Xanthone Synthesis through Catalysis: Exploring the Green Limits of Homogeneous and Heterogeneous Methods

Autores
Mendioroz, Pamela; Casoni, Andrés Iván; Volpe, María Alicia; Gerbino, Darío César
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The transition from traditional stoichiometric methods to catalytic processes has significantly advanced the synthesis of xanthones, privileged structures with diverse biological activities. This review critically examines various homogeneous and heterogeneous catalytic methodologies, emphasising their efficiency, and adherence to green chemistry principles. Through comparative analysis of key metrics such as Reaction Mass Efficiency (RME), Process Mass Intensity (PMI), E-factor, and Turnover Number (TON), we highlight the superior performance of heterogeneous catalysts, which demonstrate high reusability, selectivity, and minimal waste generation. The choice of solvent, a crucial factor in the environmental footprint of these processes, is also assessed, focusing on greener alternatives. The robust nature and economic viability of heterogeneous catalysts make them ideal for large-scale applications, offering suitable solutions for more environmentally-friendly xanthone production. Furthermore, the reduction in byproducts and the importance of catalyst purity in pharmaceutical applications are discussed, underscoring the relevance of these advancements in meeting the rigorous standards of the industry. This review provides valuable insights into the ongoing evolution of catalytic strategies in xanthone synthesis, driving future developments in medicinal chemistry and green chemistry.
Fil: Mendioroz, Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Casoni, Andrés Iván. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Volpe, María Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Gerbino, Darío César. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Materia
Xanthone synthesis
Catalytic methodologies
Green chemistry
Homogeneous catalysis
Heterogeneous catalysis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/260605
Acceder
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spelling Xanthone Synthesis through Catalysis: Exploring the Green Limits of Homogeneous and Heterogeneous MethodsMendioroz, PamelaCasoni, Andrés IvánVolpe, María AliciaGerbino, Darío CésarXanthone synthesisCatalytic methodologiesGreen chemistryHomogeneous catalysisHeterogeneous catalysishttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The transition from traditional stoichiometric methods to catalytic processes has significantly advanced the synthesis of xanthones, privileged structures with diverse biological activities. This review critically examines various homogeneous and heterogeneous catalytic methodologies, emphasising their efficiency, and adherence to green chemistry principles. Through comparative analysis of key metrics such as Reaction Mass Efficiency (RME), Process Mass Intensity (PMI), E-factor, and Turnover Number (TON), we highlight the superior performance of heterogeneous catalysts, which demonstrate high reusability, selectivity, and minimal waste generation. The choice of solvent, a crucial factor in the environmental footprint of these processes, is also assessed, focusing on greener alternatives. The robust nature and economic viability of heterogeneous catalysts make them ideal for large-scale applications, offering suitable solutions for more environmentally-friendly xanthone production. Furthermore, the reduction in byproducts and the importance of catalyst purity in pharmaceutical applications are discussed, underscoring the relevance of these advancements in meeting the rigorous standards of the industry. This review provides valuable insights into the ongoing evolution of catalytic strategies in xanthone synthesis, driving future developments in medicinal chemistry and green chemistry.Fil: Mendioroz, Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Casoni, Andrés Iván. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Volpe, María Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Gerbino, Darío César. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaWiley VCH Verlag2024-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/260605Mendioroz, Pamela; Casoni, Andrés Iván; Volpe, María Alicia; Gerbino, Darío César; Xanthone Synthesis through Catalysis: Exploring the Green Limits of Homogeneous and Heterogeneous Methods; Wiley VCH Verlag; European Journal of Organic Chemistry; 28; 2; 11-2024; 1-121434-193XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.202401027info:eu-repo/semantics/altIdentifier/doi/10.1002/ejoc.202401027info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:25Zoai:ri.conicet.gov.ar:11336/260605instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:25.327CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Xanthone Synthesis through Catalysis: Exploring the Green Limits of Homogeneous and Heterogeneous Methods
title Xanthone Synthesis through Catalysis: Exploring the Green Limits of Homogeneous and Heterogeneous Methods
spellingShingle Xanthone Synthesis through Catalysis: Exploring the Green Limits of Homogeneous and Heterogeneous Methods
Mendioroz, Pamela
Xanthone synthesis
Catalytic methodologies
Green chemistry
Homogeneous catalysis
