Functionalization of hydroxyapatite scaffolds with ZnO
- Autores
- Martinez, Cristian; Gilabert, Ulises Eduardo; Garrido, Liliana Beatriz; Rosenbusch, Mariana Lidia; Ozols, Andres
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- This paper analyzes the effectiveness of a new method for treating the surface of bioceramics scaffolds intended for bone substitutes (SO). This employs hydroxyapatite (Ca5(PO4)3(OH), HA) obtained from the chemical treatment (weak acid) and pyrolysis (at 900°C) of fresh bovine bone. The inorganic matrix is formed by an interconnected pore structure and hydrophilic, very similar to the human cancellous bone, which is used in reconstructive surgery. The SO biologic response can be improved by surface modification with Zn, element known for its antibacterial action. The Zn fixing in HA is frequently performed by chemicalsynthesis processes, where Zn2 +, Ca2 + and PO43- ions co-precipitation processes take place. The proposed method begins with the chemical treatment of the HA with an aqueous solution of phosphoric acid (30 wt. %). These scaffolds are submerged (under vacuum) in a dispersion of ZnO in an alcohol-glycerin solution, which allows relatively uniform distribution of oxide on the porous medium, when it is dried. The Zn chemical bonding on HA surface is accomplished by sintering (900 to 1100°C). This promotes a solid state reaction, which leads to the formation of Zn phosphates (in hydrated and non-hydrated forms), according to the analysis of X-ray diffraction, energy spectroscopy and electron microscopy observation. This process is of simpleimplementation and it would allow SO functionalization with other therapeutic agents of interest, represented by different ions.
Fil: Martinez, Cristian. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina. Universidad Nacional de Cuyo. Facultad de Odontologia; Argentina
Fil: Gilabert, Ulises Eduardo. Secretaría de Industria y Minería. Servicio Geológico Minero Argentino; Argentina
Fil: Garrido, Liliana Beatriz. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Tecnología de Recursos Minerales y Cerámica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Tecnología de Recursos Minerales y Cerámica; Argentina
Fil: Rosenbusch, Mariana Lidia. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes. Gerencia de Investigación y Aplicaciones; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ozols, Andres. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
HYDROXYPATITE
BIOCERAMIC FUNCTIONALIZATION
ZNO
BONE SUBSTITUTES
POROUS SCAFFOLDS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/113100
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/113100 |
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CONICET Digital (CONICET) |
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Functionalization of hydroxyapatite scaffolds with ZnOMartinez, CristianGilabert, Ulises EduardoGarrido, Liliana BeatrizRosenbusch, Mariana LidiaOzols, AndresHYDROXYPATITEBIOCERAMIC FUNCTIONALIZATIONZNOBONE SUBSTITUTESPOROUS SCAFFOLDShttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3This paper analyzes the effectiveness of a new method for treating the surface of bioceramics scaffolds intended for bone substitutes (SO). This employs hydroxyapatite (Ca5(PO4)3(OH), HA) obtained from the chemical treatment (weak acid) and pyrolysis (at 900°C) of fresh bovine bone. The inorganic matrix is formed by an interconnected pore structure and hydrophilic, very similar to the human cancellous bone, which is used in reconstructive surgery. The SO biologic response can be improved by surface modification with Zn, element known for its antibacterial action. The Zn fixing in HA is frequently performed by chemicalsynthesis processes, where Zn2 +, Ca2 + and PO43- ions co-precipitation processes take place. The proposed method begins with the chemical treatment of the HA with an aqueous solution of phosphoric acid (30 wt. %). These scaffolds are submerged (under vacuum) in a dispersion of ZnO in an alcohol-glycerin solution, which allows relatively uniform distribution of oxide on the porous medium, when it is dried. The Zn chemical bonding on HA surface is accomplished by sintering (900 to 1100°C). This promotes a solid state reaction, which leads to the formation of Zn phosphates (in hydrated and non-hydrated forms), according to the analysis of X-ray diffraction, energy spectroscopy and electron microscopy observation. This process is of simpleimplementation and it would allow SO functionalization with other therapeutic agents of interest, represented by different ions.Fil: Martinez, Cristian. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina. Universidad Nacional de Cuyo. Facultad de Odontologia; ArgentinaFil: Gilabert, Ulises Eduardo. Secretaría de Industria y Minería. Servicio Geológico Minero Argentino; ArgentinaFil: Garrido, Liliana Beatriz. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Tecnología de Recursos Minerales y Cerámica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Tecnología de Recursos Minerales y Cerámica; ArgentinaFil: Rosenbusch, Mariana Lidia. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes. Gerencia de Investigación y Aplicaciones; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ozols, Andres. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/113100Martinez, Cristian; Gilabert, Ulises Eduardo; Garrido, Liliana Beatriz; Rosenbusch, Mariana Lidia; Ozols, Andres; Functionalization of hydroxyapatite scaffolds with ZnO; Elsevier; Procedia Materials Science; 9; 9-2015; 484-4902211-8128CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211812815002047info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mspro.2015.05.020info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:36:15Zoai:ri.conicet.gov.ar:11336/113100instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:36:15.386CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Functionalization of hydroxyapatite scaffolds with ZnO |
