Boron neutron capture therapy (BNCT) inhibits tumor development from precancerous tissue: An experimental study that supports a potential new application of BNCT

Autores
Monti Hughes, Andrea; Heber, Elisa Mercedes; Pozzi, Emiliano César Cayetano; Nigg, D. W.; Calzetta, O.; Blaumann, Herman Roberto; Longhino, Juan Manuel; Nievas, Silvia Irene; Aromando, Romina Flavia; Itoiz, María Elina; Trivillin, Verónica Andrea; Schwint, Amanda Elena
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We previously demonstrated the efficacy of boron neutron capture therapy (BNCT) mediated by boronophenylalanine (BPA), GB-10 (Na2 10B10H10) and (GB-10+BPA) to control tumors, with no normal tissue radiotoxicity, in the hamster cheek pouch oral cancer model. Herein we developed a novel experimental model of field-cancerization and precancerous lesions (globally termed herein precancerous tissue) in the hamster cheek pouch to explore the long-term potential inhibitory effect of the same BNCT protocols on the development of second primary tumors from precancerous tissue. Clinically, second primary tumor recurrences occur in field-cancerized tissue, causing therapeutic failure. Weperformed boronbiodistribution studies followed by in vivo BNCTstudies, with 8 months followup. All 3 BNCT protocols induced a statistically significant reduction in tumor development from precancerous tissue, reaching a maximum inhibition of 77–100%. The inhibitory effect of BPA-BNCTand (GB-10+BPA)-BNCT persisted at 51% at the end of follow-up (8 months), whereas for GB-10-BNCT it faded after 2 months. Likewise, beam-only elicited a significant but transient reduction in tumor development. No normal tissue radiotoxicity was observed. At 8 months post-treatment with BPA-BNCT or (GB-10+BPA)-BNCT, the precancerous pouches that did not develop tumors had regained the macroscopic and histological appearance of normal (non-cancerized) pouches. A potential new clinical application of BNCT would lie in its capacity to inhibit local regional recurrences.
Fil: Monti Hughes, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina
Fil: Heber, Elisa Mercedes. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina
Fil: Pozzi, Emiliano César Cayetano. Comisión Nacional de Energía Atómica; Argentina
Fil: Nigg, D. W.. Idaho National Laboratory; Estados Unidos
Fil: Calzetta, O.. Comision Nacional de Energia Atomica. Centro Atomico Bariloche. Departamento de Ingeniería Nuclear; Argentina
Fil: Blaumann, Herman Roberto. Comision Nacional de Energia Atomica. Centro Atomico Bariloche. Departamento de Ingeniería Nuclear; Argentina
Fil: Longhino, Juan Manuel. Comision Nacional de Energia Atomica. Centro Atomico Bariloche. Departamento de Ingeniería Nuclear; Argentina
Fil: Nievas, Silvia Irene. Comisión Nacional de Energía Atómica; Argentina
Fil: Aromando, Romina Flavia. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Itoiz, María Elina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Trivillin, Verónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina
Fil: Schwint, Amanda Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina
Materia
BNCT
ORAL CANCER
PRECANCEROUS TISSUE
HAMSTER CHEEK POUCH
LOCOREGIONAL RECURRENCES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/157837
Acceder
id CONICETDig_2c920f7fdbf86b76da0562c2ef255752
oai_identifier_str oai:ri.conicet.gov.ar:11336/157837
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Boron neutron capture therapy (BNCT) inhibits tumor development from precancerous tissue: An experimental study that supports a potential new application of BNCTMonti Hughes, AndreaHeber, Elisa MercedesPozzi, Emiliano César CayetanoNigg, D. W.Calzetta, O.Blaumann, Herman RobertoLonghino, Juan ManuelNievas, Silvia IreneAromando, Romina FlaviaItoiz, María ElinaTrivillin, Verónica AndreaSchwint, Amanda ElenaBNCTORAL CANCERPRECANCEROUS TISSUEHAMSTER CHEEK POUCHLOCOREGIONAL RECURRENCEShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3We previously demonstrated the efficacy of boron neutron capture therapy (BNCT) mediated by boronophenylalanine (BPA), GB-10 (Na2 10B10H10) and (GB-10+BPA) to control tumors, with no normal tissue radiotoxicity, in the hamster cheek pouch oral cancer model. Herein we developed a novel experimental model of field-cancerization and precancerous lesions (globally termed herein precancerous tissue) in the hamster cheek pouch to explore the long-term potential inhibitory effect of the same BNCT protocols on the development of second primary tumors from precancerous tissue. Clinically, second primary tumor recurrences occur in field-cancerized tissue, causing therapeutic failure. Weperformed boronbiodistribution studies followed by in vivo BNCTstudies, with 8 months followup. All 3 BNCT protocols induced a statistically significant