Heterogeneous catalysis
title_short Xanthone Synthesis through Catalysis: Exploring the Green Limits of Homogeneous and Heterogeneous Methods
title_full Xanthone Synthesis through Catalysis: Exploring the Green Limits of Homogeneous and Heterogeneous Methods
title_fullStr Xanthone Synthesis through Catalysis: Exploring the Green Limits of Homogeneous and Heterogeneous Methods
title_full_unstemmed Xanthone Synthesis through Catalysis: Exploring the Green Limits of Homogeneous and Heterogeneous Methods
title_sort Xanthone Synthesis through Catalysis: Exploring the Green Limits of Homogeneous and Heterogeneous Methods
dc.creator.none.fl_str_mv Mendioroz, Pamela
Casoni, Andrés Iván
Volpe, María Alicia
Gerbino, Darío César
author Mendioroz, Pamela
author_facet Mendioroz, Pamela
Casoni, Andrés Iván
Volpe, María Alicia
Gerbino, Darío César
author_role author
author2 Casoni, Andrés Iván
Volpe, María Alicia
Gerbino, Darío César
author2_role author
author
author
dc.subject.none.fl_str_mv Xanthone synthesis
Catalytic methodologies
Green chemistry
Homogeneous catalysis
Heterogeneous catalysis
topic Xanthone synthesis
Catalytic methodologies
Green chemistry
Homogeneous catalysis
Heterogeneous catalysis
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The transition from traditional stoichiometric methods to catalytic processes has significantly advanced the synthesis of xanthones, privileged structures with diverse biological activities. This review critically examines various homogeneous and heterogeneous catalytic methodologies, emphasising their efficiency, and adherence to green chemistry principles. Through comparative analysis of key metrics such as Reaction Mass Efficiency (RME), Process Mass Intensity (PMI), E-factor, and Turnover Number (TON), we highlight the superior performance of heterogeneous catalysts, which demonstrate high reusability, selectivity, and minimal waste generation. The choice of solvent, a crucial factor in the environmental footprint of these processes, is also assessed, focusing on greener alternatives. The robust nature and economic viability of heterogeneous catalysts make them ideal for large-scale applications, offering suitable solutions for more environmentally-friendly xanthone production. Furthermore, the reduction in byproducts and the importance of catalyst purity in pharmaceutical applications are discussed, underscoring the relevance of these advancements in meeting the rigorous standards of the industry. This review provides valuable insights into the ongoing evolution of catalytic strategies in xanthone synthesis, driving future developments in medicinal chemistry and green chemistry.
Fil: Mendioroz, Pamela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Casoni, Andrés Iván. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Volpe, María Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Gerbino, Darío César. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
description The transition from traditional stoichiometric methods to catalytic processes has significantly advanced the synthesis of xanthones, privileged structures with diverse biological activities. This review critically examines various homogeneous and heterogeneous catalytic methodologies, emphasising their efficiency, and adherence to green chemistry principles. Through comparative analysis of key metrics such as Reaction Mass Efficiency (RME), Process Mass Intensity (PMI), E-factor, and Turnover Number (TON), we highlight the superior performance of heterogeneous catalysts, which demonstrate high reusability, selectivity, and minimal waste generation. The choice of solvent, a crucial factor in the environmental footprint of these processes, is also assessed, focusing on greener alternatives. The robust nature and economic viability of heterogeneous catalysts make them ideal for large-scale applications, offering suitable solutions for more environmentally-friendly xanthone production. Furthermore, the reduction in byproducts and the importance of catalyst purity in pharmaceutical applications are discussed, underscoring the relevance of these advancements in meeting the rigorous standards of the industry. This review provides valuable insights into the ongoing evolution of catalytic strategies in xanthone synthesis, driving future developments in medicinal chemistry and green chemistry.
publishDate 2024
dc.date.none.fl_str_mv 2024-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/260605
Mendioroz, Pamela; Casoni, Andrés Iván; Volpe, María Alicia; Gerbino, Darío César; Xanthone Synthesis through Catalysis: Exploring the Green Limits of Homogeneous and Heterogeneous Methods; Wiley VCH Verlag; European Journal of Organic Chemistry; 28; 2; 11-2024; 1-12
1434-193X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/260605
identifier_str_mv Mendioroz, Pamela; Casoni, Andrés Iván; Volpe, María Alicia; Gerbino, Darío César; Xanthone Synthesis through Catalysis: Exploring the Green Limits of Homogeneous and Heterogeneous Methods; Wiley VCH Verlag; European Journal of Organic Chemistry; 28; 2; 11-2024; 1-12
1434-193X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.202401027
info:eu-repo/semantics/altIdentifier/doi/10.1002/ejoc.202401027
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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