Sequential treatment for idiopathic osteoporosis in premenopausal women: A case report
- Autores
- Mastaglia, Silvina Rosana
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Idiopathic osteoporosis (IOP) affects young, otherwise healthy individuals with intact gonadal function and no secondary cause for bone loss or fragility. IOP may be associated with major osteoporotic fractures such as low-trauma spine or hip. Aim: To evaluate the safety and effectiveness of sequential treatment in premenopausal women diagnosed with IOP. Case Presentation: A33-year-old premenopausal woman was referred by the Gynecology Department to evaluate bone and mineral metabolism.At 28 years of age, the patient had shown a fracture for bone fragility on her right hip. Attaining menarche at age 9, she had regular menstrual cycles (estradiol: 39.3pg/ml and follicle-stimulating hormone: 8.4mIU/l).At the time of consultation, she showed a bone mineral density (BMD, Hologic Equipment, Discovery Wi) in lumbar spine:0.720g/cm2; Z-score: -3.2, and in total left femur: 0.536g/cm2; Z-score: -3.3. No osteoporosis-provoking secondary causes were identified; thus, it was interpreted as IOP. She received sequential therapy (ST) with teriparatide(PTH1-34; Forteo; Eli Lilly&Co., Indianapolis, IN, USA) for two years, and then with densoumab 60mg s.c. (Prolia; Amgen Inc., California, CA, USA) associated with a calcium dietary supply of 1000mg/day and vitamin D3100.000IU/bi-monthly. Results: A 19% increase in LS BMD (least significant change [LSC]: 2.2%) and 16% in FIT (LSC: 3.0%) was observed. Conclusion: The ST was associated with large increase in BMD of LS and FIT in our patient. No adverse effects associated with teriparatide or denosumab were observed. Further clinical studies are necessary to determine the safety and effectiveness of ST in those premenopausal women withIOP. Until then, ST should be used with caution.
Fil: Mastaglia, Silvina Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
The Argentinian Society of Osteology and Mineral Metabolism Annual Meeting
Ciudad de Buenos Aires
Argentina
Asociación Argentina de Osteología y Metabolismo Mineral - Materia
-
OSTEOPOROSIS IDIOPATICA
TRATAMIENTO SECUENCIAL - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/154115
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Sequential treatment for idiopathic osteoporosis in premenopausal women: A case reportMastaglia, Silvina RosanaOSTEOPOROSIS IDIOPATICATRATAMIENTO SECUENCIALhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Idiopathic osteoporosis (IOP) affects young, otherwise healthy individuals with intact gonadal function and no secondary cause for bone loss or fragility. IOP may be associated with major osteoporotic fractures such as low-trauma spine or hip. Aim: To evaluate the safety and effectiveness of sequential treatment in premenopausal women diagnosed with IOP. Case Presentation: A33-year-old premenopausal woman was referred by the Gynecology Department to evaluate bone and mineral metabolism.At 28 years of age, the patient had shown a fracture for bone fragility on her right hip. Attaining menarche at age 9, she had regular menstrual cycles (estradiol: 39.3pg/ml and follicle-stimulating hormone: 8.4mIU/l).At the time of consultation, she showed a bone mineral density (BMD, Hologic Equipment, Discovery Wi) in lumbar spine:0.720g/cm2; Z-score: -3.2, and in total left femur: 0.536g/cm2; Z-score: -3.3. No osteoporosis-provoking secondary causes were identified; thus, it was interpreted as IOP. She received sequential therapy (ST) with teriparatide(PTH1-34; Forteo; Eli Lilly&Co., Indianapolis, IN, USA) for two years, and then with densoumab 60mg s.c. (Prolia; Amgen Inc., California, CA, USA) associated with a calcium dietary supply of 1000mg/day and vitamin D3100.000IU/bi-monthly. Results: A 19% increase in LS BMD (least significant change [LSC]: 2.2%) and 16% in FIT (LSC: 3.0%) was observed. Conclusion: The ST was associated with large increase in BMD of LS and FIT in our patient. No adverse effects associated with teriparatide or denosumab were observed. Further clinical studies are necessary to determine the safety and effectiveness of ST in those premenopausal women withIOP. Until then, ST should be used with caution.Fil: Mastaglia, Silvina Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaThe Argentinian Society of Osteology and Mineral Metabolism Annual MeetingCiudad de Buenos AiresArgentinaAsociación Argentina de Osteología y Metabolismo MineralWiley2020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/154115Sequential treatment for idiopathic osteoporosis in premenopausal women: A case report; The Argentinian Society of Osteology and Mineral Metabolism Annual Meeting; Ciudad de Buenos Aires; Argentina; 2019; 2-22473-4039CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://asbmr.onlinelibrary.wiley.com/doi/epdf/10.1002/jbm4.10340info:eu-repo/semantics/altIdentifier/doi/10.1002/jbm4.10340Nacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:45Zoai:ri.conicet.gov.ar:11336/154115instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:46.001CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Sequential treatment for idiopathic osteoporosis in premenopausal women: A case report |
title |
Sequential treatment for idiopathic osteoporosis in premenopausal women: A case report |
spellingShingle |
Sequential treatment for idiopathic osteoporosis in premenopausal women: A case report Mastaglia, Silvina Rosana OSTEOPOROSIS IDIOPATICA TRATAMIENTO SECUENCIAL |
title_short |
Sequential treatment for idiopathic osteoporosis in premenopausal women: A case report |
title_full |
