Revisting the roles of progesterone and allopregnanolone in the nervous system: resurgence of the progesterone receptors

Autores
Schumacher, M.; Mattern, C.; Ghoumari, A.; Oudinet, J. P.; Liere, P.; Labombarda, Maria Florencia; Sitruk Ware, Régine; de Nicola, Alejandro Federico; Guennoun, R.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Progesterone is commonly considered as a female reproductive hormone and is well-known for its role in pregnancy. It is less well appreciated that progesterone and its metabolite allopregnanolone are also male hormones, as they are produced in both sexes by the adrenal glands. In addition, they are synthesized within the nervous system. Progesterone and allopregnanolone are associated with adaptation to stress, and increased production of progesterone within the brain may be part of the response of neural cells to injury. Progesterone receptors (PR) are widely distributed throughout the brain, but their study has been mainly limited to the hypothalamus and reproductive functions, and the extra-hypothalamic receptors have been neglected. This lack of information about brain functions of PR is unexpected, as the protective and trophic effects of progesterone are much investigated, and as the therapeutic potential of progesterone as a neuroprotective and promyelinating agent is currently being assessed in clinical trials. The little attention devoted to the brain functions of PR may relate to the widely accepted assumption that non-reproductive actions of progesterone may be mainly mediated by allopregnanolone, which does not bind to PR, but acts as a potent positive modulator of γ-aminobutyric acid type A (GABA(A) receptors. The aim of this review is to critically discuss effects of progesterone on the nervous system via PR, and of allopregnanolone via its modulation of GABA(A) receptors, with main focus on the brain.
Fil: Schumacher, M.. Inserm; Francia
Fil: Mattern, C.. MetP Pharma AG ; Suiza
Fil: Ghoumari, A.. Inserm; Francia
Fil: Oudinet, J. P.. Inserm; Francia
Fil: Liere, P.. Inserm; Francia
Fil: Labombarda, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Sitruk Ware, Régine. The Rockefeller University; Estados Unidos. Population Council. Center for Biomedical Research ; Estados Unidos
Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Guennoun, R.. Inserm; Francia
Materia
Progesterone Receptors
Allopregnanolone
Neuroprotection
Myelin
Gab a (A)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6678
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/6678
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Revisting the roles of progesterone and allopregnanolone in the nervous system: resurgence of the progesterone receptorsSchumacher, M.Mattern, C.Ghoumari, A.Oudinet, J. P.Liere, P.Labombarda, Maria FlorenciaSitruk Ware, Réginede Nicola, Alejandro FedericoGuennoun, R.Progesterone ReceptorsAllopregnanoloneNeuroprotectionMyelinGab a (A)https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Progesterone is commonly considered as a female reproductive hormone and is well-known for its role in pregnancy. It is less well appreciated that progesterone and its metabolite allopregnanolone are also male hormones, as they are produced in both sexes by the adrenal glands. In addition, they are synthesized within the nervous system. Progesterone and allopregnanolone are associated with adaptation to stress, and increased production of progesterone within the brain may be part of the response of neural cells to injury. Progesterone receptors (PR) are widely distributed throughout the brain, but their study has been mainly limited to the hypothalamus and reproductive functions, and the extra-hypothalamic receptors have been neglected. This lack of information about brain functions of PR is unexpected, as the protective and trophic effects of progesterone are much investigated, and as the therapeutic potential of progesterone as a neuroprotective and promyelinating agent is currently being assessed in clinical trials. The little attention devoted to the brain functions of PR may relate to the widely accepted assumption that non-reproductive actions of progesterone may be mainly mediated by allopregnanolone, which does not bind to PR, but acts as a potent positive modulator of γ-aminobutyric acid type A (GABA(A) receptors. The aim of this review is to critically discuss effects of progesterone on the nervous system via PR, and of allopregnanolone via its modulation of GABA(A) receptors, with main focus on the brain.Fil: Schumacher, M.. Inserm; FranciaFil: Mattern, C.. MetP Pharma AG ; SuizaFil: Ghoumari, A.. Inserm; FranciaFil: Oudinet, J. P.. Inserm; FranciaFil: Liere, P.. Inserm; FranciaFil: Labombarda, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Sitruk Ware, Régine. The Rockefeller University; Estados Unidos. Population Council. Center for Biomedical Research ; Estados UnidosFil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Guennoun, R.. Inserm; FranciaElsevier2014-02-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6678Schumacher, M.; Mattern, C.; Ghoumari, A.; Oudinet, J. P.; Liere, P.; et al.; Revisting the roles of progesterone and allopregnanolone in the nervous system: resurgence of the progesterone receptors; Elsevier; Progress In Neurobiology; 113; 28-2-2014; 6-390301-00821873-5118enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.pneurobio.2013.09.004info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/pmid/24172649info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S030100821300097Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:58Zoai:ri.conicet.gov.ar:11336/6678instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:58.697CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Revisting the roles of progesterone and allopregnanolone in the nervous system: resurgence of the progesterone receptors
title Revisting the roles of progesterone and allopregnanolone in the nervous system: resurgence of the progesterone receptors
spellingShingle Revisting the roles of progesterone and allopregnanolone in the nervous system: resurgence of the progesterone receptors
Schumacher, M.
