Hybrid hard - and soft - modeling of spectrophotometric data for monitoring of ciprofloxacin, oxacin and its main photodegradation products at different pH values

Autores
Razuc, Mariela Fernanda; Garrido, Mariano Enrique; Caro, Yamile S.; Teglia, Carla Mariela; Goicoechea, Hector Casimiro; Fernández Band, Beatriz Susana
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A simple and fast on line spectrophotometric method combined with a hybrid hard–soft modeling multivariate curve resolution (HS-MCR) was proposed for the monitoring of photodegradation reaction of ciprofloxacin under UV radiation. The studied conditions attempt to emulate the effect of sunlight on these antibiotics that could be eventually present in the environment. The continuous flow system made it possible to study the ciprofloxacin degradation at different pH values almost at real time, avoiding errors that could arise from typical batch monitoring of the reaction. On the base of a concentration profiles obtained by previous pure soft-modeling approach, reaction pathways have been proposed for the parent compound and its photoproducts at different pH values. These kinetic models were used as a constraint in the HS-MCR analysis. The kinetic profiles and the corresponding pure response profile (UV–Vis spectra) of ciprofloxacin and its main degradation products were recovered after the application of HS-MCR analysis to the spectra recorded throughout the reaction. The observed behavior showed a good agreement with the photodegradation studies reported in the bibliography. Accordingly, the photodegradation reaction was studied by high performance liquid chromatography coupled with UV–Vis diode array detector (HPLC-DAD). The spectra recorded during the chromatographic analysis present a good correlation with the ones recovered by UV–Vis/HS-MCR method.
Fil: Razuc, Mariela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina
Fil: Garrido, Mariano Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina
Fil: Caro, Yamile S.. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; Argentina
Fil: Teglia, Carla Mariela. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; Argentina
Fil: Goicoechea, Hector Casimiro. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; Argentina
Fil: Fernández Band, Beatriz Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina
Materia
Ciprofloxacin
Photodegradation
Multivariate Curve Resolution
Hard-Soft Modeling
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6521
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Hybrid hard - and soft - modeling of spectrophotometric data for monitoring of ciprofloxacin, oxacin and its main photodegradation products at different pH valuesRazuc, Mariela FernandaGarrido, Mariano EnriqueCaro, Yamile S.Teglia, Carla MarielaGoicoechea, Hector CasimiroFernández Band, Beatriz SusanaCiprofloxacinPhotodegradationMultivariate Curve ResolutionHard-Soft Modelinghttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A simple and fast on line spectrophotometric method combined with a hybrid hard–soft modeling multivariate curve resolution (HS-MCR) was proposed for the monitoring of photodegradation reaction of ciprofloxacin under UV radiation. The studied conditions attempt to emulate the effect of sunlight on these antibiotics that could be eventually present in the environment. The continuous flow system made it possible to study the ciprofloxacin degradation at different pH values almost at real time, avoiding errors that could arise from typical batch monitoring of the reaction. On the base of a concentration profiles obtained by previous pure soft-modeling approach, reaction pathways have been proposed for the parent compound and its photoproducts at different pH values. These kinetic models were used as a constraint in the HS-MCR analysis. The kinetic profiles and the corresponding pure response profile (UV–Vis spectra) of ciprofloxacin and its main degradation products were recovered after the application of HS-MCR analysis to the spectra recorded throughout the reaction. The observed behavior showed a good agreement with the photodegradation studies reported in the bibliography. Accordingly, the photodegradation reaction was studied by high performance liquid chromatography coupled with UV–Vis diode array detector (HPLC-DAD). The spectra recorded during the chromatographic analysis present a good correlation with the ones recovered by UV–Vis/HS-MCR method.Fil: Razuc, Mariela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; ArgentinaFil: Garrido, Mariano Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; ArgentinaFil: Caro, Yamile S.. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; ArgentinaFil: Teglia, Carla Mariela. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; ArgentinaFil: Goicoechea, Hector Casimiro. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; ArgentinaFil: Fernández Band, Beatriz Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; ArgentinaElsevier2013-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6521Razuc, Mariela Fernanda; Garrido, Mariano Enrique; Caro, Yamile S.; Teglia, Carla Mariela; Goicoechea, Hector Casimiro; et al.; Hybrid hard - and soft - modeling of spectrophotometric data for monitoring of ciprofloxacin, oxacin and its main photodegradation products at different pH values; Elsevier; Spectrochimica Acta A: Molecular and Biomolecular Spectroscopy; 146; 1-2013; 146-1541386-1425enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1386142513000048info:eu-repo/semantics/altIdentifier/url/10.1016/j.saa.2012.12.085info:eu-repo/semantics/altIdentifier/doi/10.1016/j.saa.2012.12.085info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:42:50Zoai:ri.conicet.gov.ar:11336/6521instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:42:50.98CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hybrid hard - and soft - modeling of spectrophotometric data for monitoring of ciprofloxacin, oxacin and its main photodegradation products at different pH values
title Hybrid hard - and soft - modeling of spectrophotometric data for monitoring of ciprofloxacin, oxacin and its main photodegradation products at different pH values
spellingShingle Hybrid hard - and soft - modeling of spectrophotometric data for monitoring of ciprofloxacin, oxacin and its main photodegradation products at different pH values
Razuc, Mariela Fernanda
Ciprofloxacin
Photodegradation
Multivariate Curve Resolution
Hard-Soft Modeling
title_short Hybrid hard - and soft - modeling of spectrophotometric data for monitoring of ciprofloxacin, oxacin and its main photodegradation products at different pH values
title_full Hybrid hard - and soft - modeling of spectrophotometric data for monitoring of ciprofloxacin, oxacin and its main photodegradation products at different pH values
title_fullStr Hybrid hard - and soft - modeling of spectrophotometric data for monitoring of ciprofloxacin, oxacin and its main photodegradation products at different pH values
title_full_unstemmed Hybrid hard - and soft - modeling of spectrophotometric data for monitoring of ciprofloxacin, oxacin and its main photodegradation products at different pH values
title_sort Hybrid hard - and soft - modeling of spectrophotometric data for monitoring of ciprofloxacin, oxacin and its main photodegradation products at different pH values
dc.creator.none.fl_str_mv Razuc, Mariela Fernanda
Garrido, Mariano Enrique
Caro, Yamile S.
