Antibacterial Activity of Extracts from Plants of Central Argentina—Isolation of an Active Principle from Achyrocline satureioides

Autores
Joray, Mariana Belén; Rollán, María del Rosario; Ruiz, Gustavo Miguel; Palacios, Sara Maria; Carpinella, Maria Cecilia
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The great increase in bacterial infections is fueling interest in the search for antibacterial products of plant origin. Extracts obtained from 51 native and naturalized plants from central Argentina were therefore evaluated for their in vitro inhibitory activity on pathogenic bacteria with the aim of selecting the most active ones as new sources of effective antibiotics. The susceptibility of reference and clinical strains of Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella enterica serovar Enteritidis, and Staphylococcus aureus was determined. Extracts from Achyrocline satureioides, Flourensia oolepis, Lepechinia floribunda, and Lithrea molleoides were the most potent, with MIC and MBC values ranging from 0.006 to 2 and 0.012 to 10 mg/mL, respectively, on both gram-positive and negative bacteria. The antibacterial activity-guided isolation of A. satureioides ethanol extract showed 23-methyl-6-O-desmethylauricepyrone (1) to be the most active compound. This compound showed inhibitory effects against gram-positive bacteria with MIC and MBC values of 0.002 and 0.008 mg/mL, respectively, while on gram-negative strains, the MIC and MBC were 0.062–0.250 and 0.062–0.500 mg/mL, respectively. The strong antibacterial activity shown by the four plant extracts or the compound isolated from A. satureioides suggests that they could become part of the arsenal of antibacterial drugs currently used.
Fil: Joray, Mariana Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Rollán, María del Rosario. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Ruiz, Gustavo Miguel. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina
Fil: Palacios, Sara Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Carpinella, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina
Materia
NATURAL ANTIBACTERIALS
23-METHYL-6-O-DESMETHYLAURICEPYRONE
NATIVE PLANTS
ACYROCLINE SATUREIOIDES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/254581
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antibacterial Activity of Extracts from Plants of Central Argentina—Isolation of an Active Principle from Achyrocline satureioidesJoray, Mariana BelénRollán, María del RosarioRuiz, Gustavo MiguelPalacios, Sara MariaCarpinella, Maria CeciliaNATURAL ANTIBACTERIALS23-METHYL-6-O-DESMETHYLAURICEPYRONENATIVE PLANTSACYROCLINE SATUREIOIDEShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The great increase in bacterial infections is fueling interest in the search for antibacterial products of plant origin. Extracts obtained from 51 native and naturalized plants from central Argentina were therefore evaluated for their in vitro inhibitory activity on pathogenic bacteria with the aim of selecting the most active ones as new sources of effective antibiotics. The susceptibility of reference and clinical strains of Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella enterica serovar Enteritidis, and Staphylococcus aureus was determined. Extracts from Achyrocline satureioides, Flourensia oolepis, Lepechinia floribunda, and Lithrea molleoides were the most potent, with MIC and MBC values ranging from 0.006 to 2 and 0.012 to 10 mg/mL, respectively, on both gram-positive and negative bacteria. The antibacterial activity-guided isolation of A. satureioides ethanol extract showed 23-methyl-6-O-desmethylauricepyrone (1) to be the most active compound. This compound showed inhibitory effects against gram-positive bacteria with MIC and MBC values of 0.002 and 0.008 mg/mL, respectively, while on gram-negative strains, the MIC and MBC were 0.062–0.250 and 0.062–0.500 mg/mL, respectively. The strong antibacterial activity shown by the four plant extracts or the compound isolated from A. satureioides suggests that they could become part of the arsenal of antibacterial drugs currently used.Fil: Joray, Mariana Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; ArgentinaFil: Rollán, María del Rosario. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; ArgentinaFil: Ruiz, Gustavo Miguel. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; ArgentinaFil: Palacios, Sara Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; ArgentinaFil: Carpinella, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; ArgentinaGeorg Thieme Verlag Kg2011-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/254581Joray, Mariana Belén; Rollán, María del Rosario; Ruiz, Gustavo Miguel; Palacios, Sara Maria; Carpinella, Maria Cecilia; Antibacterial Activity of Extracts from Plants of Central Argentina—Isolation of an Active Principle from Achyrocline satureioides; Georg Thieme Verlag Kg; Planta Medica; 77; 01; 1-2011; 95-1000032-0943CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0030-1250133info:eu-repo/semantics/altIdentifier/doi/10.1055/s-0030-1250133info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T09:41:30Zoai:ri.conicet.gov.ar:11336/254581instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 09:41:30.666CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antibacterial Activity of Extracts from Plants of Central Argentina—Isolation of an Active Principle from Achyrocline satureioides
title Antibacterial Activity of Extracts from Plants of Central Argentina—Isolation of an Active Principle from Achyrocline satureioides
spellingShingle Antibacterial Activity of Extracts from Plants of Central Argentina—Isolation of an Active Principle from Achyrocline satureioides
Joray, Mariana Belén
NATURAL ANTIBACTERIALS
23-METHYL-6-O-DESMETHYLAURICEPYRONE
NATIVE PLANTS
ACYROCLINE SATUREIOIDES
