pH and ion-selective swelling behaviour of keratin and keratose 3D hydrogels
- Autores
- Galaburri, Gonzalo; Peralta Ramos, María Luz; Lazaro Martinez, Juan Manuel; Fernández de Luis, Roberto; Arriortua, María Isabel; Villanueva, María Emilia; Copello, Guillermo Javier
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The oxidation of keratin hydrogels was optimized aiming to obtain keratose hydrogels while maintaining the original 3D structure and pH-responsive behaviour. In addition, we present a comparative study of their dual-stimuli responsive behaviour regarding the pH-responsiveness and their previously non-described ion selective responsiveness. Keratose and keratin hydrogels showed similar swellings when contracted at low pH, and the former showed steeper expansion and higher swelling than the latter at high pH. In addition, both hydrogels showed selective responsiveness toward Ca2+ ions when expanded, and toward Cu2+ ions when contracted. IR, Raman, ss-NMR, HRMAS NMR, SAXS, and thermal characterization demonstrated that oxidation does not interfere with the stimuli-responsive mechanisms related to protein conformation. The higher swelling of keratose hydrogels would be originated in the increase of the mobility of the chains after oxidation coupled to the hydration of sulfonic acid groups.
Fil: Galaburri, Gonzalo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química Analítica Instrumental; Argentina
Fil: Peralta Ramos, María Luz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química Analítica Instrumental; Argentina
Fil: Lazaro Martinez, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Fernández de Luis, Roberto. No especifíca;
Fil: Arriortua, María Isabel. Universidad del País Vasco; España
Fil: Villanueva, María Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Copello, Guillermo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina - Materia
-
HYDROGEL
KERATIN
KERATOSE
SMART MATERIAL
STIMULI-RESPONSIVE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/120283
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/120283 |
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CONICET Digital (CONICET) |
spelling |
pH and ion-selective swelling behaviour of keratin and keratose 3D hydrogelsGalaburri, GonzaloPeralta Ramos, María LuzLazaro Martinez, Juan ManuelFernández de Luis, RobertoArriortua, María IsabelVillanueva, María EmiliaCopello, Guillermo JavierHYDROGELKERATINKERATOSESMART MATERIALSTIMULI-RESPONSIVEhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The oxidation of keratin hydrogels was optimized aiming to obtain keratose hydrogels while maintaining the original 3D structure and pH-responsive behaviour. In addition, we present a comparative study of their dual-stimuli responsive behaviour regarding the pH-responsiveness and their previously non-described ion selective responsiveness. Keratose and keratin hydrogels showed similar swellings when contracted at low pH, and the former showed steeper expansion and higher swelling than the latter at high pH. In addition, both hydrogels showed selective responsiveness toward Ca2+ ions when expanded, and toward Cu2+ ions when contracted. IR, Raman, ss-NMR, HRMAS NMR, SAXS, and thermal characterization demonstrated that oxidation does not interfere with the stimuli-responsive mechanisms related to protein conformation. The higher swelling of keratose hydrogels would be originated in the increase of the mobility of the chains after oxidation coupled to the hydration of sulfonic acid groups.Fil: Galaburri, Gonzalo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química Analítica Instrumental; ArgentinaFil: Peralta Ramos, María Luz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química Analítica Instrumental; ArgentinaFil: Lazaro Martinez, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Fernández de Luis, Roberto. No especifíca;Fil: Arriortua, María Isabel. Universidad del País Vasco; EspañaFil: Villanueva, María Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Copello, Guillermo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaPergamon-Elsevier Science Ltd2019-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/120283Galaburri, Gonzalo; Peralta Ramos, María Luz; Lazaro Martinez, Juan Manuel; Fernández de Luis, Roberto; Arriortua, María Isabel; et al.; pH and ion-selective swelling behaviour of keratin and keratose 3D hydrogels; Pergamon-Elsevier Science Ltd; European Polymer Journal; 118; 9-2019; 1-90014-3057CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0014305719303623info:eu-repo/semantics/altIdentifier/doi/10.1016/j.eurpolymj.2019.05.043info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:47:41Zoai:ri.conicet.gov.ar:11336/120283instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:47:41.415CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
pH and ion-selective swelling behaviour of keratin and keratose 3D hydrogels |
title |
pH and ion-selective swelling behaviour of keratin and keratose 3D hydrogels |
spellingShingle |
