Anti-inflammatory effect of Lithrea molleoides extracts and isolated active compounds

Autores
Gorzalczany, Susana Beatriz; López, Paula Gladys; Acevedo, C.; Ferraro, Graciela Ester
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aim of the study: In this study the anti-inflammatory activity of aqueous, dichloromethane (CH2Cl2) and methanolic (MeOH) extracts and two major compounds isolated from Lithrea molleoides (Vell.) Engl. (Anacardiaceae) were evaluated. Materials and methods: Two classical experimental models were used, carrageenan-induced rat paw edema and 12-O-tetradecanoylphorbol-13 acetate (TPA) induced mouse ear edema. Results: MeOH extracts exhibited a significant systemical anti-inflammatory effect in the carrageenan (inhibition of 46% at 3 h) and in the TPA-ear edema test (inhibition of 21%). The presence of methyl gallate (inhibition of 63% in TPA ear edema), as one of the main compounds in the active fraction from MeOH extract may be explained the effect observed. Also, 1,3-dihydroxy-(Z,Z)-5-(tridec-4,7ˇıdienyl) benzene obtained from CH2Cl2 extract showed a significant topical anti-inflammatory activity (inhibition of 68%). Furthermore, no signs of toxicity were observed with doses up to 3 g/kg in an acute toxicity assay. Conclusions: The results of this study present evidence that Lithrea molleoides given either systemically or topically has anti-inflammatory properties.
Fil: Gorzalczany, Susana Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: López, Paula Gladys. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Acevedo, C.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina
Fil: Ferraro, Graciela Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Materia
1,3-DIHYDROXY-(Z,Z)-5-(TRIDEC-4′,7DIENYL) BENZENE
ANACARDIACEAE
ANTI-INFLAMMATORY
CARRAGEENAN
LITHREA MOLLEOIDES
METHYL GALLATE
TPA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/198437
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/198437
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Anti-inflammatory effect of Lithrea molleoides extracts and isolated active compoundsGorzalczany, Susana BeatrizLópez, Paula GladysAcevedo, C.Ferraro, Graciela Ester1,3-DIHYDROXY-(Z,Z)-5-(TRIDEC-4′,7DIENYL) BENZENEANACARDIACEAEANTI-INFLAMMATORYCARRAGEENANLITHREA MOLLEOIDESMETHYL GALLATETPAhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Aim of the study: In this study the anti-inflammatory activity of aqueous, dichloromethane (CH2Cl2) and methanolic (MeOH) extracts and two major compounds isolated from Lithrea molleoides (Vell.) Engl. (Anacardiaceae) were evaluated. Materials and methods: Two classical experimental models were used, carrageenan-induced rat paw edema and 12-O-tetradecanoylphorbol-13 acetate (TPA) induced mouse ear edema. Results: MeOH extracts exhibited a significant systemical anti-inflammatory effect in the carrageenan (inhibition of 46% at 3 h) and in the TPA-ear edema test (inhibition of 21%). The presence of methyl gallate (inhibition of 63% in TPA ear edema), as one of the main compounds in the active fraction from MeOH extract may be explained the effect observed. Also, 1,3-dihydroxy-(Z,Z)-5-(tridec-4,7ˇıdienyl) benzene obtained from CH2Cl2 extract showed a significant topical anti-inflammatory activity (inhibition of 68%). Furthermore, no signs of toxicity were observed with doses up to 3 g/kg in an acute toxicity assay. Conclusions: The results of this study present evidence that Lithrea molleoides given either systemically or topically has anti-inflammatory properties.Fil: Gorzalczany, Susana Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: López, Paula Gladys. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Acevedo, C.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; ArgentinaFil: Ferraro, Graciela Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaElsevier Ireland2011-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/198437Gorzalczany, Susana Beatriz; López, Paula Gladys; Acevedo, C.; Ferraro, Graciela Ester; Anti-inflammatory effect of Lithrea molleoides extracts and isolated active compounds; Elsevier Ireland; Journal of Ethnopharmacology; 133; 3; 2-2011; 994-9980378-8741CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0378874110008160?via%3Dihubinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jep.2010.11.031info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T09:33:32Zoai:ri.conicet.gov.ar:11336/198437instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 09:33:32.721CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Anti-inflammatory effect of Lithrea molleoides extracts and isolated active compounds
title Anti-inflammatory effect of Lithrea molleoides extracts and isolated active compounds
spellingShingle Anti-inflammatory effect of Lithrea molleoides extracts and isolated active compounds
Gorzalczany, Susana Beatriz
1,3-DIHYDROXY-(Z,Z)-5-(TRIDEC-4′,7DIENYL) BENZENE
ANACARDIACEAE
ANTI-INFLAMMATORY
CARRAGEENAN
LITHREA MOLLEOIDES
METHYL GALLATE
TPA
title_short Anti-inflammatory effect of Lithrea molleoides extracts and isolated active compounds
title_full Anti-inflammatory effect of Lithrea molleoides extracts and isolated active compounds
title_fullStr Anti-inflammatory effect of Lithrea molleoides extracts and isolated active compounds
title_full_unstemmed Anti-inflammatory effect of Lithrea molleoides extracts and isolated active compounds
title_sort Anti-inflammatory effect of Lithrea molleoides extracts and isolated active compounds
dc.creator.none.fl_str_mv Gorzalczany, Susana Beatriz
López, Paula Gladys
Acevedo, C.
