Allopregnanolone and progesterone in experimental neuropathic pain: former and new insights with a translational perspective

Autores
Gonzalez, Susana Laura; Meyer, Laurence; Raggio, María Celeste; Taleb, Omar; Coronel, Maria Florencia; Patte Mensah, Christine; Mensah-Nyagan, Ayikoe Guy
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In the last decades, an active and stimulating area of research has been devoted to explore the role of neuroactive steroids in pain modulation. Despite challenges, these studies have clearly contributed to unravel the multiple and complex actions and potential mechanisms underlying steroid effects in several experimental conditions that mimic human chronic pain states. Based on the available data, this review focuses mainly on progesterone and its reduced derivative allopregnanolone (also called 3α,5α-tetrahydroprogesterone) which have been shown to prevent or even reverse the complex maladaptive changes and pain behaviors that arise in the nervous system after injury or disease. Because the characterization of new related molecules with improved specificity and enhanced pharmacological profiles may represent a crucial step to develop more efficient steroid-based therapies, we have also discussed the potential of novel synthetic analogs of allopregnanolone as valuable molecules for the treatment of neuropathic pain.
Fil: Gonzalez, Susana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
Fil: Meyer, Laurence. Université de Strasbourg; Francia
Fil: Raggio, María Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Taleb, Omar. Université de Strasbourg; Francia
Fil: Coronel, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Patte Mensah, Christine. Université de Strasbourg; Francia
Fil: Mensah-Nyagan, Ayikoe Guy. Université de Strasbourg; Francia
Materia
CHRONIC PAIN
ALLOPREGNANOLONE
PROGESTERONE
ALLODYNIA
MITOCHONDRIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/87375
Acceder
id CONICETDig_f4daea117eb2bd018beba74fc8b79358
oai_identifier_str oai:ri.conicet.gov.ar:11336/87375
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Allopregnanolone and progesterone in experimental neuropathic pain: former and new insights with a translational perspectiveGonzalez, Susana LauraMeyer, LaurenceRaggio, María CelesteTaleb, OmarCoronel, Maria FlorenciaPatte Mensah, ChristineMensah-Nyagan, Ayikoe GuyCHRONIC PAINALLOPREGNANOLONEPROGESTERONEALLODYNIAMITOCHONDRIAhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In the last decades, an active and stimulating area of research has been devoted to explore the role of neuroactive steroids in pain modulation. Despite challenges, these studies have clearly contributed to unravel the multiple and complex actions and potential mechanisms underlying steroid effects in several experimental conditions that mimic human chronic pain states. Based on the available data, this review focuses mainly on progesterone and its reduced derivative allopregnanolone (also called 3α,5α-tetrahydroprogesterone) which have been shown to prevent or even reverse the complex maladaptive changes and pain behaviors that arise in the nervous system after injury or disease. Because the characterization of new related molecules with improved specificity and enhanced pharmacological profiles may represent a crucial step to develop more efficient steroid-based therapies, we have also discussed the potential of novel synthetic analogs of allopregnanolone as valuable molecules for the treatment of neuropathic pain.Fil: Gonzalez, Susana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; ArgentinaFil: Meyer, Laurence. Université de Strasbourg; FranciaFil: Raggio, María Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Taleb, Omar. Université de Strasbourg; FranciaFil: Coronel, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Patte Mensah, Christine. Université de Strasbourg; FranciaFil: Mensah-Nyagan, Ayikoe Guy. Université de Strasbourg; FranciaSpringer/Plenum Publishers2018-09-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/87375Gonzalez, Susana Laura; Meyer, Laurence; Raggio, María Celeste; Taleb, Omar; Coronel, Maria Florencia; et al.; Allopregnanolone and progesterone in experimental neuropathic pain: former and new insights with a translational perspective; Springer/Plenum Publishers; Cellular And Molecular Neurobiology.; 39; 4; 30-9-2018; 523-5370272-4340CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs10571-018-0618-info:eu-repo/semantics/altIdentifier/url/10.1007%2Fs10571-018-0618-1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:43:12Zoai:ri.conicet.gov.ar:11336/87375instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:43:12.349CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Allopregnanolone and progesterone in experimental neuropathic pain: former and new insights with a translational perspective
title Allopregnanolone and progesterone in experimental neuropathic pain: former and new insights with a translational perspective
spellingShingle Allopregnanolone and progesterone in experimental neuropathic pain: former and new insights with a translational perspective
Gonzalez, Susana Laura
CHRONIC PAIN
ALLOPREGNANOLONE
PROGESTERONE
ALLODYNIA
