High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling

Autores
Morrison, Christopher D.; Pistell, Paul J.; Ingram, Donald K.; Johnson, William D.; Liu, Ying; Fernandez Kim, Sun Ok; White, Christy L.; Purpera, Megan N.; Uranga, Romina Maria; Bruce Keller, Annadora J.; Keller, Jeffrey N.
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Long term consumption of a high fat diet (HFD) contributes to increased morbidity and mortality. Yet the specific effects of HFD consumption on brain aging are poorly understood. In the present study 20-month old male C57Bl/6 mice were fed either “Western Diet” (WD, 41% fat), very high fat lard diet (HFL, 60% fat), or corresponding control diets for 16 weeks and then assessed for changes in metabolism and brain homeostasis. Although both HFDs increased adiposity and fasting blood glucose, only the HFL diet increased age-related oxidative damage (protein carbonyls) and impaired retention in the behavioral test. This selective increase in oxidative damage and cognitive decline was also associated with a decline in Nrf2 levels and Nrf2 activity, suggesting a potential role for decreased antioxidant response. Taken together, these data suggest that while adiposity and insulin resistance following HFD consumption are linked to increased morbidity, the relationship between these factors and brain homeostasis during aging is not a linear relationship. More specifically, these data implicate impaired Nrf2 signaling and increased cerebral oxidative stress as mechanisms underlying HFD-induced declines in cognitive performance in the aged brain.
Fil: Morrison, Christopher D.. Pennington Biomedical Research Center; Estados Unidos
Fil: Pistell, Paul J.. Pennington Biomedical Research Center; Estados Unidos
Fil: Ingram, Donald K.. Pennington Biomedical Research Center; Estados Unidos
Fil: Johnson, William D.. Pennington Biomedical Research Center; Estados Unidos
Fil: Liu, Ying. Pennington Biomedical Research Center; Estados Unidos
Fil: Fernandez Kim, Sun Ok. Pennington Biomedical Research Center; Estados Unidos
Fil: White, Christy L.. Pennington Biomedical Research Center; Estados Unidos
Fil: Purpera, Megan N.. Pennington Biomedical Research Center; Estados Unidos
Fil: Uranga, Romina Maria. Pennington Biomedical Research Center; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Bruce Keller, Annadora J.. Pennington Biomedical Research Center; Estados Unidos
Fil: Keller, Jeffrey N.. Pennington Biomedical Research Center; Estados Unidos
Materia
OXIDATIE STRESS
AGING
COGNITION
HIGH-FAT DIET
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/43269
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/43269
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signalingMorrison, Christopher D.Pistell, Paul J.Ingram, Donald K.Johnson, William D.Liu, YingFernandez Kim, Sun OkWhite, Christy L.Purpera, Megan N.Uranga, Romina MariaBruce Keller, Annadora J.Keller, Jeffrey N.OXIDATIE STRESSAGINGCOGNITIONHIGH-FAT DIEThttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Long term consumption of a high fat diet (HFD) contributes to increased morbidity and mortality. Yet the specific effects of HFD consumption on brain aging are poorly understood. In the present study 20-month old male C57Bl/6 mice were fed either “Western Diet” (WD, 41% fat), very high fat lard diet (HFL, 60% fat), or corresponding control diets for 16 weeks and then assessed for changes in metabolism and brain homeostasis. Although both HFDs increased adiposity and fasting blood glucose, only the HFL diet increased age-related oxidative damage (protein carbonyls) and impaired retention in the behavioral test. This selective increase in oxidative damage and cognitive decline was also associated with a decline in Nrf2 levels and Nrf2 activity, suggesting a potential role for decreased antioxidant response. Taken together, these data suggest that while adiposity and insulin resistance following HFD consumption are linked to increased morbidity, the relationship between these factors and brain homeostasis during aging is not a linear relationship. More specifically, these data implicate impaired Nrf2 signaling and increased cerebral oxidative stress as mechanisms underlying HFD-induced declines in cognitive performance in the aged brain.Fil: Morrison, Christopher D.. Pennington Biomedical Research Center; Estados UnidosFil: Pistell, Paul J.. Pennington Biomedical Research Center; Estados UnidosFil: Ingram, Donald K.. Pennington Biomedical Research Center; Estados UnidosFil: Johnson, William D.. Pennington Biomedical Research Center; Estados UnidosFil: Liu, Ying. Pennington Biomedical Research Center; Estados UnidosFil: Fernandez Kim, Sun Ok. Pennington Biomedical Research Center; Estados UnidosFil: White, Christy L.. Pennington Biomedical Research Center; Estados UnidosFil: Purpera, Megan N.. Pennington Biomedical Research Center; Estados UnidosFil: Uranga, Romina Maria. Pennington Biomedical Research Center; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Bruce Keller, Annadora J.. Pennington Biomedical Research Center; Estados UnidosFil: Keller, Jeffrey N.. Pennington Biomedical Research Center; Estados UnidosWiley Blackwell Publishing, Inc2010-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/43269Morrison, Christopher D.; Pistell, Paul J.; Ingram, Donald K.; Johnson, William D.; Liu, Ying; et al.; High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 114; 6; 9-2010; 1581-15890022-3042CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945419/info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1471-4159.2010.06865.xinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.2010.06865.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:12:05Zoai:ri.conicet.gov.ar:11336/43269instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:12:05.946CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling
title High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling
spellingShingle High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling
Morrison, Christopher D.