reduction in tumor development from precancerous tissue, reaching a maximum inhibition of 77–100%. The inhibitory effect of BPA-BNCTand (GB-10+BPA)-BNCT persisted at 51% at the end of follow-up (8 months), whereas for GB-10-BNCT it faded after 2 months. Likewise, beam-only elicited a significant but transient reduction in tumor development. No normal tissue radiotoxicity was observed. At 8 months post-treatment with BPA-BNCT or (GB-10+BPA)-BNCT, the precancerous pouches that did not develop tumors had regained the macroscopic and histological appearance of normal (non-cancerized) pouches. A potential new clinical application of BNCT would lie in its capacity to inhibit local regional recurrences.Fil: Monti Hughes, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; ArgentinaFil: Heber, Elisa Mercedes. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; ArgentinaFil: Pozzi, Emiliano César Cayetano. Comisión Nacional de Energía Atómica; ArgentinaFil: Nigg, D. W.. Idaho National Laboratory; Estados UnidosFil: Calzetta, O.. Comision Nacional de Energia Atomica. Centro Atomico Bariloche. Departamento de Ingeniería Nuclear; ArgentinaFil: Blaumann, Herman Roberto. Comision Nacional de Energia Atomica. Centro Atomico Bariloche. Departamento de Ingeniería Nuclear; ArgentinaFil: Longhino, Juan Manuel. Comision Nacional de Energia Atomica. Centro Atomico Bariloche. Departamento de Ingeniería Nuclear; ArgentinaFil: Nievas, Silvia Irene. Comisión Nacional de Energía Atómica; ArgentinaFil: Aromando, Romina Flavia. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Itoiz, María Elina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Trivillin, Verónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; ArgentinaFil: Schwint, Amanda Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; ArgentinaPergamon-Elsevier Science Ltd2009-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/157837Monti Hughes, Andrea; Heber, Elisa Mercedes; Pozzi, Emiliano César Cayetano; Nigg, D. W.; Calzetta, O.; et al.; Boron neutron capture therapy (BNCT) inhibits tumor development from precancerous tissue: An experimental study that supports a potential new application of BNCT; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 67; 7-8; 7-2009; 313-3170969-8043CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.apradiso.2009.03.070info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0969804309003133info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:12:06Zoai:ri.conicet.gov.ar:11336/157837instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:12:07.141CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Boron neutron capture therapy (BNCT) inhibits tumor development from precancerous tissue: An experimental study that supports a potential new application of BNCT
title Boron neutron capture therapy (BNCT) inhibits tumor development from precancerous tissue: An experimental study that supports a potential new application of BNCT
spellingShingle Boron neutron capture therapy (BNCT) inhibits tumor development from precancerous tissue: An experimental study that supports a potential new application of BNCT
Monti Hughes, Andrea
BNCT
ORAL CANCER
PRECANCEROUS TISSUE
HAMSTER CHEEK POUCH
LOCOREGIONAL RECURRENCES
title_short Boron neutron capture therapy (BNCT) inhibits tumor development from precancerous tissue: An experimental study that supports a potential new application of BNCT
title_full Boron neutron capture therapy (BNCT) inhibits tumor development from precancerous tissue: An experimental study that supports a potential new application of BNCT
title_fullStr Boron neutron capture therapy (BNCT) inhibits tumor development from precancerous tissue: An experimental study that supports a potential new application of BNCT
title_full_unstemmed Boron neutron capture therapy (BNCT) inhibits tumor development from precancerous tissue: An experimental study that supports a potential new application of BNCT
title_sort Boron neutron capture therapy (BNCT) inhibits tumor development from precancerous tissue: An experimental study that supports a potential new application of BNCT
dc.creator.none.fl_str_mv Monti Hughes, Andrea
Heber, Elisa Mercedes
Pozzi, Emiliano César Cayetano
Nigg, D. W.
Calzetta, O.
Blaumann, Herman Roberto
Longhino, Juan Manuel
Nievas, Silvia Irene
Aromando, Romina Flavia
Itoiz, María Elina
Trivillin, Verónica Andrea
Schwint, Amanda Elena
author Monti Hughes, Andrea
author_facet Monti Hughes, Andrea
Heber, Elisa Mercedes
Pozzi, Emiliano César Cayetano
Nigg, D. W.
Calzetta, O.
Blaumann, Herman Roberto
Longhino, Juan Manuel
Nievas, Silvia Irene
Aromando, Romina Flavia
Itoiz, María Elina
Trivillin, Verónica Andrea
Schwint, Amanda Elena
author_role author
author2 Heber, Elisa Mercedes
Pozzi, Emiliano César Cayetano
Nigg, D. W.
Calzetta, O.
