Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA

Autores
Garabalino, Marcela Alejandra; Heber, Elisa Mercedes; Monti Hughes, Andrea; Pozzi, Emiliano César Cayetano; Molinari, Ana Julia; Nigg, David W.; Bauer, William; Trivillin, Verónica Andrea; Schwint, Amanda Elena
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Sodium mercaptoundecahydro-closo-dodecaborate (BSH) is being investigated clinically for BNCT. We examined the biodistribution of BSH and BPA administered jointly in different proportions in the hamster cheek pouch oral cancer model. The 3 assayed protocols were non-toxic, and showed preferential tumor boron uptake versus precancerous and normal tissue and therapeutic tumor boron concentration values (70-85ppm). All 3 protocols warrant assessment in BNCT studies to contribute to the knowledge of (BSH+BPA)-BNCT radiobiology for head and neck cancer and optimize therapeutic efficacy.
Fil: Garabalino, Marcela Alejandra. Comisión Nacional de Energía Atómica; Argentina
Fil: Heber, Elisa Mercedes. Comisión Nacional de Energía Atómica; Argentina
Fil: Monti Hughes, Andrea. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pozzi, Emiliano César Cayetano. Comisión Nacional de Energía Atómica; Argentina
Fil: Molinari, Ana Julia. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Nigg, David W.. Idaho National Laboratory; Estados Unidos
Fil: Bauer, William. Idaho National Laboratory; Estados Unidos
Fil: Trivillin, Verónica Andrea. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Schwint, Amanda Elena. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Boron Neutron Capture Therapy
Bnct
Oral Cancer
Bpa
Bsh
Hamster Cheek Pouch Oral Cancer Model
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24103
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/24103
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPAGarabalino, Marcela AlejandraHeber, Elisa MercedesMonti Hughes, AndreaPozzi, Emiliano César CayetanoMolinari, Ana JuliaNigg, David W.Bauer, WilliamTrivillin, Verónica AndreaSchwint, Amanda ElenaBoron Neutron Capture TherapyBnctOral CancerBpaBshHamster Cheek Pouch Oral Cancer Modelhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Sodium mercaptoundecahydro-closo-dodecaborate (BSH) is being investigated clinically for BNCT. We examined the biodistribution of BSH and BPA administered jointly in different proportions in the hamster cheek pouch oral cancer model. The 3 assayed protocols were non-toxic, and showed preferential tumor boron uptake versus precancerous and normal tissue and therapeutic tumor boron concentration values (70-85ppm). All 3 protocols warrant assessment in BNCT studies to contribute to the knowledge of (BSH+BPA)-BNCT radiobiology for head and neck cancer and optimize therapeutic efficacy.Fil: Garabalino, Marcela Alejandra. Comisión Nacional de Energía Atómica; ArgentinaFil: Heber, Elisa Mercedes. Comisión Nacional de Energía Atómica; ArgentinaFil: Monti Hughes, Andrea. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pozzi, Emiliano César Cayetano. Comisión Nacional de Energía Atómica; ArgentinaFil: Molinari, Ana Julia. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Nigg, David W.. Idaho National Laboratory; Estados UnidosFil: Bauer, William. Idaho National Laboratory; Estados UnidosFil: Trivillin, Verónica Andrea. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Schwint, Amanda Elena. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2013-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24103Garabalino, Marcela Alejandra; Heber, Elisa Mercedes; Monti Hughes, Andrea; Pozzi, Emiliano César Cayetano; Molinari, Ana Julia; et al.; Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA; Elsevier; Applied Radiation and Isotopes; 88; 12-2013; 64-680969-8043CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.apradiso.2013.11.118info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0969804313005678info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:34Zoai:ri.conicet.gov.ar:11336/24103instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:34.35CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA
title Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA
spellingShingle Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA
Garabalino, Marcela Alejandra
Boron Neutron Capture Therapy
Bnct
Oral Cancer
Bpa
Bsh
Hamster Cheek Pouch Oral Cancer Model
title_short Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA
title_full Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA
title_fullStr Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA
title_full_unstemmed Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA
title_sort Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA
dc.creator.none.fl_str_mv Garabalino, Marcela Alejandra
Heber, Elisa Mercedes
Monti Hughes, Andrea
Pozzi, Emiliano César Cayetano
Molinari, Ana Julia
Nigg, David W.