Progesterone Receptors
Allopregnanolone
Neuroprotection
Myelin
Gab a (A)
title_short Revisting the roles of progesterone and allopregnanolone in the nervous system: resurgence of the progesterone receptors
title_full Revisting the roles of progesterone and allopregnanolone in the nervous system: resurgence of the progesterone receptors
title_fullStr Revisting the roles of progesterone and allopregnanolone in the nervous system: resurgence of the progesterone receptors
title_full_unstemmed Revisting the roles of progesterone and allopregnanolone in the nervous system: resurgence of the progesterone receptors
title_sort Revisting the roles of progesterone and allopregnanolone in the nervous system: resurgence of the progesterone receptors
dc.creator.none.fl_str_mv Schumacher, M.
Mattern, C.
Ghoumari, A.
Oudinet, J. P.
Liere, P.
Labombarda, Maria Florencia
Sitruk Ware, Régine
de Nicola, Alejandro Federico
Guennoun, R.
author Schumacher, M.
author_facet Schumacher, M.
Mattern, C.
Ghoumari, A.
Oudinet, J. P.
Liere, P.
Labombarda, Maria Florencia
Sitruk Ware, Régine
de Nicola, Alejandro Federico
Guennoun, R.
author_role author
author2 Mattern, C.
Ghoumari, A.
Oudinet, J. P.
Liere, P.
Labombarda, Maria Florencia
Sitruk Ware, Régine
de Nicola, Alejandro Federico
Guennoun, R.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Progesterone Receptors
Allopregnanolone
Neuroprotection
Myelin
Gab a (A)
topic Progesterone Receptors
Allopregnanolone
Neuroprotection
Myelin
Gab a (A)
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Progesterone is commonly considered as a female reproductive hormone and is well-known for its role in pregnancy. It is less well appreciated that progesterone and its metabolite allopregnanolone are also male hormones, as they are produced in both sexes by the adrenal glands. In addition, they are synthesized within the nervous system. Progesterone and allopregnanolone are associated with adaptation to stress, and increased production of progesterone within the brain may be part of the response of neural cells to injury. Progesterone receptors (PR) are widely distributed throughout the brain, but their study has been mainly limited to the hypothalamus and reproductive functions, and the extra-hypothalamic receptors have been neglected. This lack of information about brain functions of PR is unexpected, as the protective and trophic effects of progesterone are much investigated, and as the therapeutic potential of progesterone as a neuroprotective and promyelinating agent is currently being assessed in clinical trials. The little attention devoted to the brain functions of PR may relate to the widely accepted assumption that non-reproductive actions of progesterone may be mainly mediated by allopregnanolone, which does not bind to PR, but acts as a potent positive modulator of γ-aminobutyric acid type A (GABA(A) receptors. The aim of this review is to critically discuss effects of progesterone on the nervous system via PR, and of allopregnanolone via its modulation of GABA(A) receptors, with main focus on the brain.
Fil: Schumacher, M.. Inserm; Francia
Fil: Mattern, C.. MetP Pharma AG ; Suiza
Fil: Ghoumari, A.. Inserm; Francia
Fil: Oudinet, J. P.. Inserm; Francia
Fil: Liere, P.. Inserm; Francia
Fil: Labombarda, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Sitruk Ware, Régine. The Rockefeller University; Estados Unidos. Population Council. Center for Biomedical Research ; Estados Unidos
Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Guennoun, R.. Inserm; Francia
description Progesterone is commonly considered as a female reproductive hormone and is well-known for its role in pregnancy. It is less well appreciated that progesterone and its metabolite allopregnanolone are also male hormones, as they are produced in both sexes by the adrenal glands. In addition, they are synthesized within the nervous system. Progesterone and allopregnanolone are associated with adaptation to stress, and increased production of progesterone within the brain may be part of the response of neural cells to injury. Progesterone receptors (PR) are widely distributed throughout the brain, but their study has been mainly limited to the hypothalamus and reproductive functions, and the extra-hypothalamic receptors have been neglected. This lack of information about brain functions of PR is unexpected, as the protective and trophic effects of progesterone are much investigated, and as the therapeutic potential of progesterone as a neuroprotective and promyelinating agent is currently being assessed in clinical trials. The little attention devoted to the brain functions of PR may relate to the widely accepted assumption that non-reproductive actions of progesterone may be mainly mediated by allopregnanolone, which does not bind to PR, but acts as a potent positive modulator of γ-aminobutyric acid type A (GABA(A) receptors. The aim of this review is to critically discuss effects of progesterone on the nervous system via PR, and of allopregnanolone via its modulation of GABA(A) receptors, with main focus on the brain.
publishDate 2014
dc.date.none.fl_str_mv 2014-02-28
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6678
Schumacher, M.; Mattern, C.; Ghoumari, A.; Oudinet, J. P.; Liere, P.; et al.; Revisting the roles of progesterone and allopregnanolone in the nervous system: resurgence of the progesterone receptors; Elsevier; Progress In Neurobiology; 113; 28-2-2014; 6-39
0301-0082
1873-5118
url http://hdl.handle.net/11336/6678
identifier_str_mv Schumacher, M.; Mattern, C.; Ghoumari, A.; Oudinet, J. P.; Liere, P.; et al.; Revisting the roles of progesterone and allopregnanolone in the nervous system: resurgence of the progesterone receptors; Elsevier; Progress In Neurobiology; 113; 28-2-2014; 6-39
0301-0082
1873-5118
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pneurobio.2013.09.004
info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/pmid/24172649
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S030100821300097X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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