Blaumann, Herman Roberto
Longhino, Juan Manuel
Nievas, Silvia Irene
Aromando, Romina Flavia
Itoiz, María Elina
Trivillin, Verónica Andrea
Schwint, Amanda Elena
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BNCT
ORAL CANCER
PRECANCEROUS TISSUE
HAMSTER CHEEK POUCH
LOCOREGIONAL RECURRENCES
topic BNCT
ORAL CANCER
PRECANCEROUS TISSUE
HAMSTER CHEEK POUCH
LOCOREGIONAL RECURRENCES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We previously demonstrated the efficacy of boron neutron capture therapy (BNCT) mediated by boronophenylalanine (BPA), GB-10 (Na2 10B10H10) and (GB-10+BPA) to control tumors, with no normal tissue radiotoxicity, in the hamster cheek pouch oral cancer model. Herein we developed a novel experimental model of field-cancerization and precancerous lesions (globally termed herein precancerous tissue) in the hamster cheek pouch to explore the long-term potential inhibitory effect of the same BNCT protocols on the development of second primary tumors from precancerous tissue. Clinically, second primary tumor recurrences occur in field-cancerized tissue, causing therapeutic failure. Weperformed boronbiodistribution studies followed by in vivo BNCTstudies, with 8 months followup. All 3 BNCT protocols induced a statistically significant reduction in tumor development from precancerous tissue, reaching a maximum inhibition of 77–100%. The inhibitory effect of BPA-BNCTand (GB-10+BPA)-BNCT persisted at 51% at the end of follow-up (8 months), whereas for GB-10-BNCT it faded after 2 months. Likewise, beam-only elicited a significant but transient reduction in tumor development. No normal tissue radiotoxicity was observed. At 8 months post-treatment with BPA-BNCT or (GB-10+BPA)-BNCT, the precancerous pouches that did not develop tumors had regained the macroscopic and histological appearance of normal (non-cancerized) pouches. A potential new clinical application of BNCT would lie in its capacity to inhibit local regional recurrences.
Fil: Monti Hughes, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina
Fil: Heber, Elisa Mercedes. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina
Fil: Pozzi, Emiliano César Cayetano. Comisión Nacional de Energía Atómica; Argentina
Fil: Nigg, D. W.. Idaho National Laboratory; Estados Unidos
Fil: Calzetta, O.. Comision Nacional de Energia Atomica. Centro Atomico Bariloche. Departamento de Ingeniería Nuclear; Argentina
Fil: Blaumann, Herman Roberto. Comision Nacional de Energia Atomica. Centro Atomico Bariloche. Departamento de Ingeniería Nuclear; Argentina
Fil: Longhino, Juan Manuel. Comision Nacional de Energia Atomica. Centro Atomico Bariloche. Departamento de Ingeniería Nuclear; Argentina
Fil: Nievas, Silvia Irene. Comisión Nacional de Energía Atómica; Argentina
Fil: Aromando, Romina Flavia. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Itoiz, María Elina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Trivillin, Verónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina
Fil: Schwint, Amanda Elena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia de Área de Aplicaciones de la Tecnología Nuclear. Departamento de Radiobiología; Argentina
description We previously demonstrated the efficacy of boron neutron capture therapy (BNCT) mediated by boronophenylalanine (BPA), GB-10 (Na2 10B10H10) and (GB-10+BPA) to control tumors, with no normal tissue radiotoxicity, in the hamster cheek pouch oral cancer model. Herein we developed a novel experimental model of field-cancerization and precancerous lesions (globally termed herein precancerous tissue) in the hamster cheek pouch to explore the long-term potential inhibitory effect of the same BNCT protocols on the development of second primary tumors from precancerous tissue. Clinically, second primary tumor recurrences occur in field-cancerized tissue, causing therapeutic failure. Weperformed boronbiodistribution studies followed by in vivo BNCTstudies, with 8 months followup. All 3 BNCT protocols induced a statistically significant reduction in tumor development from precancerous tissue, reaching a maximum inhibition of 77–100%. The inhibitory effect of BPA-BNCTand (GB-10+BPA)-BNCT persisted at 51% at the end of follow-up (8 months), whereas for GB-10-BNCT it faded after 2 months. Likewise, beam-only elicited a significant but transient reduction in tumor development. No normal tissue radiotoxicity was observed. At 8 months post-treatment with BPA-BNCT or (GB-10+BPA)-BNCT, the precancerous pouches that did not develop tumors had regained the macroscopic and histological appearance of normal (non-cancerized) pouches. A potential new clinical application of BNCT would lie in its capacity to inhibit local regional recurrences.
publishDate 2009
dc.date.none.fl_str_mv 2009-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/157837
Monti Hughes, Andrea; Heber, Elisa Mercedes; Pozzi, Emiliano César Cayetano; Nigg, D. W.; Calzetta, O.; et al.; Boron neutron capture therapy (BNCT) inhibits tumor development from precancerous tissue: An experimental study that supports a potential new application of BNCT; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 67; 7-8; 7-2009; 313-317
0969-8043
CONICET Digital
CONICET
url http://hdl.handle.net/11336/157837
identifier_str_mv Monti Hughes, Andrea; Heber, Elisa Mercedes; Pozzi, Emiliano César Cayetano; Nigg, D. W.; Calzetta, O.; et al.; Boron neutron capture therapy (BNCT) inhibits tumor development from precancerous tissue: An experimental study that supports a potential new application of BNCT; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 67; 7-8; 7-2009; 313-317
0969-8043
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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