Teglia, Carla Mariela
Goicoechea, Hector Casimiro
Fernández Band, Beatriz Susana
author Razuc, Mariela Fernanda
author_facet Razuc, Mariela Fernanda
Garrido, Mariano Enrique
Caro, Yamile S.
Teglia, Carla Mariela
Goicoechea, Hector Casimiro
Fernández Band, Beatriz Susana
author_role author
author2 Garrido, Mariano Enrique
Caro, Yamile S.
Teglia, Carla Mariela
Goicoechea, Hector Casimiro
Fernández Band, Beatriz Susana
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ciprofloxacin
Photodegradation
Multivariate Curve Resolution
Hard-Soft Modeling
topic Ciprofloxacin
Photodegradation
Multivariate Curve Resolution
Hard-Soft Modeling
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A simple and fast on line spectrophotometric method combined with a hybrid hard–soft modeling multivariate curve resolution (HS-MCR) was proposed for the monitoring of photodegradation reaction of ciprofloxacin under UV radiation. The studied conditions attempt to emulate the effect of sunlight on these antibiotics that could be eventually present in the environment. The continuous flow system made it possible to study the ciprofloxacin degradation at different pH values almost at real time, avoiding errors that could arise from typical batch monitoring of the reaction. On the base of a concentration profiles obtained by previous pure soft-modeling approach, reaction pathways have been proposed for the parent compound and its photoproducts at different pH values. These kinetic models were used as a constraint in the HS-MCR analysis. The kinetic profiles and the corresponding pure response profile (UV–Vis spectra) of ciprofloxacin and its main degradation products were recovered after the application of HS-MCR analysis to the spectra recorded throughout the reaction. The observed behavior showed a good agreement with the photodegradation studies reported in the bibliography. Accordingly, the photodegradation reaction was studied by high performance liquid chromatography coupled with UV–Vis diode array detector (HPLC-DAD). The spectra recorded during the chromatographic analysis present a good correlation with the ones recovered by UV–Vis/HS-MCR method.
Fil: Razuc, Mariela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina
Fil: Garrido, Mariano Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina
Fil: Caro, Yamile S.. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; Argentina
Fil: Teglia, Carla Mariela. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; Argentina
Fil: Goicoechea, Hector Casimiro. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe; Argentina
Fil: Fernández Band, Beatriz Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina
description A simple and fast on line spectrophotometric method combined with a hybrid hard–soft modeling multivariate curve resolution (HS-MCR) was proposed for the monitoring of photodegradation reaction of ciprofloxacin under UV radiation. The studied conditions attempt to emulate the effect of sunlight on these antibiotics that could be eventually present in the environment. The continuous flow system made it possible to study the ciprofloxacin degradation at different pH values almost at real time, avoiding errors that could arise from typical batch monitoring of the reaction. On the base of a concentration profiles obtained by previous pure soft-modeling approach, reaction pathways have been proposed for the parent compound and its photoproducts at different pH values. These kinetic models were used as a constraint in the HS-MCR analysis. The kinetic profiles and the corresponding pure response profile (UV–Vis spectra) of ciprofloxacin and its main degradation products were recovered after the application of HS-MCR analysis to the spectra recorded throughout the reaction. The observed behavior showed a good agreement with the photodegradation studies reported in the bibliography. Accordingly, the photodegradation reaction was studied by high performance liquid chromatography coupled with UV–Vis diode array detector (HPLC-DAD). The spectra recorded during the chromatographic analysis present a good correlation with the ones recovered by UV–Vis/HS-MCR method.
publishDate 2013
dc.date.none.fl_str_mv 2013-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6521
Razuc, Mariela Fernanda; Garrido, Mariano Enrique; Caro, Yamile S.; Teglia, Carla Mariela; Goicoechea, Hector Casimiro; et al.; Hybrid hard - and soft - modeling of spectrophotometric data for monitoring of ciprofloxacin, oxacin and its main photodegradation products at different pH values; Elsevier; Spectrochimica Acta A: Molecular and Biomolecular Spectroscopy; 146; 1-2013; 146-154
1386-1425
url http://hdl.handle.net/11336/6521
identifier_str_mv Razuc, Mariela Fernanda; Garrido, Mariano Enrique; Caro, Yamile S.; Teglia, Carla Mariela; Goicoechea, Hector Casimiro; et al.; Hybrid hard - and soft - modeling of spectrophotometric data for monitoring of ciprofloxacin, oxacin and its main photodegradation products at different pH values; Elsevier; Spectrochimica Acta A: Molecular and Biomolecular Spectroscopy; 146; 1-2013; 146-154
1386-1425
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1386142513000048
info:eu-repo/semantics/altIdentifier/url/10.1016/j.saa.2012.12.085
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.saa.2012.12.085
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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