Functionalization of hydroxyapatite scaffolds with ZnO

Autores
Martinez, Cristian; Gilabert, Ulises Eduardo; Garrido, Liliana Beatriz; Rosenbusch, Mariana Lidia; Ozols, Andres
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This paper analyzes the effectiveness of a new method for treating the surface of bioceramics scaffolds intended for bone substitutes (SO). This employs hydroxyapatite (Ca5(PO4)3(OH), HA) obtained from the chemical treatment (weak acid) and pyrolysis (at 900°C) of fresh bovine bone. The inorganic matrix is formed by an interconnected pore structure and hydrophilic, very similar to the human cancellous bone, which is used in reconstructive surgery. The SO biologic response can be improved by surface modification with Zn, element known for its antibacterial action. The Zn fixing in HA is frequently performed by chemicalsynthesis processes, where Zn2 +, Ca2 + and PO43- ions co-precipitation processes take place. The proposed method begins with the chemical treatment of the HA with an aqueous solution of phosphoric acid (30 wt. %). These scaffolds are submerged (under vacuum) in a dispersion of ZnO in an alcohol-glycerin solution, which allows relatively uniform distribution of oxide on the porous medium, when it is dried. The Zn chemical bonding on HA surface is accomplished by sintering (900 to 1100°C). This promotes a solid state reaction, which leads to the formation of Zn phosphates (in hydrated and non-hydrated forms), according to the analysis of X-ray diffraction, energy spectroscopy and electron microscopy observation. This process is of simpleimplementation and it would allow SO functionalization with other therapeutic agents of interest, represented by different ions.
Fil: Martinez, Cristian. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina. Universidad Nacional de Cuyo. Facultad de Odontologia; Argentina
Fil: Gilabert, Ulises Eduardo. Secretaría de Industria y Minería. Servicio Geológico Minero Argentino; Argentina
Fil: Garrido, Liliana Beatriz. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Tecnología de Recursos Minerales y Cerámica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Tecnología de Recursos Minerales y Cerámica; Argentina
Fil: Rosenbusch, Mariana Lidia. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes. Gerencia de Investigación y Aplicaciones; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ozols, Andres. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
HYDROXYPATITE
BIOCERAMIC FUNCTIONALIZATION
ZNO
BONE SUBSTITUTES
POROUS SCAFFOLDS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/113100
Acceder
id CONICETDig_b303017122f6c106ba97a8472b64fba2
oai_identifier_str oai:ri.conicet.gov.ar:11336/113100
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Functionalization of hydroxyapatite scaffolds with ZnOMartinez, CristianGilabert, Ulises EduardoGarrido, Liliana BeatrizRosenbusch, Mariana LidiaOzols, AndresHYDROXYPATITEBIOCERAMIC FUNCTIONALIZATIONZNOBONE SUBSTITUTESPOROUS SCAFFOLDShttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3This paper analyzes the effectiveness of a new method for treating the surface of bioceramics scaffolds intended for bone substitutes (SO). This employs hydroxyapatite (Ca5(PO4)3(OH), HA) obtained from the chemical treatment (weak acid) and pyrolysis (at 900°C) of fresh bovine bone. The inorganic matrix is formed by an interconnected pore structure and hydrophilic, very similar to the human cancellous bone, which is used in reconstructive surgery. The SO biologic response can be improved by surface modification with Zn, element known for its antibacterial action. The Zn fixing in HA is frequently performed by chemicalsynthesis processes, where Zn2 +, Ca2 + and PO43- ions co-precipitation processes take place. The proposed method begins with the chemical treatment of the HA with an aqueous solution of phosphoric acid (30 wt. %). These scaffolds are submerged (under vacuum) in a dispersion of ZnO in an alcohol-glycerin solution, which allows relatively uniform distribution of oxide on the porous medium, when it is dried. The Zn chemical bonding on HA surface is accomplished by sintering (900 to 1100°C). This promotes a solid state reaction, which leads to the formation of Zn phosphates (in hydrated and non-hydrated forms), according to the analysis of X-ray diffraction, energy spectroscopy and electron microscopy observation. This process is of simpleimplementation and it would allow SO functionalization with other therapeutic agents of interest, represented by different ions.Fil: Martinez, Cristian. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina. Universidad Nacional de Cuyo. Facultad de Odontologia; ArgentinaFil: Gilabert, Ulises Eduardo. Secretaría de Industria y Minería. Servicio Geológico Minero Argentino; ArgentinaFil: Garrido, Liliana Beatriz. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Tecnología de Recursos Minerales y Cerámica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Tecnología de Recursos Minerales y Cerámica; ArgentinaFil: Rosenbusch, Mariana Lidia. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes. Gerencia de Investigación y Aplicaciones; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ozols, Andres. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/113100Martinez, Cristian; Gilabert, Ulises Eduardo; Garrido, Liliana Beatriz; Rosenbusch, Mariana Lidia; Ozols, Andres; Functionalization of hydroxyapatite scaffolds with ZnO; Elsevier; Procedia Materials Science; 9; 9-2015; 484-4902211-8128CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211812815002047info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mspro.2015.05.020info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:33:51Zoai:ri.conicet.gov.ar:11336/113100instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:33:51.645CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Functionalization of hydroxyapatite scaffolds with ZnO
