0.66-0.89, P = 0.001). For CCC, the rs2043055 showed an association with protection from cardiomyopathy in the Colombian cohort (OR: 0.79, CI: 0.64-0.99, P = 0.037), with adjustment for sex and age, and after applying multiple testing adjustments. The meta-analysis of the CCC vs. asymptomatic patients from the four cohorts showed no evidence of association. In conclusion, our results validated the association found previously in the Colombian cohort suggesting that IL18 rs360719 plays an important role in the susceptibility to T. cruzi infection and no evidence of association was found between the IL18 genetic variants and CCC in the Latin American population studied.
Fil: Strauss, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Acosta Herrera, Marialbert. Consejo Superior de Investigaciones Científicas; España
Fil: Alcaraz, Alexia. Consejo Superior de Investigaciones Científicas; España
Fil: Casares Marfil, Desiré. Consejo Superior de Investigaciones Científicas; España
Fil: Bosch Nicolau, Pau. Internacional Hospital Universitari Vall d’Hebron; España
Fil: Lo Presti, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Molina, Israel. Internacional Hospital Universitari Vall d’Hebron; España
Fil: González, Clara Isabel. Universidad Industrial Santander; Colombia
Fil: Martín, Javier. Consejo Superior de Investigaciones Científicas; España
Fil: Chagas Genetics CYTED Network. No especifíca;
description Host genetic factors have been suggested to play an important role in the susceptibility to Chagas disease. Given the influence of interleukin 18 (IL-18) in the development of the disease, in the present study, we analyzed three IL18 genetic variants (rs2043055, rs1946518, rs360719) regarding the predisposition to Trypanosoma cruzi infection and the development of chronic Chagas cardiomyopathy (CCC), in different Latin America populations. Genetic data of 3,608 patients from Colombia, Bolivia, Argentina, and Brazil were meta-analyzed to validate previous findings with increased statistical power. Seropositive and seronegative individuals were compared for T. cruzi infection susceptibility. In the Colombian cohort, the allelic frequencies of the three variants showed a significant association, with adjustment for sex and age, and also after applying multiple testing adjustments. Among the Colombian and Argentinean cohorts, rs360719 showed a significant genetic effect in a fixed-effects meta-analysis after a Bonferroni correction (OR: 0.76, CI: 0.66-0.89, P = 0.001). For CCC, the rs2043055 showed an association with protection from cardiomyopathy in the Colombian cohort (OR: 0.79, CI: 0.64-0.99, P = 0.037), with adjustment for sex and age, and after applying multiple testing adjustments. The meta-analysis of the CCC vs. asymptomatic patients from the four cohorts showed no evidence of association. In conclusion, our results validated the association found previously in the Colombian cohort suggesting that IL18 rs360719 plays an important role in the susceptibility to T. cruzi infection and no evidence of association was found between the IL18 genetic variants and CCC in the Latin American population studied.
publishDate 2019
dc.date.none.fl_str_mv 2019-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/125654
Strauss, Mariana; Acosta Herrera, Marialbert; Alcaraz, Alexia; Casares Marfil, Desiré; Bosch Nicolau, Pau; et al.; Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations; Public Library of Science; Neglected Tropical Diseases; 13; 11; 10-2019; 1-13
1935-2735
CONICET Digital
CONICET
url http://hdl.handle.net/11336/125654
identifier_str_mv Strauss, Mariana; Acosta Herrera, Marialbert; Alcaraz, Alexia; Casares Marfil, Desiré; Bosch Nicolau, Pau; et al.; Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations; Public Library of Science; Neglected Tropical Diseases; 13; 11; 10-2019; 1-13
1935-2735
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0007859
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0007859
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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