Ferraro, Graciela Ester
author Gorzalczany, Susana Beatriz
author_facet Gorzalczany, Susana Beatriz
López, Paula Gladys
Acevedo, C.
Ferraro, Graciela Ester
author_role author
author2 López, Paula Gladys
Acevedo, C.
Ferraro, Graciela Ester
author2_role author
author
author
dc.subject.none.fl_str_mv 1,3-DIHYDROXY-(Z,Z)-5-(TRIDEC-4′,7DIENYL) BENZENE
ANACARDIACEAE
ANTI-INFLAMMATORY
CARRAGEENAN
LITHREA MOLLEOIDES
METHYL GALLATE
TPA
topic 1,3-DIHYDROXY-(Z,Z)-5-(TRIDEC-4′,7DIENYL) BENZENE
ANACARDIACEAE
ANTI-INFLAMMATORY
CARRAGEENAN
LITHREA MOLLEOIDES
METHYL GALLATE
TPA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Aim of the study: In this study the anti-inflammatory activity of aqueous, dichloromethane (CH2Cl2) and methanolic (MeOH) extracts and two major compounds isolated from Lithrea molleoides (Vell.) Engl. (Anacardiaceae) were evaluated. Materials and methods: Two classical experimental models were used, carrageenan-induced rat paw edema and 12-O-tetradecanoylphorbol-13 acetate (TPA) induced mouse ear edema. Results: MeOH extracts exhibited a significant systemical anti-inflammatory effect in the carrageenan (inhibition of 46% at 3 h) and in the TPA-ear edema test (inhibition of 21%). The presence of methyl gallate (inhibition of 63% in TPA ear edema), as one of the main compounds in the active fraction from MeOH extract may be explained the effect observed. Also, 1,3-dihydroxy-(Z,Z)-5-(tridec-4,7ˇıdienyl) benzene obtained from CH2Cl2 extract showed a significant topical anti-inflammatory activity (inhibition of 68%). Furthermore, no signs of toxicity were observed with doses up to 3 g/kg in an acute toxicity assay. Conclusions: The results of this study present evidence that Lithrea molleoides given either systemically or topically has anti-inflammatory properties.
Fil: Gorzalczany, Susana Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: López, Paula Gladys. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Acevedo, C.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina
Fil: Ferraro, Graciela Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
description Aim of the study: In this study the anti-inflammatory activity of aqueous, dichloromethane (CH2Cl2) and methanolic (MeOH) extracts and two major compounds isolated from Lithrea molleoides (Vell.) Engl. (Anacardiaceae) were evaluated. Materials and methods: Two classical experimental models were used, carrageenan-induced rat paw edema and 12-O-tetradecanoylphorbol-13 acetate (TPA) induced mouse ear edema. Results: MeOH extracts exhibited a significant systemical anti-inflammatory effect in the carrageenan (inhibition of 46% at 3 h) and in the TPA-ear edema test (inhibition of 21%). The presence of methyl gallate (inhibition of 63% in TPA ear edema), as one of the main compounds in the active fraction from MeOH extract may be explained the effect observed. Also, 1,3-dihydroxy-(Z,Z)-5-(tridec-4,7ˇıdienyl) benzene obtained from CH2Cl2 extract showed a significant topical anti-inflammatory activity (inhibition of 68%). Furthermore, no signs of toxicity were observed with doses up to 3 g/kg in an acute toxicity assay. Conclusions: The results of this study present evidence that Lithrea molleoides given either systemically or topically has anti-inflammatory properties.
publishDate 2011
dc.date.none.fl_str_mv 2011-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/198437
Gorzalczany, Susana Beatriz; López, Paula Gladys; Acevedo, C.; Ferraro, Graciela Ester; Anti-inflammatory effect of Lithrea molleoides extracts and isolated active compounds; Elsevier Ireland; Journal of Ethnopharmacology; 133; 3; 2-2011; 994-998
0378-8741
CONICET Digital
CONICET
url http://hdl.handle.net/11336/198437
identifier_str_mv Gorzalczany, Susana Beatriz; López, Paula Gladys; Acevedo, C.; Ferraro, Graciela Ester; Anti-inflammatory effect of Lithrea molleoides extracts and isolated active compounds; Elsevier Ireland; Journal of Ethnopharmacology; 133; 3; 2-2011; 994-998
0378-8741
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0378874110008160?via%3Dihub
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jep.2010.11.031
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.082534

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