Emerging technologies for the integration and intensification of downstream bioprocesses

Autores
D’Souza, Roy N.; Azevedo, Ana M.; Aires Barros, M. Raquel; Krajnc, Nika Lendero; Kramberger, Petra; Carbajal, Maria Laura; Grasselli, Mariano; Meyer, Ronald; Fernandez Lahore, Marcelo
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Downstream processing is currently the major bottleneck for bioproduct generation. In contrast to the advances in fermentation processes, the tools used for downstream processes have struggled to keep pace in the last 20 years. Purification bottlenecks are quite serious, as these processes can account for up to 80% of the total production cost. Coupled with the emergence of new classes of bioproducts, for example, virus-like particles or plasmidic DNA, this has created a great need for superior alternatives. In this review, improved downstream technologies, including aqueous two-phase systems, expanded bed adsorption chromatography, convective flow systems, and fibre-based adsorbent systems, have been discussed. These adaptive methods are more suited to the burgeoning downstream processing needs of the future, enabling the cost-efficient production of new classes biomaterials with a high degree of purity, and thereby hold the promise to become indispensable tools in the pharmaceutical and food industries.
Fil: D’Souza, Roy N.. Universitat Bremen; Alemania
Fil: Azevedo, Ana M.. Universidad de Lisboa; Portugal
Fil: Aires Barros, M. Raquel. Universidad de Lisboa; Portugal
Fil: Krajnc, Nika Lendero. BIA Separations; Eslovenia
Fil: Kramberger, Petra. BIA Separations; Eslovenia
Fil: Carbajal, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Grasselli, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Meyer, Ronald. Universitat Bremen; Alemania
Fil: Fernandez Lahore, Marcelo. Universitat Bremen; Alemania
Materia
Monoclonal antibodies
pDNA
Virus-like particle
Aqueous two-phase separation
Expanded bed adsorption chromatography
Monolith
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/23762
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/23762
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Emerging technologies for the integration and intensification of downstream bioprocessesD’Souza, Roy N.Azevedo, Ana M.Aires Barros, M. RaquelKrajnc, Nika LenderoKramberger, PetraCarbajal, Maria LauraGrasselli, MarianoMeyer, RonaldFernandez Lahore, MarceloMonoclonal antibodiespDNAVirus-like particleAqueous two-phase separationExpanded bed adsorption chromatographyMonolithhttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2Downstream processing is currently the major bottleneck for bioproduct generation. In contrast to the advances in fermentation processes, the tools used for downstream processes have struggled to keep pace in the last 20 years. Purification bottlenecks are quite serious, as these processes can account for up to 80% of the total production cost. Coupled with the emergence of new classes of bioproducts, for example, virus-like particles or plasmidic DNA, this has created a great need for superior alternatives. In this review, improved downstream technologies, including aqueous two-phase systems, expanded bed adsorption chromatography, convective flow systems, and fibre-based adsorbent systems, have been discussed. These adaptive methods are more suited to the burgeoning downstream processing needs of the future, enabling the cost-efficient production of new classes biomaterials with a high degree of purity, and thereby hold the promise to become indispensable tools in the pharmaceutical and food industries.Fil: D’Souza, Roy N.. Universitat Bremen; AlemaniaFil: Azevedo, Ana M.. Universidad de Lisboa; PortugalFil: Aires Barros, M. Raquel. Universidad de Lisboa; PortugalFil: Krajnc, Nika Lendero. BIA Separations; EsloveniaFil: Kramberger, Petra. BIA Separations; EsloveniaFil: Carbajal, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Grasselli, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Meyer, Ronald. Universitat Bremen; AlemaniaFil: Fernandez Lahore, Marcelo. Universitat Bremen; AlemaniaFuture Science Ltd.2013-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/23762D’Souza, Roy N.; Azevedo, Ana M.; Aires Barros, M. Raquel; Krajnc, Nika Lendero; Kramberger, Petra; et al.; Emerging technologies for the integration and intensification of downstream bioprocesses; Future Science Ltd.; Pharmaceutical Bioprocessing; 1; 5; 1-2013; 423-4402048-9145CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.openaccessjournals.com/abstract/emerging-technologies-for-the-integration-and-intensification-of-downstream-bioprocesses-8126.htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-01-08T12:47:56Zoai:ri.conicet.gov.ar:11336/23762instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-01-08 12:47:56.739CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Emerging technologies for the integration and intensification of downstream bioprocesses
title Emerging technologies for the integration and intensification of downstream bioprocesses
spellingShingle Emerging technologies for the integration and intensification of downstream bioprocesses
D’Souza, Roy N.
