Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are Endemic
- Autores
- Levecke, Bruno; Montresor, Antonio; Albonico, Marco; Ame, Shaali M.; Behnke, Jerzy M.; Bethony, Jeffrey M.; Noumedem, Calvine D.; Engels, Dirk; Guillard, Bertrand; Kotze, Andrew; Krolewiecki, Alejandro Javier; McCarthy, James; Mekonnen, Zeleke; Periago, Maria V.; Sopheak, Hem; Tchuem Tchuente, Louis Albert; Duong, Tran Thanh; Huong, Nguyen Thu; Zeynudin, Ahmed; Vercruysse, Jozef
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: Robust reference values for fecal egg count reduction (FECR) rates of the most widely used anthelmintic drugsin preventive chemotherapy (PC) programs for controlling soil-transmitted helminths (STHs; Ascaris lumbricoides, Trichuristrichiura, and hookworm) are still lacking. However, they are urgently needed to ensure detection of reduced efficacies thatare predicted to occur due to growing drug pressure. Here, using a standardized methodology, we assessed the FECR rateof a single oral dose of mebendazole (MEB; 500 mg) against STHs in six trials in school children in different locations aroundthe world. Our results are compared with those previously obtained for similarly conducted trials of a single oral dose ofalbendazole (ALB; 400 mg).Methodology: The efficacy of MEB, as assessed by FECR, was determined in six trials involving 5,830 school children in Brazil,Cambodia, Cameroon, Ethiopia, United Republic of Tanzania, and Vietnam. The efficacy of MEB was compared to that of ALBas previously assessed in 8,841 school children in India and all the above-mentioned study sites, using identicalmethodologies.Principal Findings: The estimated FECR rate [95% confidence interval] of MEB was highest for A. lumbricoides (97.6% [95.8;99.5]), followed by hookworm (79.6% [71.0; 88.3]). For T. trichiura, the estimated FECR rate was 63.1% [51.6; 74.6]. Comparedto MEB, ALB was significantly more efficacious against hookworm (96.2% [91.1; 100], p,0.001) and only marginally,although significantly, better against A. lumbricoides infections (99.9% [99.0; 100], p = 0.012), but equally efficacious for T.trichiura infections (64.5% [44.4; 84.7], p = 0.906).Conclusions/Significance: A minimum FECR rate of 95% for A. lumbricoides, 70% for hookworm, and 50% for T. trichiura isexpected in MEB-dependent PC programs. Lower FECR results may indicate the development of potential drug resistance
Fil: Levecke, Bruno. University Of Ghent. Department of Virology, Parasitology and Immunology; Bélgica
Fil: Montresor, Antonio. World Health Organization. Department of Control of Neglected Tropical Diseases; Suiza
Fil: Albonico, Marco. Fondazione Ivo de Carneri; Italia
Fil: Ame, Shaali M.. Public Health Laboratory-Ivo De Carneri; Tanzania
Fil: Behnke, Jerzy M.. The University Of Nottingham; Reino Unido
Fil: Bethony, Jeffrey M.. The George Washington University; Estados Unidos
Fil: Noumedem, Calvine D.. University of Yaoundé; Camerún
Fil: Engels, Dirk. World Health Organization. Department of Control of Neglected Tropical Diseases; Suiza
Fil: Guillard, Bertrand. Pasteur Institute; Camboya
Fil: Kotze, Andrew. Commonwealth Scientific and Industrial Research Organisation; Australia
Fil: Krolewiecki, Alejandro Javier. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina
Fil: McCarthy, James. The University Of Queensland; Australia
Fil: Mekonnen, Zeleke. Jimma University; Etiopía
Fil: Periago, Maria V.. Fundación Oswaldo Cruz. Instituto Rene Rachou; Brasil
Fil: Sopheak, Hem. Pasteur Institute; Camboya
Fil: Tchuem Tchuente, Louis Albert. University of Youndé; Camerún
Fil: Duong, Tran Thanh. National Institute of Malariology; Vietnam
Fil: Huong, Nguyen Thu. National Institute of Malariology; Vietnam
Fil: Zeynudin, Ahmed. Jimma University; Etiopía
Fil: Vercruysse, Jozef. University Of Ghent. Department of Virology, Parasitology and Immunology; Bélgica - Materia
-
MEBENDAZOL
TRICHURIS TRICHIURA
ASCARIS LUMBRICOIDES
HOOKWORM - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/7017
Ver los metadatos del registro completo