pH and ion-selective swelling behaviour of keratin and keratose 3D hydrogels Galaburri, Gonzalo HYDROGEL KERATIN KERATOSE SMART MATERIAL STIMULI-RESPONSIVE |
title_short |
pH and ion-selective swelling behaviour of keratin and keratose 3D hydrogels |
title_full |
pH and ion-selective swelling behaviour of keratin and keratose 3D hydrogels |
title_fullStr |
pH and ion-selective swelling behaviour of keratin and keratose 3D hydrogels |
title_full_unstemmed |
pH and ion-selective swelling behaviour of keratin and keratose 3D hydrogels |
title_sort |
pH and ion-selective swelling behaviour of keratin and keratose 3D hydrogels |
dc.creator.none.fl_str_mv |
Galaburri, Gonzalo Peralta Ramos, María Luz Lazaro Martinez, Juan Manuel Fernández de Luis, Roberto Arriortua, María Isabel Villanueva, María Emilia Copello, Guillermo Javier |
author |
Galaburri, Gonzalo |
author_facet |
Galaburri, Gonzalo Peralta Ramos, María Luz Lazaro Martinez, Juan Manuel Fernández de Luis, Roberto Arriortua, María Isabel Villanueva, María Emilia Copello, Guillermo Javier |
author_role |
author |
author2 |
Peralta Ramos, María Luz Lazaro Martinez, Juan Manuel Fernández de Luis, Roberto Arriortua, María Isabel Villanueva, María Emilia Copello, Guillermo Javier |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
HYDROGEL KERATIN KERATOSE SMART MATERIAL STIMULI-RESPONSIVE |
topic |
HYDROGEL KERATIN KERATOSE SMART MATERIAL STIMULI-RESPONSIVE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The oxidation of keratin hydrogels was optimized aiming to obtain keratose hydrogels while maintaining the original 3D structure and pH-responsive behaviour. In addition, we present a comparative study of their dual-stimuli responsive behaviour regarding the pH-responsiveness and their previously non-described ion selective responsiveness. Keratose and keratin hydrogels showed similar swellings when contracted at low pH, and the former showed steeper expansion and higher swelling than the latter at high pH. In addition, both hydrogels showed selective responsiveness toward Ca2+ ions when expanded, and toward Cu2+ ions when contracted. IR, Raman, ss-NMR, HRMAS NMR, SAXS, and thermal characterization demonstrated that oxidation does not interfere with the stimuli-responsive mechanisms related to protein conformation. The higher swelling of keratose hydrogels would be originated in the increase of the mobility of the chains after oxidation coupled to the hydration of sulfonic acid groups. Fil: Galaburri, Gonzalo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química Analítica Instrumental; Argentina Fil: Peralta Ramos, María Luz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química Analítica Instrumental; Argentina Fil: Lazaro Martinez, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina Fil: Fernández de Luis, Roberto. No especifíca; Fil: Arriortua, María Isabel. Universidad del País Vasco; España Fil: Villanueva, María Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina Fil: Copello, Guillermo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina |
description |
The oxidation of keratin hydrogels was optimized aiming to obtain keratose hydrogels while maintaining the original 3D structure and pH-responsive behaviour. In addition, we present a comparative study of their dual-stimuli responsive behaviour regarding the pH-responsiveness and their previously non-described ion selective responsiveness. Keratose and keratin hydrogels showed similar swellings when contracted at low pH, and the former showed steeper expansion and higher swelling than the latter at high pH. In addition, both hydrogels showed selective responsiveness toward Ca2+ ions when expanded, and toward Cu2+ ions when contracted. IR, Raman, ss-NMR, HRMAS NMR, SAXS, and thermal characterization demonstrated that oxidation does not interfere with the stimuli-responsive mechanisms related to protein conformation. The higher swelling of keratose hydrogels would be originated in the increase of the mobility of the chains after oxidation coupled to the hydration of sulfonic acid groups. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/120283 Galaburri, Gonzalo; Peralta Ramos, María Luz; Lazaro Martinez, Juan Manuel; Fernández de Luis, Roberto; Arriortua, María Isabel; et al.; pH and ion-selective swelling behaviour of keratin and keratose 3D hydrogels; Pergamon-Elsevier Science Ltd; European Polymer Journal; 118; 9-2019; 1-9 0014-3057 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/120283 |
identifier_str_mv |
Galaburri, Gonzalo; Peralta Ramos, María Luz; Lazaro Martinez, Juan Manuel; Fernández de Luis, Roberto; Arriortua, María Isabel; et al.; pH and ion-selective swelling behaviour of keratin and keratose 3D hydrogels; Pergamon-Elsevier Science Ltd; European Polymer Journal; 118; 9-2019; 1-9 0014-3057 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0014305719303623 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.eurpolymj.2019.05.043 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613485296615424 |
score |
13.070432 |