MITOCHONDRIA
title_short Allopregnanolone and progesterone in experimental neuropathic pain: former and new insights with a translational perspective
title_full Allopregnanolone and progesterone in experimental neuropathic pain: former and new insights with a translational perspective
title_fullStr Allopregnanolone and progesterone in experimental neuropathic pain: former and new insights with a translational perspective
title_full_unstemmed Allopregnanolone and progesterone in experimental neuropathic pain: former and new insights with a translational perspective
title_sort Allopregnanolone and progesterone in experimental neuropathic pain: former and new insights with a translational perspective
dc.creator.none.fl_str_mv Gonzalez, Susana Laura
Meyer, Laurence
Raggio, María Celeste
Taleb, Omar
Coronel, Maria Florencia
Patte Mensah, Christine
Mensah-Nyagan, Ayikoe Guy
author Gonzalez, Susana Laura
author_facet Gonzalez, Susana Laura
Meyer, Laurence
Raggio, María Celeste
Taleb, Omar
Coronel, Maria Florencia
Patte Mensah, Christine
Mensah-Nyagan, Ayikoe Guy
author_role author
author2 Meyer, Laurence
Raggio, María Celeste
Taleb, Omar
Coronel, Maria Florencia
Patte Mensah, Christine
Mensah-Nyagan, Ayikoe Guy
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CHRONIC PAIN
ALLOPREGNANOLONE
PROGESTERONE
ALLODYNIA
MITOCHONDRIA
topic CHRONIC PAIN
ALLOPREGNANOLONE
PROGESTERONE
ALLODYNIA
MITOCHONDRIA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In the last decades, an active and stimulating area of research has been devoted to explore the role of neuroactive steroids in pain modulation. Despite challenges, these studies have clearly contributed to unravel the multiple and complex actions and potential mechanisms underlying steroid effects in several experimental conditions that mimic human chronic pain states. Based on the available data, this review focuses mainly on progesterone and its reduced derivative allopregnanolone (also called 3α,5α-tetrahydroprogesterone) which have been shown to prevent or even reverse the complex maladaptive changes and pain behaviors that arise in the nervous system after injury or disease. Because the characterization of new related molecules with improved specificity and enhanced pharmacological profiles may represent a crucial step to develop more efficient steroid-based therapies, we have also discussed the potential of novel synthetic analogs of allopregnanolone as valuable molecules for the treatment of neuropathic pain.
Fil: Gonzalez, Susana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
Fil: Meyer, Laurence. Université de Strasbourg; Francia
Fil: Raggio, María Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Taleb, Omar. Université de Strasbourg; Francia
Fil: Coronel, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Patte Mensah, Christine. Université de Strasbourg; Francia
Fil: Mensah-Nyagan, Ayikoe Guy. Université de Strasbourg; Francia
description In the last decades, an active and stimulating area of research has been devoted to explore the role of neuroactive steroids in pain modulation. Despite challenges, these studies have clearly contributed to unravel the multiple and complex actions and potential mechanisms underlying steroid effects in several experimental conditions that mimic human chronic pain states. Based on the available data, this review focuses mainly on progesterone and its reduced derivative allopregnanolone (also called 3α,5α-tetrahydroprogesterone) which have been shown to prevent or even reverse the complex maladaptive changes and pain behaviors that arise in the nervous system after injury or disease. Because the characterization of new related molecules with improved specificity and enhanced pharmacological profiles may represent a crucial step to develop more efficient steroid-based therapies, we have also discussed the potential of novel synthetic analogs of allopregnanolone as valuable molecules for the treatment of neuropathic pain.
publishDate 2018
dc.date.none.fl_str_mv 2018-09-30
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/87375
Gonzalez, Susana Laura; Meyer, Laurence; Raggio, María Celeste; Taleb, Omar; Coronel, Maria Florencia; et al.; Allopregnanolone and progesterone in experimental neuropathic pain: former and new insights with a translational perspective; Springer/Plenum Publishers; Cellular And Molecular Neurobiology.; 39; 4; 30-9-2018; 523-537
0272-4340
CONICET Digital
CONICET
url http://hdl.handle.net/11336/87375
identifier_str_mv Gonzalez, Susana Laura; Meyer, Laurence; Raggio, María Celeste; Taleb, Omar; Coronel, Maria Florencia; et al.; Allopregnanolone and progesterone in experimental neuropathic pain: former and new insights with a translational perspective; Springer/Plenum Publishers; Cellular And Molecular Neurobiology.; 39; 4; 30-9-2018; 523-537
0272-4340
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs10571-018-0618-
info:eu-repo/semantics/altIdentifier/url/10.1007%2Fs10571-018-0618-1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer/Plenum Publishers
publisher.none.fl_str_mv Springer/Plenum Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613360053649408
score 13.070432

Publicaciones similares