Versatile preparation of silica nanocapsules for biomedical applications

Autores
Jiang, Shuai; Mottola, Milagro; Han, Shen; Thiramanas, Raweewan; Graf, Robert; Lieberwirth, Ingo; Mailänder, Volker; Crespy, Daniel; Landfester, Katharina
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Core–shell nanocapsules are receiving increasing interest for drug delivery applications. Silica nanocapsules have been the focus of intensive studies due to their biocompatibility, versatile silica chemistry, and tunable porosity. However, a versatile one-step preparation of silica nanocapsules with well-defined core–shell structure, tunable size, flexible interior loading, and tailored shell composition, permeability, and surface functionalization for site-specific drug release and therapeutic tracking remains a challenge. Herein, an interfacially confined sol–gel process in miniemulsion for the one-step versatile preparation of functional silica nanocapsules is developed. Uniform nanocapsules with diameters from 60 to 400 nm are obtained and a large variety of hydrophobic liquids are encapsulated in the core. When solvents with low boiling point are loaded, subsequent solvent evaporation converts the initially hydrophobic cavity into an aqueous environment. Stimuli-responsive permeability of nanocapsules is programmed by introducing disulfide or tetrasulfide bonds in the shell. Selective and sustained release of dexamethasone in response to glutathione tripeptide for over 10 d is achieved. Fluorescence labeling of the silica shell and magnetic loading in the internal cavity enable therapeutic tracking of nanocapsules by fluorescence and electron microscopies. Thus, silica nanocapsules represent a promising theranostic nanoplatform for targeted drug delivery applications.
Fil: Jiang, Shuai. Max Planck Institute for Polymer Research; Alemania
Fil: Mottola, Milagro. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Max Planck Institute For Polymer Research; Alemania
Fil: Han, Shen. Max Planck Institute For Polymer Research; Alemania
Fil: Thiramanas, Raweewan. Max Planck Institute For Polymer Research; Alemania
Fil: Graf, Robert. Max Planck Institute For Polymer Research; Alemania
Fil: Lieberwirth, Ingo. Max Planck Institute For Polymer Research; Alemania
Fil: Mailänder, Volker. Max Planck Institute For Polymer Research; Alemania
Fil: Crespy, Daniel. Max Planck Institute For Polymer Research; Alemania
Fil: Landfester, Katharina. Max Planck Institute For Polymer Research; Alemania
Materia
CONTROLLED RELEASE
CORE–SHELL NANOCAPSULES
DRUG DELIVERY
SILICA NANOCARRIERS
THERANOSTIC NANOPLATFORMS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/125538
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/125538
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Versatile preparation of silica nanocapsules for biomedical applicationsJiang, ShuaiMottola, MilagroHan, ShenThiramanas, RaweewanGraf, RobertLieberwirth, IngoMailänder, VolkerCrespy, DanielLandfester, KatharinaCONTROLLED RELEASECORE–SHELL NANOCAPSULESDRUG DELIVERYSILICA NANOCARRIERSTHERANOSTIC NANOPLATFORMShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Core–shell nanocapsules are receiving increasing interest for drug delivery applications. Silica nanocapsules have been the focus of intensive studies due to their biocompatibility, versatile silica chemistry, and tunable porosity. However, a versatile one-step preparation of silica nanocapsules with well-defined core–shell structure, tunable size, flexible interior loading, and tailored shell composition, permeability, and surface functionalization for site-specific drug release and therapeutic tracking remains a challenge. Herein, an interfacially confined sol–gel process in miniemulsion for the one-step versatile preparation of functional silica nanocapsules is developed. Uniform nanocapsules with diameters from 60 to 400 nm are obtained and a large variety of hydrophobic liquids are encapsulated in the core. When solvents with low boiling point are loaded, subsequent solvent evaporation converts the initially hydrophobic cavity into an aqueous environment. Stimuli-responsive permeability of nanocapsules is programmed by introducing disulfide or tetrasulfide bonds in the shell. Selective and sustained release of dexamethasone in response to glutathione tripeptide for over 10 d is achieved. Fluorescence labeling of the silica shell and magnetic loading in the internal cavity enable therapeutic tracking of nanocapsules by fluorescence and electron microscopies. Thus, silica nanocapsules represent a promising theranostic nanoplatform for targeted drug delivery applications.Fil: Jiang, Shuai. Max Planck Institute for Polymer Research; AlemaniaFil: Mottola, Milagro. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Max Planck Institute For Polymer Research; AlemaniaFil: Han, Shen. Max Planck Institute For Polymer Research; AlemaniaFil: Thiramanas, Raweewan. Max Planck Institute For Polymer Research; AlemaniaFil: Graf, Robert. Max Planck Institute For Polymer Research; AlemaniaFil: Lieberwirth, Ingo. Max Planck Institute For Polymer Research; AlemaniaFil: Mailänder, Volker. Max Planck Institute For Polymer Research; AlemaniaFil: Crespy, Daniel. Max Planck Institute For Polymer Research; AlemaniaFil: Landfester, Katharina. Max Planck Institute For Polymer Research; AlemaniaWiley VCH Verlag2020-04-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/125538Jiang, Shuai; Mottola, Milagro; Han, Shen; Thiramanas, Raweewan; Graf, Robert; et al.; Versatile preparation of silica nanocapsules for biomedical applications; Wiley VCH Verlag; Particle & Particle Systems Characterization; 37; 4; 14-4-2020; 1-12; 19004840934-08661521-4117CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ppsc.201900484info:eu-repo/semantics/altIdentifier/doi/10.1002/ppsc.201900484info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:40:49Zoai:ri.conicet.gov.ar:11336/125538instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:40:49.956CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Versatile preparation of silica nanocapsules for biomedical applications
title Versatile preparation of silica nanocapsules for biomedical applications
spellingShingle Versatile preparation of silica nanocapsules for biomedical applications
Jiang, Shuai
CONTROLLED RELEASE
CORE–SHELL NANOCAPSULES
DRUG DELIVERY
SILICA NANOCARRIERS
THERANOSTIC NANOPLATFORMS
title_short Versatile preparation of silica nanocapsules for biomedical applications
title_full Versatile preparation of silica nanocapsules for biomedical applications
title_fullStr Versatile preparation of silica nanocapsules for biomedical applications
title_full_unstemmed Versatile preparation of silica nanocapsules for biomedical applications
title_sort Versatile preparation of silica nanocapsules for biomedical applications
dc.creator.none.fl_str_mv Jiang, Shuai
Mottola, Milagro
Han, Shen
Thiramanas, Raweewan
Graf, Robert
Lieberwirth, Ingo
Mailänder, Volker
Crespy, Daniel
Landfester, Katharina
author Jiang, Shuai
author_facet Jiang, Shuai
Mottola, Milagro
Han, Shen
Thiramanas, Raweewan
Graf, Robert
Lieberwirth, Ingo
Mailänder, Volker
Crespy, Daniel
Landfester, Katharina
author_role author
author2 Mottola, Milagro
Han, Shen
Thiramanas, Raweewan
Graf, Robert
Lieberwirth, Ingo
Mailänder, Volker
Crespy, Daniel
Landfester, Katharina
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CONTROLLED RELEASE
CORE–SHELL NANOCAPSULES
DRUG DELIVERY
SILICA NANOCARRIERS
THERANOSTIC NANOPLATFORMS
topic CONTROLLED RELEASE
CORE–SHELL NANOCAPSULES
DRUG DELIVERY
SILICA NANOCARRIERS
THERANOSTIC NANOPLATFORMS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Core–shell nanocapsules are receiving increasing interest for drug delivery applications. Silica nanocapsules have been the focus of intensive studies due to their biocompatibility, versatile silica chemistry, and tunable porosity. However, a versatile one-step preparation of silica nanocapsules with well-defined core–shell structure, tunable size, flexible interior loading, and tailored shell composition, permeability, and surface functionalization for site-specific drug release and therapeutic tracking remains a challenge. Herein, an interfacially confined sol–gel process in miniemulsion for the one-step versatile preparation of functional silica nanocapsules is developed. Uniform nanocapsules with diameters from 60 to 400 nm are obtained and a large variety of hydrophobic liquids are encapsulated in the core. When solvents with low boiling point are loaded, subsequent solvent evaporation converts the initially hydrophobic cavity into an aqueous environment. Stimuli-responsive permeability of nanocapsules is programmed by introducing disulfide or tetrasulfide bonds in the shell. Selective and sustained release of dexamethasone in response to glutathione tripeptide for over 10 d is achieved. Fluorescence labeling of the silica shell and magnetic loading in the internal cavity enable therapeutic tracking of nanocapsules by fluorescence and electron microscopies. Thus, silica nanocapsules represent a promising theranostic nanoplatform for targeted drug delivery applications.