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Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are EndemicLevecke, BrunoMontresor, AntonioAlbonico, MarcoAme, Shaali M.Behnke, Jerzy M.Bethony, Jeffrey M.Noumedem, Calvine D.Engels, DirkGuillard, BertrandKotze, AndrewKrolewiecki, Alejandro JavierMcCarthy, JamesMekonnen, ZelekePeriago, Maria V.Sopheak, HemTchuem Tchuente, Louis AlbertDuong, Tran ThanhHuong, Nguyen ThuZeynudin, AhmedVercruysse, JozefMEBENDAZOLTRICHURIS TRICHIURAASCARIS LUMBRICOIDESHOOKWORMhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: Robust reference values for fecal egg count reduction (FECR) rates of the most widely used anthelmintic drugsin preventive chemotherapy (PC) programs for controlling soil-transmitted helminths (STHs; Ascaris lumbricoides, Trichuristrichiura, and hookworm) are still lacking. However, they are urgently needed to ensure detection of reduced efficacies thatare predicted to occur due to growing drug pressure. Here, using a standardized methodology, we assessed the FECR rateof a single oral dose of mebendazole (MEB; 500 mg) against STHs in six trials in school children in different locations aroundthe world. Our results are compared with those previously obtained for similarly conducted trials of a single oral dose ofalbendazole (ALB; 400 mg).Methodology: The efficacy of MEB, as assessed by FECR, was determined in six trials involving 5,830 school children in Brazil,Cambodia, Cameroon, Ethiopia, United Republic of Tanzania, and Vietnam. The efficacy of MEB was compared to that of ALBas previously assessed in 8,841 school children in India and all the above-mentioned study sites, using identicalmethodologies.Principal Findings: The estimated FECR rate [95% confidence interval] of MEB was highest for A. lumbricoides (97.6% [95.8;99.5]), followed by hookworm (79.6% [71.0; 88.3]). For T. trichiura, the estimated FECR rate was 63.1% [51.6; 74.6]. Comparedto MEB, ALB was significantly more efficacious against hookworm (96.2% [91.1; 100], p,0.001) and only marginally,although significantly, better against A. lumbricoides infections (99.9% [99.0; 100], p = 0.012), but equally efficacious for T.trichiura infections (64.5% [44.4; 84.7], p = 0.906).Conclusions/Significance: A minimum FECR rate of 95% for A. lumbricoides, 70% for hookworm, and 50% for T. trichiura isexpected in MEB-dependent PC programs. Lower FECR results may indicate the development of potential drug resistanceFil: Levecke, Bruno. University Of Ghent. Department of Virology, Parasitology and Immunology; BélgicaFil: Montresor, Antonio. World Health Organization. Department of Control of Neglected Tropical Diseases; SuizaFil: Albonico, Marco. Fondazione Ivo de Carneri; ItaliaFil: Ame, Shaali M.. Public Health Laboratory-Ivo De Carneri; TanzaniaFil: Behnke, Jerzy M.. The University Of Nottingham; Reino UnidoFil: Bethony, Jeffrey M.. The George Washington University; Estados UnidosFil: Noumedem, Calvine D.. University of Yaoundé; CamerúnFil: Engels, Dirk. World Health Organization. Department of Control of Neglected Tropical Diseases; SuizaFil: Guillard, Bertrand. Pasteur Institute; CamboyaFil: Kotze, Andrew. Commonwealth Scientific and Industrial Research Organisation; AustraliaFil: Krolewiecki, Alejandro Javier. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; ArgentinaFil: McCarthy, James. The University Of Queensland; AustraliaFil: Mekonnen, Zeleke. Jimma University; EtiopíaFil: Periago, Maria V.. Fundación Oswaldo Cruz. Instituto Rene Rachou; BrasilFil: Sopheak, Hem. Pasteur Institute; CamboyaFil: Tchuem Tchuente, Louis Albert. University of Youndé; CamerúnFil: Duong, Tran Thanh. National Institute of Malariology; VietnamFil: Huong, Nguyen Thu. National Institute of Malariology; VietnamFil: Zeynudin, Ahmed. Jimma University; EtiopíaFil: Vercruysse, Jozef. University Of Ghent. Department of Virology, Parasitology and Immunology; BélgicaPublic Library Of Science2014-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7017Levecke, Bruno; Montresor, Antonio; Albonico, Marco; Ame, Shaali M.; Behnke, Jerzy M.; et al.; Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are Endemic; Public Library Of Science; Neglected Tropical Diseases; 8; 10; 10-2014; 1-121935-2735enginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0003204info:eu-repo/semantics/altIdentifier/pmid/PMC4191962info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191962/info:eu-repo/semantics/altIdentifier/url/https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-016-1406-8info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:16Zoai:ri.conicet.gov.ar:11336/7017instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:16.523CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are Endemic |