title Functionalization of hydroxyapatite scaffolds with ZnO
spellingShingle Functionalization of hydroxyapatite scaffolds with ZnO
Martinez, Cristian
HYDROXYPATITE
BIOCERAMIC FUNCTIONALIZATION
ZNO
BONE SUBSTITUTES
POROUS SCAFFOLDS
title_short Functionalization of hydroxyapatite scaffolds with ZnO
title_full Functionalization of hydroxyapatite scaffolds with ZnO
title_fullStr Functionalization of hydroxyapatite scaffolds with ZnO
title_full_unstemmed Functionalization of hydroxyapatite scaffolds with ZnO
title_sort Functionalization of hydroxyapatite scaffolds with ZnO
dc.creator.none.fl_str_mv Martinez, Cristian
Gilabert, Ulises Eduardo
Garrido, Liliana Beatriz
Rosenbusch, Mariana Lidia
Ozols, Andres
author Martinez, Cristian
author_facet Martinez, Cristian
Gilabert, Ulises Eduardo
Garrido, Liliana Beatriz
Rosenbusch, Mariana Lidia
Ozols, Andres
author_role author
author2 Gilabert, Ulises Eduardo
Garrido, Liliana Beatriz
Rosenbusch, Mariana Lidia
Ozols, Andres
author2_role author
author
author
author
dc.subject.none.fl_str_mv HYDROXYPATITE
BIOCERAMIC FUNCTIONALIZATION
ZNO
BONE SUBSTITUTES
POROUS SCAFFOLDS
topic HYDROXYPATITE
BIOCERAMIC FUNCTIONALIZATION
ZNO
BONE SUBSTITUTES
POROUS SCAFFOLDS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This paper analyzes the effectiveness of a new method for treating the surface of bioceramics scaffolds intended for bone substitutes (SO). This employs hydroxyapatite (Ca5(PO4)3(OH), HA) obtained from the chemical treatment (weak acid) and pyrolysis (at 900°C) of fresh bovine bone. The inorganic matrix is formed by an interconnected pore structure and hydrophilic, very similar to the human cancellous bone, which is used in reconstructive surgery. The SO biologic response can be improved by surface modification with Zn, element known for its antibacterial action. The Zn fixing in HA is frequently performed by chemicalsynthesis processes, where Zn2 +, Ca2 + and PO43- ions co-precipitation processes take place. The proposed method begins with the chemical treatment of the HA with an aqueous solution of phosphoric acid (30 wt. %). These scaffolds are submerged (under vacuum) in a dispersion of ZnO in an alcohol-glycerin solution, which allows relatively uniform distribution of oxide on the porous medium, when it is dried. The Zn chemical bonding on HA surface is accomplished by sintering (900 to 1100°C). This promotes a solid state reaction, which leads to the formation of Zn phosphates (in hydrated and non-hydrated forms), according to the analysis of X-ray diffraction, energy spectroscopy and electron microscopy observation. This process is of simpleimplementation and it would allow SO functionalization with other therapeutic agents of interest, represented by different ions.
Fil: Martinez, Cristian. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina. Universidad Nacional de Cuyo. Facultad de Odontologia; Argentina
Fil: Gilabert, Ulises Eduardo. Secretaría de Industria y Minería. Servicio Geológico Minero Argentino; Argentina
Fil: Garrido, Liliana Beatriz. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Tecnología de Recursos Minerales y Cerámica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Tecnología de Recursos Minerales y Cerámica; Argentina
Fil: Rosenbusch, Mariana Lidia. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes. Gerencia de Investigación y Aplicaciones; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ozols, Andres. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description This paper analyzes the effectiveness of a new method for treating the surface of bioceramics scaffolds intended for bone substitutes (SO). This employs hydroxyapatite (Ca5(PO4)3(OH), HA) obtained from the chemical treatment (weak acid) and pyrolysis (at 900°C) of fresh bovine bone. The inorganic matrix is formed by an interconnected pore structure and hydrophilic, very similar to the human cancellous bone, which is used in reconstructive surgery. The SO biologic response can be improved by surface modification with Zn, element known for its antibacterial action. The Zn fixing in HA is frequently performed by chemicalsynthesis processes, where Zn2 +, Ca2 + and PO43- ions co-precipitation processes take place. The proposed method begins with the chemical treatment of the HA with an aqueous solution of phosphoric acid (30 wt. %). These scaffolds are submerged (under vacuum) in a dispersion of ZnO in an alcohol-glycerin solution, which allows relatively uniform distribution of oxide on the porous medium, when it is dried. The Zn chemical bonding on HA surface is accomplished by sintering (900 to 1100°C). This promotes a solid state reaction, which leads to the formation of Zn phosphates (in hydrated and non-hydrated forms), according to the analysis of X-ray diffraction, energy spectroscopy and electron microscopy observation. This process is of simpleimplementation and it would allow SO functionalization with other therapeutic agents of interest, represented by different ions.
publishDate 2015
dc.date.none.fl_str_mv 2015-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/113100
Martinez, Cristian; Gilabert, Ulises Eduardo; Garrido, Liliana Beatriz; Rosenbusch, Mariana Lidia; Ozols, Andres; Functionalization of hydroxyapatite scaffolds with ZnO; Elsevier; Procedia Materials Science; 9; 9-2015; 484-490
2211-8128
CONICET Digital
CONICET
url http://hdl.handle.net/11336/113100
identifier_str_mv Martinez, Cristian; Gilabert, Ulises Eduardo; Garrido, Liliana Beatriz; Rosenbusch, Mariana Lidia; Ozols, Andres; Functionalization of hydroxyapatite scaffolds with ZnO; Elsevier; Procedia Materials Science; 9; 9-2015; 484-490
2211-8128
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211812815002047
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mspro.2015.05.020
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083467840847872
score 13.22299

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