title |
Functionalization of hydroxyapatite scaffolds with ZnO |
spellingShingle |
Functionalization of hydroxyapatite scaffolds with ZnO Martinez, Cristian HYDROXYPATITE BIOCERAMIC FUNCTIONALIZATION ZNO BONE SUBSTITUTES POROUS SCAFFOLDS |
title_short |
Functionalization of hydroxyapatite scaffolds with ZnO |
title_full |
Functionalization of hydroxyapatite scaffolds with ZnO |
title_fullStr |
Functionalization of hydroxyapatite scaffolds with ZnO |
title_full_unstemmed |
Functionalization of hydroxyapatite scaffolds with ZnO |
title_sort |
Functionalization of hydroxyapatite scaffolds with ZnO |
dc.creator.none.fl_str_mv |
Martinez, Cristian Gilabert, Ulises Eduardo Garrido, Liliana Beatriz Rosenbusch, Mariana Lidia Ozols, Andres |
author |
Martinez, Cristian |
author_facet |
Martinez, Cristian Gilabert, Ulises Eduardo Garrido, Liliana Beatriz Rosenbusch, Mariana Lidia Ozols, Andres |
author_role |
author |
author2 |
Gilabert, Ulises Eduardo Garrido, Liliana Beatriz Rosenbusch, Mariana Lidia Ozols, Andres |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
HYDROXYPATITE BIOCERAMIC FUNCTIONALIZATION ZNO BONE SUBSTITUTES POROUS SCAFFOLDS |
topic |
HYDROXYPATITE BIOCERAMIC FUNCTIONALIZATION ZNO BONE SUBSTITUTES POROUS SCAFFOLDS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.4 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
This paper analyzes the effectiveness of a new method for treating the surface of bioceramics scaffolds intended for bone substitutes (SO). This employs hydroxyapatite (Ca5(PO4)3(OH), HA) obtained from the chemical treatment (weak acid) and pyrolysis (at 900°C) of fresh bovine bone. The inorganic matrix is formed by an interconnected pore structure and hydrophilic, very similar to the human cancellous bone, which is used in reconstructive surgery. The SO biologic response can be improved by surface modification with Zn, element known for its antibacterial action. The Zn fixing in HA is frequently performed by chemicalsynthesis processes, where Zn2 +, Ca2 + and PO43- ions co-precipitation processes take place. The proposed method begins with the chemical treatment of the HA with an aqueous solution of phosphoric acid (30 wt. %). These scaffolds are submerged (under vacuum) in a dispersion of ZnO in an alcohol-glycerin solution, which allows relatively uniform distribution of oxide on the porous medium, when it is dried. The Zn chemical bonding on HA surface is accomplished by sintering (900 to 1100°C). This promotes a solid state reaction, which leads to the formation of Zn phosphates (in hydrated and non-hydrated forms), according to the analysis of X-ray diffraction, energy spectroscopy and electron microscopy observation. This process is of simpleimplementation and it would allow SO functionalization with other therapeutic agents of interest, represented by different ions. Fil: Martinez, Cristian. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina. Universidad Nacional de Cuyo. Facultad de Odontologia; Argentina Fil: Gilabert, Ulises Eduardo. Secretaría de Industria y Minería. Servicio Geológico Minero Argentino; Argentina Fil: Garrido, Liliana Beatriz. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Tecnología de Recursos Minerales y Cerámica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Tecnología de Recursos Minerales y Cerámica; Argentina Fil: Rosenbusch, Mariana Lidia. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes. Gerencia de Investigación y Aplicaciones; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Ozols, Andres. Universidad de Buenos Aires. Facultad de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
This paper analyzes the effectiveness of a new method for treating the surface of bioceramics scaffolds intended for bone substitutes (SO). This employs hydroxyapatite (Ca5(PO4)3(OH), HA) obtained from the chemical treatment (weak acid) and pyrolysis (at 900°C) of fresh bovine bone. The inorganic matrix is formed by an interconnected pore structure and hydrophilic, very similar to the human cancellous bone, which is used in reconstructive surgery. The SO biologic response can be improved by surface modification with Zn, element known for its antibacterial action. The Zn fixing in HA is frequently performed by chemicalsynthesis processes, where Zn2 +, Ca2 + and PO43- ions co-precipitation processes take place. The proposed method begins with the chemical treatment of the HA with an aqueous solution of phosphoric acid (30 wt. %). These scaffolds are submerged (under vacuum) in a dispersion of ZnO in an alcohol-glycerin solution, which allows relatively uniform distribution of oxide on the porous medium, when it is dried. The Zn chemical bonding on HA surface is accomplished by sintering (900 to 1100°C). This promotes a solid state reaction, which leads to the formation of Zn phosphates (in hydrated and non-hydrated forms), according to the analysis of X-ray diffraction, energy spectroscopy and electron microscopy observation. This process is of simpleimplementation and it would allow SO functionalization with other therapeutic agents of interest, represented by different ions. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/113100 Martinez, Cristian; Gilabert, Ulises Eduardo; Garrido, Liliana Beatriz; Rosenbusch, Mariana Lidia; Ozols, Andres; Functionalization of hydroxyapatite scaffolds with ZnO; Elsevier; Procedia Materials Science; 9; 9-2015; 484-490 2211-8128 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/113100 |
identifier_str_mv |
Martinez, Cristian; Gilabert, Ulises Eduardo; Garrido, Liliana Beatriz; Rosenbusch, Mariana Lidia; Ozols, Andres; Functionalization of hydroxyapatite scaffolds with ZnO; Elsevier; Procedia Materials Science; 9; 9-2015; 484-490 2211-8128 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211812815002047 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mspro.2015.05.020 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614382767570944 |
score |
13.070432 |