Second Order Advantage Applied to the Spectrophotometric Analysis of Ciprofloxacin and Dexamethasone in Ophthalmic Drops; Automatic Green Method Using On-line Photodegradation

Autores
Razuc, Mariela Fernanda; Grunhut, Marcos; Garrido, Mariano Enrique; Fernández Band, Beatriz Susana
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
On-line photodegradation and spectrophotometric analysis assisted by multivariate curve resolution-alternating least squares (MCR-ALS) was developed the simultaneous determination of ciprofloxacin (CIP) and dexamethasone (DEX) in ophthalmic suspensions using an automated flow-batch analysis (FBA) system. CIP and DEX have strongly overlapped UV spectra. Overcoming this lack of selectivity involves augmenting data dimensionality. This could be performed by adding information about the sample photodegradation to obtain the so-called second order advantage. Commercial sample analysis was successfully performed and no statistical differences (α = 0.05) with respect to pharmacopeia methods were obtained. The proposed method offers several advantages over the methods developed to date. In agreement with the principles of green chemistry, only water was used as solvent, low amounts of waste were generated and on-line waste treatment was included in the system. Moreover, the cost per analysis was significantly reduced compared to methods that employ separative techniques.
Fil: Razuc, Mariela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Grunhut, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Garrido, Mariano Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Fernández Band, Beatriz Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Materia
PHOTODEGRADATION
SECOND ORDER ADVANTAGE
FLOW-BATCH
GREEN CHEMISTRY
CIPROFLOXACIN
DEXAMETHASONE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/30344
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/30344
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Second Order Advantage Applied to the Spectrophotometric Analysis of Ciprofloxacin and Dexamethasone in Ophthalmic Drops; Automatic Green Method Using On-line PhotodegradationRazuc, Mariela FernandaGrunhut, MarcosGarrido, Mariano EnriqueFernández Band, Beatriz SusanaPHOTODEGRADATIONSECOND ORDER ADVANTAGEFLOW-BATCHGREEN CHEMISTRYCIPROFLOXACINDEXAMETHASONEhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1On-line photodegradation and spectrophotometric analysis assisted by multivariate curve resolution-alternating least squares (MCR-ALS) was developed the simultaneous determination of ciprofloxacin (CIP) and dexamethasone (DEX) in ophthalmic suspensions using an automated flow-batch analysis (FBA) system. CIP and DEX have strongly overlapped UV spectra. Overcoming this lack of selectivity involves augmenting data dimensionality. This could be performed by adding information about the sample photodegradation to obtain the so-called second order advantage. Commercial sample analysis was successfully performed and no statistical differences (α = 0.05) with respect to pharmacopeia methods were obtained. The proposed method offers several advantages over the methods developed to date. In agreement with the principles of green chemistry, only water was used as solvent, low amounts of waste were generated and on-line waste treatment was included in the system. Moreover, the cost per analysis was significantly reduced compared to methods that employ separative techniques.Fil: Razuc, Mariela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Grunhut, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Garrido, Mariano Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Fernández Band, Beatriz Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaJapan Society for Analytical Chemistry2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/30344Razuc, Mariela Fernanda; Grunhut, Marcos; Garrido, Mariano Enrique; Fernández Band, Beatriz Susana; Second Order Advantage Applied to the Spectrophotometric Analysis of Ciprofloxacin and Dexamethasone in Ophthalmic Drops; Automatic Green Method Using On-line Photodegradation; Japan Society for Analytical Chemistry; Analytical Sciences; 30; 12; 12-2014; 1121-11280910-63401348-2246CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2116/analsci.30.1121info:eu-repo/semantics/altIdentifier/url/https://www.jstage.jst.go.jp/article/analsci/30/12/30_1121/_articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:45Zoai:ri.conicet.gov.ar:11336/30344instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:45.442CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Second Order Advantage Applied to the Spectrophotometric Analysis of Ciprofloxacin and Dexamethasone in Ophthalmic Drops; Automatic Green Method Using On-line Photodegradation
title Second Order Advantage Applied to the Spectrophotometric Analysis of Ciprofloxacin and Dexamethasone in Ophthalmic Drops; Automatic Green Method Using On-line Photodegradation
spellingShingle Second Order Advantage Applied to the Spectrophotometric Analysis of Ciprofloxacin and Dexamethasone in Ophthalmic Drops; Automatic Green Method Using On-line Photodegradation
Razuc, Mariela Fernanda
PHOTODEGRADATION
SECOND ORDER ADVANTAGE
FLOW-BATCH
GREEN CHEMISTRY
CIPROFLOXACIN
DEXAMETHASONE