title_short Antibacterial Activity of Extracts from Plants of Central Argentina—Isolation of an Active Principle from Achyrocline satureioides
title_full Antibacterial Activity of Extracts from Plants of Central Argentina—Isolation of an Active Principle from Achyrocline satureioides
title_fullStr Antibacterial Activity of Extracts from Plants of Central Argentina—Isolation of an Active Principle from Achyrocline satureioides
title_full_unstemmed Antibacterial Activity of Extracts from Plants of Central Argentina—Isolation of an Active Principle from Achyrocline satureioides
title_sort Antibacterial Activity of Extracts from Plants of Central Argentina—Isolation of an Active Principle from Achyrocline satureioides
dc.creator.none.fl_str_mv Joray, Mariana Belén
Rollán, María del Rosario
Ruiz, Gustavo Miguel
Palacios, Sara Maria
Carpinella, Maria Cecilia
author Joray, Mariana Belén
author_facet Joray, Mariana Belén
Rollán, María del Rosario
Ruiz, Gustavo Miguel
Palacios, Sara Maria
Carpinella, Maria Cecilia
author_role author
author2 Rollán, María del Rosario
Ruiz, Gustavo Miguel
Palacios, Sara Maria
Carpinella, Maria Cecilia
author2_role author
author
author
author
dc.subject.none.fl_str_mv NATURAL ANTIBACTERIALS
23-METHYL-6-O-DESMETHYLAURICEPYRONE
NATIVE PLANTS
ACYROCLINE SATUREIOIDES
topic NATURAL ANTIBACTERIALS
23-METHYL-6-O-DESMETHYLAURICEPYRONE
NATIVE PLANTS
ACYROCLINE SATUREIOIDES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The great increase in bacterial infections is fueling interest in the search for antibacterial products of plant origin. Extracts obtained from 51 native and naturalized plants from central Argentina were therefore evaluated for their in vitro inhibitory activity on pathogenic bacteria with the aim of selecting the most active ones as new sources of effective antibiotics. The susceptibility of reference and clinical strains of Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella enterica serovar Enteritidis, and Staphylococcus aureus was determined. Extracts from Achyrocline satureioides, Flourensia oolepis, Lepechinia floribunda, and Lithrea molleoides were the most potent, with MIC and MBC values ranging from 0.006 to 2 and 0.012 to 10 mg/mL, respectively, on both gram-positive and negative bacteria. The antibacterial activity-guided isolation of A. satureioides ethanol extract showed 23-methyl-6-O-desmethylauricepyrone (1) to be the most active compound. This compound showed inhibitory effects against gram-positive bacteria with MIC and MBC values of 0.002 and 0.008 mg/mL, respectively, while on gram-negative strains, the MIC and MBC were 0.062–0.250 and 0.062–0.500 mg/mL, respectively. The strong antibacterial activity shown by the four plant extracts or the compound isolated from A. satureioides suggests that they could become part of the arsenal of antibacterial drugs currently used.
Fil: Joray, Mariana Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Rollán, María del Rosario. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Ruiz, Gustavo Miguel. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina
Fil: Palacios, Sara Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Carpinella, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina
description The great increase in bacterial infections is fueling interest in the search for antibacterial products of plant origin. Extracts obtained from 51 native and naturalized plants from central Argentina were therefore evaluated for their in vitro inhibitory activity on pathogenic bacteria with the aim of selecting the most active ones as new sources of effective antibiotics. The susceptibility of reference and clinical strains of Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella enterica serovar Enteritidis, and Staphylococcus aureus was determined. Extracts from Achyrocline satureioides, Flourensia oolepis, Lepechinia floribunda, and Lithrea molleoides were the most potent, with MIC and MBC values ranging from 0.006 to 2 and 0.012 to 10 mg/mL, respectively, on both gram-positive and negative bacteria. The antibacterial activity-guided isolation of A. satureioides ethanol extract showed 23-methyl-6-O-desmethylauricepyrone (1) to be the most active compound. This compound showed inhibitory effects against gram-positive bacteria with MIC and MBC values of 0.002 and 0.008 mg/mL, respectively, while on gram-negative strains, the MIC and MBC were 0.062–0.250 and 0.062–0.500 mg/mL, respectively. The strong antibacterial activity shown by the four plant extracts or the compound isolated from A. satureioides suggests that they could become part of the arsenal of antibacterial drugs currently used.
publishDate 2011
dc.date.none.fl_str_mv 2011-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/254581
Joray, Mariana Belén; Rollán, María del Rosario; Ruiz, Gustavo Miguel; Palacios, Sara Maria; Carpinella, Maria Cecilia; Antibacterial Activity of Extracts from Plants of Central Argentina—Isolation of an Active Principle from Achyrocline satureioides; Georg Thieme Verlag Kg; Planta Medica; 77; 01; 1-2011; 95-100
0032-0943
CONICET Digital
CONICET
url http://hdl.handle.net/11336/254581
identifier_str_mv Joray, Mariana Belén; Rollán, María del Rosario; Ruiz, Gustavo Miguel; Palacios, Sara Maria; Carpinella, Maria Cecilia; Antibacterial Activity of Extracts from Plants of Central Argentina—Isolation of an Active Principle from Achyrocline satureioides; Georg Thieme Verlag Kg; Planta Medica; 77; 01; 1-2011; 95-100
0032-0943
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0030-1250133
info:eu-repo/semantics/altIdentifier/doi/10.1055/s-0030-1250133
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Georg Thieme Verlag Kg
publisher.none.fl_str_mv Georg Thieme Verlag Kg
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.087074

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