Tyrosinase inhibitory activity of native plants from central Argentina: Isolation of an active principle from Lithrea molleoides

Autores
Chiari, Maria Eugenia; Joray, Mariana Belén; Ruiz, Gustavo Miguel; Palacios, Sara Maria; Carpinella, Maria Cecilia
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Screening of 91 native plants from central Argentina was carried out with the aim of finding new sources of anti-tyrosinase compounds. Extracts obtained from Achyrocline satureioides, Artemisia verlotiorum, Cotoneaster glaucophylla, Dalea elegans, Flourensia campestris, Jodina rhombifolia, Kageneckia lanceolata, Lepechinia floribunda, Lepechinia meyenii, Lithrea molleoides, Porlieria microphylla, Pterocaulon alopecuroides, Ruprechtia apetala, Senna aphylla, Sida rhombifolia, Solanum argentinum, Tagetes minuta and Thalictrum decipiens exhibited more than 90% inhibition of tyrosinase monophenolase activity at 1000 μg ml-1. D. elegans, L. meyenii and L. molleoides were the most potent with IC50 values of 0.48, 10.43 and 3.77 μg ml-1, respectively. D. elegans, L. molleoides and T. decipiens also showed more than 90% inhibition of diphenolase activity at 1000 μg ml-1, with the first of these being the most effective (IC50 = 49.27 μg ml-1). (Z,Z)-5-(trideca-4,7-dienyl)-resorcinol (1) was isolated from L. molleoides as an effective tyrosinase inhibitor with l-tyrosine or l-DOPA as substrates (IC50 = 0.49 and 14.94 μg ml-1, respectively). Compound 1 was 37 times more active in monophenolase inhibitory activity than kojic acid used as a reference. Effective extracts as well as (Z,Z)-5-(trideca-4,7-dienyl)-resorcinol could prove to be promising preservative agents for use in the food industry.
Fil: Chiari, Maria Eugenia. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Joray, Mariana Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Ruiz, Gustavo Miguel. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Palacios, Sara Maria. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Carpinella, Maria Cecilia. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Materia
(Z,Z)-5-(TRIDECA-4,7-DIENYL)-RESORCINOL
ARGENTINE PLANTS
LITHREA MOLLEOIDES
TYROSINASE INHIBITORS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/187430
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Tyrosinase inhibitory activity of native plants from central Argentina: Isolation of an active principle from Lithrea molleoidesChiari, Maria EugeniaJoray, Mariana BelénRuiz, Gustavo MiguelPalacios, Sara MariaCarpinella, Maria Cecilia(Z,Z)-5-(TRIDECA-4,7-DIENYL)-RESORCINOLARGENTINE PLANTSLITHREA MOLLEOIDESTYROSINASE INHIBITORShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Screening of 91 native plants from central Argentina was carried out with the aim of finding new sources of anti-tyrosinase compounds. Extracts obtained from Achyrocline satureioides, Artemisia verlotiorum, Cotoneaster glaucophylla, Dalea elegans, Flourensia campestris, Jodina rhombifolia, Kageneckia lanceolata, Lepechinia floribunda, Lepechinia meyenii, Lithrea molleoides, Porlieria microphylla, Pterocaulon alopecuroides, Ruprechtia apetala, Senna aphylla, Sida rhombifolia, Solanum argentinum, Tagetes minuta and Thalictrum decipiens exhibited more than 90% inhibition of tyrosinase monophenolase activity at 1000 μg ml-1. D. elegans, L. meyenii and L. molleoides were the most potent with IC50 values of 0.48, 10.43 and 3.77 μg ml-1, respectively. D. elegans, L. molleoides and T. decipiens also showed more than 90% inhibition of diphenolase activity at 1000 μg ml-1, with the first of these being the most effective (IC50 = 49.27 μg ml-1). (Z,Z)-5-(trideca-4,7-dienyl)-resorcinol (1) was isolated from L. molleoides as an effective tyrosinase inhibitor with l-tyrosine or l-DOPA as substrates (IC50 = 0.49 and 14.94 μg ml-1, respectively). Compound 1 was 37 times more active in monophenolase inhibitory activity than kojic acid used as a reference. Effective extracts as well as (Z,Z)-5-(trideca-4,7-dienyl)-resorcinol could prove to be promising preservative agents for use in the food industry.Fil: Chiari, Maria Eugenia. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Joray, Mariana Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; ArgentinaFil: Ruiz, Gustavo Miguel. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Palacios, Sara Maria. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Carpinella, Maria Cecilia. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaElsevier2010-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/187430Chiari, Maria Eugenia; Joray, Mariana Belén; Ruiz, Gustavo Miguel; Palacios, Sara Maria; Carpinella, Maria Cecilia; Tyrosinase inhibitory activity of native plants from central Argentina: Isolation of an active principle from Lithrea molleoides; Elsevier; Food Chemistry; 120; 1; 5-2010; 10-140308-8146CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0308814609011212info:eu-repo/semantics/altIdentifier/doi/10.1016/j.foodchem.2009.09.061info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:48:08Zoai:ri.conicet.gov.ar:11336/187430instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:48:09.007CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tyrosinase inhibitory activity of native plants from central Argentina: Isolation of an active principle from Lithrea molleoides
title Tyrosinase inhibitory activity of native plants from central Argentina: Isolation of an active principle from Lithrea molleoides
spellingShingle Tyrosinase inhibitory activity of native plants from central Argentina: Isolation of an active principle from Lithrea molleoides
Chiari, Maria Eugenia
(Z,Z)-5-(TRIDECA-4,7-DIENYL)-RESORCINOL
ARGENTINE PLANTS
LITHREA MOLLEOIDES
TYROSINASE INHIBITORS
title_short Tyrosinase inhibitory activity of native plants from central Argentina: Isolation of an active principle from Lithrea molleoides
title_full Tyrosinase inhibitory activity of native plants from central Argentina: Isolation of an active principle from Lithrea molleoides
title_fullStr Tyrosinase inhibitory activity of native plants from central Argentina: Isolation of an active principle from Lithrea molleoides
title_full_unstemmed Tyrosinase inhibitory activity of native plants from central Argentina: Isolation of an active principle from Lithrea molleoides
title_sort Tyrosinase inhibitory activity of native plants from central Argentina: Isolation of an active principle from Lithrea molleoides
dc.creator.none.fl_str_mv Chiari, Maria Eugenia
Joray, Mariana Belén
Ruiz, Gustavo Miguel
Palacios, Sara Maria
Carpinella, Maria Cecilia
author Chiari, Maria Eugenia
author_facet Chiari, Maria Eugenia
Joray, Mariana Belén
Ruiz, Gustavo Miguel
Palacios, Sara Maria
Carpinella, Maria Cecilia
author_role author
author2 Joray, Mariana Belén
Ruiz, Gustavo Miguel
Palacios, Sara Maria
Carpinella, Maria Cecilia
author2_role author
author
author
author
dc.subject.none.fl_str_mv (Z,Z)-5-(TRIDECA-4,7-DIENYL)-RESORCINOL
ARGENTINE PLANTS
LITHREA MOLLEOIDES
TYROSINASE INHIBITORS
topic (Z,Z)-5-(TRIDECA-4,7-DIENYL)-RESORCINOL
ARGENTINE PLANTS
LITHREA MOLLEOIDES
TYROSINASE INHIBITORS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Screening of 91 native plants from central Argentina was carried out with the aim of finding new sources of anti-tyrosinase compounds. Extracts obtained from Achyrocline satureioides, Artemisia verlotiorum, Cotoneaster glaucophylla, Dalea elegans, Flourensia campestris, Jodina rhombifolia, Kageneckia lanceolata, Lepechinia floribunda, Lepechinia meyenii, Lithrea molleoides, Porlieria microphylla, Pterocaulon alopecuroides, Ruprechtia apetala, Senna aphylla, Sida rhombifolia, Solanum argentinum, Tagetes minuta and Thalictrum decipiens exhibited more than 90% inhibition of tyrosinase monophenolase activity at 1000 μg ml-1. D. elegans, L. meyenii and L. molleoides were the most potent with IC50 values of 0.48, 10.43 and 3.77 μg ml-1, respectively. D. elegans, L. molleoides and T. decipiens also showed more than 90% inhibition of diphenolase activity at 1000 μg ml-1, with the first of these being the most effective (IC50 = 49.27 μg ml-1). (Z,Z)-5-(trideca-4,7-dienyl)-resorcinol (1) was isolated from L. molleoides as an effective tyrosinase inhibitor with l-tyrosine or l-DOPA as substrates (IC50 = 0.49 and 14.94 μg ml-1, respectively). Compound 1 was 37 times more active in monophenolase inhibitory activity than kojic acid used as a reference. Effective extracts as well as (Z,Z)-5-(trideca-4,7-dienyl)-resorcinol could prove to be promising preservative agents for use in the food industry.
