Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain

Autores
Pardi, Belén; Ogando, Mora; Schinder, Alejandro Fabian; Marin Burgin, Antonia
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Adult hippocampal neurogenesis provides the dentate gyrus (DG) with heterogeneous populations of granule cells (GC) originated at different times. The specific contribution of these cells to the encoding of information arriving to the hippocampus is under current investigation. Here we show that spike trains arriving to the DG are channeled into activation of different populations of GC determined by the stimulation frequency and GC age. Immature GC respond to a wider range of afferent stimuli arriving at 1-40 Hz, whereas mature GC are less effective in following higher frequencies. This difference is dictated by the activation of feed forward inhibition, which predominantly restricts mature GC activation. Although it restricts frequency responsiveness, the stronger inhibition of mature GC results in a higher temporal fidelity compared to that of immature GC. Thus, activity arriving to the hippocampus at different frequencies activates two populations of neurons with variable frequency filters: immature cells, with wide range of responses, that are reliable transmitters of the incoming frequency, and mature neurons, with narrow responses to frequency, that are precise at informing the beginning of the stimulus, but with a sparse activity.
Fil: Pardi, Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación En Biomedicina de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina
Fil: Ogando, Mora. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación En Biomedicina de Buenos Aires; Argentina
Fil: Schinder, Alejandro Fabian. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina
Fil: Marin Burgin, Antonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación En Biomedicina de Buenos Aires; Argentina
Materia
NEUROGENESIS
INHIBICION
CIRCUITOS NEURONALES
ELECTROFISIOLOGIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/12310
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gainPardi, BelénOgando, MoraSchinder, Alejandro FabianMarin Burgin, AntoniaNEUROGENESISINHIBICIONCIRCUITOS NEURONALESELECTROFISIOLOGIAhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Adult hippocampal neurogenesis provides the dentate gyrus (DG) with heterogeneous populations of granule cells (GC) originated at different times. The specific contribution of these cells to the encoding of information arriving to the hippocampus is under current investigation. Here we show that spike trains arriving to the DG are channeled into activation of different populations of GC determined by the stimulation frequency and GC age. Immature GC respond to a wider range of afferent stimuli arriving at 1-40 Hz, whereas mature GC are less effective in following higher frequencies. This difference is dictated by the activation of feed forward inhibition, which predominantly restricts mature GC activation. Although it restricts frequency responsiveness, the stronger inhibition of mature GC results in a higher temporal fidelity compared to that of immature GC. Thus, activity arriving to the hippocampus at different frequencies activates two populations of neurons with variable frequency filters: immature cells, with wide range of responses, that are reliable transmitters of the incoming frequency, and mature neurons, with narrow responses to frequency, that are precise at informing the beginning of the stimulus, but with a sparse activity.Fil: Pardi, Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación En Biomedicina de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; ArgentinaFil: Ogando, Mora. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación En Biomedicina de Buenos Aires; ArgentinaFil: Schinder, Alejandro Fabian. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; ArgentinaFil: Marin Burgin, Antonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación En Biomedicina de Buenos Aires; ArgentinaeLife Sciences Publications2015-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12310Pardi, Belén; Ogando, Mora; Schinder, Alejandro Fabian; Marin Burgin, Antonia; Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain; eLife Sciences Publications; eLife; 4; 7-2015; 1-17; e087642050-084Xenginfo:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/content/4/e08764info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.08764info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:41:24Zoai:ri.conicet.gov.ar:11336/12310instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:41:25.146CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain
title Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain
spellingShingle Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain
Pardi, Belén
NEUROGENESIS
INHIBICION
CIRCUITOS NEURONALES
ELECTROFISIOLOGIA
title_short Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain
title_full Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain
title_fullStr Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain
title_full_unstemmed Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain
title_sort Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain
dc.creator.none.fl_str_mv Pardi, Belén
Ogando, Mora
Schinder, Alejandro Fabian
Marin Burgin, Antonia
author Pardi, Belén
author_facet Pardi, Belén
Ogando, Mora
Schinder, Alejandro Fabian
Marin Burgin, Antonia
author_role author
author2 Ogando, Mora
Schinder, Alejandro Fabian
Marin Burgin, Antonia
author2_role author
author
author
dc.subject.none.fl_str_mv NEUROGENESIS
INHIBICION
CIRCUITOS NEURONALES
ELECTROFISIOLOGIA
topic NEUROGENESIS
INHIBICION
CIRCUITOS NEURONALES
ELECTROFISIOLOGIA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Adult hippocampal neurogenesis provides the dentate gyrus (DG) with heterogeneous populations of granule cells (GC) originated at different times. The specific contribution of these cells to the encoding of information arriving to the hippocampus is under current investigation. Here we show that spike trains arriving to the DG are channeled into activation of different populations of GC determined by the stimulation frequency and GC age. Immature GC respond to a wider range of afferent stimuli arriving at 1-40 Hz, whereas mature GC are less effective in following higher frequencies. This difference is dictated by the activation of feed forward inhibition, which predominantly restricts mature GC activation. Although it restricts frequency responsiveness, the stronger inhibition of mature GC results in a higher temporal fidelity compared to that of immature GC. Thus, activity arriving to the hippocampus at different frequencies activates two populations of neurons with variable frequency filters: immature cells, with wide range of responses, that are reliable transmitters of the incoming frequency, and mature neurons, with narrow responses to frequency, that are precise at informing the beginning of the stimulus, but with a sparse activity.
Fil: Pardi, Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación En Biomedicina de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina
Fil: Ogando, Mora. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación En Biomedicina de Buenos Aires; Argentina
Fil: Schinder, Alejandro Fabian. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina
Fil: Marin Burgin, Antonia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación En Biomedicina de Buenos Aires; Argentina
description Adult hippocampal neurogenesis provides the dentate gyrus (DG) with heterogeneous populations of granule cells (GC) originated at different times. The specific contribution of these cells to the encoding of information arriving to the hippocampus is under current investigation. Here we show that spike trains arriving to the DG are channeled into activation of different populations of GC determined by the stimulation frequency and GC age. Immature GC respond to a wider range of afferent stimuli arriving at 1-40 Hz, whereas mature GC are less effective in following higher frequencies. This difference is dictated by the activation of feed forward inhibition, which predominantly restricts mature GC activation. Although it restricts frequency responsiveness, the stronger inhibition of mature GC results in a higher temporal fidelity compared to that of immature GC. Thus, activity arriving to the hippocampus at different frequencies activates two populations of neurons with variable frequency filters: immature cells, with wide range of responses, that are reliable transmitters of the incoming frequency, and mature neurons, with narrow responses to frequency, that are precise at informing the beginning of the stimulus, but with a sparse activity.
publishDate 2015
dc.date.none.fl_str_mv 2015-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/12310
Pardi, Belén; Ogando, Mora; Schinder, Alejandro Fabian; Marin Burgin, Antonia; Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain; eLife Sciences Publications; eLife; 4; 7-2015; 1-17; e08764
2050-084X
url http://hdl.handle.net/11336/12310
identifier_str_mv Pardi, Belén; Ogando, Mora; Schinder, Alejandro Fabian; Marin Burgin, Antonia; Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain; eLife Sciences Publications; eLife; 4; 7-2015; 1-17; e08764
2050-084X
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/content/4/e08764
info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.08764
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv eLife Sciences Publications
publisher.none.fl_str_mv eLife Sciences Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.891075

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