| title |
Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are Endemic |
| spellingShingle |
Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are Endemic Levecke, Bruno MEBENDAZOL TRICHURIS TRICHIURA ASCARIS LUMBRICOIDES HOOKWORM |
| title_short |
Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are Endemic |
| title_full |
Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are Endemic |
| title_fullStr |
Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are Endemic |
| title_full_unstemmed |
Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are Endemic |
| title_sort |
Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are Endemic |
| dc.creator.none.fl_str_mv |
Levecke, Bruno Montresor, Antonio Albonico, Marco Ame, Shaali M. Behnke, Jerzy M. Bethony, Jeffrey M. Noumedem, Calvine D. Engels, Dirk Guillard, Bertrand Kotze, Andrew Krolewiecki, Alejandro Javier McCarthy, James Mekonnen, Zeleke Periago, Maria V. Sopheak, Hem Tchuem Tchuente, Louis Albert Duong, Tran Thanh Huong, Nguyen Thu Zeynudin, Ahmed Vercruysse, Jozef |
| author |
Levecke, Bruno |
| author_facet |
Levecke, Bruno Montresor, Antonio Albonico, Marco Ame, Shaali M. Behnke, Jerzy M. Bethony, Jeffrey M. Noumedem, Calvine D. Engels, Dirk Guillard, Bertrand Kotze, Andrew Krolewiecki, Alejandro Javier McCarthy, James Mekonnen, Zeleke Periago, Maria V. Sopheak, Hem Tchuem Tchuente, Louis Albert Duong, Tran Thanh Huong, Nguyen Thu Zeynudin, Ahmed Vercruysse, Jozef |
| author_role |
author |
| author2 |
Montresor, Antonio Albonico, Marco Ame, Shaali M. Behnke, Jerzy M. Bethony, Jeffrey M. Noumedem, Calvine D. Engels, Dirk Guillard, Bertrand Kotze, Andrew Krolewiecki, Alejandro Javier McCarthy, James Mekonnen, Zeleke Periago, Maria V. Sopheak, Hem Tchuem Tchuente, Louis Albert Duong, Tran Thanh Huong, Nguyen Thu Zeynudin, Ahmed Vercruysse, Jozef |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
MEBENDAZOL TRICHURIS TRICHIURA ASCARIS LUMBRICOIDES HOOKWORM |
| topic |
MEBENDAZOL TRICHURIS TRICHIURA ASCARIS LUMBRICOIDES HOOKWORM |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Background: Robust reference values for fecal egg count reduction (FECR) rates of the most widely used anthelmintic drugsin preventive chemotherapy (PC) programs for controlling soil-transmitted helminths (STHs; Ascaris lumbricoides, Trichuristrichiura, and hookworm) are still lacking. However, they are urgently needed to ensure detection of reduced efficacies thatare predicted to occur due to growing drug pressure. Here, using a standardized methodology, we assessed the FECR rateof a single oral dose of mebendazole (MEB; 500 mg) against STHs in six trials in school children in different locations aroundthe world. Our results are compared with those previously obtained for similarly conducted trials of a single oral dose ofalbendazole (ALB; 400 mg).Methodology: The efficacy of MEB, as assessed by FECR, was determined in six trials involving 5,830 school children in Brazil,Cambodia, Cameroon, Ethiopia, United Republic of Tanzania, and Vietnam. The efficacy of MEB was compared to that of ALBas previously assessed in 8,841 school children in India and all the above-mentioned study sites, using identicalmethodologies.Principal Findings: The estimated FECR rate [95% confidence interval] of MEB was highest for A. lumbricoides (97.6% [95.8;99.5]), followed by hookworm (79.6% [71.0; 88.3]). For T. trichiura, the estimated FECR rate was 63.1% [51.6; 74.6]. Comparedto MEB, ALB was significantly more efficacious against hookworm (96.2% [91.1; 100], p,0.001) and only marginally,although significantly, better against A. lumbricoides infections (99.9% [99.0; 100], p = 0.012), but equally efficacious for T.trichiura infections (64.5% [44.4; 84.7], p = 0.906).Conclusions/Significance: A minimum FECR rate of 95% for A. lumbricoides, 70% for hookworm, and 50% for T. trichiura isexpected in MEB-dependent PC programs. Lower FECR results may indicate the development of potential drug resistance Fil: Levecke, Bruno. University Of Ghent. Department of Virology, Parasitology and Immunology; Bélgica Fil: Montresor, Antonio. World Health Organization. Department of Control of Neglected Tropical Diseases; Suiza Fil: Albonico, Marco. Fondazione Ivo de Carneri; Italia Fil: Ame, Shaali M.. Public Health Laboratory-Ivo De Carneri; Tanzania Fil: Behnke, Jerzy M.. The University Of Nottingham; Reino Unido Fil: Bethony, Jeffrey M.. The George Washington University; Estados Unidos Fil: Noumedem, Calvine D.. University of Yaoundé; Camerún Fil: Engels, Dirk. World Health Organization. Department of Control of Neglected Tropical Diseases; Suiza Fil: Guillard, Bertrand. Pasteur Institute; Camboya Fil: Kotze, Andrew. Commonwealth Scientific and Industrial Research Organisation; Australia Fil: Krolewiecki, Alejandro Javier. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Patología Experimental; Argentina Fil: McCarthy, James. The University Of Queensland; Australia Fil: Mekonnen, Zeleke. Jimma University; Etiopía Fil: Periago, Maria V.. Fundación Oswaldo Cruz. Instituto Rene Rachou; Brasil Fil: Sopheak, Hem. Pasteur Institute; Camboya Fil: Tchuem Tchuente, Louis Albert. University of Youndé; Camerún Fil: Duong, Tran Thanh. National Institute of Malariology; Vietnam Fil: Huong, Nguyen Thu. National Institute of Malariology; Vietnam Fil: Zeynudin, Ahmed. Jimma University; Etiopía Fil: Vercruysse, Jozef. University Of Ghent. Department of Virology, Parasitology and Immunology; Bélgica |
| description |
Background: Robust reference values for fecal egg count reduction (FECR) rates of the most widely used anthelmintic drugsin preventive chemotherapy (PC) programs for controlling soil-transmitted helminths (STHs; Ascaris lumbricoides, Trichuristrichiura, and hookworm) are still lacking. However, they are urgently needed to ensure detection of reduced efficacies thatare predicted to occur due to growing drug pressure. Here, using a standardized methodology, we assessed the FECR rateof a single oral dose of mebendazole (MEB; 500 mg) against STHs in six trials in school children in different locations aroundthe world. Our results are compared with those previously obtained for similarly conducted trials of a single oral dose ofalbendazole (ALB; 400 mg).Methodology: The efficacy of MEB, as assessed by FECR, was determined in six trials involving 5,830 school children in Brazil,Cambodia, Cameroon, Ethiopia, United Republic of Tanzania, and Vietnam. The efficacy of MEB was compared to that of ALBas previously assessed in 8,841 school children in India and all the above-mentioned study sites, using identicalmethodologies.Principal Findings: The estimated FECR rate [95% confidence interval] of MEB was highest for A. lumbricoides (97.6% [95.8;99.5]), followed by hookworm (79.6% [71.0; 88.3]). For T. trichiura, the estimated FECR rate was 63.1% [51.6; 74.6]. Comparedto MEB, ALB was significantly more efficacious against hookworm (96.2% [91.1; 100], p,0.001) and only marginally,although significantly, better against A. lumbricoides infections (99.9% [99.0; 100], p = 0.012), but equally efficacious for T.trichiura infections (64.5% [44.4; 84.7], p = 0.906).Conclusions/Significance: A minimum FECR rate of 95% for A. lumbricoides, 70% for hookworm, and 50% for T. trichiura isexpected in MEB-dependent PC programs. Lower FECR results may indicate the development of potential drug resistance |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014-10 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/7017 Levecke, Bruno; Montresor, Antonio; Albonico, Marco; Ame, Shaali M.; Behnke, Jerzy M.; et al.; Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are Endemic; Public Library Of Science; Neglected Tropical Diseases; 8; 10; 10-2014; 1-12 1935-2735 |
| url |
http://hdl.handle.net/11336/7017 |
| identifier_str_mv |
Levecke, Bruno; Montresor, Antonio; Albonico, Marco; Ame, Shaali M.; Behnke, Jerzy M.; et al.; Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are Endemic; Public Library Of Science; Neglected Tropical Diseases; 8; 10; 10-2014; 1-12 1935-2735 |
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eng |
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eng |
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info:eu-repo/semantics/altIdentifier/doi/ info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0003204 info:eu-repo/semantics/altIdentifier/pmid/PMC4191962 info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191962/ info:eu-repo/semantics/altIdentifier/url/https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-016-1406-8 |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
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Public Library Of Science |
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