Monoclonal antibodies
pDNA
Virus-like particle
Aqueous two-phase separation
Expanded bed adsorption chromatography
Monolith
title_short Emerging technologies for the integration and intensification of downstream bioprocesses
title_full Emerging technologies for the integration and intensification of downstream bioprocesses
title_fullStr Emerging technologies for the integration and intensification of downstream bioprocesses
title_full_unstemmed Emerging technologies for the integration and intensification of downstream bioprocesses
title_sort Emerging technologies for the integration and intensification of downstream bioprocesses
dc.creator.none.fl_str_mv D’Souza, Roy N.
Azevedo, Ana M.
Aires Barros, M. Raquel
Krajnc, Nika Lendero
Kramberger, Petra
Carbajal, Maria Laura
Grasselli, Mariano
Meyer, Ronald
Fernandez Lahore, Marcelo
author D’Souza, Roy N.
author_facet D’Souza, Roy N.
Azevedo, Ana M.
Aires Barros, M. Raquel
Krajnc, Nika Lendero
Kramberger, Petra
Carbajal, Maria Laura
Grasselli, Mariano
Meyer, Ronald
Fernandez Lahore, Marcelo
author_role author
author2 Azevedo, Ana M.
Aires Barros, M. Raquel
Krajnc, Nika Lendero
Kramberger, Petra
Carbajal, Maria Laura
Grasselli, Mariano
Meyer, Ronald
Fernandez Lahore, Marcelo
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Monoclonal antibodies
pDNA
Virus-like particle
Aqueous two-phase separation
Expanded bed adsorption chromatography
Monolith
topic Monoclonal antibodies
pDNA
Virus-like particle
Aqueous two-phase separation
Expanded bed adsorption chromatography
Monolith
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Downstream processing is currently the major bottleneck for bioproduct generation. In contrast to the advances in fermentation processes, the tools used for downstream processes have struggled to keep pace in the last 20 years. Purification bottlenecks are quite serious, as these processes can account for up to 80% of the total production cost. Coupled with the emergence of new classes of bioproducts, for example, virus-like particles or plasmidic DNA, this has created a great need for superior alternatives. In this review, improved downstream technologies, including aqueous two-phase systems, expanded bed adsorption chromatography, convective flow systems, and fibre-based adsorbent systems, have been discussed. These adaptive methods are more suited to the burgeoning downstream processing needs of the future, enabling the cost-efficient production of new classes biomaterials with a high degree of purity, and thereby hold the promise to become indispensable tools in the pharmaceutical and food industries.
Fil: D’Souza, Roy N.. Universitat Bremen; Alemania
Fil: Azevedo, Ana M.. Universidad de Lisboa; Portugal
Fil: Aires Barros, M. Raquel. Universidad de Lisboa; Portugal
Fil: Krajnc, Nika Lendero. BIA Separations; Eslovenia
Fil: Kramberger, Petra. BIA Separations; Eslovenia
Fil: Carbajal, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Grasselli, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Meyer, Ronald. Universitat Bremen; Alemania
Fil: Fernandez Lahore, Marcelo. Universitat Bremen; Alemania
description Downstream processing is currently the major bottleneck for bioproduct generation. In contrast to the advances in fermentation processes, the tools used for downstream processes have struggled to keep pace in the last 20 years. Purification bottlenecks are quite serious, as these processes can account for up to 80% of the total production cost. Coupled with the emergence of new classes of bioproducts, for example, virus-like particles or plasmidic DNA, this has created a great need for superior alternatives. In this review, improved downstream technologies, including aqueous two-phase systems, expanded bed adsorption chromatography, convective flow systems, and fibre-based adsorbent systems, have been discussed. These adaptive methods are more suited to the burgeoning downstream processing needs of the future, enabling the cost-efficient production of new classes biomaterials with a high degree of purity, and thereby hold the promise to become indispensable tools in the pharmaceutical and food industries.
publishDate 2013
dc.date.none.fl_str_mv 2013-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/23762
D’Souza, Roy N.; Azevedo, Ana M.; Aires Barros, M. Raquel; Krajnc, Nika Lendero; Kramberger, Petra; et al.; Emerging technologies for the integration and intensification of downstream bioprocesses; Future Science Ltd.; Pharmaceutical Bioprocessing; 1; 5; 1-2013; 423-440
2048-9145
CONICET Digital
CONICET
url http://hdl.handle.net/11336/23762
identifier_str_mv D’Souza, Roy N.; Azevedo, Ana M.; Aires Barros, M. Raquel; Krajnc, Nika Lendero; Kramberger, Petra; et al.; Emerging technologies for the integration and intensification of downstream bioprocesses; Future Science Ltd.; Pharmaceutical Bioprocessing; 1; 5; 1-2013; 423-440
2048-9145
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.openaccessjournals.com/abstract/emerging-technologies-for-the-integration-and-intensification-of-downstream-bioprocesses-8126.html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Future Science Ltd.
publisher.none.fl_str_mv Future Science Ltd.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.25844

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