Sequential treatment for idiopathic osteoporosis in premenopausal women: A case report |
title_fullStr |
Sequential treatment for idiopathic osteoporosis in premenopausal women: A case report |
title_full_unstemmed |
Sequential treatment for idiopathic osteoporosis in premenopausal women: A case report |
title_sort |
Sequential treatment for idiopathic osteoporosis in premenopausal women: A case report |
dc.creator.none.fl_str_mv |
Mastaglia, Silvina Rosana |
author |
Mastaglia, Silvina Rosana |
author_facet |
Mastaglia, Silvina Rosana |
author_role |
author |
dc.subject.none.fl_str_mv |
OSTEOPOROSIS IDIOPATICA TRATAMIENTO SECUENCIAL |
topic |
OSTEOPOROSIS IDIOPATICA TRATAMIENTO SECUENCIAL |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Idiopathic osteoporosis (IOP) affects young, otherwise healthy individuals with intact gonadal function and no secondary cause for bone loss or fragility. IOP may be associated with major osteoporotic fractures such as low-trauma spine or hip. Aim: To evaluate the safety and effectiveness of sequential treatment in premenopausal women diagnosed with IOP. Case Presentation: A33-year-old premenopausal woman was referred by the Gynecology Department to evaluate bone and mineral metabolism.At 28 years of age, the patient had shown a fracture for bone fragility on her right hip. Attaining menarche at age 9, she had regular menstrual cycles (estradiol: 39.3pg/ml and follicle-stimulating hormone: 8.4mIU/l).At the time of consultation, she showed a bone mineral density (BMD, Hologic Equipment, Discovery Wi) in lumbar spine:0.720g/cm2; Z-score: -3.2, and in total left femur: 0.536g/cm2; Z-score: -3.3. No osteoporosis-provoking secondary causes were identified; thus, it was interpreted as IOP. She received sequential therapy (ST) with teriparatide(PTH1-34; Forteo; Eli Lilly&Co., Indianapolis, IN, USA) for two years, and then with densoumab 60mg s.c. (Prolia; Amgen Inc., California, CA, USA) associated with a calcium dietary supply of 1000mg/day and vitamin D3100.000IU/bi-monthly. Results: A 19% increase in LS BMD (least significant change [LSC]: 2.2%) and 16% in FIT (LSC: 3.0%) was observed. Conclusion: The ST was associated with large increase in BMD of LS and FIT in our patient. No adverse effects associated with teriparatide or denosumab were observed. Further clinical studies are necessary to determine the safety and effectiveness of ST in those premenopausal women withIOP. Until then, ST should be used with caution. Fil: Mastaglia, Silvina Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina The Argentinian Society of Osteology and Mineral Metabolism Annual Meeting Ciudad de Buenos Aires Argentina Asociación Argentina de Osteología y Metabolismo Mineral |
description |
Idiopathic osteoporosis (IOP) affects young, otherwise healthy individuals with intact gonadal function and no secondary cause for bone loss or fragility. IOP may be associated with major osteoporotic fractures such as low-trauma spine or hip. Aim: To evaluate the safety and effectiveness of sequential treatment in premenopausal women diagnosed with IOP. Case Presentation: A33-year-old premenopausal woman was referred by the Gynecology Department to evaluate bone and mineral metabolism.At 28 years of age, the patient had shown a fracture for bone fragility on her right hip. Attaining menarche at age 9, she had regular menstrual cycles (estradiol: 39.3pg/ml and follicle-stimulating hormone: 8.4mIU/l).At the time of consultation, she showed a bone mineral density (BMD, Hologic Equipment, Discovery Wi) in lumbar spine:0.720g/cm2; Z-score: -3.2, and in total left femur: 0.536g/cm2; Z-score: -3.3. No osteoporosis-provoking secondary causes were identified; thus, it was interpreted as IOP. She received sequential therapy (ST) with teriparatide(PTH1-34; Forteo; Eli Lilly&Co., Indianapolis, IN, USA) for two years, and then with densoumab 60mg s.c. (Prolia; Amgen Inc., California, CA, USA) associated with a calcium dietary supply of 1000mg/day and vitamin D3100.000IU/bi-monthly. Results: A 19% increase in LS BMD (least significant change [LSC]: 2.2%) and 16% in FIT (LSC: 3.0%) was observed. Conclusion: The ST was associated with large increase in BMD of LS and FIT in our patient. No adverse effects associated with teriparatide or denosumab were observed. Further clinical studies are necessary to determine the safety and effectiveness of ST in those premenopausal women withIOP. Until then, ST should be used with caution. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/conferenceObject Reunión Journal http://purl.org/coar/resource_type/c_5794 info:ar-repo/semantics/documentoDeConferencia |
status_str |
publishedVersion |
format |
conferenceObject |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/154115 Sequential treatment for idiopathic osteoporosis in premenopausal women: A case report; The Argentinian Society of Osteology and Mineral Metabolism Annual Meeting; Ciudad de Buenos Aires; Argentina; 2019; 2-2 2473-4039 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/154115 |
identifier_str_mv |
Sequential treatment for idiopathic osteoporosis in premenopausal women: A case report; The Argentinian Society of Osteology and Mineral Metabolism Annual Meeting; Ciudad de Buenos Aires; Argentina; 2019; 2-2 2473-4039 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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application/pdf application/pdf application/pdf |
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Wiley |
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Wiley |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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