title_short Second Order Advantage Applied to the Spectrophotometric Analysis of Ciprofloxacin and Dexamethasone in Ophthalmic Drops; Automatic Green Method Using On-line Photodegradation
title_full Second Order Advantage Applied to the Spectrophotometric Analysis of Ciprofloxacin and Dexamethasone in Ophthalmic Drops; Automatic Green Method Using On-line Photodegradation
title_fullStr Second Order Advantage Applied to the Spectrophotometric Analysis of Ciprofloxacin and Dexamethasone in Ophthalmic Drops; Automatic Green Method Using On-line Photodegradation
title_full_unstemmed Second Order Advantage Applied to the Spectrophotometric Analysis of Ciprofloxacin and Dexamethasone in Ophthalmic Drops; Automatic Green Method Using On-line Photodegradation
title_sort Second Order Advantage Applied to the Spectrophotometric Analysis of Ciprofloxacin and Dexamethasone in Ophthalmic Drops; Automatic Green Method Using On-line Photodegradation
dc.creator.none.fl_str_mv Razuc, Mariela Fernanda
Grunhut, Marcos
Garrido, Mariano Enrique
Fernández Band, Beatriz Susana
author Razuc, Mariela Fernanda
author_facet Razuc, Mariela Fernanda
Grunhut, Marcos
Garrido, Mariano Enrique
Fernández Band, Beatriz Susana
author_role author
author2 Grunhut, Marcos
Garrido, Mariano Enrique
Fernández Band, Beatriz Susana
author2_role author
author
author
dc.subject.none.fl_str_mv PHOTODEGRADATION
SECOND ORDER ADVANTAGE
FLOW-BATCH
GREEN CHEMISTRY
CIPROFLOXACIN
DEXAMETHASONE
topic PHOTODEGRADATION
SECOND ORDER ADVANTAGE
FLOW-BATCH
GREEN CHEMISTRY
CIPROFLOXACIN
DEXAMETHASONE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv On-line photodegradation and spectrophotometric analysis assisted by multivariate curve resolution-alternating least squares (MCR-ALS) was developed the simultaneous determination of ciprofloxacin (CIP) and dexamethasone (DEX) in ophthalmic suspensions using an automated flow-batch analysis (FBA) system. CIP and DEX have strongly overlapped UV spectra. Overcoming this lack of selectivity involves augmenting data dimensionality. This could be performed by adding information about the sample photodegradation to obtain the so-called second order advantage. Commercial sample analysis was successfully performed and no statistical differences (α = 0.05) with respect to pharmacopeia methods were obtained. The proposed method offers several advantages over the methods developed to date. In agreement with the principles of green chemistry, only water was used as solvent, low amounts of waste were generated and on-line waste treatment was included in the system. Moreover, the cost per analysis was significantly reduced compared to methods that employ separative techniques.
Fil: Razuc, Mariela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Grunhut, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Garrido, Mariano Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Fernández Band, Beatriz Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
description On-line photodegradation and spectrophotometric analysis assisted by multivariate curve resolution-alternating least squares (MCR-ALS) was developed the simultaneous determination of ciprofloxacin (CIP) and dexamethasone (DEX) in ophthalmic suspensions using an automated flow-batch analysis (FBA) system. CIP and DEX have strongly overlapped UV spectra. Overcoming this lack of selectivity involves augmenting data dimensionality. This could be performed by adding information about the sample photodegradation to obtain the so-called second order advantage. Commercial sample analysis was successfully performed and no statistical differences (α = 0.05) with respect to pharmacopeia methods were obtained. The proposed method offers several advantages over the methods developed to date. In agreement with the principles of green chemistry, only water was used as solvent, low amounts of waste were generated and on-line waste treatment was included in the system. Moreover, the cost per analysis was significantly reduced compared to methods that employ separative techniques.
publishDate 2014
dc.date.none.fl_str_mv 2014-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/30344
Razuc, Mariela Fernanda; Grunhut, Marcos; Garrido, Mariano Enrique; Fernández Band, Beatriz Susana; Second Order Advantage Applied to the Spectrophotometric Analysis of Ciprofloxacin and Dexamethasone in Ophthalmic Drops; Automatic Green Method Using On-line Photodegradation; Japan Society for Analytical Chemistry; Analytical Sciences; 30; 12; 12-2014; 1121-1128
0910-6340
1348-2246
CONICET Digital
CONICET
url http://hdl.handle.net/11336/30344
identifier_str_mv Razuc, Mariela Fernanda; Grunhut, Marcos; Garrido, Mariano Enrique; Fernández Band, Beatriz Susana; Second Order Advantage Applied to the Spectrophotometric Analysis of Ciprofloxacin and Dexamethasone in Ophthalmic Drops; Automatic Green Method Using On-line Photodegradation; Japan Society for Analytical Chemistry; Analytical Sciences; 30; 12; 12-2014; 1121-1128
0910-6340
1348-2246
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2116/analsci.30.1121
info:eu-repo/semantics/altIdentifier/url/https://www.jstage.jst.go.jp/article/analsci/30/12/30_1121/_article
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Japan Society for Analytical Chemistry
publisher.none.fl_str_mv Japan Society for Analytical Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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