Fil: Jiang, Shuai. Max Planck Institute for Polymer Research; Alemania
Fil: Mottola, Milagro. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Departamento de Química. Cátedra de Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina. Max Planck Institute For Polymer Research; Alemania
Fil: Han, Shen. Max Planck Institute For Polymer Research; Alemania
Fil: Thiramanas, Raweewan. Max Planck Institute For Polymer Research; Alemania
Fil: Graf, Robert. Max Planck Institute For Polymer Research; Alemania
Fil: Lieberwirth, Ingo. Max Planck Institute For Polymer Research; Alemania
Fil: Mailänder, Volker. Max Planck Institute For Polymer Research; Alemania
Fil: Crespy, Daniel. Max Planck Institute For Polymer Research; Alemania
Fil: Landfester, Katharina. Max Planck Institute For Polymer Research; Alemania
description Core–shell nanocapsules are receiving increasing interest for drug delivery applications. Silica nanocapsules have been the focus of intensive studies due to their biocompatibility, versatile silica chemistry, and tunable porosity. However, a versatile one-step preparation of silica nanocapsules with well-defined core–shell structure, tunable size, flexible interior loading, and tailored shell composition, permeability, and surface functionalization for site-specific drug release and therapeutic tracking remains a challenge. Herein, an interfacially confined sol–gel process in miniemulsion for the one-step versatile preparation of functional silica nanocapsules is developed. Uniform nanocapsules with diameters from 60 to 400 nm are obtained and a large variety of hydrophobic liquids are encapsulated in the core. When solvents with low boiling point are loaded, subsequent solvent evaporation converts the initially hydrophobic cavity into an aqueous environment. Stimuli-responsive permeability of nanocapsules is programmed by introducing disulfide or tetrasulfide bonds in the shell. Selective and sustained release of dexamethasone in response to glutathione tripeptide for over 10 d is achieved. Fluorescence labeling of the silica shell and magnetic loading in the internal cavity enable therapeutic tracking of nanocapsules by fluorescence and electron microscopies. Thus, silica nanocapsules represent a promising theranostic nanoplatform for targeted drug delivery applications.
publishDate 2020
dc.date.none.fl_str_mv 2020-04-14
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/125538
Jiang, Shuai; Mottola, Milagro; Han, Shen; Thiramanas, Raweewan; Graf, Robert; et al.; Versatile preparation of silica nanocapsules for biomedical applications; Wiley VCH Verlag; Particle & Particle Systems Characterization; 37; 4; 14-4-2020; 1-12; 1900484
0934-0866
1521-4117
CONICET Digital
CONICET
url http://hdl.handle.net/11336/125538
identifier_str_mv Jiang, Shuai; Mottola, Milagro; Han, Shen; Thiramanas, Raweewan; Graf, Robert; et al.; Versatile preparation of silica nanocapsules for biomedical applications; Wiley VCH Verlag; Particle & Particle Systems Characterization; 37; 4; 14-4-2020; 1-12; 1900484
0934-0866
1521-4117
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/ppsc.201900484
info:eu-repo/semantics/altIdentifier/doi/10.1002/ppsc.201900484
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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