Bauer, William
Trivillin, Verónica Andrea
Schwint, Amanda Elena
author Garabalino, Marcela Alejandra
author_facet Garabalino, Marcela Alejandra
Heber, Elisa Mercedes
Monti Hughes, Andrea
Pozzi, Emiliano César Cayetano
Molinari, Ana Julia
Nigg, David W.
Bauer, William
Trivillin, Verónica Andrea
Schwint, Amanda Elena
author_role author
author2 Heber, Elisa Mercedes
Monti Hughes, Andrea
Pozzi, Emiliano César Cayetano
Molinari, Ana Julia
Nigg, David W.
Bauer, William
Trivillin, Verónica Andrea
Schwint, Amanda Elena
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Boron Neutron Capture Therapy
Bnct
Oral Cancer
Bpa
Bsh
Hamster Cheek Pouch Oral Cancer Model
topic Boron Neutron Capture Therapy
Bnct
Oral Cancer
Bpa
Bsh
Hamster Cheek Pouch Oral Cancer Model
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Sodium mercaptoundecahydro-closo-dodecaborate (BSH) is being investigated clinically for BNCT. We examined the biodistribution of BSH and BPA administered jointly in different proportions in the hamster cheek pouch oral cancer model. The 3 assayed protocols were non-toxic, and showed preferential tumor boron uptake versus precancerous and normal tissue and therapeutic tumor boron concentration values (70-85ppm). All 3 protocols warrant assessment in BNCT studies to contribute to the knowledge of (BSH+BPA)-BNCT radiobiology for head and neck cancer and optimize therapeutic efficacy.
Fil: Garabalino, Marcela Alejandra. Comisión Nacional de Energía Atómica; Argentina
Fil: Heber, Elisa Mercedes. Comisión Nacional de Energía Atómica; Argentina
Fil: Monti Hughes, Andrea. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Pozzi, Emiliano César Cayetano. Comisión Nacional de Energía Atómica; Argentina
Fil: Molinari, Ana Julia. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Nigg, David W.. Idaho National Laboratory; Estados Unidos
Fil: Bauer, William. Idaho National Laboratory; Estados Unidos
Fil: Trivillin, Verónica Andrea. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Schwint, Amanda Elena. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Sodium mercaptoundecahydro-closo-dodecaborate (BSH) is being investigated clinically for BNCT. We examined the biodistribution of BSH and BPA administered jointly in different proportions in the hamster cheek pouch oral cancer model. The 3 assayed protocols were non-toxic, and showed preferential tumor boron uptake versus precancerous and normal tissue and therapeutic tumor boron concentration values (70-85ppm). All 3 protocols warrant assessment in BNCT studies to contribute to the knowledge of (BSH+BPA)-BNCT radiobiology for head and neck cancer and optimize therapeutic efficacy.
publishDate 2013
dc.date.none.fl_str_mv 2013-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24103
Garabalino, Marcela Alejandra; Heber, Elisa Mercedes; Monti Hughes, Andrea; Pozzi, Emiliano César Cayetano; Molinari, Ana Julia; et al.; Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA; Elsevier; Applied Radiation and Isotopes; 88; 12-2013; 64-68
0969-8043
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24103
identifier_str_mv Garabalino, Marcela Alejandra; Heber, Elisa Mercedes; Monti Hughes, Andrea; Pozzi, Emiliano César Cayetano; Molinari, Ana Julia; et al.; Boron biodistribution for BNCT in the hamster cheek pouch oral cancer model: Combined administration of BSH and BPA; Elsevier; Applied Radiation and Isotopes; 88; 12-2013; 64-68
0969-8043
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.apradiso.2013.11.118
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0969804313005678
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269917465804800
score 13.13397

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