Fil: Chiari, Maria Eugenia. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Joray, Mariana Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina
Fil: Ruiz, Gustavo Miguel. Universidad Católica de Córdoba. Facultad de Ciencias Agropecuarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Palacios, Sara Maria. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Carpinella, Maria Cecilia. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
description Screening of 91 native plants from central Argentina was carried out with the aim of finding new sources of anti-tyrosinase compounds. Extracts obtained from Achyrocline satureioides, Artemisia verlotiorum, Cotoneaster glaucophylla, Dalea elegans, Flourensia campestris, Jodina rhombifolia, Kageneckia lanceolata, Lepechinia floribunda, Lepechinia meyenii, Lithrea molleoides, Porlieria microphylla, Pterocaulon alopecuroides, Ruprechtia apetala, Senna aphylla, Sida rhombifolia, Solanum argentinum, Tagetes minuta and Thalictrum decipiens exhibited more than 90% inhibition of tyrosinase monophenolase activity at 1000 μg ml-1. D. elegans, L. meyenii and L. molleoides were the most potent with IC50 values of 0.48, 10.43 and 3.77 μg ml-1, respectively. D. elegans, L. molleoides and T. decipiens also showed more than 90% inhibition of diphenolase activity at 1000 μg ml-1, with the first of these being the most effective (IC50 = 49.27 μg ml-1). (Z,Z)-5-(trideca-4,7-dienyl)-resorcinol (1) was isolated from L. molleoides as an effective tyrosinase inhibitor with l-tyrosine or l-DOPA as substrates (IC50 = 0.49 and 14.94 μg ml-1, respectively). Compound 1 was 37 times more active in monophenolase inhibitory activity than kojic acid used as a reference. Effective extracts as well as (Z,Z)-5-(trideca-4,7-dienyl)-resorcinol could prove to be promising preservative agents for use in the food industry.
publishDate 2010
dc.date.none.fl_str_mv 2010-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/187430
Chiari, Maria Eugenia; Joray, Mariana Belén; Ruiz, Gustavo Miguel; Palacios, Sara Maria; Carpinella, Maria Cecilia; Tyrosinase inhibitory activity of native plants from central Argentina: Isolation of an active principle from Lithrea molleoides; Elsevier; Food Chemistry; 120; 1; 5-2010; 10-14
0308-8146
CONICET Digital
CONICET
url http://hdl.handle.net/11336/187430
identifier_str_mv Chiari, Maria Eugenia; Joray, Mariana Belén; Ruiz, Gustavo Miguel; Palacios, Sara Maria; Carpinella, Maria Cecilia; Tyrosinase inhibitory activity of native plants from central Argentina: Isolation of an active principle from Lithrea molleoides; Elsevier; Food Chemistry; 120; 1; 5-2010; 10-14
0308-8146
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0308814609011212
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.foodchem.2009.09.061
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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