OXIDATIE STRESS
AGING
COGNITION
HIGH-FAT DIET
title_short High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling
title_full High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling
title_fullStr High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling
title_full_unstemmed High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling
title_sort High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling
dc.creator.none.fl_str_mv Morrison, Christopher D.
Pistell, Paul J.
Ingram, Donald K.
Johnson, William D.
Liu, Ying
Fernandez Kim, Sun Ok
White, Christy L.
Purpera, Megan N.
Uranga, Romina Maria
Bruce Keller, Annadora J.
Keller, Jeffrey N.
author Morrison, Christopher D.
author_facet Morrison, Christopher D.
Pistell, Paul J.
Ingram, Donald K.
Johnson, William D.
Liu, Ying
Fernandez Kim, Sun Ok
White, Christy L.
Purpera, Megan N.
Uranga, Romina Maria
Bruce Keller, Annadora J.
Keller, Jeffrey N.
author_role author
author2 Pistell, Paul J.
Ingram, Donald K.
Johnson, William D.
Liu, Ying
Fernandez Kim, Sun Ok
White, Christy L.
Purpera, Megan N.
Uranga, Romina Maria
Bruce Keller, Annadora J.
Keller, Jeffrey N.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv OXIDATIE STRESS
AGING
COGNITION
HIGH-FAT DIET
topic OXIDATIE STRESS
AGING
COGNITION
HIGH-FAT DIET
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Long term consumption of a high fat diet (HFD) contributes to increased morbidity and mortality. Yet the specific effects of HFD consumption on brain aging are poorly understood. In the present study 20-month old male C57Bl/6 mice were fed either “Western Diet” (WD, 41% fat), very high fat lard diet (HFL, 60% fat), or corresponding control diets for 16 weeks and then assessed for changes in metabolism and brain homeostasis. Although both HFDs increased adiposity and fasting blood glucose, only the HFL diet increased age-related oxidative damage (protein carbonyls) and impaired retention in the behavioral test. This selective increase in oxidative damage and cognitive decline was also associated with a decline in Nrf2 levels and Nrf2 activity, suggesting a potential role for decreased antioxidant response. Taken together, these data suggest that while adiposity and insulin resistance following HFD consumption are linked to increased morbidity, the relationship between these factors and brain homeostasis during aging is not a linear relationship. More specifically, these data implicate impaired Nrf2 signaling and increased cerebral oxidative stress as mechanisms underlying HFD-induced declines in cognitive performance in the aged brain.
Fil: Morrison, Christopher D.. Pennington Biomedical Research Center; Estados Unidos
Fil: Pistell, Paul J.. Pennington Biomedical Research Center; Estados Unidos
Fil: Ingram, Donald K.. Pennington Biomedical Research Center; Estados Unidos
Fil: Johnson, William D.. Pennington Biomedical Research Center; Estados Unidos
Fil: Liu, Ying. Pennington Biomedical Research Center; Estados Unidos
Fil: Fernandez Kim, Sun Ok. Pennington Biomedical Research Center; Estados Unidos
Fil: White, Christy L.. Pennington Biomedical Research Center; Estados Unidos
Fil: Purpera, Megan N.. Pennington Biomedical Research Center; Estados Unidos
Fil: Uranga, Romina Maria. Pennington Biomedical Research Center; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Bruce Keller, Annadora J.. Pennington Biomedical Research Center; Estados Unidos
Fil: Keller, Jeffrey N.. Pennington Biomedical Research Center; Estados Unidos
description Long term consumption of a high fat diet (HFD) contributes to increased morbidity and mortality. Yet the specific effects of HFD consumption on brain aging are poorly understood. In the present study 20-month old male C57Bl/6 mice were fed either “Western Diet” (WD, 41% fat), very high fat lard diet (HFL, 60% fat), or corresponding control diets for 16 weeks and then assessed for changes in metabolism and brain homeostasis. Although both HFDs increased adiposity and fasting blood glucose, only the HFL diet increased age-related oxidative damage (protein carbonyls) and impaired retention in the behavioral test. This selective increase in oxidative damage and cognitive decline was also associated with a decline in Nrf2 levels and Nrf2 activity, suggesting a potential role for decreased antioxidant response. Taken together, these data suggest that while adiposity and insulin resistance following HFD consumption are linked to increased morbidity, the relationship between these factors and brain homeostasis during aging is not a linear relationship. More specifically, these data implicate impaired Nrf2 signaling and increased cerebral oxidative stress as mechanisms underlying HFD-induced declines in cognitive performance in the aged brain.
publishDate 2010
dc.date.none.fl_str_mv 2010-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/43269
Morrison, Christopher D.; Pistell, Paul J.; Ingram, Donald K.; Johnson, William D.; Liu, Ying; et al.; High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 114; 6; 9-2010; 1581-1589
0022-3042
CONICET Digital
CONICET
url http://hdl.handle.net/11336/43269
identifier_str_mv Morrison, Christopher D.; Pistell, Paul J.; Ingram, Donald K.; Johnson, William D.; Liu, Ying; et al.; High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 114; 6; 9-2010; 1581-1589
0022-3042
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945419/
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1471-4159.2010.06865.x
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.2010.06865.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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